Genetic variation in CYP4A11 and blood pressure response to mineralocorticoid receptor antagonism or ENaC inhibition: An exploratory pilot study in African Americans

Journal of the American Society of Hypertension

Volumn 8, Issue 7, 2014, Pages 475-480

  Laffer, Cheryl L ^a   Elijovich, Fernando ^a   Eckert, George J ^b   Tu, Wanzhu ^b,c   Pratt, J Howard ^b,d   Brown, Nancy J ^a  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^b INDIANA UNIVERSITY   (United States)

^c REGENSTRIEF INSTITUTE   (United States)

^d VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Amiloride; epithelial sodium channel; hypertension; spironolactone

Indexed keywords

AMILORIDE; CYTOCHROME P450 4A11; PLACEBO; SPIRONOLACTONE; ALDOSTERONE; AMLODIPINE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM CHANNEL BLOCKING AGENT; CREATININE; DIHYDROPYRIDINE; EPITHELIAL SODIUM CHANNEL; LOOP DIURETIC AGENT; MINOXIDIL; POTASSIUM; SODIUM; THIAZIDE DIURETIC AGENT; CYP4A11 PROTEIN, HUMAN; CYTOCHROME P450; DNA; MINERALOCORTICOID ANTAGONIST;

ADULT; AFRICAN AMERICAN; AGED; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; BLOOD PRESSURE; BLOOD PRESSURE MEASUREMENT; CONTROLLED STUDY; FEMALE; GENE LINKAGE DISEQUILIBRIUM; GENETIC ANALYSIS; GENETIC VARIABILITY; GENOTYPE; HOMOZYGOTE; HUMAN; LABORATORY TEST; MAJOR CLINICAL STUDY; MALE; PILOT STUDY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RESISTANT HYPERTENSION; TREATMENT RESPONSE; DIASTOLIC BLOOD PRESSURE; DOUBLE BLIND PROCEDURE; EXPLORATORY RESEARCH; GENE FREQUENCY; GENETIC ASSOCIATION; MONOTHERAPY; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; SYSTOLIC BLOOD PRESSURE; ADOLESCENT; DRUG EFFECTS; EPIDEMIOLOGY; ETHNOLOGY; GENETIC VARIATION; GENETICS; HYPERTENSION; METABOLISM; MIDDLE AGED; RADIOIMMUNOASSAY; UNITED STATES; YOUNG ADULT;

ADOLESCENT; ADULT; AFRICAN AMERICANS; AGED; BLOOD PRESSURE; CYTOCHROME P-450 ENZYME SYSTEM; DNA; DOUBLE-BLIND METHOD; FEMALE; GENETIC VARIATION; GENOTYPE; HUMANS; HYPERTENSION; MALE; MIDDLE AGED; MINERALOCORTICOID RECEPTOR ANTAGONISTS; PILOT PROJECTS; RADIOIMMUNOASSAY; UNITED STATES; YOUNG ADULT;

EID: 84905185150     PISSN: 19331711     EISSN: 18787436     Source Type: Journal    
DOI: 10.1016/j.jash.2014.04.011     Document Type: Article

References (22)

1. B.N. Zordoky, and A.O. El-Kadi Effect of cytochrome P450 polymorphism on arachidonic acid metabolism and their impact on cardiovascular diseases Pharmacol Ther 125 2010 446 463
2. R. Zhang, J. Lu, C. Hu, C. Wang, W. Yu, and X. Ma et al. A common polymorphism of CYP4A11 is associated with blood pressure in a Chinese population Hypertens Res 34 2011 645 648
3. J.V. Gainer, A. Bellamine, E.P. Dawson, K.E. Womble, S.W. Grant, and Y. Wang et al. Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension Circulation 111 2005 63 69 (Pubitemid 40070845)
4. B. Mayer, W. Lieb, A. Gotz, I.R. Konig, Z. Aherrahrou, and A. Thiemig et al. Association of the T8590C polymorphism of CYP4A11 with hypertension in the MONICA Augsburg echocardiographic substudy Hypertension 46 2005 766 771 (Pubitemid 43186751)
5. M. Hermann, J.P. Hellermann, K. Quitzau, M.M. Hoffmann, T. Gasser, and T. Meinertz et al. CYP4A11 polymorphism correlates with coronary endothelial dysfunction in patients with coronary artery disease-The ENCORE Trials Atherosclerosis 207 2009 476 479
6. J.V. Gainer, M.S. Lipkowitz, C. Yu, M.R. Waterman, E.P. Dawson, and J.H. Capdevila et al. Association of a CYP4A11 variant and blood pressure in black men J Am Soc Nephrol 19 2008 1606 1612
7. J.S. Williams, P.N. Hopkins, X. Jeunemaitre, and N.J. Brown CYP4A11 T8590C polymorphism, salt-sensitive hypertension, and renal blood flow J Hypertens 29 2011 1913 1918
8. K. Nakagawa, V.R. Holla, Y. Wei, W.H. Wang, A. Gatica, and S. Wei et al. Salt-sensitive hypertension is associated with dysfunctional Cyp4a10 gene and kidney epithelial sodium channel J Clin Invest 116 2006 1696 1702
9. J.H. Hansson, L. Schild, Y. Lu, T.A. Wilson, I. Gautschi, and R. Shimkets et al. A de novo missense mutation of the beta subunit of the epithelial sodium channel causes hypertension and Liddle syndrome, identifying a proline-rich segment critical for regulation of channel activity Proc Natl Acad Sci U S A 92 1995 11495 11499
10. J.H. Hansson, C. Nelson-Williams, H. Suzuki, L. Schild, R. Shimkets, and Y. Lu et al. Hypertension caused by a truncated epithelial sodium channel gamma subunit: genetic heterogeneity of Liddle syndrome Nat Genet 11 1995 76 82
11. C. Saha, G.J. Eckert, W.T. Ambrosius, T.Y. Chun, M.A. Wagner, and Q. Zhao et al. Improvement in blood pressure with inhibition of the epithelial sodium channel in blacks with hypertension Hypertension 46 2005 481 487 (Pubitemid 41376826)
12. R.G. Dluhy, L. Axelrod, R.H. Underwood, and G.H. Williams Studies of the control of plasma aldosterone concentration in normal man. II. Effect of dietary potassium and acute potassium infusion J Clin Invest 51 1972 1950 1957
13. J.H. Pratt, G.J. Eckert, S. Newman, and W.T. Ambrosius Blood pressure responses to small doses of amiloride and spironolactone in normotensive subjects Hypertension 38 2001 1124 1129 (Pubitemid 34252817)
14. The 1000 Genomes Project Consortium An integrated map of genetic variation from 1,092 human genomes Nature 491 2012 56 65
15. Y. Kakizoe, K. Kitamura, T. Ko, N. Wakida, A. Maekawa, and T. Miyoshi et al. Aberrant ENaC activation in Dahl salt-sensitive rats J Hypertens 27 2009 1679 1689
16. J.M. Williams, A. Sarkis, K.M. Hoagland, K. Fredrich, R.P. Ryan, and C. Moreno et al. Transfer of the CYP4A region of chromosome 5 from Lewis to Dahl S rats attenuates renal injury Am J Physiol Renal Physiol 295 2008 F1764 F1777
17. M.H. Weinberger Salt sensitivity of blood pressure in humans Hypertension 27 1996 481 490 (Pubitemid 26084617)
18. W.T. Ambrosius, L.J. Bloem, L. Zhou, J.F. Rebhun, P.M. Snyder, and M.A. Wagner et al. Genetic variants in the epithelial sodium channel in relation to aldosterone and potassium excretion and risk for hypertension Hypertension 34 1999 631 637 (Pubitemid 29496445)
19. E.H. Baker, Y.B. Dong, G.A. Sagnella, M. Rothwell, A.K. Onipinla, and N.D. Markandu et al. Association of hypertension with T594M mutation in beta subunit of epithelial sodium channels in black people resident in London Lancet 351 1998 1388 1392 (Pubitemid 28209996)
20. J.K. Bubien Epithelial Na+ channel (ENaC), hormones, and hypertension J Biol Chem 285 2010 23527 23531
21. D.A. Calhoun, M.K. Nishizaka, M.A. Zaman, R.B. Thakkar, and P. Weissmann Hyperaldosteronism among black and white subjects with resistant hypertension Hypertension 40 2002 892 896 (Pubitemid 35434912)
22. M.H. Weinberger, W.B. White, L.M. Ruilope, T.M. MacDonald, R.C. Davidson, and B. Roniker et al. Effects of eplerenone versus losartan in patients with low-renin hypertension Am Heart J 150 2005 426 433 (Pubitemid 41317608)