Practical β-lactone synthesis: Epoxide carbonylation at 1 atm

Organic Letters

Volumn 8, Issue 17, 2006, Pages 3709-3712

  Kramer, John W ^a   Lobkovsky, Emil B ^a   Coates, Geoffrey W ^a  

^a Department of Obstetrics Gynecology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHROMIUM; EPOXIDE; KETONE; LACTONE; ORGANOMETALLIC COMPOUND;

ARTICLE; CATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; STEREOISOMERISM; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

CATALYSIS; CHROMIUM; CRYSTALLOGRAPHY, X-RAY; EPOXY COMPOUNDS; KETONES; LACTONES; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; ORGANOMETALLIC COMPOUNDS; STEREOISOMERISM;

EID: 33748590526     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol061292x     Document Type: Article

References (31)

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26. See Supporting Information.
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31. Though this procedure produces small amounts of ketone as a side product, the ketone and lactone can easily be separated because of the large disparity in their boiling points (e.g., acetone bp = 56 °C at 760 mmHg, β-butyrolactone bp = 72 °C at 29 mmHg).