18-HEPE, an n-3 fatty acid metabolite released by macrophages, prevents pressure overload-induced maladaptive cardiac remodeling

Journal of Experimental Medicine

Volumn 211, Issue 8, 2014, Pages 1673-1687

  Endo, Jin ^a,b,c   Sano, Motoaki ^c   Isobe, Yosuke ^a,b   Fukuda, Keiichi ^c   Kang, Jing X ^d   Arai, Hiroyuki ^a   Arita, Makoto ^a,b,e  

^a UNIVERSITY OF TOKYO   (Japan)

^b RIKEN Center for Integrative Medical Sciences   (Japan)

^c KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

^e JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

18 HYDROXYEICOSAPENTAENOIC ACID; FATTY ACID DERIVATIVE; ICOSAPENTAENOIC ACID; OMEGA 3 FATTY ACID; UNCLASSIFIED DRUG;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BONE MARROW TRANSPLANTATION; CONTROLLED STUDY; DRUG EFFECT; FIBROBLAST CULTURE; HEART LEFT VENTRICLE FUNCTION; HEART LEFT VENTRICLE OVERLOAD; HEART MUSCLE FIBROSIS; HEART VENTRICLE REMODELING; IN VIVO STUDY; LIPIDOMICS; MACROPHAGE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; TRANSGENIC MOUSE;

ANIMALS; AORTA; BONE MARROW CELLS; CADHERINS; CARDIOTONIC AGENTS; COCULTURE TECHNIQUES; CONSTRICTION, PATHOLOGIC; EICOSAPENTAENOIC ACID; FIBROBLASTS; FIBROSIS; GENE EXPRESSION PROFILING; HUMANS; INFLAMMATION; LIPID METABOLISM; MACROPHAGES; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MYOCARDIUM; PRESSURE; VENTRICULAR FUNCTION, LEFT;

EID: 84905104449     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20132011     Document Type: Article

References (36)

1. Arita, M. 2012. Mediator lipidomics in acute inflammation and resolution. J. Biochem. 152:313-319. http://dx.doi.org/10.1093/jb/mvs092.
2. Bligh, E.G., and W.J. Dyer. 1959. A rapid method of total lipid extraction and purification. Can. J. Biochem. Physiol. 37:911-917. http://dx.doi.org/10 .1139/o59-099.
3. Chen, J., G.C. Shearer, Q. Chen, C.L. Healy, A.J. Beyer, V.B. Nareddy, A.M. Gerdes, W.S. Harris, T.D. O'Connell, and D. Wang. 2011. Omega-3 fatty acids prevent pressure overload-induced cardiac fibrosis through activation of cyclic GMP/protein kinase G signaling in cardiac fibroblasts. Circulation. 123:584-593. http://dx.doi.org/10.1161/CIRCULATIONAHA.110 .971853.
4. Duda, M.K., K.M. O'Shea, B. Lei, B.R. Barrows, A.M. Azimzadeh, T.E. McElfresh, B.D. Hoit, W.J. Kop, and W.C. Stanley. 2007. Dietary supplementation with ω-3 PUFA increases adiponectin and attenuates ventricular remodeling and dysfunction with pressure overload. Cardiovasc. Res. 76:303-310. http://dx.doi.org/10.1016/j.cardiores.2007.07.002.
5. Endo, J., M. Sano, J. Fujita, K. Hayashida, S. Yuasa, N. Aoyama, Y. Takehara, O. Kato, S. Makino, S. Ogawa, and K. Fukuda. 2007. Bone marrow derived cells are involved in the pathogenesis of cardiac hypertrophy in response to pressure overload. Circulation. 116:1176-1184. http://dx.doi .org/10.1161/CIRCULATIONAHA.106.650903.
6. Epelman, S., K.J. Lavine, A.E. Beaudin, D.K. Sojka, J.A. Carrero, B. Calderon, T. Brija, E.L. Gautier, S. Ivanov, A.T. Satpathy, et al. 2014. Embryonic and adult-derived resident cardiac macrophages are maintained through distinct mechanisms at steady state and during inflammation. Immunity. 40:91-104. http://dx.doi.org/10.1016/j.immuni.2013.11.019.
7. Fritsche, K. 2006. Fatty acids as modulators of the immune response. Annu. Rev. Nutr. 26:45-73. http://dx.doi.org/10.1146/annurev.nutr.25.050304 .092610.
8. Huang, M.J., L. Wang, X.C. Zheng, Z.M. Zhang, B. Yan, T.Y. Chen, X.C. Bai, and D.D. Jin. 2012. Intra-articular lentivirus-mediated insertion of the fat-1 gene ameliorates osteoarthritis. Med. Hypotheses. 79:614-616. http://dx.doi.org/10.1016/j.mehy.2012.07.035.
9. Hudert, C.A., K.H. Weylandt, Y. Lu, J. Wang, S. Hong, A. Dignass, C.N. Serhan, and J.X. Kang. 2006. Transgenic mice rich in endogenous omega-3 fatty acids are protected from colitis. Proc. Natl. Acad. Sci. USA. 103: 11276-11281. http://dx.doi.org/10.1073/pnas.0601280103.
10. Isobe, Y., M. Arita, R. Iwamoto, D. Urabe, H. Todoroki, K. Masuda, M. Inoue, and H. Arai. 2013. Stereochemical assignment and anti-inflammatory properties of the omega-3 lipid mediator resolvin E3. J. Biochem. 153:355-360. http://dx.doi.org/10.1093/jb/mvs151.
11. Kai, H., T. Mori, K. Tokuda, N. Takayama, N. Tahara, K. Takemiya, H. Kudo, Y. Sugi, D. Fukui, H. Yasukawa, et al. 2006. Pressure overload-induced transient oxidative stress mediates perivascular inflammation and cardiac fibrosis through angiotensin II. Hypertens. Res. 29:711-718. http://dx .doi.org/10.1291/hypres.29.711.
12. Kang, J.X., J. Wang, L. Wu, and Z.B. Kang. 2004. Transgenic mice: fat-1 mice convert n-6 to n-3 fatty acids. Nature. 427:504. http://dx.doi.org/10 .1038/427504a.
13. Kayama, Y., T. Minamino, H. Toko, M. Sakamoto, I. Shimizu, H. Takahashi, S. Okada, K. Tateno, J. Moriya, M. Yokoyama, et al. 2009. Cardiac 12/15 lipoxygenase-induced inflammation is involved in heart failure. J. Exp. Med. 206:1565-1574. http://dx.doi.org/10.1084/jem.20082596.
14. Koyanagi, M., K. Egashira, S. Kitamoto, W. Ni, H. Shimokawa, M. Takeya, T. Yoshimura, and A. Takeshita. 2000. Role of monocyte chemoattractant protein-1 in cardiovascular remodeling induced by chronic blockade of nitric oxide synthesis. Circulation. 102:2243-2248. http://dx.doi.org/10.1161/01.CIR.102.18.2243.
15. Kuwahara, F., H. Kai, K. Tokuda, M. Takeya, A. Takeshita, K. Egashira, and T. Imaizumi. 2004. Hypertensive myocardial fibrosis and diastolic dysfunction: another model of inflammation? Hypertension. 43:739-745. http://dx.doi.org/10.1161/01.HYP.0000118584.33350.7d.
16. Leuschner, F., P.J. Rauch, T. Ueno, R. Gorbatov, B. Marinelli, W.W. Lee, P. Dutta, Y. Wei, C. Robbins, Y. Iwamoto, et al. 2012. Rapid monocyte kinetics in acute myocardial infarction are sustained by extramedullary monocytopoiesis. J. Exp. Med. 209:123-137. http://dx.doi.org/10.1084/jem.20111009.
17. Ma, F., Y. Li, L. Jia, Y. Han, J. Cheng, H. Li, Y. Qi, and J. Du. 2012. Macrophagestimulated cardiac fibroblast production of IL-6 is essential for TGF β/Smad activation and cardiac fibrosis induced by angiotensin II. PLoS ONE. 7:e35144. http://dx.doi.org/10.1371/journal.pone.0035144.
18. Meléndez, G.C., J.L. McLarty, S.P. Levick, Y. Du, J.S. Janicki, and G.L. Brower. 2010. Interleukin 6 mediates myocardial fibrosis, concentric hypertrophy, and diastolic dysfunction in rats. Hypertension. 56:225-231. http://dx.doi.org/10.1161/HYPERTENSIONAHA.109.148635.
19. Mozaffarian, D., and J.H.Y. Wu. 2011. Omega-3 fatty acids and cardiovascular disease: effects on risk factors, molecular pathways, and clinical events. J. Am. Coll. Cardiol. 58:2047-2067. http://dx.doi.org/10.1016/j.jacc.2011.06.063.
20. Nahrendorf, M., F.K. Swirski, E. Aikawa, L. Stangenberg, T. Wurdinger, J.-L. Figueiredo, P. Libby, R. Weissleder, and M.J. Pittet. 2007. The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions. J. Exp. Med. 204:3037-3047. http://dx.doi.org/10.1084/jem.20070885.
21. Nicoletti, A., D. Heudes, C. Mandet, N. Hinglais, J. Bariety, and J.B. Michel. 1996. Inflammatory cells and myocardial fibrosis: spatial and temporal distribution in renovascular hypertensive rats. Cardiovasc. Res. 32:1096-1107. http://dx.doi.org/10.1016/S0008-6363(96)00158-7.
22. Nodari, S., M. Triggiani, U. Campia, A. Manerba, G. Milesi, B.M. Cesana, M. Gheorghiade, and L. Dei Cas. 2011. Effects of n-3 polyunsaturated fatty acids on left ventricular function and functional capacity in patients with dilated cardiomyopathy. J. Am. Coll. Cardiol. 57:870-879. http://dx.doi.org/10.1016/j.jacc.2010.11.017.
23. Ogawa, S., D. Urabe, Y. Yokokura, H. Arai, M. Arita, and M. Inoue. 2009. Total synthesis and bioactivity of resolvin E2. Org. Lett. 11:3602-3605. http://dx.doi.org/10.1021/ol901350g.
24. Oh, D.Y., S. Talukdar, E.J. Bae, T. Imamura, H. Morinaga, W. Fan, P. Li, W.J. Lu, S.M. Watkins, and J.M. Olefsky. 2010. GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulinsensitizing effects. Cell. 142:687-698. http://dx.doi.org/10.1016/j.cell .2010.07.041.
25. Opie, L.H., P.J. Commerford, B.J. Gersh, and M.A. Pfeffer. 2006. Controversies in ventricular remodelling. Lancet. 367:356-367. http://dx.doi.org/10 .1016/S0140-6736(06)68074-4.
26. Sano, M., K. Fukuda, H. Kodama, J. Pan, M. Saito, J. Matsuzaki, T. Takahashi, S. Makino, T. Kato, and S. Ogawa. 2000. Interleukin-6 family of cytokines mediate angiotensin II-induced cardiac hypertrophy in rodent cardiomyocytes. J. Biol. Chem. 275:29717-29723. http://dx.doi.org/10.1074/jbc.M003128200.
27. Tavazzi, L., A.P. Maggioni, R. Marchioli, S. Barlera, M.G. Franzosi, R. Latini, D. Lucci, G.L. Nicolosi, M. Porcu, and G. TognoniGissi-HF Investigators. 2008. Effect of n-3 polyunsaturated fatty acids in patients with chronic heart failure (the GISSI-HF trial): a randomised, double-blind, placebocontrolled trial. Lancet. 372:1223-1230. http://dx.doi.org/10.1016/S0140-6736(08)61239-8.
28. Wan, J.-B., L.-L. Huang, R. Rong, R. Tan, J. Wang, and J.X. Kang. 2010. Endogenously decreasing tissue n-6/n-3 fatty acid ratio reduces atherosclerotic lesions in apolipoprotein E-deficient mice by inhibiting systemic and vascular inflammation. Arterioscler. Thromb. Vasc. Biol. 30:2487-2494. http://dx.doi.org/10.1161/ATVBAHA.110.210054.
29. Weber, K.T., Y. Sun, S.K. Bhattacharya, R.A. Ahokas, and I.C. Gerling. 2013. Myofibroblast-mediated mechanisms of pathological remodelling of the heart. Nat. Rev. Cardiol. 10:15-26. http://dx.doi.org/10.1038/nrcardio .2012.158.
30. Weylandt, K.H., A. Nadolny, L. Kahlke, T. Köhnke, C. Schmöcker, J. Wang, G.Y. Lauwers, J.N. Glickman, and J.X. Kang. 2008. Reduction of inflammation and chronic tissue damage by omega-3 fatty acids in fat-1 transgenic mice with pancreatitis. Biochim. Biophys. Acta. 1782:634-641. http://dx.doi.org/10.1016/j.bbadis.2008.08.011.
31. Weylandt, K.H., L.F. Krause, B. Gomolka, C.-Y. Chiu, S. Bilal, A. Nadolny, S.F. Waechter, A. Fischer, M. Rothe, and J.X. Kang. 2011. Suppressed liver tumorigenesis in fat-1 mice with elevated omega-3 fatty acids is associated with increased omega-3 derived lipid mediators and reduced TNF-α. Carcinogenesis. 32:897-903. http://dx.doi.org/10.1093/carcin/bgr049.
32. White, P.J., M. Arita, R. Taguchi, J.X. Kang, and A. Marette. 2010. Transgenic restoration of long-chain n-3 fatty acids in insulin target tissues improves resolution capacity and alleviates obesity-linked inflammation and insulin resistance in high-fat-fed mice. Diabetes. 59:3066-3073. http://dx.doi .org/10.2337/db10-0054.
33. Wynn, T.A., and T.R. Ramalingam. 2012. Mechanisms of fibrosis: therapeutic translation for fibrotic disease. Nat. Med. 18:1028-1040. http://dx.doi .org/10.1038/nm.2807.
34. Xia, S., Y. Lu, J. Wang, C. He, S. Hong, C.N. Serhan, and J.X. Kang. 2006. Melanoma growth is reduced in fat-1 transgenic mice: impact of omega-6/omega-3 essential fatty acids. Proc. Natl. Acad. Sci. USA. 103:12499-12504. http://dx.doi.org/10.1073/pnas.0605394103.
35. Yokoyama, M., H. Origasa, M. Matsuzaki, Y. Matsuzawa, Y. Saito, Y. Ishikawa, S. Oikawa, J. Sasaki, H. Hishida, H. Itakura, et al. Japan EPA lipid intervention study (JELIS) Investigators. 2007. Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis. Lancet. 369:1090-1098. http://dx.doi.org/10.1016/S0140-6736(07)60527-3.
36. Zhang, M.J., and M. Spite. 2012. Resolvins: anti-inflammatory and proresolving mediators derived from omega-3 polyunsaturated fatty acids. Annu. Rev. Nutr. 32:203-227. http://dx.doi.org/10.1146/annurev-nutr-071811-150726.