Honeybee apisimin and plant arabinogalactans in honey costimulate monocytes

Food Chemistry

Volumn 168, Issue , 2015, Pages 34-40

  Gannabathula, Swapna ^a   Krissansen, Geoffrey W ^a   Skinner, Margot ^a   Steinhorn, Gregor ^b   Schlothauer, Ralf ^b  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b Chief Technology Officer   (New Zealand)

Author keywords

Apisimin; Arabinogalactan protein; Honey; Monocytes; TNF

Indexed keywords

CELL PROLIFERATION; PROTEINS;

APISIMIN; ARABINOGALACTAN PROTEINS; BLOOD MONOCYTES; HONEY; LYMPHOCYTE PROLIFERATION; MONOCYTES; NEW ZEALAND; ROYAL JELLY;

FOOD PRODUCTS;

APISIMIN; ARABINOGALACTAN; IMMUNOSTIMULATING AGENT; NATURAL PRODUCT; ROYAL JELLY; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ARABINOGALACTAN PROTEIN; GUM ARABIC; INSECT PROTEIN; VEGETABLE PROTEIN; ARABINOGALACTAN PROTEINS; FATTY ACID; MUCOPROTEIN;

AGAR DIFFUSION; AGAR GEL ELECTROPHORESIS; ARTICLE; CONTROLLED STUDY; HONEY; IMMUNOREACTIVITY; IMMUNOSTIMULATION; LYMPHOCYTE PROLIFERATION; MOLECULAR WEIGHT; MONOCYTE; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN SECRETION; ADULT; APIS MELLIFERA; CELL STIMULATION; CLOVER; COMPLEX FORMATION; CYTOKINE RELEASE; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG POTENTIATION; HONEYBEE; HUMAN; HUMAN CELL; KUNZEA; KUNZEA ERICOIDES; LEPTOSPERMUM; LEPTOSPERMUM SCOPARIUM; NEW ZEALAND; NORMAL HUMAN; ANALYSIS; ANIMAL; BEE; CELL CULTURE; DRUG EFFECTS; IMMUNOLOGY;

ANIMALS; BEES; CELLS, CULTURED; FATTY ACIDS; HONEY; HUMANS; INSECT PROTEINS; MONOCYTES; MUCOPROTEINS; NEW ZEALAND; PLANT PROTEINS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84904962612     PISSN: 03088146     EISSN: 18737072     Source Type: Journal    
DOI: 10.1016/j.foodchem.2014.07.007     Document Type: Article

References (38)

1. F. Ausubel Current protocols in molecular biology 1999 John Wiley & Sons New York Vol. 2, 10.12B.15-10.12B.11
2. J. Bardy, N.J. Slevin, K.L. Mais, and A. Molassiotis A systematic review of honey uses and its potential value within oncology care Journal of Clinical Nursing 17 2008 2604 2623
3. Bean, A. (2012). Investigating the anti-inflammatory activity of honey (Ph.D. thesis). University of Waikato. < http://hdl.handle.net/10289/6218 >.
4. B. Biglari, A. Moghaddam, K. Santos, G. Blaser, A. Büchler, and G. Jansen et al. Multicentre prospective observational study on professional wound care using honey (Medihoney™) International Wound Journal 10 2013 252 259
5. K. Bilikova, J. Hanes, E. Nordhoff, W. Saenger, J. Klaudiny, and J. Simuth Apisimin, a new serine-valine-rich peptide from honeybee (Apis mellifera L.) royal jelly: Purification and molecular characterization FEBS Letters 528 2002 125 129 (Pubitemid 35258011)
6. A.S. Bischofberger, C.M. Dart, N.R. Perkins, A. Kelly, L. Jeffcott, and A.J. Dart The effect of short- and long-term treatment with manuka honey on second intention healing of contaminated and noncontaminated wounds on the distal aspect of the forelimbs in horses Veterinary Surgery 42 2013 154 160
7. R. Cooper, K. Jones, and K. Morris Immunomodulatory properties of honey that may be relevant to wound repair R. White, R. Cooper, P. Molan, Honey: A modern wound management product 2005 Advancis Medical 143 148
8. X. Fu, H. Tian, S. Hsu, D. Wang, and Z. Sheng In vivo effects of tumor necrosis factor-α on incised wound and gunshot wound healing Journal of Trauma 40 1996 S140 S143
9. S. Gannabathula, M.A. Skinner, D. Rosendale, J.M. Greenwood, A.N. Mutukumira, and G. Steinhorn et al. Arabinogalactan proteins contribute to the immunostimulatory properties of New Zealand honeys Immunopharmacology and Immunotoxicology 34 2012 598 607
10. S.K. Ha, E. Moon, and S.Y. Kim Chrysin suppresses LPS-stimulated proinflammatory responses by blocking NF-κB and JNK activations in microglia cells Neuroscience Letters 485 2010 143 147
11. Jull, A. B.; Rodgers, A.; & Walker, N. (2008). Honey as a topical treatment for wounds. The Cochrane Database of Systematic Reviews, 4, CD005083.
12. Jull, A. B.; Walker, N.; & Deshpande, S. (2013). Honey as a topical treatment for wounds. The Cochrane Database of Systematic Reviews, 2, CD005083.
13. A.V. Kamaratos, K.N. Tzirogiannis, S.A. Iraklianou, G.I. Panoutsopoulos, I.E. Kanellos, and A.I. Melidonis Manuka honey-impregnated dressings in the treatment of neuropathic diabetic foot ulcers International Wound Journal 11 2014 259 263
14. P. Komalavilas, J.K. Zhu, and E.A. Nothnagel Arabinogalactan-proteins from the suspension culture medium and plasma membrane of rose cells Journal of Biological Chemistry 266 1991 15956 15965 (Pubitemid 21907750)
15. D.S. Lee, S. Sinno, and A. Khachemoune Honey and wound healing: An overview American Journal of Clinical Dermatology 12 2011 181 190
16. J. Majtan, J. Bohova, R. Garcia-Villalba, F.A. Tomas-Barberan, Z. Madakova, and T. Majtan et al. Fir honeydew honey flavonoids inhibit TNF-α-induced MMP-9 expression in human keratinocytes: A new action of honey in wound healing Archives of Dermatological Research 305 2013 619 627
17. J. Majtan, E. Kovacova, K. Bilikova, and J. Simuth The immunostimulatory effect of the recombinant apalbumin 1-major honeybee royal jelly protein-on TNF-α release International Immunopharmacology 6 2006 269 278 (Pubitemid 43052824)
18. J. Majtan, P. Kumar, T. Majtan, A.F. Walls, and J. Klaudiny Effect of honey and its major royal jelly protein 1 on cytokine and MMP-9 mRNA transcripts in human keratinocytes Experimental Dermatology 19 2010 e73 e79
19. P.C. Molan The evidence supporting the use of honey as a wound dressing International Journal of Lower Extremity Wounds 5 2006 40 54 (Pubitemid 43260786)
20. D.P. Mooney, M. O'Reilly, and R.L. Gamelli Tumor necrosis factor and wound healing Annals of Surgery 211 1990 124 129 (Pubitemid 20063197)
21. A. Raynaud, L. Ghezali, V. Gloaguen, B. Liagre, F. Quero, and J.M. Petit Honey-induced macrophage stimulation: AP-1 and NF-κB activation and cytokine production are unrelated to LPS content of honey International Immunopharmacology 17 2013 874 879
22. R. Rossano, M. Larocca, T. Polito, A.M. Perna, M.C. Padula, and G. Martelli et al. What are the proteolytic enzymes of honey and what they do tell us? A fingerprint analysis by 2-D zymography of unifloral honeys PLoS One 7 2012 e49164
23. C. Sanchez, C. Schmitt, E. Kolodziejczyk, A. Lapp, C. Gaillard, and D. Renard The acacia gum arabinogalactan fraction is a thin oblate ellipsoid: A new model based on small-angle neutron scattering and ab initio calculation Biophysical Journal 94 2008 629 639
24. U. Savla, H.J. Appel, P.H. Sporn, and C.M. Waters Prostaglandin E(2) regulates wound closure in airway epithelium American Journal of Physiology - Lung Cellular and Molecular Physiology 280 2001 L421 L431
25. H. Schägger, H. Aquila, and G. Von Jagow Coomassie blue-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for direct visualization of polypeptides during electrophoresis Analytical Biochemistry 173 1988 201 205
26. H. Schägger, and G. Von Jagow Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa Analytical Biochemistry 166 1987 368 379 (Pubitemid 18004907)
27. J. Šimúth, K. Bíliková, E. Kovácová, Z. Kuzmová, and W. Schroder Immunochemical approach to detection of adulteration in honey: Physiologically active royal jelly protein stimulating TNF-α release is a regular component of honey Journal of Agricultural and Food Chemistry 52 2004 2154 2158
28. G. Steinhorn, I.M. Sims, S.M. Carnachan, A.J. Carr, and R. Schlothauer Isolation and characterisation of arabinogalactan-proteins from New Zealand kanuka honey Food Chemistry 128 2011 949 956
29. M. Talwar, T.N. Moyana, B. Bharadwaj, and L.K. Tan The effect of a synthetic analogue of prostaglandin E2 on wound healing in rats Annals of Clinical and Laboratory Science 26 1996 451 457 (Pubitemid 26296344)
30. S. Tamura, S. Amano, T. Kono, J. Kondoh, K. Yamaguchi, and S. Kobayashi et al. Molecular characteristics and physiological functions of major royal jelly protein 1 oligomer Proteomics 9 2009 5534 5543
31. M. Timm, S. Bartelt, and E.W. Hansen Immunomodulatory effects of honey cannot be distinguished from endotoxin Cytokine 42 2008 113 120
32. A.J. Tonks, R.A. Cooper, K.P. Jones, S. Blair, J. Parton, and A. Tonks Honey stimulates inflammatory cytokine production from monocytes Cytokine 21 2003 242 247 (Pubitemid 36765416)
33. A. Tonks, R.A. Cooper, A.J. Price, P.C. Molan, and K.P. Jones Stimulation of TNF-alpha release in monocytes by honey Cytokine 14 2001 240 242 (Pubitemid 32619906)
34. A.J. Tonks, E. Dudley, N. Porter, J. Parton, J. Brazier, and E. Smith et al. A 5.8-kDa component of manuka honey stimulates immune cells via TLR4 Journal of Leukocyte Biology 82 2007 1147 1155 (Pubitemid 350133512)
35. G.J. van Holst, and A.E. Clarke Quantification of arabinogalactan-protein in plant extracts by single radial gel diffusion Analytical Biochemistry 148 1985 446 450
36. J. Wang, and Q.X. Li Chemical composition, characterization, and differentiation of honey botanical and geographical origins Advances in Food and Nutrition Research 62 2011 89 137
37. E. Wiśniewska, and A. Majewska-Sawka Arabinogalactan-proteins stimulate the organogenesis of guard cell protoplasts-derived callus in sugar beet Plant Cell Reports 26 2007 1457 1467 (Pubitemid 47282764)
38. A. Zumla, and A. Lulat Honey - A remedy rediscovered Journal of the Royal Society of Medicine 182 1989 384 385 (Pubitemid 19174273)