Vanilloid-like agents inhibit aggregation of human platelets

Thrombosis Research

Volumn 134, Issue 2, 2014, Pages 412-417

  Almaghrabi, Safa Y ^a   Geraghty, Dominic P ^a   Ahuja, Kiran D K ^a   Adams, Murray J ^a  

^a UNIVERSITY OF TASMANIA   (Australia)

Author keywords

Capsaicin; Dihydrocapsaicin; N arachidonoyl dopamine; N oleoyldopamine; TRPV1

Indexed keywords

ADENOSINE DIPHOSPHATE; ANTITHROMBOCYTIC AGENT; ARACHIDONIC ACID; CAPSAICIN; COLLAGEN; DIHYDROCAPSAICIN; LACTATE DEHYDROGENASE; N ARACHIDONOYL DOPAMINE; N OLEOYLDOPAMINE; UNCLASSIFIED DRUG; UREA DERIVATIVE; VANILLOID RECEPTOR 1; VANILLOID RECEPTOR 1 ANTAGONIST; [N (2 BROMOPHENYL) N' [2 [ETHYL(3METHYLPHENYL)AMINO]ETHYL]UREA]; ARACHIDONIC ACID DERIVATIVE; ARACHIDONYL DOPAMINE; DOPAMINE; N-OLEOYLDOPAMINE; VANILLOID RECEPTOR; VANILLOID RECEPTOR SUBTYPE 1;

ADULT; AGED; ARTICLE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME RELEASE; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; IN VITRO STUDY; NORMAL HUMAN; PRIORITY JOURNAL; THROMBOCYTE AGGREGATION; THROMBOCYTE AGGREGATION INHIBITION; ADOLESCENT; ANALOGS AND DERIVATIVES; CHEMISTRY; DRUG EFFECTS; METABOLISM; MIDDLE AGED; PLANT; THROMBOCYTE; YOUNG ADULT;

ADENOSINE DIPHOSPHATE; ADOLESCENT; ADULT; AGED; ARACHIDONIC ACIDS; BLOOD PLATELETS; CAPSAICIN; DOPAMINE; HUMANS; MIDDLE AGED; PLANTS; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; TRPV CATION CHANNELS; YOUNG ADULT;

EID: 84905098167     PISSN: 00493848     EISSN: 18792472     Source Type: Journal    
DOI: 10.1016/j.thromres.2014.05.038     Document Type: Article

References (23)

1. L.A. Harker, R. Ross, and J. Glomset Role of the platelet in atherogenesis Ann N Y Acad Sci 275 1976 321 329
2. M.B. Zucker The functioning of blood platelets Sci Am 242 1980 86 103
3. M.J. Adams, K.D. Ahuja, and D.P. Geraghty Effect of capsaicin and dihydrocapsaicin on in vitro blood coagulation and platelet aggregation Thromb Res 124 2009 721 723
4. C.M. Hogaboam, and J.L. Wallace Inhibition of platelet aggregation by capsaicin. An effect unrelated to actions on sensory afferent neurons Eur J Pharmacol 202 1991 129 131
5. R.H. Raghavendra, and K.A. Naidu Spice active principles as the inhibitors of human platelet aggregation and thromboxane biosynthesis Prostaglandins Leukot Essent Fatty Acids 81 2009 73 78
6. C. Aza-Gonzalez, H.G. Nunez-Palenius, and N. Ochoa-Alejo Molecular biology of capsaicinoid biosynthesis in chili pepper (Capsicum spp.) Plant Cell Rep 30 2011 695 706
7. M.J. Caterina, M.A. Schumacher, and M. Tominaga et al. The capsaicin receptor: a heat-activated ion channel in the pain pathway Nature 389 1997 816 824
8. M.J. Caterina, and D. Julius The vanilloid receptor: a molecular gateway to the pain pathway Annu Rev Neurosci 24 2001 487 517
9. B. Zhong, and D.H. Wang N-oleoyldopamine, a novel endogenous capsaicin-like lipid, protects the heart against ischemia-reperfusion injury via activation of TRPV1 Am J Physiol Heart Circ Physiol 295 2008 H728 H735
10. A.G. Harper, S.L. Brownlow, and S.O. Sage A role for TRPV1 in agonist-evoked activation of human platelets J Thromb Haemost 7 2009 330 338
11. S.W. Mittelstadt, R.A. Nelson, and J.F. Daanen et al. Capsaicin-induced inhibition of platelet aggregation is not mediated by transient receptor potential vanilloid type 1 Blood Coagul Fibrinolysis 23 2012 94 97
12. K.D. Ahuja, M.J. Adams, and I.K. Robertson et al. Acute effect of a high-carbohydrate low-fat meal on platelet aggregation Platelets 20 2009 606 609
13. K.D. Ahuja, G.A. Thomas, and M.J. Adams et al. Postprandial platelet aggregation: effects of different meals and glycemic index Eur J Clin Nutr 66 2012 722 726
14. C. Patrono, B. Coller, and G.A. FitzGerald et al. Platelet-active drugs: the relationships among dose, effectiveness, and side effects: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy Chest 126 2004 234S 264S
15. T.D.T.T.S. Group A comparison of two doses of aspirin (30 mg vs. 283 mg a day) in patients after a transient ischemic attack or minor ischemic stroke. The Dutch TIA Trial Study Group N Engl J Med 325 1991 1261 1266
16. L. Mastalerz, M. Setkowicz, and M. Sanak et al. Hypersensitivity to aspirin: common eicosanoid alterations in urticaria and asthma J Allergy Clin Immunol 113 2004 771 775
17. K. Ito, T. Nakazato, and K. Yamato et al. Induction of apoptosis in leukemic cells by homovanillic acid derivative, capsaicin, through oxidative stress: implication of phosphorylation of p53 at Ser-15 residue by reactive oxygen species Cancer Res 64 2004 1071 1078
18. C.A. Reilly, M.E. Johansen, and D.L. Lanza et al. Calcium-dependent and independent mechanisms of capsaicin receptor (TRPV1)-mediated cytokine production and cell death in human bronchial epithelial cells J Biochem Mol Toxicol 19 2005 266 275
19. C.I. Saunders, R.G. Fassett, and D.P. Geraghty Up-regulation of TRPV1 in mononuclear cells of end-stage kidney disease patients increases susceptibility to N-arachidonoyl-dopamine (NADA)-induced cell death Biochim Biophys Acta 1792 2009 1019 1026
20. H.K. Rami, M. Thompson, and P. Wyman et al. Discovery of small molecule antagonists of TRPV1 Bioorg Med Chem Lett 14 2004 3631 3634
21. S. Braud, C. Bon, and L. Touqui et al. Activation of rabbit blood platelets by anandamide through its cleavage into arachidonic acid FEBS Lett 471 2000 12 16
22. M. Maccarrone, M. Bari, and A. Menichelli et al. Anandamide activates human platelets through a pathway independent of the arachidonate cascade FEBS Lett 447 1999 277 282
23. M. MacCarrone, M. Bari, and A. Menichelli et al. Human platelets bind and degrade 2-arachidonoylglycerol, which activates these cells through a cannabinoid receptor Eur J Biochem 268 2001 819 825