P28GANK prevents degradation of Oct4 and promotes expansion of tumor-initiating cells in hepatocarcinogenesis

Gastroenterology

Volumn 142, Issue 7, 2012, Pages

  Qian, You Wen ^a   Chen, Yao ^a   Yang, Wen ^a   Fu, Jing ^a   Cao, Jie ^a   Ren, Yi Bin ^a   Zhu, Jun Jie ^a   Su, Bo ^a   Luo, Tao ^a   Zhao, Xiao Fang ^a   Dai, Rong Yang ^a   Li, Juan Juan ^a   Sun, Wen ^a   Wu, Meng Chao ^a   Feng, Gen Sheng ^a,b   Wang, Hong Yang ^a,c  

^a Eastern Hepatobiliary Surgery Institute/Hospital   (China)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Cancer Stem Cell; Liver Cancer; Response to Chemotherapy; Self Renewal

Indexed keywords

OCTAMER TRANSCRIPTION FACTOR 4; ONCOPROTEIN; OV6 PROTEIN; PROTEIN P28; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; WWP2 PROTEIN;

ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER GROWTH; CANCER RESISTANCE; CANCER STEM CELL; CARCINOGENICITY; CARCINOMA CELL; CELL ACTIVATION; CELL DIFFERENTIATION; CELL ISOLATION; CELL RENEWAL; CELL SELECTION; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; IN VITRO STUDY; LIVER CARCINOGENESIS; LIVER CELL; LIVER CELL CARCINOMA; LUNG METASTASIS; MAJOR CLINICAL STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCID MOUSE; SPHEROID CELL; STEM CELL EXPANSION; UBIQUITINATION;

EID: 84861587167     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2012.02.042     Document Type: Article

References (35)

1. J.E. Visvader Cells of origin in cancer Nature 469 2011 314 322
2. D.M. Parkin, F. Bray, J. Ferlay Global cancer statistics, 2002 CA Cancer J Clin 55 2005 74 108
3. S. Ma, K.W. Chan, L. Hu Identification and characterization of tumorigenic liver cancer stem/progenitor cells Gastroenterology 132 2007 2542 2556
4. Z.F. Yang, D.W. Ho, M.N. Ng Significance of CD90+ cancer stem cells in human liver cancer Cancer Cell 13 2008 153 166
5. T. Yamashita, J. Ji, A. Budhu EpCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem/progenitor cell features Gastroenterology 136 2009 1012 1024
6. T.K. Lee, A. Castilho, V.C. Cheung CD24(+) liver tumor-initiating cells drive self-renewal and tumor initiation through STAT3-mediated NANOG regulation Cell Stem Cell 9 2011 50 63
7. N. Haraguchi, H. Ishii, K. Mimori CD13 is a therapeutic target in human liver cancer stem cells J Clin Invest 120 2010 3326 3339
8. W. Yang, H.X. Yan, L. Chen Wnt/beta-catenin signaling contributes to activation of normal and tumorigenic liver progenitor cells Cancer Res 68 2008 4287 4295
9. H. Higashitsuji, K. Itoh, T. Nagao Reduced stability of retinoblastoma protein by gankyrin, an oncogenic ankyrin-repeat protein overexpressed in hepatomas Nat Med 6 2000 96 99
10. H. Higashitsuji, K. Itoh, T. Sakurai The oncoprotein gankyrin binds to MDM2/HDM2, enhancing ubiquitylation and degradation of p53 Cancer Cell 8 2005 75 87
11. H. Higashitsuji, Y. Liu, T. Masuda The oncoprotein gankyrin interacts with RelA and suppresses NF-kappaB activity Biochem Biophys Res Commun 363 2007 879 884
12. Y. Chen, H.H. Li, J. Fu Oncoprotein p28 GANK binds to RelA and retains NF-kappaB in the cytoplasm through nuclear export Cell Res 17 2007 1020 1029
13. H. Li, X. Fu, Y. Chen Use of adenovirus-delivered siRNA to target oncoprotein p28GANK in hepatocellular carcinoma Gastroenterology 128 2005 2029 2041
14. J. Fu, Y. Chen, J. Cao p28GANK overexpression accelerates hepatocellular carcinoma invasiveness and metastasis via phosphoinositol 3-kinase/AKT/hypoxia- inducible factor-1alpha pathways Hepatology 53 2011 181 192
15. J. Nichols, B. Zevnik, K. Anastassiadis Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4 Cell 95 1998 379 391
16. G. Dontu, W.M. Abdallah, J.M. Foley In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells Genes Dev 17 2003 1253 1270
17. D. Fang, T.K. Nguyen, K. Leishear A tumorigenic subpopulation with stem cell properties in melanomas Cancer Res 65 2005 9328 9337
18. S.H. Chiou, M.L. Wang, Y.T. Chou Coexpression of Oct4 and Nanog enhances malignancy in lung adenocarcinoma by inducing cancer stem cell-like properties and epithelial-mesenchymal transdifferentiation Cancer Res 70 2010 10433 10444
19. H. Xu, W. Wang, C. Li WWP2 promotes degradation of transcription factor OCT4 in human embryonic stem cells Cell Res 19 2009 561 573
20. Y. Saeki, E.A. Toh, T. Kudo Multiple proteasome-interacting proteins assist the assembly of the yeast 19S regulatory particle Cell 137 2009 900 913
21. C.M. Ortiz, T. Ito, E. Tanaka Gankyrin oncoprotein overexpression as a critical factor for tumor growth in human esophageal squamous cell carcinoma and its clinical significance Int J Cancer 122 2008 325 332
22. J.H. Man, B. Liang, Y.X. Gu Gankyrin plays an essential role in Ras-induced tumorigenesis through regulation of the RhoA/ROCK pathway in mammalian cells J Clin Invest 120 2010 2829 2841
23. Y.F. Shan, W.P. Zhou, X.Y. Fu The role of p28GANK in rat oval cells activation and proliferation Liver Int 26 2006 240 247
24. W. Sun, J. Ding, K. Wu Gankyrin-mediated dedifferentiation facilitates the tumorigenicity of rat hepatocytes and hepatoma cells Hepatology 54 2011 1259 1272
25. T. Chiba, Y.W. Zheng, K. Kita Enhanced self-renewal capability in hepatic stem/progenitor cells drives cancer initiation Gastroenterology 133 2007 937 950
26. Y. Atlasi, S.J. Mowla, S.A. Ziaee OCT-4, an embryonic stem cell marker, is highly expressed in bladder cancer Int J Cancer 120 2007 1598 1602
27. X.Q. Wang, W.M. Ongkeko, L. Chen Octamer 4 (Oct4) mediates chemotherapeutic drug resistance in liver cancer cells through a potential Oct4-AKT-ATP-binding cassette G2 pathway Hepatology 52 2010 528 539
28. D.H. Scoville, T. Sato, X.C. He Current view: intestinal stem cells and signaling Gastroenterology 134 2008 849 864
29. L.W. Dong, G.Z. Yang, Y.F. Pan The oncoprotein p28(GANK) establishes a positive feedback loop in beta-catenin signaling Cell Res 21 2011 1248 1261
30. H. Hong, K. Takahashi, T. Ichisaka Suppression of induced pluripotent stem cell generation by the p53-p21 pathway Nature 460 2009 1132 1135
31. J.E. Visvader, G.J. Lindeman Cancer stem cells in solid tumours: accumulating evidence and unresolved questions Nat Rev Cancer 8 2008 755 768
32. H. Li, X. Fu, Y. Chen Use of adenovirus-delivered siRNA to target oncoprotein p28GANK in hepatocellular carcinoma Gastroenterology 128 2005 2029 2041
33. J. Fu, Y. Chen, J. Cao p28GANK overexpression accelerates hepatocellular carcinoma invasiveness and metastasis via phosphoinositol 3-kinase/AKT/hypoxia- inducible factor-1alpha pathways Hepatology 53 2011 181 192
34. H. Xu, W. Wang, C. Li WWP2 promotes degradation of transcription factor OCT4 in human embryonic stem cells Cell Res 19 2009 561 573
35. Y. Chen, H.H. Li, J. Fu Oncoprotein p28 GANK binds to RelA and retains NF-kappaB in the cytoplasm through nuclear export Cell Res 17 2007 1020 1029