Chemerin aggravates DSS-induced colitis by suppressing M2 macrophage polarization

Cellular and Molecular Immunology

Volumn 11, Issue 4, 2014, Pages 355-366

  Lin, Yuli ^a   Yang, Xuguang ^a   Yue, Wenjie ^b   Xu, Xiaofei ^a   Li, Bingji ^a   Zou, Linlin ^a   He, Rui ^a,c  

^a Institute of Pathogenic Biology   (China)

^b FUDAN UNIVERSITY   (China)

^c FUDAN UNIVERSITY   (China)

Author keywords

chemerin; intestinal inflammation; macrophage

Indexed keywords

ARGINASE 1; CHEMERIN; DEXTRAN SULFATE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 4; INTERLEUKIN 6; STAT6 PROTEIN; TUMOR NECROSIS FACTOR ALPHA; ARG1 PROTEIN, MOUSE; ARGINASE; AUTACOID; BETA N ACETYLHEXOSAMINIDASE; CHI3L3 PROTEIN, MOUSE; CHIMERIN; CYTOKINE; LECTIN; PEPTIDE FRAGMENT; RETNLA PROTEIN, MOUSE; SIGNAL PEPTIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARGINASE 1 GENE; ARTICLE; CONTROLLED STUDY; DISEASE ACTIVITY; DISEASE ASSOCIATION; DISEASE SEVERITY; FEMALE; FIZZ1 GENE; GENE; GENE FUNCTION; GENE IDENTIFICATION; HUMAN; HUMAN TISSUE; IN VIVO STUDY; INTERLEUKIN 10 GENE; MACROPHAGE FUNCTION; MOLECULAR PATHOLOGY; MOUSE; NONHUMAN; POLARIZATION; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; SCORING SYSTEM; ULCERATIVE COLITIS; YM1 GENE; ANIMAL; C57BL MOUSE; CELL CULTURE; CELL DIFFERENTIATION; CHEMICALLY INDUCED; COLITIS; COLON; DISEASE COURSE; DISEASE MODEL; DOWN REGULATION; GENETICS; IMMUNOLOGY; MACROPHAGE; METABOLISM;

ANIMALS; ARGINASE; BETA-N-ACETYLHEXOSAMINIDASES; CELL DIFFERENTIATION; CELLS, CULTURED; CHIMERIN 1; COLITIS; COLITIS, ULCERATIVE; COLON; CYTOKINES; DEXTRAN SULFATE; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; DOWN-REGULATION; FEMALE; HUMANS; INFLAMMATION MEDIATORS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LECTINS; MACROPHAGES; MICE; MICE, INBRED C57BL; PEPTIDE FRAGMENTS; STAT6 TRANSCRIPTION FACTOR;

EID: 84905051685     PISSN: 16727681     EISSN: None     Source Type: Journal    
DOI: 10.1038/cmi.2014.15     Document Type: Article

References (42)

1. Vermi W, Riboldi E, Wittamer V, Gentili F, Luini W, Marrelli S et al. Role of ChemR23 in Directing the migration of myeloid and plasmacytoid dendritic cells to lymphoid organs and inflamed skin. J Exp Med 2005; 201: 509
2. Parolini S, Santoro A, Marcenaro E, Luini W, Massardi L, Facchetti F et al. The role of chemerin in the colocalization of NK and dendritic cell subsets into inflamed tissues. Blood 2007; 109: 3625
3. Bozaoglu K, Bolton K, McMillan J, Zimmet P, Jowett J, Collier G et al. Chemerin is a novel adipokine associated with obesity and metabolic syndrome. Endocrinology 2007; 148: 4687
4. Goralski KB, McCarthy TC, Hanniman EA, Zabel BA, Butcher EC, Parlee SD et al. Chemerin, a novel adipokine that regulates adipogenesis and adipocyte metabolism. J Biol Chem 2007; 282: 28175
5. Wittamer V, Bondue B, Guillabert A, Vassart G, Parmentier M, Communi D. Neutrophil-mediated maturation of chemerin: A link between innate and adaptive immunity. J Immunol 2005; 175: 487
6. de Palma G, Castellano G, del Prete A, Sozzani S, Fiore N, Loverre A et al. The possible role of ChemR23/Chemerin axis in the recruitment of dendritic cells in lupus nephritis. Kidney Int 2011; 79: 1228
7. Albanesi C, Scarponi C, Pallotta S, Daniele R, Bosisio D, Madonna S et al. Chemerin expression marks early psoriatic skin lesions and correlates with plasmacytoid dendritic cell recruitment. J Exp Med 2009; 206: 249
8. Cash JL, Hart R, Russ A, Dixon JP, Colledge WH, Doran J et al. Synthetic chemerin-derived peptides suppress inflammation through ChemR23. J Exp Med 2008; 205: 767
9. Luangsay S, Wittamer V, Bondue B, de Henau O, Rouger L, Brait M et al. Mouse ChemR23 is expressed in Dendritic cell subsets and macrophages, and mediates an anti-inflammatory activity of chemerin in a lung disease model. J Immunol 2009; 183: 6489
10. Wittamer V, Gregoire F, Robberecht P, Vassart G, Communi D, Parmentier M. The C-Terminal nonapeptide of mature chemerin activates the chemerin receptor with low nanomolar potency. J Biol Chem 2004; 279: 9956
11. Cash JL, Christian AR, Greaves DR. Chemerin peptides promote phagocytosis in a ChemR23- And Syk-dependent manner. J Immunol 2010; 184: 5315
12. Mayer L. Evolving paradigms in the pathogenesis of IBD. J Gastroenterol 2010; 45: 9
13. Zigmond E, Varol C, Farache J, Elmaliah E, Satpathy AT, Friedlander G et al. Ly6C hi monocytes in the inflamed colon give rise to proinflammatory effector cells and migratory antigen-presenting cells. Immunity 2012; 37: 1076
14. Chaudhry A, Samstein RM, Treuting P, Liang Y, Pils MC, Heinrich JM et al. Interleukin-10 signaling in regulatory T cells is required for suppression of Th17 cell-mediated inflammation. Immunity 2011; 34: 566
15. Maloy KJ, Powrie F. Intestinal homeostasis and its breakdown in inflammatory bowel disease. Nature 2011; 474: 298
16. Swamy M, Jamora C, Havran W, Hayday A. Epithelial decision makers: In search of the 'epimmunome'. Nat Immunol 2010; 11: 656
17. Elson CO, Sartor RB, Tennyson GS, Riddell RH. Experimental models of inflammatory bowel disease. Gastroenterology 1995; 109: 1344
18. Perse M, Cerar A. Dextran sodium sulphate colitis mouse model: Traps and tricks. J Biomed Biotechnol 2012; 2012: 718617
19. Farooq SM, Stillie R, Svensson M, Svanborg C, Strieter RM, Stadnyk AW. Therapeutic effect of blocking CXCR2 on neutrophil recruitment and dextran sodium sulfate-induced colitis. J Pharmacol Exp Ther 2009; 329: 123
20. Arranz A, Doxaki C, Vergadi E, Martinez de la Torre Y, Vaporidi K, Lagoudaki ED et al. Akt1 and Akt2 protein kinases differentially contribute to macrophage polarization. Proc Natl Acad Sci USA 2012; 109: 9517
21. Berndt BE, Zhang M, Chen GH, Huffnagle GB, Kao JY. The role of dendritic cells in the development of acute dextran sulfate sodium colitis. J Immunol 2007; 179: 6255
22. Dieleman LA, Ridwan BU, Tennyson GS, Beagley KW, Bucy RP, Elson CO. Dextran sulfate sodium-induced colitis occurs in severe combined immunodeficient mice. Gastroenterology 1994; 107: 1643
23. Okayasu I, Hatakeyama S, Yamada M, Ohkusa T, Inagaki Y, Nakaya R. A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice. Gastroenterology 1990; 98: 694
24. Heinsbroek SE, Gordon S. The role of macrophages in inflammatory bowel diseases. Expert Rev Mol Med 2009; 11: E14
25. Gordon S, Martinez FO. Alternative activation of macrophages: Mechanism and functions. Immunity 2010; 32: 593
26. Hunter MM, Wang A, Parhar KS, Johnston MJ, van Rooijen N, Beck PL et al. In vitro-derived alternatively activated macrophages reduce colonic inflammation in mice. Gastroenterology 2010; 138: 1395
27. Weisser SB, Brugger HK, Voglmaier NS, McLarren KW, van Rooijen N, Sly LM. SHIP-deficient, alternatively activated macrophages protect mice during DSS-induced colitis. J Leukoc Biol 2011; 90: 483
28. Sindrilaru A, Peters T, Wieschalka S, Baican C, Baican A, Peter H et al. An unrestrained proinflammatory M1 macrophage population induced by iron impairs wound healing in humans and mice. J Clin Invest 2011; 121: 985
29. Weigert J, Obermeier F, Neumeier M, Wanninger J, Filarsky M, Bauer S et al. Circulating levels of chemerin and adiponectin are higher in ulcerative colitis and chemerin is elevated in Crohn's disease. Inflamm Bowel Dis 2010; 16: 630
30. Cooper HS, Murthy SN, Shah RS, Sedergran DJ. Clinicopathologic study of dextran sulfate sodium experimental murine colitis. Lab Invest 1993; 69: 238
31. Stopfer P, Obermeier F, Dunger N, Falk W, Farkas S, Janotta M et al. Blocking lymphotoxin-beta receptor activation Diminishes inflammation via reduced mucosal addressin cell adhesion molecule-1 (MAdCAM-1) expression and leucocyte margination in chronic DSS-induced colitis. Clin Exp Immunol 2004; 136: 21
32. Smith P, Mangan NE, Walsh CM, Fallon RE, McKenzie AN, van Rooijen N et al. Infection with a helminth parasite prevents experimental colitis via a macrophage-mediated mechanism. J Immunol 2007; 178: 4557
33. Lichtenstein GR, Zakko S, Gordon GL, Murthy U, Sedghi S, Pruitt R et al. Mesalazine granules 1.5 g once-daily maintain remission in patients with ulcerative colitis who switch from other 5-ASA formulations: A pooled analysis from two randomised controlled trials. Aliment Pharmacol Ther 2012; 36: 126
34. Bondue B, Vosters O, de Nadai P, Glineur S, de Henau O, Luangsay S et al. ChemR23 dampens lung inflammation and enhances anti-viral immunity in a mouse model of acute viral pneumonia. PLoS Pathog 2011; 7: E1002358
35. Murray PJ, Wynn TA. Protective and pathogenic functions of macrophage subsets. Nat Rev Immunol 2011; 11: 723
36. Zabel BA, Ohyama T, Zuniga L, Kim JY, Johnston B, Allen SJ et al. Chemokine-like receptor 1 expression by macrophages in vivo: Regulation by TGF-beta and TLR ligands. Exp Hematol 2006; 34: 1106
37. Bondue B, de Henau O, Luangsay S, Devosse T, de Nadai P, Springael JY et al. The chemerin/ChemR23 system does not affect the proinflammatory response of mouse and human macrophages ex vivo. PLoS ONE 2012; 7: E40043
38. Biswas SK, Mantovani A. Macrophage plasticity and interaction with lymphocyte subsets: Cancer as a paradigm. Nat Immunol 2010; 11: 889
39. Bondue B, Wittamer V, Parmentier M. Chemerin and its receptors in leukocyte trafficking, inflammation and metabolism. Cytokine Growth Factor Rev 2011; 22: 331
40. Gobert AP, Cheng Y, Akhtar M, Mersey BD, Blumberg DR, Cross RK et al. Protective role of arginase in a mouse model of colitis. J Immunol 2004; 173: 2109
41. Welch JS, Escoubet-Lozach L, Sykes DB, Liddiard K, Greaves DR, Glass CK. TH2 cytokines and allergic challenge induce Ym1 expression in macrophages by a STAT6-dependent mechanism. J Biol Chem 2002; 277: 42821
42. Antonios JK, Yao Z, Li C, Rao AJ, Goodman SB. Macrophage polarization in response to wear particles in vitro. Cell Mol Immunol 2013; 10: 471