Elevated plasmatic level of soluble IL-7 receptor is associated with increased mortality in septic shock patients

Intensive Care Medicine

Volumn 40, Issue 8, 2014, Pages 1089-1096

  Demaret, Julie ^a,b   Villars Méchin, Astrid ^a   Lepape, Alain ^a,b,c   Plassais, Jonathan ^a   Vallin, Hélène ^c   Malcus, Christophe ^a   Poitevin Later, Françoise ^a   Monneret, Guillaume ^a,b   Venet, Fabienne ^a,b  

^a EDOUARD HERRIOT HOSPITAL   (France)

^b UNIVERSITÉ LYON 1   (France)

^c CENTRE HOSPITALIER LYON SUD   (France)

Author keywords

Biomarker; CD127; IL 7 receptor; Mortality; Septic shock

Indexed keywords

INTERLEUKIN 7 RECEPTOR; INTERLEUKIN 7 RECEPTOR ALPHA; HYPERTENSIVE FACTOR; INTERLEUKIN 7; BIOLOGICAL MARKER;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; FEMALE; HOSPITAL INFECTION; HUMAN; MAJOR CLINICAL STUDY; MALE; MORTALITY; SEPTIC SHOCK; MONOCYTE; PREDICTIVE VALUE; SEQUENTIAL ORGAN FAILURE ASSESSMENT SCORE; SIMPLIFIED ACUTE PHYSIOLOGY SCORE; SURVIVAL PREDICTION; SURVIVAL RATE; SURVIVOR; BLOOD; MIDDLE AGED; REGRESSION ANALYSIS;

AGED; BIOLOGICAL MARKERS; FEMALE; HUMANS; INTERLEUKIN-7 RECEPTOR ALPHA SUBUNIT; MALE; MIDDLE AGED; REGRESSION ANALYSIS; SHOCK, SEPTIC;

EID: 84904857703     PISSN: 03424642     EISSN: 14321238     Source Type: Journal    
DOI: 10.1007/s00134-014-3346-0     Document Type: Article

References (29)

1. Dellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM, Sevransky JE, Sprung CL, Douglas IS, Jaeschke R, Osborn TM, Nunnally ME, Townsend SR, Reinhart K, Kleinpell RM, Angus DC, Deutschman CS, Machado FR, Rubenfeld GD, Webb S, Beale RJ, Vincent JL, Moreno R (2013) Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012. Intensive Care Med 39:165-228
2. Levy MM, Artigas A, Phillips GS, Rhodes A, Beale R, Osborn T, Vincent JL, Townsend S, Lemeshow S, Dellinger RP (2012) Outcomes of the Surviving Sepsis Campaign in intensive care units in the USA and Europe: a prospective cohort study. Lancet Infect Dis 12:919-924
3. Angus DC, van der Poll T (2013) Severe sepsis and septic shock. N Engl J Med 369:840-851
4. Hotchkiss RS, Monneret G, Payen D (2013) Immunosuppression in sepsis: a novel understanding of the disorder and a new therapeutic approach. Lancet Infect Dis 13:260-268
5. Hotchkiss RS, Monneret G, Payen D (2013) Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy. Nat Rev Immunol 13:862-874
6. Guignant C, Venet F, Planel S, Demaret J, Gouel-Cheron A, Nougier C, Friggeri A, Allaouchiche B, Lepape A, Monneret G (2013) Increased Mer TK expression in circulating innate immune cells of patients with septic shock. Intensive Care Med 39:1556-1564
7. Grimaldi D, Louis S, Pene F, Sirgo G, Rousseau C, Claessens YE, Vimeux L, Cariou A, Mira JP, Hosmalin A, Chiche JD (2011) Profound and persistent decrease of circulating dendritic cells is associated with ICU-acquired infection in patients with septic shock. Intensive Care Med 37:1438-1446
8. Venet F, Lukaszewicz AC, Payen D, Hotchkiss R, Monneret G (2013) Monitoring the immune response in sepsis: a rational approach to administration of immunoadjuvant therapies. Curr Opin Immunol 25:477-483
9. Hotchkiss RS, Opal S (2010) Immunotherapy for sepsis-a new approach against an ancient foe. N Engl J Med 363:87-89
10. Hotchkiss RS, Coopersmith CM, McDunn JE, Ferguson TA (2009) The sepsis seesaw: tilting toward immunosuppression. Nat Med 15:496-497
11. Unsinger J, Burnham CA, McDonough J, Morre M, Prakash PS, Caldwell CC, Dunne WM Jr, Hotchkiss RS (2012) Interleukin-7 ameliorates immune dysfunction and improves survival in a 2-hit model of fungal sepsis. J Infect Dis 206:606-616
12. Unsinger J, Kazama H, McDonough JS, Griffith TS, Hotchkiss RS, Ferguson TA (2010) Sepsis-induced apoptosis leads to active suppression of delayed-type hypersensitivity by CD8? regulatory T cells through a TRAIL-dependent mechanism. J Immunol 184:6766-6772
13. Unsinger J, Kazama H, McDonough JS, Hotchkiss RS, Ferguson TA (2009) Differential lymphopenia-induced homeostatic proliferation for CD4? and CD8? T cells following septic injury. J Leukoc Biol 85:382-390
14. Kasten KR, Prakash PS, Unsinger J, Goetzman HS, England LG, Cave CM, Seitz AP, Mazuski CN, Zhou TT, Morre M, Hotchkiss RS, Hildeman DA, Caldwell CC (2010) Interleukin-7 (IL- 7) treatment accelerates neutrophil recruitment through gamma delta T-cell IL-17 production in a murine model of sepsis. Infect Immun 78:4714-4722
15. Mackall CL, Fry TJ, Gress RE (2011) Harnessing the biology of IL-7 for therapeutic application. Nat Rev Immunol 11:330-342
16. Venet F, Foray AP, Villars-Mechin A, Malcus C, Poitevin-Later F, Lepape A, Monneret G (2012) IL-7 restores lymphocyte functions in septic patients. J Immunol 189:5073-5081
17. Badot V, Luijten RK, van Roon JA, Depresseux G, Aydin S, Van den Eynde BJ, Houssiau FA, Lauwerys BR (2013) Serum soluble interleukin 7 receptor is strongly associated with lupus nephritis in patients with systemic lupus erythematosus. Ann Rheum Dis 72:453-456
18. Monti P, Brigatti C, Krasmann M, Ziegler AG, Bonifacio E (2013) Concentration and activity of the soluble form of the Interleukin-7 receptor alpha in type 1 diabetes identifies an interplay between hyperglycemia and immune function. Diabetes 62:2500-2508
19. Lundstrom W, Highfill S, Walsh ST, Beq S, Morse E, Kockum I, Alfredsson L, Olsson T, Hillert J, Mackall CL (2013) Soluble IL7Ralpha potentiates IL-7 bioactivity and promotes autoimmunity. Proc Natl Acad Sci USA 110:E1761-E1770
20. Bone RC, Balk RA, Cerra FB, Dellinger RP, Fein AM, Knaus WA, Schein RM, Sibbald WJ (1992) Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest 101:1644-1655
21. Monneret G, Venet F, Pachot A, Lepape A (2008) Monitoring immune dysfunctions in the septic patient: a new skin for the old ceremony. Mol Med 14:64-78 (Pubitemid 351356886)
22. Meisel C, Schefold JC, Pschowski R, Baumann T, Hetzger K, Gregor J, Weber-Carstens S, Hasper D, Keh D, Zuckermann H, Reinke P, Volk HD (2009) Granulocyte-macrophage colony-stimulating factor to reverse sepsis-associated immunosuppression: a double-blind, randomized, placebocontrolled multicenter trial. Am J Respir Crit Care Med 180:640-648
23. Pleiman CM, Gimpel SD, Park LS, Harada H, Taniguchi T, Ziegler SF (1991) Organization of the murine and human interleukin-7 receptor genes: two mRNAs generated by differential splicing and presence of a type I-interferon-inducible promoter. Mol Cell Biol 11:3052-3059 (Pubitemid 21895691)
24. Crawley AM, Angel JB (2012) The influence of HIV on CD127 expression and its potential implications for IL-7 therapy. Semin Immunol 24:231-240
25. Crawley AM, Faucher S, Angel JB (2010) Soluble IL-7R alpha (sCD127) inhibits IL-7 activity and is increased in HIV infection. J Immunol 184:4679-4687
26. McKay FC, Swain LI, Schibeci SD, Rubio JP, Kilpatrick TJ, Heard RN, Stewart GJ, Booth DR (2008) Haplotypes of the interleukin 7 receptor alpha gene are correlated with altered expression in whole blood cells in multiple sclerosis. Genes Immun 9:1-6 (Pubitemid 351150028)
27. Korte A, Kochling J, Badiali L, Eckert C, Andreae J, Geilen W, Kebelmann-Betzing C, Taube T, Wu S, Henze G, Seeger K (2000) Expression analysis and characterization of alternatively spliced transcripts of human IL-7Ralpha chain encoding two truncated receptor proteins in relapsed childhood all. Cytokine 12:1597-1608
28. Gouel-Cheron A, Allaouchiche B, Guignant C, Davin F, Floccard B, Monneret G (2012) Early interleukin-6 and slope of monocyte human leukocyte antigen-DR: a powerful association to predict the development of sepsis after major trauma. PLoS One 7:e33095
29. Rubulotta F, Marshall JC, Ramsay G, Nelson D, Levy M, Williams M (2009) Predisposition, insult/infection, response, and organ dysfunction: a new model for staging severe sepsis. Crit Care Med 37:1329-1335