Hemophagocytic lymphohistiocytosis associated with viral infections: Diagnostic challenges and therapeutic dilemmas;Linfohistiocitosis hemofagocítica asociada a infecciones virales: reto diagnóstico y dilema terapéutico

Revista Clinica Espanola

Volumn 214, Issue 6, 2014, Pages 320-327

  Mostaza Fernandez J L ^a   Guerra Laso, J ^a   Carriedo Ule, D ^a   Ruiz De Morales, J M G ^a  

^a Gerencia Regional de Salud de Castilla y León   (Spain)

Author keywords

Hemophagocytic lymphohistiocytosis; Hemophagocytosis; Perforin; Viral infections

Indexed keywords

IMMUNOSUPPRESSIVE AGENT;

ARTICLE; BLOOD CLOTTING DISORDER; CLINICAL FEATURE; DISEASE ASSOCIATION; EARLY DIAGNOSIS; EPSTEIN BARR VIRUS; FEVER; HEMOPHAGOCYTIC SYNDROME; IMMUNE RESPONSE; INFLAMMATION; LIVER DYSFUNCTION; MORTALITY; PANCYTOPENIA; VIRUS INFECTION;

EID: 84904877419     PISSN: 00142565     EISSN: 15781860     Source Type: Journal    
DOI: 10.1016/j.rce.2014.03.009     Document Type: Article

References (47)

1. R. Bodley Scott, and A. Robb-Smith Histiocytic medullary reticulosis Lancet 234 1939 194 198
2. G.E. Janka Familial and acquired hemophagocytic lymphohistiocytosis Annu Rev Med 63 2012 233 246
3. N.G. Rouphael, N.J. Talati, C. Vaughan, K. Cunningham, R. Moreira, and C. Gould Infections associated with haemophagocytic syndrome Lancet Infect Dis 7 2007 814 822
4. S. Deane, C. Selmi, S.S. Teuber, and M.E. Gershwin Macrophage activation syndrome in autoimmune disease Int Arch Allergy Immunol 153 2010 109 120
5. G. Janka, S. Imashuku, G. Elinder, M. Schneider, and J.I. Henter Infection- and malignancy-associated hemophagocytic syndromes. Secondary hemophagocytic lymphohistiocytosis Hematol Oncol Clin North Am 12 1998 435 444
6. J-I. Henter, A. Horne, M. Aricò, R.M. Egeler, A.H. Filipovich, and S. Imashuku et al. HLH-2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis Pediatr Blood Cancer 48 2007 124 131
7. E. Ishii, S. Ohga, S. Imashuku, M. Yasukawa, H. Tsuda, and I. Miura et al. Nationwide survey of hemophagocytic lymphohistiocytosis in Japan Int J Hematol 86 2007 58 65
8. M. Machaczka, J. Vaktnas, M. Klimkowska, and H. Hägglund Malignancy-associated hemophagocytic lymphohistiocytosis in adults: A retrospective population-based analysis from a single center Leuk Lymphoma 52 2011 613 619
9. J-I. Henter, G. Elinder, O. Söder, and Å. Öst Incidence in Sweden and clinical features of familial hemophagocytic lymphohistiocytosis Acta Paediatr Scand 80 1991 428 435
10. S.E. Stepp, R. Dufourcq-Lagelouse, F. le Deist, S. Bhawan, S. Certain, and P.A. Mathew et al. Perforin gene defects in familial hemophagocytic lymphohistiocytosis Science 286 1999 Dec 3 1957 1959
11. Y. Osugi, J. Hara, S. Tagawa, K. Takai, G. Hosoi, and Y. Matsuda et al. Cytokine production regulating Th1 and Th2 cytokines in hemophagocytic lymphohistiocytosis Blood 89 1997 4100 4103
12. S. Goel, J.M. Polski, and H. Imran Sensitivity and specificity of bone marrow hemophagocytosis in hemophagocytic lymphohistiocytosis Ann Clin Lab Sci 42 2012 21 25
13. G.N. Usmani, B.A. Woda, and P.E. Newburger Advances in understanding the pathogenesis of HLH Br J Haematol 161 2013 609 622
14. K. Zhang, M.B. Jordan, R.A. Marsh, J.A. Johnson, D. Kissell, and J. Meller et al. Hypomorphic mutations in PRF1, MUNC13-4, and STXBP2 are associated with adult-onset familial HLH Blood 118 2011 5794 5798
15. L. Castillo, and J. Carcillo Secondary hemophagocytic lymphohistiocytosis and severe sepsis/systemic inflammatory response syndrome/multiorgan dysfunction syndrome/macrophage activation syndrome share common intermediate phenotypes on a spectrum of inflammation Pediatr Crit Care Med 10 2009 387 392
16. F.G.N. Rosado, and A.S. Kim Hemophagocytic lymphohistiocytosis: An update on diagnosis and pathogenesis Am J Clin Pathol 139 2013 713 727
17. C.E. Allen, X. Yu, C.A. Kozinetz, and K.L. McClain Highly elevated ferritin levels and the diagnosis of hemophagocytic lymphohistiocytosis Pediatr Blood Cancer 50 2008 1227 1235
18. V. Ansuini, D. Rigante, and S. Esposito Debate around infection-dependent hemophagocytic syndrome in paediatrics BMC Infect Dis 13 2013 15
19. M. Ramos-Casals, P. Brito-Zerón, A. López-Guillermo, M.A. Khamashta, and X. Bosch Adult haemophagocytic syndrome Lancet 2013 10.1016/S0140-6736(14)60124-0
20. A. Horne, G. Janka, R. Maarten Egeler, H. Gadner, S. Imashuku, and S. Ladisch et al. Haematopoietic stem cell transplantation in haemophagocytic lymphohistiocytosis Br J Haematol 129 2005 622 630
21. D. Chellapandian, R. Das, K. Zelley, S.J. Wiener, H. Zhao, and D.T. Teachey et al. Treatment of Epstein Barr virus-induced haemophagocytic lymphohistiocytosis with rituximab-containing chemo-immunotherapeutic regimens Br J Haematol 162 2013 376 382
22. U. Emmenegger, P.J. Spaeth, and K.A. Neftel Intravenous immunoglobulin for hemophagocytic lymphohistiocytosis? J Clin Oncol 20 2002 599 601
23. McClain KL. Treatment and prognosis of hemophagocytic lymphohistiocytosis [Internet]. uptodate.com. [citado 24 Feb 2014]. Disponible en: http://www.uptodate.com/contents/treatment-and-prognosis-of-hemophagocytic- lymphohistiocytosis?source=related-link
24. J.I. Henter, A. Ehrnst, J. Andersson, and G. Elinder Familial hemophagocytic lymphohistiocytosis and viral infections Acta Paediatr 82 1993 369 372
25. J.W. Verbsky, and W.J. Grossman Hemophagocytic lymphohistiocytosis: Diagnosis, pathophysiology, treatment, and future perspectives Ann Med 38 2006 20 31
26. E. Sieni, V. Cetica, A. Piccin, F. Gherlinzoni, F.C. Sasso, and M. Rabusin et al. Familial hemophagocytic lymphohistiocytosis may present during adulthood: Clinical and genetic features of a small series PLoS One 7 2012 e44649
27. R.J. Risdall, R.W. McKenna, M.E. Nesbit, W. Krivit, H.H. Balfour, and R.L. Simmons et al. Virus-associated hemophagocytic syndrome: A benign histiocytic proliferation distinct from malignant histiocytosis Cancer 44 1979 993 1002
28. S. Imashuku Clinical features and treatment strategies of Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis Crit Rev Oncol Hematol 44 2002 259 272
29. J.W. Farquhar, and A.E. Claireaux Familial haemophagocytic reticulosis Arch Dis Child 27 1952 519 525
30. L.A. García-Astudillo, A. Fontalba, F. Mazorra, M.J. Marín, A. Castellanos, and S. Fernández et al. Severe course of community-acquired pneumonia in an adult patient who is heterozygous for Q481P in the perforin gene: Are carriers of the mutation free of risk? J Investig Allergol Clin Immunol 19 2009 311 316
31. T. Teramura, Y. Tabata, T. Yagi, A. Morimoto, S. Hibi, and S.I.R.M.H. comdoiabs Quantitative analysis of cell-free Epstein-Barr virus genome copy number in patients with EBV-associated hemophagocytic lymphohistiocytosis Leuk Lymphoma 43 2002 173 179
32. K. Kogawa, H. Sato, T. Asano, S. Ohga, K. Kudo, and A. Morimoto et al. Prognostic factors of Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis in children: Report of the Japan Histiocytosis Study Group Pediatr Blood Cancer 2014 10.1002/pbc.24980
33. S. Bakhshi, and J.L. Pautu EBV associated hemophagocytic lymphohistiocytosis with spontaneous regression Indian Pediatr 42 2005 1253 1255
34. M.G. Lichtenheld, K.J. Olsen, P. Lu, D.M. Lowrey, A. Hameed, and H. Hengartner et al. Structure and function of human perforin Nature 335 1988 448 451
35. N. Rouphael-Maakaroun, A. Moanna, J.T. Jacob, and H. Albrecht Viral infections associated with haemophagocytic syndrome Rev Med Virol 20 2010 93 105
36. E.H. Danish, B.B. Dahms, and M.L. Kumar Cytomegalovirus-associated hemophagocytic syndrome Pediatrics 75 1985 280 283
37. A. Abdelkefi, W.B. Jamil, L. Torjman, S. Ladeb, H. Ksouri, and A. Lakhal et al. Hemophagocytic syndrome after hematopoietic stem cell transplantation: A prospective observational study Int J Hematol 89 2009 368 373
38. S. Imashuku, I. Ueda, T. Teramura, K. Mori, A. Morimoto, and M. Sako et al. Occurrence of haemophagocytic lymphohistiocytosis at less than 1 year of age: analysis of 96 patients Eur J Pediatr 164 2005 315 319
39. M. Amenomori, K. Migita, T. Miyashita, S. Yoshida, M. Ito, and K. Eguchi et al. Cytomegalovirus-associated hemophagocytic syndrome in a patient with adult onset Still's disease Clin Exp Rheumatol 23 2005 100 102
40. C. Créput, L. Galicier, S. Buyse, and E. Azoulay Understanding organ dysfunction in hemophagocytic lymphohistiocytosis Intensive Care Med 34 2008 1177 1187
41. R.D. Pastore, A. Chadburn, C. Kripas, and E.J. Schattner Novel association of haemophagocytic syndrome with Kaposi's sarcoma-associated herpesvirus-related primary effusion lymphoma Br J Haematol 111 2008 1112 1115
42. S. Imashuku, S. Hibi, M. Sako, Y. Ishida, H. Mugishima, and J. Chen et al. Soluble interleukin-2 receptor: A useful prognostic factor for patients with hemophagocytic lymphohistiocytosis Blood 86 1995 4706 4707
43. J. Stebbing, S. Ngan, H. Ibrahim, P. Charles, M. Nelson, and P. Kelleher et al. The successful treatment of haemophagocytic syndrome in patients with human immunodeficiency virus associated multi-centric Castleman's disease Clin Exp Immunol 154 2008 399 405
44. N. Suzuki, A. Morimoto, S. Ohga, K. Kudo, Y. Ishida, and E. Ishii Characteristics of hemophagocytic lymphohistiocytosis in neonates: A nationwide survey in Japan J Pediatr 155 2009 235 2380
45. A. Cusini, H.F. Gunthard, G. Stussi, U. Schwarz, T. Fehr, and E. Grueter et al. Hemophagocytic syndrome caused by primary herpes simplex virus 1 infection: Report of a first case Infection 38 2010 423 426
46. G.W. Niedt, and R.A. Schinella Acquired immunodeficiency syndrome. Clinicopathologic study of 56 autopsies Arch Pathol Lab Med 109 1985 727 734
47. L. Fardet, O. Lambotte, J-L. Meynard, W. Kamouh, L. Galicier, and C. Marzac et al. Reactive haemophagocytic syndrome in 58 HIV-1-infected patients: Clinical features, underlying diseases and prognosis AIDS 24 2010 1299 1306