Effect of valproic acid and injury on lesion size and endothelial glycocalyx shedding in a rodent model of isolated traumatic brain injury

Journal of Trauma and Acute Care Surgery

Volumn 77, Issue 2, 2014, Pages 292-297

  Jepsen, Cecilie Heerdegen ^a,b   Demoya, Marc A ^a   Perner, Anders ^b   Sillesen, Martin ^a,b   Ostrowski, Sisse R ^b   Alam, Hasan B ^c   Johansson, Pär I ^b,d  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b University of Copenhagen   (Denmark)

^c UNIVERSITY OF MICHIGAN   (United States)

^d UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

Endothelial dysfunction; Rats; S100 ; Traumatic brain injury; Valproic acid

Indexed keywords

PROTEIN S100B; SYNDECAN 1; VALPROIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CELL ACTIVATION; CONFERENCE PAPER; CONTROLLED STUDY; DRUG EFFECT; ENDOTHELIUM; GLYCOCALYX; MALE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; TRAUMATIC BRAIN INJURY; TREATMENT OUTCOME;

ANIMALS; BRAIN; BRAIN INJURIES; DISEASE MODELS, ANIMAL; ENDOTHELIUM, VASCULAR; GLYCOCALYX; HISTONE DEACETYLASE INHIBITORS; MALE; NEUROPROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY; S100 CALCIUM BINDING PROTEIN BETA SUBUNIT; SYNDECAN-1; VALPROIC ACID;

EID: 84905029022     PISSN: 21630755     EISSN: 21630763     Source Type: Journal    
DOI: 10.1097/TA.0000000000000333     Document Type: Conference Paper

References (23)

1. Henrich M, Gruss M, Weigand MA. Sepsis-induced degradation of endothelial glycocalix. ScientificWorldJournal. 2010;10:917-923.
2. Johansson PI, Stensballe J, Rasmussen LS, Ostrowski SR. A high admission syndecan-1 level, a marker of endothelial glycocalyx degradation, is associated with inflammation, protein C depletion, fibrinolysis, and increased mortality in trauma patients. Ann Surg. 2011;254:194-200.
3. Ostrowski SR, Johansson PI. Endothelial glycocalyx degradation induces endogenous heparinization in patients with severe injury and early traumatic coagulopathy. J Trauma Acute Care Surg. 2012;73:60-66.
4. Li Y, Alam HB. Modulation of acetylation: Creating a pro-survival and anti-inflammatory phenotype in lethal hemorrhagic and septic shock. J Biomed Biotechnol. 2011;2011:523481.
5. Alam HB, Shuja F, ButtMU, Duggan M, Li Y, Zacharias N, Fukudome EY, Liu B, Demoya M, Velmahos G. Surviving blood loss without blood transfusion in a swine poly-Trauma model. Surgery. 2009;146:325-333.
6. Causey MW, Salgar S, Singh N, Martin M, Stallings JD. Valproic acid reversed pathologic endothelial cell gene expression profile associated with ischemia-reperfusion injury in a swine hemorrhagic shock model. J Vasc Surg. 2012;55:1096-1103.
7. Jin G, Dugan M, Imam A, Demoya MA, Sillesen M, Hwabejire J, Jepsen CH, Liu B, Mejaddam AY, Lu J, et al. Pharmacologic resuscitation for hemorrhagic shock combined with traumatic brain injury. J Trauma Acute Care Surg. 2012;73:1459-1468.
8. Kleindiest A, BullockMR. A critical analysis of the role of the neurotrophic protein S100B in acute brain injury. J Neurotrauma. 2006;23:1185-1200.
9. SteinDM, LindellAL,MurdockKR,Kufera JA,Menaker J, BochicchioGV, Aarabi B, Scalea TM. Use of serum biomarkers to predict cerebral hypoxia after severe traumatic brain injury. J Neurotrauma. 2012;29:1140-1149.
10. Babcock L, Byczkowski T, Mookerjee S, Bazarian JJ. Ability of S100B to predict severity and cranial CT results in children with TBI. Brain Inj. 2012;26:1372-1380.
11. Pelinka LE, Kroepfl A, Leixnering M, Buchinger W, Raabe A, Redl H. GFAP versus S100B in serum after traumatic brain injuryVrelationship to brain damage and outcome. J Neurotrauma. 2004;21:1553-1561.
12. Kövesdi E, Lückl J, Bukovics P, Farkas O, Pal J, Czeiter E, Szellar D,Do czi T, Komoly S, Büki A. Update on protein biomarkers in traumatic brain injury with emphasis on clinical use in adults and pediatrics. Acta Neurochir (Wien). 2010;152:1-17.
13. Egea-Guerrero JJ, Revuelto-Rey J, Murillo-Cabezas F, Muñoz-Sanchez MA, Vilches-Arenas A, Sanchez-Linares P, Dominguez-Roldan JM, Leon-Carrion J. Accuracy of the S100B protein as a marker of brain damage in traumatic brain injury. Brain Inj. 2012;26:76-82.
14. da Rocha AB, Schneider RF, de Freitas GR, Andre C, Grivicich I, Zanoni C, Fossa A, Gehrke JT, Jotz GP, Kaufmann M, et al. Role of serum S100B as a predictive marker of fatal outcome following isolated severe head injury or multitrauma in males. Clin Chem Lab Med. 2006;44:1234-1242.
15. Dash PK, Orsi SA, Zhang M, Grill RJ, Pati S, Zhao J, Moore AN. Valproate administered after traumatic brain injury provides neuroprotection and improves cognitive function in rats. PLoS One. 2010;5:e11383.
16. Kim HJ, Rowe M, Ren M, Hong JS, Chen PS, Chuang DM. Histone deacetylase inhibitors exhibit anti-inflammatory and neuroprotective effects in a rat permanent ischemic model of stroke: Multiple mechanisms of action. J Pharmacol Exp Ther. 2007;321:892-901.
17. Kozar RA, Peng Z, Zhang R, Holcomb JB, Pati S, Park P, Ko TC, Paredes A. Plasma restoration of endothelial glycocalyx in a rodent model of hemorrhagic shock. Anesth Analg. 2011;112:1289-1295.
18. Haywood-Watson RJ, Holcomb JB, Gonzalez EB, Peng Z, Pati S, Park PW, WangW, ZaskeAM,Menge T,Kozar RA.Modulation of syndecan-1 shedding after hemorrhagic shock and resuscitation. PloS One. 2011;6:e23530.
19. Chodobski A, Zink BJ, Szmydynger-Chodobska J. BloodYbrain barrier pathophysiology in traumatic brain injury. Transl Stroke Res. 2011;2:492-516.
20. Johansson PI, Ostrowski SR. Acute coagulopathy of trauma: Balancing progressive catecholamine induced endothelial activation and damage by fluid phase anticoagulation. Med Hypotheses. 2010;75:564-567.
21. Genet GF, Johansson PI, Meyer MA, Sølbeck S, Sørensen AM, Larsen CF, Welling KL,Windeløv NA, Rasmussen LS, Ostrowski SR. Trauma-induced coagulopathy: Standard coagulation tests, biomarkers of coagulopathy, and endothelial damage in patients with traumatic brain injury. J Neurotrauma. 2013;30:301-306.
22. Properzi F, Lin R, Kwok J, Naidu M, van Kuppevelt TH, Ten Dam GB, Camargo LM, Raha-Chowdury R, Fufukawa Y, Mikami T. Heparan sulphate proteoglycans in glia and in the normal and injured CNS: Expression of sulphotransferases and changes in sulphation. Eur J Neurosci. 2008;27:593-604.
23. Iseki K, Hagino S, Mori T, Zhang Y, Yokoya S, Takaki H, Tase C, Murakawa M, Wanaka A. Increased syndecan expression by pleiotrophin and FGF receptor-expressing astrocytes in injured brain tissue. Glia. 2002;39:1-9.