CYP4A11 T8590C polymorphism, salt-sensitive hypertension, and renal blood flow

Journal of Hypertension

Volumn 29, Issue 10, 2011, Pages 1913-1918

  Williams, Jonathan S ^a   Hopkins, Paul N ^b   Jeunemaitre, Xavier ^c   Brown, Nancy J ^d,e  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^c HÔPITAL EUROPÉEN GEORGES POMPIDOU   (France)

^d VANDERBILT UNIVERSITY   (United States)

^e VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Blood pressure; CYP4A11; Dietary salt intake; Hypertension; Renal blood flow; Salt sensitivity

Indexed keywords

ALDOSTERONE; ANGIOTENSIN II; CELL DNA; CYTOCHROME P450 4A11; CYTOSINE; NORADRENALIN; RENIN; SODIUM CHLORIDE; THYMIDINE; CYP4A11 PROTEIN, HUMAN; CYTOCHROME P450;

ADULT; ALDOSTERONE BLOOD LEVEL; ALLELE; ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DNA SEQUENCE; FEMALE; GENETIC ASSOCIATION; GENOTYPE; HEART RATE; HUMAN; HUMAN CELL; HYPERTENSION; KIDNEY BLOOD FLOW; LOSS OF FUNCTION MUTATION; MAJOR CLINICAL STUDY; MALE; MEAN ARTERIAL PRESSURE; PLASMA RENIN ACTIVITY; PRIORITY JOURNAL; SALT INTAKE; SALT TOLERANCE; SINGLE NUCLEOTIDE POLYMORPHISM; SODIUM RESTRICTION; SYSTOLIC BLOOD PRESSURE; BLOOD PRESSURE; DIET THERAPY; DRUG EFFECT; GENETICS; KIDNEY CIRCULATION; MIDDLE AGED; PATHOPHYSIOLOGY; PHYSIOLOGY;

ADULT; ALLELES; ANGIOTENSIN II; BLOOD PRESSURE; CYTOCHROME P-450 ENZYME SYSTEM; DIET, SODIUM-RESTRICTED; FEMALE; GENETIC ASSOCIATION STUDIES; HUMANS; HYPERTENSION; MALE; MIDDLE AGED; NOREPINEPHRINE; POLYMORPHISM, SINGLE NUCLEOTIDE; RENAL CIRCULATION; SODIUM CHLORIDE, DIETARY;

EID: 84856020126     PISSN: 02636352     EISSN: 14735598     Source Type: Journal    
DOI: 10.1097/HJH.0b013e32834aa786     Document Type: Article

References (29)

1. Lloyd-Jones D, Adams RJ, Brown TM, Carnethon M, Dai S, De SG, et al. Executive summary: heart disease and stroke statistics - 2010 update - a report fromthe American Heart Association. Circulation 2010;121:948-954.
2. Weinberger MH, Fineberg NS, Fineberg SE, Weinberger M. Salt sensitivity, pulse pressure, and death in normal and hypertensive humans. Hypertension 2001;37(2 Part 2):429-432. (Pubitemid 32199006)
3. Capdevila JH, Falck JR. The CYP P450 arachidonic acid monooxygenases: from cell signaling to blood pressure regulation. Biochem Biophys Res Commun 2001;285:571-576. (Pubitemid 32924808)
4. Sarkis A, Lopez B, Roman RJ. Role of 20-hydroxyeicosatetraenoic acid and epoxyeicosatrienoic acids in hypertension. Curr Opin Nephrol Hypertens 2004;13:205-214. (Pubitemid 38373143)
5. Imig JD. Epoxygenase metabolites. Epithelial and vascular actions. Mol Biotechnol 2000;16:233-251. (Pubitemid 32217202)
6. Dos Santos EA, Dahly-Vernon AJ, Hoagland KM, Roman RJ. Inhibition of the formation of EETs and 20-HETE with 1-aminobenzotriazole attenuates pressure natriuresis. Am J Physiol Regul Integr Comp Physiol 2004;287:R58-R68. (Pubitemid 38856311)
7. Zou AP, Fleming JT, Falck JR, Jacobs ER, Gebremedhin D, Harder DR, et al. 20-HETE is an endogenous inhibitor of the large-conductance Ca (2+) - activated K+ channel in renal arterioles. Am J Physiol 1996;270(1 Pt 2):R228-R237.
8. Oyekan A, Balazy M, McGiff JC. Renal oxygenases: differential contribution to vasoconstriction induced by ET-1 and ANG II. Am J Physiol 1997;273(1 Pt 2):R293-R300.
9. Alonso-Galicia M, Maier KG, Greene AS, Cowley AW Jr, Roman RJ. Role of 20-hydroxyeicosatetraenoic acid in the renal and vasoconstrictor actions of angiotensin II. Am J Physiol Regul Integr Comp Physiol 2002;283:R60-R68. (Pubitemid 34863911)
10. Nakagawa K, Holla VR, Wei Y, Wang WH, Gatica A, Wei S, et al. Saltsensitive hypertension is associated with dysfunctional Cyp4a10 gene and kidney epithelial sodium channel. J Clin Invest 2006;116:1696-1702.
11. Roman RJ, Alonso-Galicia M, Wilson TW. Renal P450 metabolites of arachidonic acid and the development of hypertension in Dahl salt-sensitive rats. Am J Hypertens 1997;10(5 Pt 2):63S-67S. (Pubitemid 27239833)
12. Gainer JV, Bellamine A, Dawson EP, Womble KE, Grant SW, Wang Y, et al. Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension. Circulation 2005;111:63-69. (Pubitemid 40070845)
13. Mayer B, Lieb W, Gotz A, Konig IR, Aherrahrou Z, Thiemig A, et al. Association of the T8590C polymorphism of CYP4A11 with hypertension in the MONICA Augsburg echocardiographic substudy. Hypertension 2005;46:766-771. (Pubitemid 43186751)
14. Fava C, Montagnana M, Almgren P, Rosberg L, Lippi G, Hedblad B, et al. The V433M variant of the CYP4F2 is associated with ischemic stroke in male Swedes beyond its effect on blood pressure. Hypertension 2008;52:373-380.
15. Gainer JV, Lipkowitz MS, Yu C, Waterman MR, Dawson EP, Capdevila JH, et al. Association of a CYP4A11 variant and blood pressure in black men. J Am Soc Nephrol 2008;19:1606-1612.
16. Laffer CL, Gainer JV, Waterman MR, Capdevila JH, Laniado-Schwartzman M, Nasjletti A, et al. The T8590C polymorphism of CYP4A11 and 20- hydroxyeicosatetraenoic acid in essential hypertension. Hypertension 2008;51:767-772. (Pubitemid 351301533)
17. Watkins WS, Hunt SC, Williams GH, Tolpinrud W, Jeunemaitre X, Lalouel JM, et al. Genotype-phenotype analysis of angiotensinogen polymorphisms and essential hypertension: the importance of haplotypes. J Hypertens 2010;28:65-75.
18. Sun B, Williams JS, Pojoga L, Chamarthi B, Lasky-Su J, Raby BA, et al. Renin gene polymorphism: its relationship to hypertension, renin levels and vascular responses. J Renin Angiotensin Aldosterone Syst 2011.
19. Gumieniak O, Perlstein TS, Williams JS, Hopkins PN, Brown NJ, Raby BA, et al. Ala92 type 2 deiodinase allele increases risk for the development of hypertension. Hypertension 2007;49:461-466.
20. Schnurr E, Lahme W, Kuppers H. Measurement of renal clearance of inulin and PAH in the steady state without urine collection. Clin Nephrol 1980;13:26-29. (Pubitemid 10139745)
21. Williams GH, Dluhy RG, Lifton RP, Moore TJ, Gleason R, Williams R, et al. Nonmodulation as an intermediate phenotype in essential hypertensives. Hypertension 1992;20:788-796.
22. Hopkins PN, Hunt SC, Jeunemaitre X, Smith B, Solorio D, Fisher N D L, et al. Angiotensinogen genotype affects renal and adrenal responses to angiotensin II in essential hypertension. Circulation 2002;105:1921-1927. (Pubitemid 34437619)
23. Roman RJ, Ma YH, Frohlich B, Markham B. Clofibrate prevents the development of hypertension in Dahl salt-sensitive rats. Hypertension 1993;21(6 Pt 2):985-988. (Pubitemid 23166953)
24. Moreno C, Maier KG, Hoagland KM, Yu M, Roman RJ. Abnormal pressurenatriuresis in hypertension: role of cytochrome P450 metabolites of arachidonic acid. Am J Hypertens 2001;14(6 Pt 2):90S-97S. (Pubitemid 32506702)
25. Weinberger MH, Miller TZ, Luft FC, Grim CE, Fineberg NS. Definitions and characteristics of sodium sensitivity and blood pressure resistance. Hypertension 1986;8(Suppl II):127-134.
26. Ji W, Foo JN, O'Roak BJ, Zhao H, Larson MG, Simon DB, et al. Rare independent mutations in renal salt handling genes contribute to blood pressure variation. Nat Genet 2008;40:592-599. (Pubitemid 351601207)
27. Imig JD, Pham BT, Le Blanc EA, Reddy KM, Falck JR, Inscho EW. Cytochrome P450 and cyclooxygenase metabolites contribute to the endothelin-1 afferent arteriolar vasoconstrictor and calcium responses. Hypertension 2000;35(1 Pt 2):307-312. (Pubitemid 30054191)
28. Wang J, Roman RJ, Falck JR, De La Cruz L, Lombard JH. Effects of high-salt diet on CYP450-4A omega-hydroxylase expression and active tone in mesenteric resistance arteries. Am J Physiol Heart Circ Physiol 2005;288:H1557-H1565. (Pubitemid 40417975)
29. Ward NC, Tsai IJ, Barden A, van Bockxmeer FM, Puddey IB, Hodgson JM, et al. A single nucleotide polymorphism in the CYP4F2 but not CYP4A11 gene is associated with increased 20-HETE excretion and blood pressure. Hypertension 2008;51:1393-1398. (Pubitemid 351555955)