Role of serum S100B as a predictive marker of fatal outcome following isolated severe head injury or multitrauma in males

Clinical Chemistry and Laboratory Medicine

Volumn 44, Issue 10, 2006, Pages 1234-1242

  Da Rocha, Adriana Brondani ^a   Schneider, Rogerio Fett ^a   De Freitas, Gabriel R ^b   André, Charles ^b   Grivicich, Ivana ^a   Zanoni, Caroline ^a   Fossá, Aline ^a   Gehrke, Junia T ^a   Jotz, Geraldo Pereira ^a   Kaufmann, Mauro ^c   Simon, Daniel ^a   Regner, Andrea ^a,d  

^a UNIVERSIDADE LUTERANA DO BRASIL   (Brazil)

^b FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^c Hospital Cristo Redentor   (Brazil)

^d Hospital de Pronto Socorro   (Brazil)

Author keywords

Biomarkers; Humans; Multitrauma; Outcome; S100B protein; Traumatic brain injury

Indexed keywords

PROTEIN S100B;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; DISEASE MARKER; DISEASE SEVERITY; FATALITY; GLASGOW COMA SCALE; GLASGOW OUTCOME SCALE; HEAD INJURY; HUMAN; IMMUNOASSAY; INTENSIVE CARE; INTENSIVE CARE UNIT; LUMINESCENCE; MALE; MORTALITY; MULTIPLE TRAUMA; OUTCOME ASSESSMENT; PREDICTION; PREDICTOR VARIABLE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SENSITIVITY AND SPECIFICITY; SURVIVAL; TRAUMATIC BRAIN INJURY;

ADULT; BIOLOGICAL MARKERS; BRAIN INJURIES; BRAZIL; HUMANS; MALE; MIDDLE AGED; NERVE GROWTH FACTORS; PREDICTIVE VALUE OF TESTS; ROC CURVE; S100 PROTEINS; SURVIVAL ANALYSIS;

EID: 33750049667     PISSN: 14346621     EISSN: 14346621     Source Type: Journal    
DOI: 10.1515/CCLM.2006.218     Document Type: Article

References (44)

1. Bruns JR, Hauser WA. The epidemiology of traumatic brain injury: a review. Epilepsia 2003;44:2-10.
2. Kraus JF, MacArthur DL, Silverman TA, Jayaraman N. Epidemiology of brain injury. In: Narayan RK, Wilberger Jr JE, Povlishock JT, editors. Neurotrauma. New York: McGraw-Hill, 1996:13-30.
3. Ghajar J. Traumatic brain injury. Lancet 2000;356:923-9.
4. Wilson JT, Pettigrew LE, Teasdale GM. Structured interviews for the Glasgow Outcome Scale and the Extended Glasgow Outcome Scale: guidelines for their use. J Neurotrauma 1998;15:573-85.
5. Duff D. Altered states of consciousness, theories of recovery and assessment following a severe traumatic brain injury. Axone 2003;23:18-23.
6. Faden AL. Neuroprotection and traumatic brain injury: theoretical option or realistic proposition. Curr Opin Neurol 2002;15:707-12.
7. Chen Y, Swanson RA. Astrocytes and brain injury. J Cereb Blood Flow Metab 2003;23:137-49.
8. Petzold A, Green AJE, Keir G, Fairley S, Kitchen N, Smith M, et al. Role of serum S100B as an early predictor of high intracranial pressure and mortality in brain injury: a pilot study. Crit Care Med 2002;30:2705-10.
9. Kanner AA, Marchi N, Fazio V, Mayberg MR, Koltz MT, Siomin V, et al. Serum S100B: a noninvasive marker of blood-brain barrier function and brain lesions. Cancer 2003;97:2806-13.
10. Elting J-W, Jager AE, Teelken AW, Schaaf MJ, Maurits NM, Van Der Naalt J, et al. Comparison of serum S-100 protein levels following stroke and traumatic brain injury. J Neurol Sci 2000;181:104-10.
11. Jönsson H, Johnsson P, Höglund P, Ailing C, Blomquist S. Elimination of S100B and renal function after cardiac surgery. J Cardiothorac Vasc Anesth 2000;14:698-701.
12. Martens P, Raabe A, Johnsson P. Serum S-100 and neuron-specific enolase for prediction of regaining consciousness after global cerebral ischemia. Stroke 1998;29:2363-6.
13. Mussack T, Biberthaler P, Kanz K, Wiedemann E, Mutschler W, et al. Serum S-100B and interleukin-8 as predictive markers for comparative neurologic outcome analysis of patients after cardiac arrest and severe traumatic brain injury. Crit Care Med 2002;30:2669-74.
14. Raabe A, Kopetsch O, Woszczyk A, Lang J, Gerlach R. Serum S100B protein as a molecular marker in severe traumatic brain injury. Restor Neurol Neurosci 2003;21:159-69.
15. Regner A, Kaufman M, Friedman G, Chemale I. Increased serum S100B protein concentrations following severe head injury in humans: a biochemical marker of brain death? NeuroReport 2001;12:691-4.
16. Rosén H, Rosengren L, Herlitz J, Blomstrand C. Increased serum levels of the S-100 protein are associated with hypoxic brain damage after cardiac arrest. Stroke 1998;29:473-7.
17. Snyder-Ramos SA, Böttiger BW. Molecular markers of brain damage - clinical and ethical implications with particular focus on cardiac arrest. Restor Neurol Neurosci 2003;21:123-39.
18. Ingebrigtsen T, Waterloo K, Jacobsen EA, Langbakk B, Romner B. Traumatic brain damage in minor head injury: relation of serum S-100 protein measurements to magnetic resonance imaging and neurobehavioral outcome. Neurosurgery 1999;45:468-76.
19. Raabe A, Grolms C, Keller M, Döhnert J, Sorge O, Seifert V. Correlation of computed tomography findings and serum brain damage markers following severe head injury. Acta Neurochir Wien 1998;140:787-92.
20. Anderson RE, Hansson L-O, Nilsson O, Dijlai-Merzoug R, Settergren G. High serum S100B levels for trauma patients without head injuries. Neurosurgery 2001;48:1255-60.
21. Roof RL, Hall ED. Gender differences in acute CNS trauma and stroke: neuroprotective effects of estrogen and progesterone. J Neurotrauma 2000;17:367-88.
22. Jarrar D, Wang P, Cioffi WG, Bland KI, Chaudry IH. The female reproductive cycle is an important variable in the response to trauma-hemorrhage. Am J Physiol Heart Circ Physiol 2000;279:H1015-21.
23. Lai YC, Chen FG, Goh MH, Koh KF. Predictors of long-term outcome in severe head injury. Ann Acad Med Singapore 1998;27:326-31.
24. Masson F, Thicoipe M, Mokui T, Aye P, Erny P, Dabadie P. Epidemiology of traumatic comas: a prospective population-based study. Brain Injury 2003;17:279-93.
25. Leone M, Albanase J, Rousseau S, Antonini F, Dubuc M, Alliez B, et al. Pulmonary contusion in severe head trauma patient: impact on gas exchange and outcome. Chest 2003;124:2261-6.
26. Zagara G, Scaravilli P, Mastorgio P, Seveso M. Validation of a prognostic system in severe brain-injured patients. J Neurosurg Sci 1992;35:77-81.
27. Herrmann M, Curio N, Jost S, Wunderlich MT, Synowitz H, Wallesch CW, et al. Release of biochemical markers of damage to neuronal and glial brain tissue is associated with short and long term neuropsychological outcome after traumatic brain injury. Neurol Neurosurg Psychiatry 2001;70:95-100.
28. Hu J, Ferreira A, van Eldik LJ. S100B induces neuronal cell death through nitric oxide release from astrocytes. J Neurochem 1997;69:2294-301.
29. McAdory BS, van Eldik LJ, Norden JJ. S100B, a neurotrophic protein that modulates neuronal protein phosphorylation, is upregulated during lesion-induced collateral sprouting and reactive synaptogenesis. Brain Res 1998;813:211-7.
30. Neuwelt EA. Mechanisms of disease: the blood-brain barrier. Neurosurgery 2004;54:131-40.
31. Petzold A, Keir G, Lim D, Smith M, Thompson EJ. Cerebrospinal fluid (CSF) and serum S100B: release and wash-out pattern. Brain Res Bull 2003;61:281-5.
32. Woertgen C, Rothoerl D, Brawanski A. Early S-100B serum level correlates to quality of life in patients after severe head injury. Brain Injury 2002;16:807-16.
33. Dimopoulou I, Korfias S, Dafni U, Anthi A, Psachoulia C, Jullien G, et al. Protein S-100b serum levels in trauma-induced brain death. Neurology 2003;60:947-51.
34. Marshall LF. Head injury: recent past, present, and future. Neurosurgery 2000;47:546-61.
35. Da Rocha AB, Zanoni C, de Freitas GR, Andre C, Himelfarb S, Schneider R, et al. Serum Hsp70 as an early predictor of fatal outcome after severe traumatic brain injury in males. J Neurotrauma 2005;15:385-92.
36. Pelinka LE, Kroepfl A, Schmidhammer R, Redl H. Serum procalcitonin and S100B are associated with mortality after traumatic brain injury. Eur J Trauma 2003;5:316-23.
37. Herrmann M, Curio N, Jost S, Wunderlich MT, Synowitz H, Wallesch C-W. Protein S-100B and neuron specific enolase as early neurobiochemical markers of the severity of traumatic brain injury. Restor Neurol Neurosci 1999;14:109-14.
38. Rothoerl RD, Woertgen C, Holzschuh M, Metz C, Brawanski A. S-100 serum levels after minor and major head injury. J Trauma 1998;45:765-7.
39. Mussack T, Biberthaler P, Gippner-Steppert C, Kanz KG, Wiedemann E, Mutschler W, et al. Early cellular brain damage and systemic inflammatory response after cardiopulmonary resuscitation or isolated severe head trauma: a comparative pilot study on common pathomechanisms. Resuscitation 2001;49:193-9.
40. Townend WJ, Guy MJ, Pani MA, Martin B, Yates DW. Head injury outcome prediction in the emergency department: a role for protein S-100B? J Neurol Neurosurg Psychiatry 2002;73:542-6.
41. Finfer SR, Cohen J. Severe traumatic brain injury. Resuscitation 2001;48:77-90.
42. Jönsson H. S100B and cardiac surgery: possibilities and limitations. Restor Neurol Neurosci 2003;21:151-7.
43. Pelinka LE, Szalay L, Jafarmadar M, Schmidhammer R, Redl H, Bahrami S. Circulating S100B is increased after bilateral femur fracture without brain injury in the rat. Br J Anaesth 2003;91:595-7.
44. Savola O, Pyhtinen J, Leino TK, Siitonen S, Niemela O, Hillbom M. Effects of head and extracranial injuries on serum protein S100B levels in trauma patients. J Trauma 2004;56:1229-34.