Core site-moiety maps reveal inhibitors and binding mechanisms of orthologous proteins by screening compound libraries

PLoS ONE

Volumn 7, Issue 2, 2012, Pages

  Hsu, Kai Cheng ^a   Cheng, Wen Chi ^b   Chen, Yen Fu ^a   Wang, Hung Jung ^b   Li, Ling Ting ^a   Wang, Wen Ching ^b   Yang, Jinn Moon ^a  

^a NATIONAL CHIAO TUNG UNIVERSITY   (Taiwan)

^b NATIONAL TSING HUA UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHOTRANSFERASE; SHIKIMATE KINASE; UNCLASSIFIED DRUG; ENZYME INHIBITOR;

ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; GENETIC CONSERVATION; HELICOBACTER PYLORI; HYDROGEN BOND; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; ORTHOLOGY; PROTEIN BINDING; PROTEIN DETERMINATION; PROTEIN PROTEIN INTERACTION; SCREENING TEST; SITE DIRECTED MUTAGENESIS; STRUCTURE ANALYSIS; ALGORITHM; BIOLOGY; CIRCULAR DICHROISM; DRUG ANTAGONISM; DRUG DESIGN; GENE LIBRARY; IC 50; METABOLISM; METHODOLOGY; MICROBIOLOGICAL EXAMINATION; PROTEIN DATABASE; REPRODUCIBILITY;

HELICOBACTER PYLORI; MYCOBACTERIUM TUBERCULOSIS;

ALGORITHMS; BINDING SITES; CIRCULAR DICHROISM; COMPUTATIONAL BIOLOGY; DATABASES, PROTEIN; DRUG DESIGN; ENZYME INHIBITORS; GENE LIBRARY; HELICOBACTER PYLORI; INHIBITORY CONCENTRATION 50; MICROBIAL SENSITIVITY TESTS; MUTAGENESIS, SITE-DIRECTED; MYCOBACTERIUM TUBERCULOSIS; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PROTEIN BINDING; REPRODUCIBILITY OF RESULTS;

EID: 84863257777     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0032142     Document Type: Article

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