Antiviral activity of ginsenosides against coxsackievirus B3, enterovirus 71, and human rhinovirus 3

Journal of Ginseng Research

Volumn 38, Issue 3, 2014, Pages 173-179

  Song, Jae Hyoung ^a   Choi, Hwa Jung ^b   Song, Hyuk Hwan ^c   Hong, Eun Hye ^a   Lee, Bo Ra ^a   Oh, Sei Ryang ^c   Choi, Kwangman ^c   Yeo, Sang Gu ^d   Lee, Yong Pyo ^d   Cho, Sungchan ^c   Ko, Hyun Jeong ^a  

^a Kangwon National University   (South Korea)

^b Kwangju Women University   (South Korea)

^c Korea Research Institute of Bioscience and Biotechnology   (South Korea)

^d Korea National Institute of Health   (South Korea)

Author keywords

Antiviral activity; CVB3; EV71; Ginsenosides; HRV3

Indexed keywords

ANTIVIRUS AGENT; GINSENOSIDE; GINSENOSIDE RB 1; GINSENOSIDE RB 2; GINSENOSIDE RC; GINSENOSIDE RD; GINSENOSIDE RE; GINSENOSIDE RF; GINSENOSIDE RG 2; RIBAVIRIN;

ANTIVIRAL ACTIVITY; ARTICLE; CELL DEATH; CONTROLLED STUDY; COXSACKIE VIRUS B3; COXSACKIE VIRUS INFECTION; CYTOTOXICITY; DRUG EFFICACY; ENTEROVIRUS 71; ENTEROVIRUS INFECTION; FEMALE; HUMAN; HUMAN CELL; HUMAN RHINOVIRUS; HUMAN RHINOVIRUS 3; NONHUMAN; PRIORITY JOURNAL; RHINOVIRUS INFECTION;

EID: 84904860017     PISSN: 12268453     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jgr.2014.04.003     Document Type: Article

References (41)

1. Whitton JL, Cornell CT, Feuer R. Host and virus determinants of picornavirus pathogenesis and tropism. Nat Rev Microbiol 2005;3:765-76.
2. Chumakov M, Voroshilova M, Shindarov L, Lavrova I, Gracheva L, Koroleva G, Vasilenko S, Brodvarova I, Nikolova M, Gyurova S, et al. Enterovirus 71 isolated from cases of epidemic poliomyelitis-like disease in Bulgaria. Arch Virol 1979;60:329-40.
3. McMinn PC. An overview of the evolution of enterovirus 71 and its clinical and public health significance. FEMS Microbiol Rev 2002;6:91-107.
4. Wang SM, Lei HY, Huang KJ, Wu JM, Wang JR, Yu CK, Su IJ, Liu CC. Pathogenesis of enterovirus 71 brainstem encephalitis in pediatric patients: roles of cytokines and cellular immune activation in patients with pulmonary edema. J Infect Dis 2003;188:564-70.
5. Song J, Yeo SG, Hong EH, Lee BR, Kim JW, Kim J, Jeong H, Kwon Y, Kim H, Lee S, et al. Antiviral activity of Hederasaponin B from Hedera helix against Enterovirus 71 subgenotypes C3 and C4a. Biomol Ther 2014;22:41-6.
6. Makela MJ, Puhakka T, Ruuskanen O, Leinonen M, Saikku P, Kimpimaki M, Blomqvist S, Hyypia T, Arstila P. Viruses and bacteria in the etiology of the common cold. J Clin Microbiol 1998;36:539-42.
7. Zhu J, Message SD, Qiu Y, Mallia P, Kebadze T, Contoli M, Ward CK, Barnathan ES, Mascelli MA, Kon OM, et al. Airway inflammation and illness severity in response to experimental rhinovirus infection in asthma. Chest 2014;156:1219-29.
8. Turner RB. The treatment of rhinovirus infections: progress and potential. Antiviral Res 2001;49:1-14.
9. Vlietinck AJ, Vanden Berghe DA. Can ethnopharmacology contribute to the development of antiviral drugs? J Ethnopharmacol 1991;32:141-53.
10. Cowan MM. Plant products as antimicrobial agents. Clin Microbiol Rev 1999;12:564-82.
11. Briskin DP. Medicinal plants and phytomedicines. Linking plant biochemistry and physiology to human health. Plant Physiol 2000;124:507-14.
12. Williams JE. Review of antiviral and immunomodulating properties of plants of the Peruvian rainforest with a particular emphasis on Una de Gato and Sangre de Grado. Altern Med Rev 2001;6:567-79.
13. Jassim SA, Naji MA. Novel antiviral agents: a medicinal plant perspective. J Appl Microbiol 2003;95:412-27.
14. Fuzzati N. Analysis methods of ginsenosides. J Chromatogr B Analyt Technol Biomed Life Sci 2004;812:119-33.
15. Song X, Chen J, Sakwiwatkul K, Li R, Hu S. Enhancement of immune responses to influenza vaccine (H3N2) by ginsenoside Re. Int Immunopharmacol 2010;10:351-6.
16. Peng D, Wang H, Qu C, Xie L, Wicks SM, Xie J. Ginsenoside Re: its chemistry, metabolism and pharmacokinetics. Chin Med 2012 Feb 7;7:2.
17. Chae S, Kang KA, Chang WY, Kim MJ, Lee SJ, Lee YS, Kim HS, Kim DH, Hyun JW. Effect of compound K, a metabolite of ginseng saponin, combined with gamma-ray radiation in human lung cancer cells in vitro and in vivo. J Agric Food Chem 2009;57:5777-82.
18. Cho WC, Chung WS, Lee SK, Leung AW, Cheng CH, Yue KK. Ginsenoside Re of Panax ginseng possesses significant antioxidant and antihyperlipidemic efficacies in streptozotocin-induced diabetic rats. Eur J Pharmacol 2006;550: 173-9.
19. Kim MS. Korean red ginseng tonic extends lifespan in D. melanogaster. Biomol Ther 2013;21:241-5.
20. Wang W, Rayburn ER, Hao M, Zhao Y, Hill DL, Zhang R, Wang H. Experimental therapy of prostate cancer with novel natural product anti-cancer ginsenosides. Prostate 2008;68:809-19.
21. Lee MH, Lee BH, Jung JY, Cheon DS, Kim KT, Choi C. Antiviral effect of Korean red ginseng extract and ginsenosides on murine norovirus and feline calicivirus as surrogates for human norovirus. J Ginseng Res 2011;35: 429-35.
22. Kang LJ, Choi YJ, Lee SG. Stimulation of TRAF6/TAK1 degradation and inhibition of JNK/AP-1 signalling by ginsenoside Rg3 attenuates hepatitis B virus replication. Int J Biochem Cell Biol 2013;45:2612-21.
23. Choi HJ, Kim JH, Lee CH, Ahn YJ, Song JH, Baek SH, Kwon DH. Antiviral activity of quercetin 7-rhamnoside against porcine epidemic diarrhea virus. Antiviral Res 2009;81:77-81.
24. Yun TK. Brief introduction of Panax ginseng C.A. Meyer. J Korean Med Sci 2001;16:S3-5.
25. Rivera E, Ekholm Pettersson F, Inganas M, Paulie S, Gronvik KO. The Rb1 fraction of ginseng elicits a balanced Th1 and Th2 immune response. Vaccine 2005;23:5411-9.
26. Yoo YC, Lee J, Park SR, Nam KY, Cho YH, Choi JE. Protective effect of ginsenoside-Rb2 from Korean red ginseng on the lethal infection of haemagglutinating virus of Japan in mice. J Ginseng Res 2013;37:80-6.
27. Lee MH, Lee BH, Lee S, Choi C. Reduction of hepatitis A virus on FRhK-4 cells treated with Korean red ginseng extract and ginsenosides. J Food Sci 2013;78: M1412-5.
28. Nakayama T, Urano T, Osano M, Hayashi Y, Sekine S, Ando T, Makinom S. Outbreak of herpangina associated with Coxsackievirus B3 infection. Pediatr Infect Dis J 1989;8:495-8.
29. Graci JD, Cameron CE. Mechanisms of action of ribavirin against distinct viruses. Rev Med Virol 2006;16:37-48.
30. Choi HJ, Lim CH, Song JH, Baek SH, Kwon DH. Antiviral activity of raoulic acid from Raoulia australis against Picornaviruses. Phytomedicine 2009;16:35-9.
31. Choi HJ, Song JH, Lim CH, Baek SH, Kwon DH. Anti-human rhinovirus activity of raoulic acid from Raoulia australis. J Med Food 2010;13:326-8.
32. Aquino R, De Simone F, Pizza C, Conti C, Stein ML. Plant metabolites. Structure and in vitro antiviral activity of quinovic acid glycosides from Uncaria tomentosa and Guettarda platypoda. J Nat Prod 1989;52:679-85.
33. Aquino R, Conti C, De Simone F, Orsi N, Pizza C, Stein ML. Antiviral activity of constituents of Tamus communis. J Chemother 1991;3:305-9.
34. De Tommasi N, Conti C, Stein ML, Pizza C. Structure and in vitro antiviral activity of triterpenoid saponins from Calendula arvensis. Planta Med 1991;57: 250-3.
35. Weber ND, Andersen DO, North JA, Murray BK, Lawson LD, Hughes BG. In vitro virucidal effects of Allium sativum (garlic) extract and compounds. Planta Med 1992;58:417-23.
36. Denyer CV, Jackson P, Loakes DM, Ellis MR, Young DA. Isolation of antirhinoviral sesquiterpenes from ginger (Zingiber officinale). J Nat Prod 1994;57: 658-62.
37. Glatthaar-Saalmuller B, Sacher F, Esperester A. Antiviral activity of an extract derived from roots of Eleutherococcus senticosus. Antiviral Res 2001;50:223-8.
38. Pevear DC, Fancher MJ, Felock PJ, Rossmann MG, Miller MS, Diana G, Treasurywala AM, McKinlay MA, Dutko FJ. Conformational change in the floor of the human rhinovirus canyon blocks adsorption to HeLa cell receptors. J Virol 1989;63:2002-7.
39. Zeichhardt H, Otto MJ, McKinlay MA, Willingmann P, Habermehl KO. Inhibition of poliovirus uncoating by disoxaril (WIN 51711). Virology 1987;160: 281-5.
40. Fleischer R, Laessig K. Safety and efficacy evaluation of pleconaril for treatment of the common cold. Clin Infect Dis 2003;37:17-22.
41. Kim JH, Kang SA, Han SM, Shim I. Comparison of the antiobesity effects of the protopanaxadiol-and protopanaxatriol-type saponins of red ginseng. Phytother Res 2009;23:78-85.