In silico identification and biological evaluation of novel selective serum/glucocorticoid-inducible kinase 1 inhibitors based on the pyrazolo-pyrimidine scaffold

Journal of Chemical Information and Modeling

Volumn 54, Issue 7, 2014, Pages 1828-1832

  Ortuso, Francesco ^a   Amato, Rosario ^a   Artese, Anna ^a   Dantona, Lucia ^a   Costa, Giosue ^a   Talarico, Cristina ^a   Gigliotti, Francesco ^a   Bianco, Cataldo ^a   Trapasso, Francesco ^a   Schenone, Silvia ^b   Musumeci, Francesca ^b   Botta, Lorenzo ^c   Perrotti, Nicola ^a   Alcaro, Stefano ^a  

^a UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

^b UNIVERSITY OF GENOA   (Italy)

^c UNIVERSITY OF SIENA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; AROMATIC COMPOUNDS;

ANTI-CANCER THERAPIES; ANTIAPOPTOTIC; BIOLOGICAL EVALUATION; CELL SURVIVAL; CRYSTALLOGRAPHIC MODELS; IN-SILICO; IN-VITRO; PYRIMIDINE DERIVATIVES;

ENZYMES;

PROTEIN KINASE INHIBITOR; PROTEIN SERINE THREONINE KINASE; PYRAZOLE; PYRAZOLE DERIVATIVE; PYRIMIDINE; PYRIMIDINE DERIVATIVE; SERUM-INDUCIBLE KINASE;

ANTAGONISTS AND INHIBITORS; CHEMISTRY; COMPUTER SIMULATION; DRUG DEVELOPMENT; HUMAN; METABOLISM; MOLECULAR DOCKING; PROTEIN CONFORMATION; TUMOR CELL LINE;

CELL LINE, TUMOR; COMPUTER SIMULATION; DRUG DISCOVERY; HUMANS; MOLECULAR DOCKING SIMULATION; PROTEIN CONFORMATION; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; PYRAZOLES; PYRIMIDINES;

EID: 84905044207     PISSN: 15499596     EISSN: 1549960X     Source Type: Journal    
DOI: 10.1021/ci500235f     Document Type: Article

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