The functionalized amino acid (S)-lacosamide subverts CRMP2-mediated tubulin polymerization to prevent constitutive and activity-dependent increase in neurite outgrowth

Frontiers in Cellular Neuroscience

Volumn 8, Issue JULY, 2014, Pages

  Wilson, Sarah M ^a   Moutal, Aubin ^b   Melemedjian, Ohannes K ^b   Wang, Yuying ^b   Ju, Weina ^a,c   François Moutal, Liberty ^b   Khanna, May ^b   Khanna, Rajesh ^a,b  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^c THE FIRST HOSPITAL OF JILIN UNIVERSITY   (China)

Author keywords

(S) lacosamide; Activity dependent; Cdk5; CRMP2; GSK3 ; Neurite outgrowth

Indexed keywords

COLLAPSIN RESPONSE MEDIATOR PROTEIN 2; CYCLIN DEPENDENT KINASE 5; GLYCOGEN SYNTHASE KINASE 3BETA; HARKOSERIDE; SMALL INTERFERING RNA; TUBULIN;

ARTICLE; CELL FUNCTION; DEPOLARIZATION; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE SILENCING; HUMAN; HUMAN CELL; IMMUNOBLOTTING; NERVE CELL CULTURE; NERVE FIBER GROWTH; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; QUANTITATIVE ANALYSIS; RECEPTOR BINDING ASSAY; WHOLE CELL PATCH CLAMP;

EID: 84905040633     PISSN: 16625102     EISSN: None     Source Type: Journal    
DOI: 10.3389/fncel.2014.00196     Document Type: Article

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