New vasorelaxant indole alkaloids, villocarines A-D from Uncaria villosa

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 13, 2011, Pages 4075-4079

  Matsuo, Hirotaka ^a   Okamoto, Ryuichi ^a   Zaima, Kazumasa ^a   Hirasawa, Yusuke ^a   Ismail, Intan Safinar ^b   Lajis, Nordin Hj ^b   Morita, Hiroshi ^a  

^a HOSHI UNIVERSITY   (Japan)

^b UNIVERSITY PUTRA MALAYSIA   (Malaysia)

Author keywords

Indole alkaloids; Rubiaceae; Uncaria villosa; Vasorelaxant activity; Villocarine A D

Indexed keywords

CALCIUM CHANNEL; CALCIUM ION; INDOLE ALKALOID; NICARDIPINE; NITRIC OXIDE; PHENYLEPHRINE; PLANT EXTRACT; POTASSIUM; RECEPTOR OPERATED CALCIUM CHANNEL; UNCARIA VILLOSA EXTRACT; UNCLASSIFIED DRUG; VILLOCARINE A; VILLOCARINE B; VILLOCARINE C; VILLOCARINE D; VOLTAGE GATED CALCIUM CHANNEL; VOLTAGE GATED POTASSIUM CHANNEL;

ANIMAL TISSUE; ARTICLE; CALCIUM TRANSPORT; CHANNEL GATING; CONTROLLED STUDY; DEPOLARIZATION; DRUG STRUCTURE; ENDOTHELIUM CELL; EXTRACELLULAR SPACE; INHIBITION KINETICS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PLANT LEAF; RAT; RUBIACEAE; UNCARIA; UNCARIA VILLOSA; VASCULAR RING; VASOCONSTRICTION; VASODILATATION;

ANIMALS; AORTA; CALCIUM; CALCIUM CHANNELS; CELLS, CULTURED; ENDOTHELIAL CELLS; INDOLE ALKALOIDS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR CONFORMATION; NITRIC OXIDE; PLANT LEAVES; POTASSIUM CHANNELS, VOLTAGE-GATED; RATS; UNCARIA; VASODILATOR AGENTS;

RATTUS; RUBIACEAE; UNCARIA; VILLOSA;

EID: 79959527482     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.05.014     Document Type: Article

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