-
1
-
-
79952232216
-
Global cancer statistics
-
Jemal, A. et al. Global cancer statistics. CA Cancer J Clin 61, 69-90 (2011).
-
(2011)
CA Cancer J Clin
, vol.61
, pp. 69-90
-
-
Jemal, A.1
-
2
-
-
0032847563
-
Genetic aspects of hepatocellular carcinogenesis
-
Ozturk, M. Genetic aspects of hepatocellular carcinogenesis. Semin Liver Dis 19, 235-242 (1999). (Pubitemid 29488766)
-
(1999)
Seminars in Liver Disease
, vol.19
, Issue.3
, pp. 235-242
-
-
Ozturk, M.1
-
3
-
-
79952038522
-
Intracellular signaling and hepatocellular carcinoma
-
Iakova, P., Timchenko, L. T. & Timchenko, N. A. Intracellular signaling and hepatocellular carcinoma. Seminars in Cancer Biology 21, 28-34 (2011).
-
(2011)
Seminars in Cancer Biology
, vol.21
, pp. 28-34
-
-
Iakova, P.1
Timchenko, L.T.2
Timchenko, N.A.3
-
4
-
-
0029155354
-
Terminology of nodular hepatocellular lesions
-
International Working Party
-
International Working Party. Terminology of nodular hepatocellular lesions. Hepatology 22, 983-993 (1995).
-
(1995)
Hepatology
, vol.22
, pp. 983-993
-
-
-
5
-
-
0033978257
-
Reduced stability of retinoblastoma protein by gankyrin, an oncogenic ankyrin-repeat protein overexpressed in hepatomas
-
DOI 10.1038/71600
-
Higashitsuji, H. et al. Reduced stability of retinoblastoma protein by gankyrin, an oncogenic ankyrin-repeat protein overexpressed in hepatomas. NatMed 6, 96-99 (2000). (Pubitemid 30048534)
-
(2000)
Nature Medicine
, vol.6
, Issue.1
, pp. 96-99
-
-
Higashitsuji, H.1
Itoh, K.2
Nagao, T.3
Dawson, S.4
Nonoguchi, K.5
Kido, T.6
Mayer, R.J.7
Arii, S.8
Fujita, J.9
-
6
-
-
0347093301
-
The Crystal Structure of Gankyrin, an Oncoprotein Found in Complexes with Cyclin-dependent Kinase 4, a 19 S Proteasomal ATPase Regulator, and the Tumor Suppressors Rb and p53
-
DOI 10.1074/jbc.M310265200
-
Krzywda, S. et al. The crystal structure of gankyrin, an oncoprotein found in complexes with cyclin-dependent kinase 4, a 19S proteasomal ATPase regulator, and the tumor suppressors Rb and p53. J Biol Chem 279, 1541-1545 (2004). (Pubitemid 38082684)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.2
, pp. 1541-1545
-
-
Krzywda, S.1
Brzozowski, A.M.2
Higashitsuji, H.3
Fujita, J.4
Welchman, R.5
Dawson, S.6
Mayer, R.J.7
Wilkinson, A.J.8
-
7
-
-
4644353678
-
Solution structure of the human oncogenic protein gankyrin containing seven ankyrin repeats and analysis of its structure-function relationship
-
DOI 10.1021/bi049116o
-
Yuan, C. et al. Solution structure of the human oncogenic protein gankyrin containing seven ankyrin repeats and analysis of its structure-function relationship. Biochemistry 43, 12152-12161 (2004). (Pubitemid 39280559)
-
(2004)
Biochemistry
, vol.43
, Issue.38
, pp. 12152-12161
-
-
Yuan, C.1
Li, J.2
Mahajan, A.3
Poi, M.J.4
Byeon, I.-J.L.5
Tsai, M.-D.6
-
8
-
-
0037177225
-
Novel insights into the INK4-CDK4/6-Rb pathway: Counter action of gankyrin against INK4 proteins regulates the CDK4-mediated phosphorylation of Rb
-
DOI 10.1021/bi011550s
-
Li, J. & Tsai, M. D. Novel insights into the INK4-CDK4/6-Rb pathway: counter action of gankyrin against INK4 proteins regulates the CDK4-mediated phosphorylation of Rb. Biochemistry 41, 3977-3983 (2002). (Pubitemid 34251036)
-
(2002)
Biochemistry
, vol.41
, Issue.12
, pp. 3977-3983
-
-
Li, J.1
Tsai, M.-D.2
-
9
-
-
0141744649
-
Role of a novel oncogenic protein, gankyrin, in hepatocyte proliferation
-
DOI 10.1007/s00535-003-1141-8
-
Iwai, A. et al. Role of a novel oncogenic protein, gankyrin, in hepatocyte proliferation. J Gastroenterol 38, 751-758 (2003). (Pubitemid 37161339)
-
(2003)
Journal of Gastroenterology
, vol.38
, Issue.8
, pp. 751-758
-
-
Iwai, A.1
Marusawa, H.2
Kiuchi, T.3
Higashitsuji, H.4
Tanaka, K.5
Fujita, J.6
Chiba, T.7
-
10
-
-
22244486994
-
The oncoprotein gankyrin binds to MDM2/HDM2, enhancing ubiquitylation and degradation of p53
-
DOI 10.1016/j.ccr.2005.06.006, PII S1535610805001947
-
Higashitsuji, H. et al. The oncoprotein gankyrin binds to MDM2/HDM2, enhancing ubiquitylation and degradation of p53. Cancer Cell 8, 75-87 (2005). (Pubitemid 40991816)
-
(2005)
Cancer Cell
, vol.8
, Issue.1
, pp. 75-87
-
-
Higashitsuji, H.1
Higashitsuji, H.2
Itoh, K.3
Sakurai, T.4
Nagao, T.5
Sumitomo, H.6
Masuda, T.7
Dawson, S.8
Shimada, Y.9
Mayer, R.J.10
Fujita, J.11
-
11
-
-
33646542006
-
Gankyrin: A new oncoprotein and regulator of prb and p53
-
DOI 10.1016/j.tcb.2006.03.001, PII S096289240600081X
-
Dawson, S., Higashitsuji, H.,Wilkinson, A. J., Fujita, J. &Mayer, R. J. Gankyrin: a new oncoprotein and regulator of pRb and p53. Trends Cell Biol 16, 229-233 (2006). (Pubitemid 43728872)
-
(2006)
Trends in Cell Biology
, vol.16
, Issue.5
, pp. 229-233
-
-
Dawson, S.1
Higashitsuji, H.2
Wilkinson, A.J.3
Fujita, J.4
Mayer, R.J.5
-
12
-
-
26444512037
-
The oncoprotein gankyrin negatively regulates both p53 and RB by enhancing proteasomal degradation
-
Higashitsuji, H., Liu, Y., Mayer, R. J. & Fujita, J. The oncoprotein gankyrin negatively regulates both p53 and RB by enhancing proteasomal degradation. Cell cycle 4, 1335-1337 (2005). (Pubitemid 41437115)
-
(2005)
Cell Cycle
, vol.4
, Issue.10
, pp. 1335-1337
-
-
Higashitsuji, H.1
Liu, Y.2
Mayer, R.J.3
Fujita, J.4
-
13
-
-
20844457318
-
GANK and its correlation with RB in human hepatocellular carcinoma
-
DOI 10.1111/j.1478-3231.2005.01003.x
-
Tan, L. et al. Expression of p28GANK and its correlation with RB in human hepatocellular carcinoma. Liver International 25, 667-676 (2005). (Pubitemid 40861916)
-
(2005)
Liver International
, vol.25
, Issue.3
, pp. 667-676
-
-
Tan, L.1
Fu, X.-Y.2
Liu, S.-Q.3
Li, H.-H.4
Hong, Y.5
Wu, M.-C.6
Wang, H.-Y.7
-
14
-
-
0035061655
-
INK4A exon 1 in hepatocellular carcinoma
-
DOI 10.1002/mc.1022
-
Park, T. J. et al. Sequential changes in hepatocarcinogenesis induced by diethylnitrosamine plus thioacetamide in Fischer 344 rats: induction of gankyrin expression in liver fibrosis, pRB degradation in cirrhosis, and methylation of p16(INK4A) exon 1 in hepatocellular carcinoma. Mol Carcinog 30, 138-150 (2001). (Pubitemid 32274077)
-
(2001)
Molecular Carcinogenesis
, vol.30
, Issue.3
, pp. 138-150
-
-
Park, T.J.1
Kim, H.S.2
Byun, K.H.3
Jang, J.J.4
Lee, Y.S.5
Lim, I.K.6
-
15
-
-
0036678085
-
Overexpression of p28/gankyrin in human hepatocellular carcinoma and its clinical significance
-
Fu, X. Y. et al. Overexpression of p28/gankyrin in human hepatocellular carcinoma and its clinical significance. World J Gastroenterol l8, 638-643 (2002).
-
(2002)
World J Gastroenterol
, pp. 638-643
-
-
Fu, X.Y.1
-
16
-
-
0036861139
-
Spectrum of molecular changes during hepatocarcinogenesis induced by DEN and other chemicals in Fischer 344 male rats
-
DOI 10.1016/S0047-6374(02)00087-8, PII S0047637402000878
-
Lim, I. K. Spectrumofmolecular changes during hepatocarcinogenesis induced by DEN and other chemicals in Fischer 344 male rats. Mech Ageing Dev 123, 1665-1680 (2002). (Pubitemid 35449230)
-
(2002)
Mechanisms of Ageing and Development
, vol.123
, Issue.12
, pp. 1665-1680
-
-
Lim, I.K.1
-
17
-
-
39549122562
-
Association of gankyrin protein expression with early clinical stages and insulin-like growth factor-binding protein 5 expression in human hepatocellular carcinoma
-
DOI 10.1002/hep.22027
-
Umemura, A. et al. Association of gankyrin protein expression with early clinical stages and insulin-like growth factor-binding protein 5 expression in human hepatocellular carcinoma. Hepatology 47, 493-502 (2008). (Pubitemid 351280717)
-
(2008)
Hepatology
, vol.47
, Issue.2
, pp. 493-502
-
-
Umemura, A.1
Itoh, Y.2
Itoh, K.3
Yamaguchi, K.4
Nakajima, T.5
Higashitsuji, H.6
Onoue, H.7
Fukumoto, M.8
Okanoue, T.9
Fujita, J.10
-
18
-
-
78751544628
-
P28GANK overexpression accelerates hepatocellular carcinoma invasiveness and metastasis via phosphoinositol 3-kinase/AKT/hypoxiainducible factor-1a pathways
-
Fu, J. et al. p28GANK overexpression accelerates hepatocellular carcinoma invasiveness and metastasis via phosphoinositol 3-kinase/AKT/hypoxiainducible factor-1a pathways. Hepatology 53, 181-192 (2011).
-
(2011)
Hepatology
, vol.53
, pp. 181-192
-
-
Fu, J.1
-
19
-
-
80053319810
-
Gankyrin-mediated dedifferentiation facilitates the tumorigenicity of rat hepatocytes and hepatoma cells
-
Sun, W. et al. Gankyrin-mediated dedifferentiation facilitates the tumorigenicity of rat hepatocytes and hepatoma cells. Hepatology 54, 1259-1272 (2011).
-
(2011)
Hepatology
, vol.54
, pp. 1259-1272
-
-
Sun, W.1
-
20
-
-
84861587167
-
P28(GANK) prevents degradation of Oct4 and promotes expansion of tumor-initiating cells in hepatocarcinogenesis
-
Qian, Y. W. et al. p28(GANK) prevents degradation of Oct4 and promotes expansion of tumor-initiating cells in hepatocarcinogenesis. Gastroenterology 142, 1547-1558 (2012).
-
(2012)
Gastroenterology
, vol.142
, pp. 1547-1558
-
-
Qian, Y.W.1
-
21
-
-
84863694597
-
Cirrhosis and pre-neoplastic lesions
-
Grazioli, L., Olivetti, L.&Orlando, E. Cirrhosis and pre-neoplastic lesions. Abdom Imaging 37, 188-214 (2012).
-
(2012)
Abdom Imaging
, vol.37
, pp. 188-214
-
-
Grazioli, L.1
Olivetti, L.2
Orlando, E.3
-
22
-
-
0035754080
-
To cycle or not to cycle: A critical decision in cancer
-
Malumbres, M. & Barbacid, M. To cycle or not to cycle: a critical decision in cancer. Nat Rev Cancer 1, 222-231 (2001). (Pubitemid 33741897)
-
(2001)
Nature Reviews Cancer
, vol.1
, Issue.3
, pp. 222-231
-
-
Malumbres, M.1
Barbacid, M.2
-
23
-
-
0037369657
-
Prospective analysis of risk factors for hepatocellular carcinoma in patients with liver cirrhosis
-
DOI 10.1053/jhep.2003.50093
-
Velazquez, R. F. et al. Prospective analysis of risk factors for hepatocellular carcinoma in patients with liver cirrhosis. Hepatology 37, 520-527 (2003). (Pubitemid 36258772)
-
(2003)
Hepatology
, vol.37
, Issue.3
, pp. 520-527
-
-
Velazquez, R.F.1
Rodriguez, M.2
Navascues, C.A.3
Linares, A.4
Perez, R.5
Sotorrios, N.G.6
Martinez, I.7
Rodrigo, L.8
-
24
-
-
8444252529
-
High levels of p53 protein expression do not correlate with p53 mutations in hepatocellular carcinoma
-
DOI 10.1111/j.1365-2893.2004.00541.x
-
Anzola, M. et al. High levels of p53 protein expression do not correlate with p53 mutations in hepatocellular carcinoma. J Viral Hepat 11, 502-510 (2004). (Pubitemid 39486613)
-
(2004)
Journal of Viral Hepatitis
, vol.11
, Issue.6
, pp. 502-510
-
-
Anzola, M.1
Saiz, A.2
Cuevas, N.3
Lopez-Martinez, M.4
Martinez De Pancorbo, M.A.5
Burgos, J.J.6
-
25
-
-
79955505615
-
Hepatocellular carcinoma
-
Bosman, F. T., Carneiro, F., Hruban, R. H. & Theise, N. D. eds 4th ed. IARC: Lyon
-
Theise, N. D. et al. Hepatocellular carcinoma. In: Bosman, F. T., Carneiro, F., Hruban, R. H. & Theise, N. D. eds.WHOclassification of tumours of the digestive system. 4th ed. IARC: Lyon, 205-216 (2010).
-
(2010)
WHO Classification of Tumours of the Digestive System
, pp. 205-216
-
-
Theise, N.D.1
-
26
-
-
84862837453
-
Repression of endometrial tumor growth by targeting SREBP1 and lipogenesis
-
Li, W. et al. Repression of endometrial tumor growth by targeting SREBP1 and lipogenesis. Cell Cycle 11, 1-11 (2012).
-
(2012)
Cell Cycle
, vol.11
, pp. 1-11
-
-
Li, W.1
-
27
-
-
36849040707
-
Gankyrin oncoprotein overexpression as a critical factor for tumor growth in human esophageal squamous cell carcinoma and its clinical significance
-
DOI 10.1002/ijc.23106
-
Ortiz, C. M. et al. Gankyrin oncoprotein overexpression as a critical factor for tumor growth in human esophageal squamous cell carcinoma and its clinical significance. Int J Cancer 122, 325-332 (2008). (Pubitemid 350234718)
-
(2008)
International Journal of Cancer
, vol.122
, Issue.2
, pp. 325-332
-
-
Ortiz, C.M.1
Ito, T.2
Tanaka, E.3
Tsunoda, S.4
Nagayama, S.5
Sakai, Y.6
Higashitsuji, H.7
Fujita, J.8
Shimada, Y.9
-
28
-
-
35148886434
-
Tumour invasion and metastasis initiated by microRNA-10b in breast cancer
-
DOI 10.1038/nature06174, PII NATURE06174
-
Ma, L., Teruya-Feldstein, J. & Weinberg, R. A. Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. Nature 449, 682-688 (2007). (Pubitemid 47552092)
-
(2007)
Nature
, vol.449
, Issue.7163
, pp. 682-688
-
-
Ma, L.1
Teruya-Feldstein, J.2
Weinberg, R.A.3
|