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Volumn 28, Issue 4, 2014, Pages 331-343

Multi-specific antibodies for cancer immunotherapy

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; ANTIBODY CONJUGATE; IMMUNOTOXIN ANTIBODY; MULTISPECIFIC ANTIBODY; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; UNCLASSIFIED DRUG; MONOCLONAL ANTIBODY;

EID: 84904857184     PISSN: 11738804     EISSN: 1179190X     Source Type: Journal    
DOI: 10.1007/s40259-014-0091-4     Document Type: Review
Times cited : (18)

References (75)
  • 1
    • 27144449009 scopus 로고    scopus 로고
    • Monoclonal antibody therapy of cancer
    • DOI 10.1038/nbt1137, PII N1137
    • Adams GP, Weiner LM. Monoclonal antibody therapy of cancer. Nat Biotechnol. 2005;23(9):1147-57. (Pubitemid 41486396)
    • (2005) Nature Biotechnology , vol.23 , Issue.9 , pp. 1147-1157
    • Adams, G.P.1    Weiner, L.M.2
  • 2
    • 27144550160 scopus 로고    scopus 로고
    • Arming antibodies: Prospects and challenges for immunoconjugates
    • DOI 10.1038/nbt1141, PII N1141
    • Wu AM, Senter PD. Arming antibodies: prospects and challenges for immunoconjugates. Nat Biotechnol. 2005;23(9):1137-46. (Pubitemid 41486395)
    • (2005) Nature Biotechnology , vol.23 , Issue.9 , pp. 1137-1146
    • Wu, A.M.1    Senter, P.D.2
  • 3
    • 80052591747 scopus 로고    scopus 로고
    • Activation of ERBB2 signaling causes resistance to the EGFR-directed therapeutic antibody cetuximab
    • Yonesaka K, Zejnullahu K, Okamoto I, Satoh T, Cappuzzo F, Souglakos J, et al. Activation of ERBB2 signaling causes resistance to the EGFR-directed therapeutic antibody cetuximab. Sci Transl Med. 2011;3(99):99ra86.
    • (2011) Sci Transl Med , vol.3 , Issue.99
    • Yonesaka, K.1    Zejnullahu, K.2    Okamoto, I.3    Satoh, T.4    Cappuzzo, F.5    Souglakos, J.6
  • 4
    • 33646712747 scopus 로고    scopus 로고
    • Mechanisms of disease: Understanding resistance to HER2-targeted therapy in human breast cancer
    • DOI 10.1038/ncponc0509, PII N0509
    • Nahta R, Yu D, Hung MC, Hortobagyi GN, Esteva FJ. Mechanisms of disease: understanding resistance to HER2-targeted therapy in human breast cancer. Nat Clin Pract Oncol. 2006;3(5):269-80. (Pubitemid 43731112)
    • (2006) Nature Clinical Practice Oncology , vol.3 , Issue.5 , pp. 269-280
    • Nahta, R.1    Yu, D.2    Hung, M.-C.3    Hortobagyi, G.N.4    Esteva, F.J.5
  • 5
    • 84861516765 scopus 로고    scopus 로고
    • Intrinsic and acquired resistance to HER2-targeted therapies in HER2 gene-amplified breast cancer: Mechanisms and clinical implications
    • Rexer BN, Arteaga CL. Intrinsic and acquired resistance to HER2-targeted therapies in HER2 gene-amplified breast cancer: mechanisms and clinical implications. Crit Rev Oncog. 2012;17(1):1-16.
    • (2012) Crit Rev Oncog , vol.17 , Issue.1 , pp. 1-16
    • Rexer, B.N.1    Arteaga, C.L.2
  • 7
    • 84873353521 scopus 로고    scopus 로고
    • Bispecific antibodies and trispecific immunocytokines for targeting the immune system against cancer: Preparing for the future
    • Fournier P, Schirrmacher V. Bispecific antibodies and trispecific immunocytokines for targeting the immune system against cancer: preparing for the future. BioDrugs. 2013;27(1):35-53.
    • (2013) BioDrugs , vol.27 , Issue.1 , pp. 35-53
    • Fournier, P.1    Schirrmacher, V.2
  • 9
    • 84875955851 scopus 로고    scopus 로고
    • Redirection of T-cell effector functions for cancer therapy: Bispecific antibodies and chimeric antigen receptors
    • Satta A, Mezzanzanica D, Turatti F, Canevari S, Figini M. Redirection of T-cell effector functions for cancer therapy: bispecific antibodies and chimeric antigen receptors. Future Oncol. 2013;9(4):527-39.
    • (2013) Future Oncol , vol.9 , Issue.4 , pp. 527-539
    • Satta, A.1    Mezzanzanica, D.2    Turatti, F.3    Canevari, S.4    Figini, M.5
  • 10
    • 84884737325 scopus 로고    scopus 로고
    • Antitumor immunity: Easy as 1, 2, 3 with monoclonal bispecific trifunctional antibodies?
    • Maher J, Adami AA. Antitumor immunity: easy as 1, 2, 3 with monoclonal bispecific trifunctional antibodies? Cancer Res. 2013;73(18):5613-7.
    • (2013) Cancer Res , vol.73 , Issue.18 , pp. 5613-5617
    • Maher, J.1    Adami, A.A.2
  • 11
    • 27144432842 scopus 로고    scopus 로고
    • Engineered antibody fragments and the rise of single domains
    • DOI 10.1038/nbt1142, PII N1142
    • Holliger P, Hudson PJ. Engineered antibody fragments and the rise of single domains. Nat Biotechnol. 2005;23(9):1126-36. (Pubitemid 41486394)
    • (2005) Nature Biotechnology , vol.23 , Issue.9 , pp. 1126-1136
    • Holliger, P.1    Hudson, P.J.2
  • 12
    • 84899066658 scopus 로고    scopus 로고
    • Multi-drug inhibition of the HER pathway in metastatic colorectal cancer: Results of a phase I study of pertuzumab plus cetuximab in cetuximab-refractory patients
    • Rubinson DA, Hochster HS, Ryan DP, Wolpin BM, McCleary NJ, Abrams TA, et al. Multi-drug inhibition of the HER pathway in metastatic colorectal cancer: results of a phase I study of pertuzumab plus cetuximab in cetuximab-refractory patients. Invest New Drugs. 2013;32(1):113-22.
    • (2013) Invest New Drugs , vol.32 , Issue.1 , pp. 113-122
    • Rubinson, D.A.1    Hochster, H.S.2    Ryan, D.P.3    Wolpin, B.M.4    McCleary, N.J.5    Abrams, T.A.6
  • 13
    • 84860620155 scopus 로고    scopus 로고
    • Cancer stromal targeting (CAST) therapy
    • Matsumura Y. Cancer stromal targeting (CAST) therapy. Adv Drug Deliv Rev. 2012;64(8):710-9.
    • (2012) Adv Drug Deliv Rev , vol.64 , Issue.8 , pp. 710-719
    • Matsumura, Y.1
  • 15
    • 79952741743 scopus 로고    scopus 로고
    • Influence of affinity and antigen internalization on the uptake and penetration of Anti-HER2 antibodies in solid tumors
    • Rudnick SI, Lou J, Shaller CC, Tang Y, Klein-Szanto AJ, Weiner LM, et al. Influence of affinity and antigen internalization on the uptake and penetration of Anti-HER2 antibodies in solid tumors. Cancer Res. 2011;71(6):2250-9.
    • (2011) Cancer Res , vol.71 , Issue.6 , pp. 2250-2259
    • Rudnick, S.I.1    Lou, J.2    Shaller, C.C.3    Tang, Y.4    Klein-Szanto, A.J.5    Weiner, L.M.6
  • 16
    • 0032862227 scopus 로고    scopus 로고
    • Radioimmunotherapy of human colon cancer xenografts using a dimeric single-chain Fv antibody construct
    • Pavlinkova G, Booth BJ, Batra SK, Colcher D. Radioimmunotherapy of human colon cancer xenografts using a dimeric singlechain Fv antibody construct. Clin Cancer Res. 1999;5(9):2613-9. (Pubitemid 29437349)
    • (1999) Clinical Cancer Research , vol.5 , Issue.9 , pp. 2613-2619
    • Pavlinkova, G.1    Booth, B.J.M.2    Batra, S.K.3    Colcher, D.4
  • 19
    • 67449156132 scopus 로고    scopus 로고
    • Bispecific T-cell engaging antibodies for cancer therapy
    • Baeuerle PA, Reinhardt C. Bispecific T-cell engaging antibodies for cancer therapy. Cancer Res. 2009;69(12):4941-4.
    • (2009) Cancer Res , vol.69 , Issue.12 , pp. 4941-4944
    • Baeuerle, P.A.1    Reinhardt, C.2
  • 20
    • 84856007019 scopus 로고    scopus 로고
    • EpCAM/CD3-Bispecific T-cell engaging antibody MT110 eliminates primary human pancreatic cancer stem cells
    • Cioffi M, Dorado J, Baeuerle PA, Heeschen C. EpCAM/CD3-Bispecific T-cell engaging antibody MT110 eliminates primary human pancreatic cancer stem cells. Clin Cancer Res. 2012;18(2):465-74.
    • (2012) Clin Cancer Res , vol.18 , Issue.2 , pp. 465-474
    • Cioffi, M.1    Dorado, J.2    Baeuerle, P.A.3    Heeschen, C.4
  • 21
    • 78149460436 scopus 로고    scopus 로고
    • Highly efficient elimination of colorectal tumor-initiating cells by an EpCAM/CD3-bispecific antibody engaging human T cells
    • Herrmann I, Baeuerle PA, Friedrich M, Murr A, Filusch S, Ruttinger D, et al. Highly efficient elimination of colorectal tumor-initiating cells by an EpCAM/CD3-bispecific antibody engaging human T cells. PLoS One. 2010;5(10):e13474.
    • (2010) PLoS One , vol.5 , Issue.10
    • Herrmann, I.1    Baeuerle, P.A.2    Friedrich, M.3    Murr, A.4    Filusch, S.5    Ruttinger, D.6
  • 22
    • 74249122446 scopus 로고    scopus 로고
    • Metastatic colorectal cancer cells from patients previously treated with chemotherapy are sensitive to T-cell killing mediated by CEA/CD3-bispecific T-cell-engaging BiTE antibody
    • Osada T, Hsu D, Hammond S, Hobeika A, Devi G, Clay TM, et al. Metastatic colorectal cancer cells from patients previously treated with chemotherapy are sensitive to T-cell killing mediated by CEA/CD3-bispecific T-cell-engaging BiTE antibody. Br J Cancer. 2010;102(1):124-33.
    • (2010) Br J Cancer , vol.102 , Issue.1 , pp. 124-133
    • Osada, T.1    Hsu, D.2    Hammond, S.3    Hobeika, A.4    Devi, G.5    Clay, T.M.6
  • 23
    • 79959312575 scopus 로고    scopus 로고
    • Targeted therapy with the T-cell-engaging antibody blinatumomab of chemotherapy-refractory minimal residual disease in B-lineage acute lymphoblastic leukemia patients results in high response rate and prolonged leukemia-free survival
    • Topp MS, Kufer P, Gokbuget N, Goebeler M, Klinger M, Neumann S, et al. Targeted therapy with the T-cell-engaging antibody blinatumomab of chemotherapy-refractory minimal residual disease in B-lineage acute lymphoblastic leukemia patients results in high response rate and prolonged leukemia-free survival. J Clin Oncol. 2011;29(18):2493-8.
    • (2011) J Clin Oncol , vol.29 , Issue.18 , pp. 2493-2498
    • Topp, M.S.1    Kufer, P.2    Gokbuget, N.3    Goebeler, M.4    Klinger, M.5    Neumann, S.6
  • 24
    • 49649120397 scopus 로고    scopus 로고
    • Tumor regression in cancer patients by very low doses of a T cell-engaging antibody
    • Bargou R, Leo E, Zugmaier G, Klinger M, Goebeler M, Knop S, et al. Tumor regression in cancer patients by very low doses of a T cell-engaging antibody. Science. 2008;321(5891):974-7.
    • (2008) Science , vol.321 , Issue.5891 , pp. 974-977
    • Bargou, R.1    Leo, E.2    Zugmaier, G.3    Klinger, M.4    Goebeler, M.5    Knop, S.6
  • 25
    • 58549109813 scopus 로고    scopus 로고
    • Combination of rituximab with blinatumomab (MT103/MEDI-538), a T cell-engaging CD19-/CD3-bispecific antibody, for highly efficient lysis of human B lymphoma cells
    • d'Argouges S, Wissing S, Brandl C, Prang N, Lutterbuese R, Kozhich A, et al. Combination of rituximab with blinatumomab (MT103/MEDI-538), a T cell-engaging CD19-/CD3-bispecific antibody, for highly efficient lysis of human B lymphoma cells. Leuk Res. 2009;33(3):465-73.
    • (2009) Leuk Res , vol.33 , Issue.3 , pp. 465-473
    • D'Argouges, S.1    Wissing, S.2    Brandl, C.3    Prang, N.4    Lutterbuese, R.5    Kozhich, A.6
  • 26
    • 84871360414 scopus 로고    scopus 로고
    • Regression of human prostate cancer xenografts in mice by AMG 212/BAY2010112, a novel PSMA/CD3-Bispecific BiTE antibody cross-reactive with non-human primate antigens
    • Friedrich M, Raum T, Lutterbuese R, Voelkel M, Deegen P, Rau D, et al. Regression of human prostate cancer xenografts in mice by AMG 212/BAY2010112, a novel PSMA/CD3-Bispecific BiTE antibody cross-reactive with non-human primate antigens. Mol Cancer Ther. 2012;11(12):2664-73.
    • (2012) Mol Cancer Ther , vol.11 , Issue.12 , pp. 2664-2673
    • Friedrich, M.1    Raum, T.2    Lutterbuese, R.3    Voelkel, M.4    Deegen, P.5    Rau, D.6
  • 29
    • 84864776718 scopus 로고    scopus 로고
    • Phase II trial of anticarcinoembryonic antigen pretargeted radioimmunotherapy in progressive metastatic medullary thyroid carcinoma: Biomarker response and survival improvement
    • Salaun PY, Campion L, Bournaud C, Faivre-Chauvet A, Vuillez JP, Taieb D, et al. Phase II trial of anticarcinoembryonic antigen pretargeted radioimmunotherapy in progressive metastatic medullary thyroid carcinoma: biomarker response and survival improvement. J Nucl Med. 2012;53(8):1185-92.
    • (2012) J Nucl Med , vol.53 , Issue.8 , pp. 1185-1192
    • Salaun, P.Y.1    Campion, L.2    Bournaud, C.3    Faivre-Chauvet, A.4    Vuillez, J.P.5    Taieb, D.6
  • 30
    • 34848861947 scopus 로고    scopus 로고
    • The dock and lock method: A novel platform technology for building multivalent, multifunctional structures of defined composition with retained bioactivity
    • DOI 10.1158/1078-0432.CCR-07-1217
    • Chang CH, Rossi EA, Goldenberg DM. The dock and lock method: a novel platform technology for building multivalent, multifunctional structures of defined composition with retained bioactivity. Clin Cancer Res. 2007;13(18 Pt 2):5586s-91s. (Pubitemid 47510391)
    • (2007) Clinical Cancer Research , vol.13 , Issue.18
    • Chang, C.-H.1    Rossi, E.A.2    Goldenberg, D.M.3
  • 31
    • 33646477258 scopus 로고    scopus 로고
    • Stably tethered multifunctional structures of defined composition made by the dock and lock method for use in cancer targeting
    • Rossi EA, Goldenberg DM, Cardillo TM, McBride WJ, Sharkey RM, Chang CH. Stably tethered multifunctional structures of defined composition made by the dock and lock method for use in cancer targeting. Proc Natl Acad Sci USA. 2006;103(18):6841-6.
    • (2006) Proc Natl Acad Sci USA , vol.103 , Issue.18 , pp. 6841-6846
    • Rossi, E.A.1    Goldenberg, D.M.2    Cardillo, T.M.3    McBride, W.J.4    Sharkey, R.M.5    Chang, C.H.6
  • 32
    • 84883173479 scopus 로고    scopus 로고
    • Development of an imagingguided CEA-pretargeted radionuclide treatment of advanced colorectal cancer: First clinical results
    • Schoffelen R, Boerman OC, Goldenberg DM, Sharkey RM, van Herpen CM, Franssen GM, et al. Development of an imagingguided CEA-pretargeted radionuclide treatment of advanced colorectal cancer: first clinical results. Br J Cancer. 2013;109(4):934-42.
    • (2013) Br J Cancer , vol.109 , Issue.4 , pp. 934-942
    • Schoffelen, R.1    Boerman, O.C.2    Goldenberg, D.M.3    Sharkey, R.M.4    Van Herpen, C.M.5    Franssen, G.M.6
  • 33
    • 67549102111 scopus 로고    scopus 로고
    • Genetic alteration of a bispecific ligand-directed toxin targeting human CD19 and CD22 receptors resulting in improved efficacy against systemic B cell malignancy
    • Vallera DA, Chen H, Sicheneder AR, Panoskaltsis-Mortari A, Taras EP. Genetic alteration of a bispecific ligand-directed toxin targeting human CD19 and CD22 receptors resulting in improved efficacy against systemic B cell malignancy. Leuk Res. 2009;33(9):1233-42.
    • (2009) Leuk Res , vol.33 , Issue.9 , pp. 1233-1242
    • Vallera, D.A.1    Chen, H.2    Sicheneder, A.R.3    Panoskaltsis-Mortari, A.4    Taras, E.P.5
  • 34
    • 18844444471 scopus 로고    scopus 로고
    • A bispecific recombinant immunotoxin, DT2219, targeting human CD19 and CD22 receptors in a mouse xenograft model of B-cell leukemia/lymphoma
    • DOI 10.1158/1078-0432.CCR-04-2290
    • Vallera DA, Todhunter DA, Kuroki DW, Shu Y, Sicheneder A, Chen H. A bispecific recombinant immunotoxin, DT2219, targeting human CD19 and CD22 receptors in a mouse xenograft model of B-cell leukemia/lymphoma. Clin Cancer Res. 2005;11(10):3879-88. (Pubitemid 40685609)
    • (2005) Clinical Cancer Research , vol.11 , Issue.10 , pp. 3879-3888
    • Vallera, D.A.1    Todhunter, D.A.2    Kuroki, D.W.3    Shu, Y.4    Sicheneder, A.5    Chen, H.6
  • 35
    • 33846471662 scopus 로고    scopus 로고
    • Denileukin diftitox: A biotherapeutic paradigm shift in the treatment of lymphoid-derived disorders
    • DOI 10.1586/14737140.7.1.11
    • Turturro F. Denileukin diftitox: a biotherapeutic paradigm shift in the treatment of lymphoid-derived disorders. Expert Rev Anticancer Ther. 2007;7(1):11-7. (Pubitemid 46157644)
    • (2007) Expert Review of Anticancer Therapy , vol.7 , Issue.1 , pp. 11-17
    • Turturro, F.1
  • 37
    • 15244363849 scopus 로고    scopus 로고
    • + malignant B cells and bypass complement-mediated rituximab resistance in vitro
    • DOI 10.1016/j.exphem.2005.01.007
    • Gall JM, Davol PA, Grabert RC, Deaver M, Lum LG. T cells armed with anti-CD3 x anti-CD20 bispecific antibody enhance killing of CD20+ malignant B cells and bypass complementmediated rituximab resistance in vitro. Exp Hematol. 2005;33(4):452-9. (Pubitemid 40387628)
    • (2005) Experimental Hematology , vol.33 , Issue.4 , pp. 452-459
    • Gall, J.M.1    Davol, P.A.2    Grabert, R.C.3    Deaver, M.4    Lum, L.G.5
  • 38
    • 84891888501 scopus 로고    scopus 로고
    • Multiple infusions of CD20-targeted T cells and low-dose IL-2 after SCT for high-risk non-Hodgkin's lymphoma: A pilot study
    • Lum LG, Thakur A, Pray C, Kouttab N, Abedi M, Deol A, et al. Multiple infusions of CD20-targeted T cells and low-dose IL-2 after SCT for high-risk non-Hodgkin's lymphoma: a pilot study. Bone Marrow Transplant. 2014;49(1):73-9.
    • (2014) Bone Marrow Transplant , vol.49 , Issue.1 , pp. 73-79
    • Lum, L.G.1    Thakur, A.2    Pray, C.3    Kouttab, N.4    Abedi, M.5    Deol, A.6
  • 39
    • 30344441648 scopus 로고    scopus 로고
    • Anti-CD3 x anti-epidermal growth factor receptor (EGFR) bispecific antibody redirects T-cell cytolytic activity to EGFR-positive cancers in vitro and in an animal model
    • DOI 10.1158/1078-0432.CCR-05-1855
    • Reusch U, Sundaram M, Davol PA, Olson SD, Davis JB, Demel K, et al. Anti-CD3 x anti-epidermal growth factor receptor (EGFR) bispecific antibody redirects T-cell cytolytic activity to EGFR-positive cancers in vitro and in an animal model. Clin Cancer Res. 2006;12(1):183-90. (Pubitemid 43166193)
    • (2006) Clinical Cancer Research , vol.12 , Issue.1 , pp. 183-190
    • Reusch, U.1    Sundaram, M.2    Davol, P.A.3    Olson, S.D.4    Davis, J.B.5    Demel, K.6    Nissim, J.7    Rathore, R.8    Liu, P.Y.9    Lum, L.G.10
  • 40
    • 84859409756 scopus 로고    scopus 로고
    • Antitumor activity of a novel bispecific antibody that targets the ErbB2/ErbB3 oncogenic unit and inhibits heregulin- induced activation of ErbB3
    • McDonagh CF, Huhalov A, Harms BD, Adams S, Paragas V, Oyama S, et al. Antitumor activity of a novel bispecific antibody that targets the ErbB2/ErbB3 oncogenic unit and inhibits heregulin- induced activation of ErbB3. Mol Cancer Ther. 2012;11(3):582-93.
    • (2012) Mol Cancer Ther , vol.11 , Issue.3 , pp. 582-593
    • McDonagh, C.F.1    Huhalov, A.2    Harms, B.D.3    Adams, S.4    Paragas, V.5    Oyama, S.6
  • 41
    • 84904854771 scopus 로고    scopus 로고
    • IMCgp100: A novel bi-specific biologic for the treatment of malignant melanoma
    • Hassan NJ, Adams K, Bossi G, Harper J, Buisson S, Paston S, et al. IMCgp100: A novel bi-specific biologic for the treatment of malignant melanoma. Cancer Res. 2012;72(8):Supplement 1.
    • (2012) Cancer Res , vol.72 , Issue.8 SUPPL. 1
    • Hassan, N.J.1    Adams, K.2    Bossi, G.3    Harper, J.4    Buisson, S.5    Paston, S.6
  • 42
    • 84904854772 scopus 로고    scopus 로고
    • IMCgp100: A novel bispecific biologic for the treatment of malignant melanoma
    • Middleton M, Evans J, Steven N, Corrie PG, Mulatero C, Baker D, et al. IMCgp100: a novel bispecific biologic for the treatment of malignant melanoma. Cancer Res. 2013;73(8):Supplement 1.
    • (2013) Cancer Res , vol.73 , Issue.8 SUPPL. 1
    • Middleton, M.1    Evans, J.2    Steven, N.3    Corrie, P.G.4    Mulatero, C.5    Baker, D.6
  • 43
    • 0030727901 scopus 로고    scopus 로고
    • Clinical experience with CD64-directed immunotherapy. An overview
    • DOI 10.1007/s002620050435
    • Curnow RT. Clinical experience with CD64-directed immunotherapy: an overview. Cancer Immunol Immunother. 1997;45(3-4):210-5. (Pubitemid 27521462)
    • (1997) Cancer Immunology Immunotherapy , vol.45 , Issue.3-4 , pp. 210-215
    • Curnow, R.T.1
  • 44
    • 77954676136 scopus 로고    scopus 로고
    • The trifunctional antibody catumaxomab for the treatment of malignant ascites due to epithelial cancer: Results of a prospective randomized phase II/III trial
    • Heiss MM, Murawa P, Koralewski P, Kutarska E, Kolesnik OO, Ivanchenko VV, et al. The trifunctional antibody catumaxomab for the treatment of malignant ascites due to epithelial cancer: results of a prospective randomized phase II/III trial. Int J Cancer. 2010;127(9):2209-21.
    • (2010) Int J Cancer , vol.127 , Issue.9 , pp. 2209-2221
    • Heiss, M.M.1    Murawa, P.2    Koralewski, P.3    Kutarska, E.4    Kolesnik, O.O.5    Ivanchenko, V.V.6
  • 45
    • 80052593787 scopus 로고    scopus 로고
    • Intraperitoneal treatment with the trifunctional bispecific antibody Catumaxomab in patients with platinumresistant epithelial ovarian cancer: A phase IIa study of the AGO Study Group
    • Baumann K, Pfisterer J, Wimberger P, Burchardi N, Kurzeder C, du Bois A, et al. Intraperitoneal treatment with the trifunctional bispecific antibody Catumaxomab in patients with platinumresistant epithelial ovarian cancer: a phase IIa study of the AGO Study Group. Gynecol Oncol. 2011;123(1):27-32.
    • (2011) Gynecol Oncol , vol.123 , Issue.1 , pp. 27-32
    • Baumann, K.1    Pfisterer, J.2    Wimberger, P.3    Burchardi, N.4    Kurzeder, C.5    Du Bois, A.6
  • 47
    • 84855401998 scopus 로고    scopus 로고
    • Immunomonitoring results of a phase II/III study of malignant ascites patients treated with the trifunctional antibody catumaxomab (anti-EpCAM x anti-CD3)
    • Jager M, Schoberth A, Ruf P, Hess J, Hennig M, Schmalfeldt B, et al. Immunomonitoring results of a phase II/III study of malignant ascites patients treated with the trifunctional antibody catumaxomab (anti-EpCAM x anti-CD3). Cancer Res. 2012;72(1):24-32.
    • (2012) Cancer Res , vol.72 , Issue.1 , pp. 24-32
    • Jager, M.1    Schoberth, A.2    Ruf, P.3    Hess, J.4    Hennig, M.5    Schmalfeldt, B.6
  • 48
    • 84890561529 scopus 로고    scopus 로고
    • Regression of liver metastases after treatment with intraperitoneal catumaxomab for malignant ascites due to breast cancer
    • Petrelli F, Borgonovo K, Lonati V, Elia S, Barni S. Regression of liver metastases after treatment with intraperitoneal catumaxomab for malignant ascites due to breast cancer. Target Oncol. 2013;8(4):291-4.
    • (2013) Target Oncol , vol.8 , Issue.4 , pp. 291-294
    • Petrelli, F.1    Borgonovo, K.2    Lonati, V.3    Elia, S.4    Barni, S.5
  • 49
    • 84893134949 scopus 로고    scopus 로고
    • The trifunctional antibody catumaxomab amplifies and shapes tumor-specific immunity when applied to gastric cancer patients in the adjuvant setting
    • Atanackovic D, Reinhard H, Meyer S, Spock S, Grob T, Luetkens T, et al. The trifunctional antibody catumaxomab amplifies and shapes tumor-specific immunity when applied to gastric cancer patients in the adjuvant setting. Hum Vaccin Immunother. 2013;9(12):2533-42.
    • (2013) Hum Vaccin Immunother , vol.9 , Issue.12 , pp. 2533-2542
    • Atanackovic, D.1    Reinhard, H.2    Meyer, S.3    Spock, S.4    Grob, T.5    Luetkens, T.6
  • 50
    • 62549086034 scopus 로고    scopus 로고
    • Immunotherapy of recurrent B-cell malignancies after allo-SCT with Bi20 (FBTA05), a trifunctional anti-CD3 x anti-CD20 antibody and donor lymphocyte infusion
    • Buhmann R, Simoes B, Stanglmaier M, Yang T, Faltin M, Bund D, et al. Immunotherapy of recurrent B-cell malignancies after allo-SCT with Bi20 (FBTA05), a trifunctional anti-CD3 x anti-CD20 antibody and donor lymphocyte infusion. Bone Marrow Transplant. 2009;43(5):383-97.
    • (2009) Bone Marrow Transplant , vol.43 , Issue.5 , pp. 383-397
    • Buhmann, R.1    Simoes, B.2    Stanglmaier, M.3    Yang, T.4    Faltin, M.5    Bund, D.6
  • 51
    • 84879832972 scopus 로고    scopus 로고
    • Immunotherapy with FBTA05 (Bi20), a trifunctional bispecific anti-CD3 x anti-CD20 antibody and donor lymphocyte infusion (DLI) in relapsed or refractory B-cell lymphoma after allogeneic stem cell transplantation: Study protocol of an investigator-driven, open-label, non-randomized, uncontrolled, dose-escalating Phase I/II-trial
    • Buhmann R, Michael S, Juergen H, Horst L, Peschel C, Kolb HJ. Immunotherapy with FBTA05 (Bi20), a trifunctional bispecific anti-CD3 x anti-CD20 antibody and donor lymphocyte infusion (DLI) in relapsed or refractory B-cell lymphoma after allogeneic stem cell transplantation: study protocol of an investigator-driven, open-label, non-randomized, uncontrolled, dose-escalating Phase I/II-trial. J Transl Med. 2013;11:160.
    • (2013) J Transl Med , vol.11 , pp. 160
    • Buhmann, R.1    Michael, S.2    Juergen, H.3    Horst, L.4    Peschel, C.5    Kolb, H.J.6
  • 53
    • 52949085848 scopus 로고    scopus 로고
    • Ertumaxomab: A trifunctional antibody for breast cancer treatment
    • Kiewe P, Thiel E. Ertumaxomab: a trifunctional antibody for breast cancer treatment. Expert Opin Investig Drugs. 2008;17(10):1553-8.
    • (2008) Expert Opin Investig Drugs , vol.17 , Issue.10 , pp. 1553-1558
    • Kiewe, P.1    Thiel, E.2
  • 54
    • 84873087647 scopus 로고    scopus 로고
    • Phase II Study of Single Agent Trifunctional Antibody Ertumaxomab (Anti-HER-2 & Anti-CD3) in HER-2 Low Expressing Hormone-Refractory Advanced Breast Cancer Patients (ABC)
    • Cardoso C, Dirix L, Conte PF, Semiglazov V, de Placido S, Jaeger M, et al. Phase II Study of Single Agent Trifunctional Antibody Ertumaxomab (Anti-HER-2 & Anti-CD3) in HER-2 Low Expressing Hormone-Refractory Advanced Breast Cancer Patients (ABC). Cancer Res. 2010;70(24):Supplement 2.
    • (2010) Cancer Res , vol.70 , Issue.24 SUPPL. 2
    • Cardoso, C.1    Dirix, L.2    Conte, P.F.3    Semiglazov, V.4    De Placido, S.5    Jaeger, M.6
  • 55
    • 84863650195 scopus 로고    scopus 로고
    • RECRUIT-TandAbs: Harnessing the immune system to kill cancer cells
    • McAleese F, Eser M. RECRUIT-TandAbs: harnessing the immune system to kill cancer cells. Future Oncol. 2012;8(6):687-95.
    • (2012) Future Oncol , vol.8 , Issue.6 , pp. 687-695
    • McAleese, F.1    Eser, M.2
  • 56
    • 84867580896 scopus 로고    scopus 로고
    • T and NK cells of B cell NHL patients exert cytotoxicity against lymphoma cells following binding of bispecific tetravalent antibody CD19 x CD3 or CD19 x CD16
    • Portner LM, Schonberg K, Hejazi M, Brunnert D, Neumann F, Galonska L, et al. T and NK cells of B cell NHL patients exert cytotoxicity against lymphoma cells following binding of bispecific tetravalent antibody CD19 x CD3 or CD19 x CD16. Cancer Immunol Immunother. 2012;61(10):1869-75.
    • (2012) Cancer Immunol Immunother , vol.61 , Issue.10 , pp. 1869-1875
    • Portner, L.M.1    Schonberg, K.2    Hejazi, M.3    Brunnert, D.4    Neumann, F.5    Galonska, L.6
  • 57
    • 79955970356 scopus 로고    scopus 로고
    • Application of dual affinity retargeting molecules to achieve optimal redirected T-cell killing of B-cell lymphoma
    • Moore PA, Zhang W, Rainey GJ, Burke S, Li H, Huang L, et al. Application of dual affinity retargeting molecules to achieve optimal redirected T-cell killing of B-cell lymphoma. Blood. 2011;117(17):4542-51.
    • (2011) Blood , vol.117 , Issue.17 , pp. 4542-4551
    • Moore, P.A.1    Zhang, W.2    Rainey, G.J.3    Burke, S.4    Li, H.5    Huang, L.6
  • 58
    • 78049395507 scopus 로고    scopus 로고
    • Multiple signaling pathways induced by hexavalent, monospecific, anti-CD20 and hexavalent, bispecific, anti-CD20/CD22 humanized antibodies correlate with enhanced toxicity to B-cell lymphomas and leukemias
    • Gupta P, Goldenberg DM, Rossi EA, Chang CH. Multiple signaling pathways induced by hexavalent, monospecific, anti-CD20 and hexavalent, bispecific, anti-CD20/CD22 humanized antibodies correlate with enhanced toxicity to B-cell lymphomas and leukemias. Blood. 2010;116(17):3258-67.
    • (2010) Blood , vol.116 , Issue.17 , pp. 3258-3267
    • Gupta, P.1    Goldenberg, D.M.2    Rossi, E.A.3    Chang, C.H.4
  • 59
    • 84860332847 scopus 로고    scopus 로고
    • Dual-targeting immunotherapy of lymphoma: Potent cytotoxicity of anti-CD20/CD74 bispecific antibodies in mantle cell and other lymphomas
    • Gupta P, Goldenberg DM, Rossi EA, Cardillo TM, Byrd JC, Muthusamy N, et al. Dual-targeting immunotherapy of lymphoma: potent cytotoxicity of anti-CD20/CD74 bispecific antibodies in mantle cell and other lymphomas. Blood. 2012;119(16):3767-78.
    • (2012) Blood , vol.119 , Issue.16 , pp. 3767-3778
    • Gupta, P.1    Goldenberg, D.M.2    Rossi, E.A.3    Cardillo, T.M.4    Byrd, J.C.5    Muthusamy, N.6
  • 60
    • 58249122185 scopus 로고    scopus 로고
    • A bispecific single-chain antibody that mediates target cellrestricted, supra-agonistic CD28 stimulation and killing of lymphoma cells
    • Otz T, Grosse-Hovest L, Hofmann M, Rammensee HG, Jung G. A bispecific single-chain antibody that mediates target cellrestricted, supra-agonistic CD28 stimulation and killing of lymphoma cells. Leukemia. 2009;23(1):71-7.
    • (2009) Leukemia , vol.23 , Issue.1 , pp. 71-77
    • Otz, T.1    Grosse-Hovest, L.2    Hofmann, M.3    Rammensee, H.G.4    Jung, G.5
  • 61
    • 34547857025 scopus 로고    scopus 로고
    • TRAIL-receptor antibodies as a potential cancer treatment
    • DOI 10.2217/14796694.3.4.405
    • Buchsbaum DJ, Forero-Torres A, LoBuglio AF. TRAIL-receptor antibodies as a potential cancer treatment. Future Oncol. 2007;3(4):405-9. (Pubitemid 47250157)
    • (2007) Future Oncology , vol.3 , Issue.4 , pp. 405-409
    • Buchsbaum, D.J.1    Forero-Torres, A.2    LoBuglio, A.F.3
  • 63
    • 70449770418 scopus 로고    scopus 로고
    • Anti-tumor activity of stability-engineered IgG-like bispecific antibodies targeting TRAIL-R2 and LTbetaR
    • Michaelson JS, Demarest SJ, Miller B, Amatucci A, Snyder WB, Wu X, et al. Anti-tumor activity of stability-engineered IgG-like bispecific antibodies targeting TRAIL-R2 and LTbetaR. MAbs. 2009;1(2):128-41.
    • (2009) MAbs , vol.1 , Issue.2 , pp. 128-141
    • Michaelson, J.S.1    Demarest, S.J.2    Miller, B.3    Amatucci, A.4    Snyder, W.B.5    Wu, X.6
  • 64
    • 85026147994 scopus 로고    scopus 로고
    • A novel CD19-directed recombinant bispecific antibody derivative with enhanced immune effector functions for human leukemic cells
    • Kellner C, Bruenke J, Stieglmaier J, Schwemmlein M, Schwenkert M, Singer H, et al. A novel CD19-directed recombinant bispecific antibody derivative with enhanced immune effector functions for human leukemic cells. J Immunother. 2008;31(9):871-84.
    • (2008) J Immunother , vol.31 , Issue.9 , pp. 871-884
    • Kellner, C.1    Bruenke, J.2    Stieglmaier, J.3    Schwemmlein, M.4    Schwenkert, M.5    Singer, H.6
  • 65
    • 77955782190 scopus 로고    scopus 로고
    • A recombinant trispecific single-chain Fv derivative directed against CD123 and CD33 mediates effective elimination of acute myeloid leukaemia cells by dual targeting
    • Kugler M, Stein C, Kellner C, Mentz K, Saul D, Schwenkert M, et al. A recombinant trispecific single-chain Fv derivative directed against CD123 and CD33 mediates effective elimination of acute myeloid leukaemia cells by dual targeting. Br J Haematol. 2010;150(5):574-86.
    • (2010) Br J Haematol , vol.150 , Issue.5 , pp. 574-586
    • Kugler, M.1    Stein, C.2    Kellner, C.3    Mentz, K.4    Saul, D.5    Schwenkert, M.6
  • 66
    • 78651404837 scopus 로고    scopus 로고
    • A single-chain triplebody with specificity for CD19 and CD33 mediates effective lysis of mixed lineage leukemia cells by dual targeting
    • Schubert I, Kellner C, Stein C, Kugler M, Schwenkert M, Saul D, et al. A single-chain triplebody with specificity for CD19 and CD33 mediates effective lysis of mixed lineage leukemia cells by dual targeting. MAbs. 2011;3(1):21-30.
    • (2011) MAbs , vol.3 , Issue.1 , pp. 21-30
    • Schubert, I.1    Kellner, C.2    Stein, C.3    Kugler, M.4    Schwenkert, M.5    Saul, D.6
  • 67
    • 68849105814 scopus 로고    scopus 로고
    • Oncogenic stress sensed by the immune system: Role of natural killer cell receptors
    • Raulet DH, Guerra N. Oncogenic stress sensed by the immune system: role of natural killer cell receptors. Nat Rev Immunol. 2009;9(8):568-80.
    • (2009) Nat Rev Immunol , vol.9 , Issue.8 , pp. 568-580
    • Raulet, D.H.1    Guerra, N.2
  • 68
    • 33344477900 scopus 로고    scopus 로고
    • A novel bispecific protein (ULBP2-BB4) targeting the NKG2D receptor on natural killer (NK) cells and CD138 activates NK cells and has potent antitumor activity against human multiple myeloma in vitro and in vivo
    • DOI 10.1182/blood-2005-05-2177
    • von Strandmann EP, Hansen HP, Reiners KS, Schnell R, Borchmann P, Merkert S, et al. A novel bispecific protein (ULBP2-BB4) targeting the NKG2D receptor on natural killer (NK) cells and CD138 activates NK cells and has potent antitumor activity against human multiple myeloma in vitro and in vivo. Blood. 2006;107(5):1955-62. (Pubitemid 43289377)
    • (2006) Blood , vol.107 , Issue.5 , pp. 1955-1962
    • Von Strandmann, E.P.1    Hansen, H.P.2    Reiners, K.S.3    Schnell, R.4    Borchmann, P.5    Merkert, S.6    Simhadri, V.R.7    Draube, A.8    Reiser, M.9    Purr, I.10    Hallek, M.11    Engert, A.12
  • 69
    • 0035099068 scopus 로고    scopus 로고
    • ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor
    • Cosman D, Mullberg J, Sutherland CL, Chin W, Armitage R, Fanslow W, et al. ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor. Immunity. 2001;14(2):123-33. (Pubitemid 32206515)
    • (2001) Immunity , vol.14 , Issue.2 , pp. 123-133
    • Cosman, D.1    Mullberg, J.2    Sutherland, C.L.3    Chin, W.4    Armitage, R.5    Fanslow, W.6    Kubin, M.7    Chalupny N.Jan8
  • 70
    • 79958733649 scopus 로고    scopus 로고
    • Induction of in vitro and in vivo NK cell cytotoxicity using high-avidity immunoligands targeting prostatespecific membrane antigen in prostate carcinoma
    • Jachimowicz RD, Fracasso G, Yazaki PJ, Power BE, Borchmann P, Engert A, et al. Induction of in vitro and in vivo NK cell cytotoxicity using high-avidity immunoligands targeting prostatespecific membrane antigen in prostate carcinoma. Mol Cancer Ther. 2011;10(6):1036-45.
    • (2011) Mol Cancer Ther , vol.10 , Issue.6 , pp. 1036-1045
    • Jachimowicz, R.D.1    Fracasso, G.2    Yazaki, P.J.3    Power, B.E.4    Borchmann, P.5    Engert, A.6
  • 71
    • 84897994273 scopus 로고    scopus 로고
    • The bispecific immunoligand ULBP2-aCEA redirects natural killer cells to tumor cells and reveals potent antitumor activity against colon carcinoma
    • Epub ahead of print
    • Rothe A, Jachimowicz RD, Borchmann S, Madlener M, Kessler J, Reiners KS, et al. The bispecific immunoligand ULBP2-aCEA redirects natural killer cells to tumor cells and reveals potent antitumor activity against colon carcinoma. Int J Cancer. 2013 [Epub ahead of print].
    • (2013) Int J Cancer
    • Rothe, A.1    Jachimowicz, R.D.2    Borchmann, S.3    Madlener, M.4    Kessler, J.5    Reiners, K.S.6
  • 72
    • 84872525097 scopus 로고    scopus 로고
    • Dual targeting of EGFR and HER3 with MEHD7945A overcomes acquired resistance to EGFR inhibitors and radiation
    • Huang S, Li C, Armstrong EA, Peet CR, Saker J, Amler LC, et al. Dual targeting of EGFR and HER3 with MEHD7945A overcomes acquired resistance to EGFR inhibitors and radiation. Cancer Res. 2013;73(2):824-33.
    • (2013) Cancer Res , vol.73 , Issue.2 , pp. 824-833
    • Huang, S.1    Li, C.2    Armstrong, E.A.3    Peet, C.R.4    Saker, J.5    Amler, L.C.6
  • 73
    • 79955675632 scopus 로고    scopus 로고
    • A stable IgG-like bispecific antibody targeting the epidermal growth factor receptor and the type I insulin-like growth factor receptor demonstrates superior anti-tumor activity
    • Dong J, Sereno A, Aivazian D, Langley E, Miller BR, Snyder WB, et al. A stable IgG-like bispecific antibody targeting the epidermal growth factor receptor and the type I insulin-like growth factor receptor demonstrates superior anti-tumor activity. MAbs. 2011;3(3):273-88.
    • (2011) MAbs , vol.3 , Issue.3 , pp. 273-288
    • Dong, J.1    Sereno, A.2    Aivazian, D.3    Langley, E.4    Miller, B.R.5    Snyder, W.B.6


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