KDM4B as a target for prostate cancer: Structural analysis and selective inhibition by a novel inhibitor

Journal of Medicinal Chemistry

Volumn 57, Issue 14, 2014, Pages 5975-5985

  Chu, Chia Han ^a,b   Wang, Ling Yu ^c   Hsu, Kai Cheng ^d   Chen, Chung Chin ^a   Cheng, Hsing Hung ^a   Wang, Szu Min ^a   Wu, Chien Ming ^a   Chen, Tsan Jan ^a   Li, Ling Ting ^d   Liu, Ruiwu ^c   Hung, Chiu Lien ^c   Yang, Jing Moon ^d   Kung, Hsing Jien ^c,e   Wang, Wen Ching ^a,b  

^a Institute of Molecular and Cellular Biology   (Taiwan)

^b NATIONAL TSING HUA UNIVERSITY   (Taiwan)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d NATIONAL CHIAO TUNG UNIVERSITY   (Taiwan)

^e NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE DEMETHYLASE; KDM4B PROTEIN; NSC 636819; OXYGENASE INHIBITOR; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER GROWTH; CATALYSIS; CELL DIVISION; CELL PROLIFERATION; CELL VIABILITY; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLIZATION; DEMETHYLATION; DOWN REGULATION; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG TARGETING; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; GENE EXPRESSION; GENE SILENCING; IC 50; LNCAP CELL LINE; PROSTATE CANCER; PROTEIN STRUCTURE; STEREOSPECIFICITY; UPREGULATION; WESTERN BLOTTING;

APOPTOSIS; CELL PROLIFERATION; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HUMANS; JUMONJI DOMAIN-CONTAINING HISTONE DEMETHYLASES; KINETICS; MALE; MODELS, MOLECULAR; MOLECULAR TARGETED THERAPY; PROSTATIC NEOPLASMS; STILBENES; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 84905039523     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm500249n     Document Type: Article

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