Histone deacetylase 8 suppresses osteogenic differentiation of bone marrow stromal cells by inhibiting histone H3K9 acetylation and RUNX2 activity

International Journal of Biochemistry and Cell Biology

Volumn 54, Issue , 2014, Pages 68-77

  Fu, Yu ^a   Zhang, Ping ^a   Ge, Jie ^a   Cheng, Jie ^a   Dong, Weijie ^a   Yuan, Hua ^a   Du, Yifei ^a   Yang, Mifang ^a   Sun, Ruoxing ^a   Jiang, Hongbing ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Bone marrow stromal cells; HDAC inhibitor; Histone deacetylase 8; Histone H3 lysine 9 acetylation; Osteogenic differentiation

Indexed keywords

ALKALINE PHOSPHATASE; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 2; HISTONE DEACETYLASE 3; HISTONE DEACETYLASE 8; HISTONE DEACETYLASE INHIBITOR; HISTONE H3; OSTEOCALCIN; OSTEOPONTIN; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR OSTERIX; TRANSCRIPTION FACTOR RUNX2; VALPROIC ACID; BETA ACTIN; ENZYME INHIBITOR; HISTONE; HISTONE DEACETYLASE; MESSENGER RNA; RUNX2 PROTEIN, RAT;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BONE DEVELOPMENT; BONE MARROW CELL; BONE MARROW STROMAL CELL; BONE MINERALIZATION; BONE REGENERATION; BONE REMODELING; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL PROLIFERATION ASSAY; CELL VIABILITY; CELL VIABILITY ASSAY; CONTROLLED STUDY; GENE REPRESSION; GENE SILENCING; GENETIC MANIPULATION; HISTONE ACETYLATION; IN VITRO STUDY; MALE; NONHUMAN; OSTEOBLAST; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; RAT; RNA INTERFERENCE; STROMA CELL; TRANSCRIPTION REGULATION; BONE MARROW STROMA CELL; ENZYME ACTIVITY; GENE ACTIVATION; GENE EXPRESSION; IMMUNOFLUORESCENCE; PROMOTER REGION; ACETYLATION; ANIMAL; ANTAGONISTS AND INHIBITORS; APOPTOSIS; CELL CULTURE; CHEMISTRY; CHROMATIN IMMUNOPRECIPITATION; CYTOLOGY; DRUG EFFECTS; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; IMMUNOPRECIPITATION; MESENCHYMAL STROMA CELL; METABOLISM; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPRAGUE DAWLEY RAT; WESTERN BLOTTING;

RATTUS;

ACETYLATION; ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; CHROMATIN IMMUNOPRECIPITATION; CORE BINDING FACTOR ALPHA 1 SUBUNIT; ENZYME INHIBITORS; FLUORESCENT ANTIBODY TECHNIQUE; HISTONE DEACETYLASES; HISTONES; IMMUNOPRECIPITATION; MALE; MESENCHYMAL STROMAL CELLS; OSTEOGENESIS; RATS; RATS, SPRAGUE-DAWLEY; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, SMALL INTERFERING; VALPROIC ACID;

EID: 84904885688     PISSN: 13572725     EISSN: 18785875     Source Type: Journal    
DOI: 10.1016/j.biocel.2014.07.003     Document Type: Article

References (40)

1. A.I. Caplan, and S.P. Bruder Mesenchymal stem cells: building blocks for molecular medicine in the 21st century Trends Mol Med 7 2001 259 264 (Pubitemid 32545522)
2. W.L. Cheung, S.D. Briggs, and C.D. Allis Acetylation and chromosomal functions Curr Opin Cell Biol 12 2000 326 333 (Pubitemid 30265062)
3. H.H. Cho, H.T. Park, Y.J. Kim, Y.C. Bae, K.T. Suh, and J.S. Jung Induction of osteogenic differentiation of human mesenchymal stem cells by histone deacetylase inhibitors J Cell Biochem 96 2005 533 542 (Pubitemid 41504651)
4. C. Choudhary, C. Kumar, F. Gnad, M.L. Nielsen, M. Rehman, and T.C. Walther et al. Lysine acetylation targets protein complexes and co-regulates major cellular functions Science 325 2009 834 840
5. P. Collas, A. Noer, and A.L. Sorensen Epigenetic basis for the differentiation potential of mesenchymal and embryonic stem cells Transfu Med Hemother 35 2008 205 215
6. S.L. Gantt, C.G. Joseph, and C.A. Fierke Activation and inhibition of histone deacetylase 8 by monovalent cations J Biol Chem 285 2010 6036 6043
7. K.B. Glaser, M.J. Staver, J.F. Waring, J. Stender, R.G. Ulrich, and S.K. Davidsen Gene expression profiling of multiple histone deacetylase (HDAC) inhibitors: defining a common gene set produced by HDAC inhibition in T24 and MDA carcinoma cell lines Mol Cancer Ther 2 2003 151 163
8. M.A. Glozak, N. Sengupta, X. Zhang, and E. Seto Acetylation and deacetylation of non-histone proteins Gene 363 2005 15 23 (Pubitemid 41691888)
9. N. Gurvich, O.M. Tsygankova, J.L. Meinkoth, and P.S. Klein Histone deacetylase is a target of valproic acid-mediated cellular differentiation Cancer Res 64 2004 1079 1086 (Pubitemid 38176913)
10. M. Haberland, M.H. Mokalled, R.L. Montgomery, and E.N. Olson Epigenetic control of skull morphogenesis by histone deacetylase 8 Gene Dev 23 2009 1625 1630
11. R. Hewitson, J. Dargan, D. Collis, A. Green, N. Moorjani, and S. Ohri et al. Heart failure: the pivotal role of histone deacetylases Int J Biochem Cell Bio 45 2013 448 453
12. H. Hezroni, B.S. Sailaja, and E. Meshorer Pluripotency-related, valproic acid (VPA)-induced genome-wide histone H3 lysine 9 (H3K9) acetylation patterns in embryonic stem cells J Biol Chem 286 2011 35977 35988
13. N. Hu, C. Wang, X. Liang, L. Yin, X. Luo, and B. Liu et al. Inhibition of histone deacetylases potentiates BMP9-induced osteogenic signaling in mouse mesenchymal stem cells Cell Physiol Biochem 32 2013 486 498
14. K. Iwami, and T. Moriyama Effects of short chain fatty acid, sodium butyrate, on osteoblastic cells and osteoclastic cells Int J Biochem 25 1993 1631 1635 (Pubitemid 23323094)
15. E.D. Jensen, R. Gopalakrishnan, and J.J. Westendorf Bone morphogenic protein 2 activates protein kinase D to regulate histone deacetylase 7 localization and repression of Runx2 J Biol Chem 284 2009 2225 2234
16. E.D. Jensen, T.M. Schroeder, J. Bailey, R. Gopalakrishnan, and J.J. Westendorf Histone deacetylase 7 associates with Runx2 and represses its activity during osteoblast maturation in a deacetylation-independent manner J Bone Miner Res 23 2007 361 372
17. E.J. Jeon, K.Y. Lee, N.S. Choi, M.H. Lee, H.N. Kim, and Y.H. Jin et al. Bone morphogenetic protein-2 stimulates Runx2 acetylation J Biol Chem 281 2006 16502 16511
18. E. Kon, G. Filardo, A. Roffi, A. Di Martino, M. Hamdan, and L. De Pasqual et al. Bone regeneration with mesenchymal stem cells Clin Cases Miner Bone Metab 9 2012 24 27
19. H.W. Lee, J.H. Suh, A.Y. Kim, Y.S. Lee, S.Y. Park, and J.B. Kim Histone deacetylase 1-mediated histone modification regulates osteoblast differentiation Mol Endocrinol 20 2006 2432 2443 (Pubitemid 44496412)
20. H. Li, H. Xie, W. Liu, R. Hu, B. Huang, and Y.F. Tan et al. A novel microRNA targeting HDAC5 regulates osteoblast differentiation in mice and contributes to primary osteoporosis in humans J Clin Investig 119 2009 3666 3677
21. M.E. McGee-Lawrence, A.L. McCleary-Wheeler, F.J. Secreto, D.F. Razidlo, M. Zhang, and B.A. Stensgard et al. Suberoylanilide hydroxamic acid (SAHA; vorinostat) causes bone loss by inhibiting immature osteoblasts Bone 48 2011 1117 1126
22. M.E. McGee-Lawrence, and J.J. Westendorf Histone deacetylases in skeletal development and bone mass maintenance Gene 474 2011 1 11
23. I. Oehme, H.E. Deubzer, D. Wegener, D. Pickert, J.P. Linke, and B. Hero et al. Histone deacetylase 8 in neuroblastoma tumorigenesis Clin Cancer Res 15 2009 91 99
24. F. Paino, M. La Noce, V. Tirino, P. Naddeo, V. Desiderio, and G. Pirozzi et al. Histone deacetylase inhibition with valproic acid downregulates osteocalcin gene expression in human dental pulp stem cells and osteoblasts: evidence for HDAC2 involvement Stem Cells 32 2014 279 289
25. J.A. Park, A.J. Kim, Y. Kang, Y.J. Jung, H.K. Kim, and K.C. Kim Deacetylation and methylation at histone H3 lysine 9 (H3K9) coordinate chromosome condensation during cell cycle progression Mol Cell 31 2011 343 349
26. D.F. Razidlo, T.J. Whitney, M.E. Casper, M.E. McGee-Lawrence, B.A. Stensgard, and X. Li et al. Histone deacetylase 3 depletion in osteo/chondroprogenitor cells decreases bone density and increases marrow fat PLoS ONE 5 2010 e11492
27. T.M. Schroeder Histone deacetylase 3 interacts with Runx2 to repress the osteocalcin promoter and regulate osteoblast differentiation J Biol Chem 279 2004 41998 42007 (Pubitemid 39313651)
28. T.M. Schroeder, R.A. Kahler, X. Li, and J.J. Westendorf Histone deacetylase 3 interacts with Runx2 to repress the osteocalcin promoter and regulate osteoblast differentiation J Biol Chem 279 2004 41998 42007 (Pubitemid 39313651)
29. E. Shimizu, N. Selvamurugan, J.J. Westendorf, E.N. Olson, and N.C. Partridge HDAC4 represses matrix metalloproteinase-13 transcription in osteoblastic cells, and parathyroid hormone controls this repression J Biol Chem 285 2010 9616 9626
30. J.R. Somoza, R.J. Skene, B.A. Katz, C. Mol, J.D. Ho, and A.J. Jennings et al. Structural snapshots of human HDAC8 provide insights into the class I histone deacetylases Structure 12 2004 1325 1334 (Pubitemid 38900774)
31. R. Sridharan, M. Gonzales-Cope, C. Chronis, G. Bonora, R. McKee, and C. Huang et al. Proteomic and genomic approaches reveal critical functions of H3K9 methylation and heterochromatin protein-1gamma in reprogramming to pluripotency Nat Cell Biol 15 2013 872 882
32. C.M. Teven, X. Liu, N. Hu, N. Tang, S.H. Kim, and E. Huang et al. Epigenetic regulation of mesenchymal stem cells: a focus on osteogenic and adipogenic differentiation Stem Cells Int 2011 2011 201371
33. A.H. Undale, J.J. Westendorf, M.J. Yaszemski, and S. Khosla Mesenchymal stem cells for bone repair and metabolic bone diseases Mayo Clin Proc 84 2009 893 902
34. R.B. Vega, K. Matsuda, J. Oh, A.C. Barbosa, X. Yang, and E. Meadows et al. Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesis Cell 119 2004 555 566 (Pubitemid 39482354)
35. A.J. Wagers, and I.L. Weissman Plasticity of adult stem cells Cell 116 2004 639 648 (Pubitemid 38326723)
36. J.J. Westendorf, S.K. Zaidi, J.E. Cascino, R. Kahler, A.J. van Wijnen, and J.B. Lian et al. Runx2 (Cbfa1, AML-3) interacts with histone deacetylase 6 and represses the p21 (CIP1/WAF1) promoter Mol Cell Biol 22 2002 7982 7992 (Pubitemid 35217306)
37. Y. Xu, K.E. Hammerick, A.W. James, A.L. Carre, P. Leucht, and A.J. Giaccia et al. Inhibition of histone deacetylase activity in reduced oxygen environment enhances the osteogenesis of mouse adipose-derived stromal cells Tissue Eng Part A 15 2009 3697 3707
38. P. Zhang, J. Men, Y. Fu, T. Shan, J. Ye, and Y. Wu et al. Contribution of SATB2 to the stronger osteogenic potential of bone marrow stromal cells from craniofacial bones Cell Tissue Res 350 2012 425 437
39. Y. Zheng, L. He, Y. Wan, and J. Song H3K9me-enhanced DNA hypermethylation of the p16INK4a gene: an epigenetic signature for spontaneous transformation of rat mesenchymal stem cells Stem Cells Dev 22 2013 256 267
40. S. Zimmermann, F. Kiefer, M. Prudenziati, C. Spiller, J. Hansen, and T. Floss et al. Reduced body size and decreased intestinal tumor rates in HDAC2-mutant mice Cancer Res 67 2007 9047 9054 (Pubitemid 47535889)