Association between genes, stressful childhood events and processing bias in depression vulnerable individuals

Genes, Brain and Behavior

Volumn 13, Issue 5, 2014, Pages 508-516

  Vrijsen, J N ^a   van Oostrom, I ^a   Arias Vasquez A ^a,b,c   Franke, B ^a,b,c   Becker, E S ^a   Speckens, A ^a  

^a RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

^b RADBOUD UNIVERSITY   (Netherlands)

^c RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

BDNF; Candidate gene; Childhood trauma; Cognitive bias; COMT; Depression; Life events; Processing bias; Stress; Working memory

Indexed keywords

ADULT; ARTICLE; BRAIN DERIVED NEUROTROPHIC FACTOR GENE; CATECHOL O METHYLTRANSFERASE GENE; CHILDHOOD INJURY; CLINICAL EXAMINATION; COGNITIVE BIAS; DEPRESSION; FEMALE; GENE FREQUENCY; GENE INTERACTION; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; QUESTIONNAIRE; REACTION TIME; STRESS; CHILD; CHILD ABUSE; COMPLICATION; EMOTION; GENETICS; MENTAL STRESS; MIDDLE AGED; PSYCHOLOGY; SINGLE NUCLEOTIDE POLYMORPHISM; VISION;

BRAIN DERIVED NEUROTROPHIC FACTOR; CATECHOL METHYLTRANSFERASE; COMT PROTEIN, HUMAN;

ADULT; BRAIN-DERIVED NEUROTROPHIC FACTOR; CATECHOL O-METHYLTRANSFERASE; CHILD; CHILD ABUSE; DEPRESSION; EMOTIONS; FEMALE; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; STRESS, PSYCHOLOGICAL; VISUAL PERCEPTION;

EID: 84904795075     PISSN: 16011848     EISSN: 1601183X     Source Type: Journal    
DOI: 10.1111/gbb.12129     Document Type: Article

References (82)

1. Aberg, E., Fandino-Losada, A., Sjoholm, L.K., Forsell, Y. & Lavebratt, C. (2011) The functional Val158Met polymorphism in catechol-O-methyltransferase (COMT) is associated with depression and motivation in men from a Swedish population-based study. J Affect Disord 129, 158-166.
2. American Psychiatric Association (1994) Diagnostic and Statistical Manual of Mental Disorders, 4th edn. American Psychiatric Association, Washington, DC.
3. Barnett, J.H., Scoriels, L. & Munafo, M.R. (2008) Meta-analysis of the cognitive effects of the catechol-O-methyltransferase gene Val158/108Met polymorphism. Biol Psychiatry 64, 137-144.
4. Beck, A.T., Steer, R.A. & Brown, G.K. (1996) Beck Depression Inventory Manual, 2nd edn. Psychological Corporation, San Antonio, TX.
5. Beevers, C.G., Wells, T.T., Ellis, A.J. & McGeary, J.E. (2009) Association of the serotonin transporter gene promoter region (5-HTTLPR) polymorphism with biased attention for emotional stimuli. J Abnorm Psychol 118, 670-681.
6. Belsky, J. & Pluess, M. (2009a) Beyond diathesis-stress: differential susceptibility to environmental influence. Psychol Bull 135, 885-908.
7. Belsky, J. & Pluess, M. (2009b) The nature (and nurture?) of plasticity in early human development. Perspect Psychol Sci 4, 345-351.
8. Belsky, J., Jonassaint, C., Pluess, M., Stanton, M., Brummett, B. & Williams, R. (2009) Vulnerability genes or plasticity genes? Mol Psychiatry 14, 746-754.
9. Bhagwagar, Z. & Cowen, P.J. (2007) It's not over when it's over: persistent neurobiological abnormalities in recovered depressed patients. Psychol Med 38, 307-313.
10. Bishop, S.J., Cohen, J.D., Fossella, J., Casey, B.J. & Farah, M.J. (2006) COMT genotype influences prefrontal response to emotional distraction. Cogn Affect Behav Neurosci 6, 62-70.
11. Bluemke, M. & Friese, M. (2008) Reliability and validity of the Single-Target IAT (ST-IAT): assessing automatic affect towards multiple attitude objects. Eur J Soc Psychol 38, 977-997.
12. Bockting, C., Spinhoven, P., Koeter, M., Wouters, L., Schene, A. Depression Evaluation Longitudinal Therapy Assessment (DELTA) Study Group (2006) Prediction of recurrence in recurrent depression and the influence of consecutive episodes on vulnerability for depression: a 2-year prospective study. J Clin Psychiatry 67, 747-755.
13. Bondy, B., Baghai, T.C., Zill, P., Bottlender, R., Jaeger, M., Minov, C., Schule, C., Zwanzger, P., Rupprecht, R. & Engel, R.R. (2002) Combined action of the ACE D- and the G-protein beta3 T-allele in major depression: a possible link to cardiovascular disease? Mol Psychiatry 7, 1120-1126.
14. Bradley, M.M., Lang, P.J. & Cuthbert, B.N. (1993) Emotion novelty and the startle reflex: habituation in humans. Behav Neurosci 107, 970-980.
15. Brewin, C.R., Andrews, B. & Gotlib, I.H. (1993) Psychopathology and early experiences: a reappraisal of retrospective reports. Psychol Bull 113, 82-98.
16. Brugha, T.S. & Cragg, D. (1990) The list of threatening experiences - the reliability and validity of a brief life events questionnaire. Acta Psychiatr Scand 82, 77-81.
17. Buckert, M., Kudielka, B.M., Reuter, M. & Fiebach, C.J. (2012) The COMT Val158Met polymorphism modulated working memory performance under acute stress. Psychoneuroendocrinology 37, 1810-1821.
18. Caspi, A., Hariri, A.R., Holmes, A., Uher, R. & Moffitt, T.E. (2010) Genetic sensitivity to the environment: the case of the serotonin transporter gene and its implications for studying complex diseases and traits. Am J Psychiatry 167, 509-527.
19. Chen, J., Lipska, B.K., Halim, N., Ma, Q.D., Matsumoto, M., Melhem, S., Kolachana, B.S., Hyde, T.M., Herman, M.M., Apud, J., Egan, M.F., Kleinman, J.E. & Weinberger, D.R. (2004a) Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): effects on mRNA, protein, and enzyme activity in postmortem human brain. Am J Hum Genet 75, 807-821.
20. Chen, Z.Y., Patel, P.D., Sant, G., Meng, C.X., Teng, K.K., Hempstead, B.L. & Lee, F.S. (2004b) Variant brain-derived neurotrophic factor (BDNF) (Met66) alters the intracellular trafficking and activity-dependent secretion of wild-type BDNF in neurosecretory cells and cortical neurons. J Neurosci 24, 4401-4411.
21. Clasen, P.C., Wells, T.T., Knopik, V.S., Mcgeary, J.E. & Beevers, C.G. (2011) 5-HTTLPR and BDNF Val66Met polymorphisms moderate effects of stress on rumination. Genes Brain Behav 10, 740-746.
22. Davidson, R.J., Pizzagalli, D., Nitschke, J.B. & Putnam, K. (2002) Depression: perspectives from affective neuroscience. Annu Rev Psychol 53, 545-574.
23. De Lissnyder, E., Koster, E.H.W. & De Raedt, R. (2012) Emotional interference inworking memory is related to rumination. Cogn Ther Res 36, 348-357.
24. De Raedt, R. & Koster, E.H. (2010) Understanding vulnerability for depression from a cognitive neuroscience perspective: a reappraisal of attentional factors and a new conceptual framework. Cogn Affect Behav Neurosci 10, 50-70.
25. Drury, S.S., Theall, K.P., Smyke, A.T., Keats, B.J., Egger, H.L., Nelson, C.A., Fox, N.A., Marshall, P.J. & Zeanah, C.H. (2010) Modification of depression by COMT val158met polymorphism in children exposed to early severe psychosocial deprivation. Child Abuse Negl 34, 387-395.
26. Egan, M.F., Goldberg, T.E., Kolachana, B.S., Callicott, J.H., Mazzanti, C.M., Straub, R.E., Goldman, D. & Weinberger, D.R. (2001) Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia. Proc Natl Acad Sci U S A 98, 6917-6922.
27. Egan, M.F., Kojima, M., Callicott, J.H., Goldberg, T.E., Kolachana, B.S., Bertolino, A., Zaitsev, E., Gold, B., Goldman, D., Dean, M., Lu, B. & Weinberger, D.R. (2003) The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell 112, 257-269.
28. Eichelbaum, M., Ingelman-Sundberg, M. & Evans, W.E. (2006) Pharmacogenomics and individualized drug therapy. Annu RevMed 57, 119-137.
29. Enoch, M.A., Schuckit, M.A., Johnson, B.A. & Goldman, D. (2003) Genetics of alcoholism using intermediate phenotypes. Alcohol Clin Exp Res 27, 169-176.
30. First, M.B., Spitzer, R.L., Gibbon, M. & Williams, J.B.W. (1996) Structured Clinical Interviewfor DSM-IV Axis I Disorders-Clinician Version (SCID-CV). American Psychiatric Press, Washington, DC.
31. Fitzgerald, D.A., Arnold, J.F., Becker, E.S., Speckens, A.E., Rinck, M., Rijpkema, M., Fernández, G. & Tendolkar, I. (2011) How mood challenges emotional memory formation: an fMRI investigation. Neuroimage 56, 1783-1790.
32. Gatt, J.M., Clark, C.R., Kemp, A.H., Liddell, B.J., Dobson-Stone, C., Kuan, S.A., Schofield, P.R. & Williams, L.M. (2007) A genotype-endophenotype-phenotype path model of depressed mood: integrating cognitive and emotional markers. J Integr Neurosci 6, 75-104.
33. Gerritsen, L., Tendolkar, I., Franke, B., Vasquez, A.A., Kooijman, S., Buitelaar, J., Fernández, G. & Rijpkema, M. (2011) BDNF Val66Met genotypemodulates the effect of childhood adversity on subgenual anterior cingulate cortex volume in healthy subjects. Mol Psychiatry 17, 597-603.
34. Geschwind, N., Peeters, F., Drukker, M., van Os, J. & Wichers, M. (2011) Mindfulness training increases momentary positive emotions and reward experience in adults vulnerable to depression: a randomized controlled trial. J Consult Clin Psychol 79, 618-628.
35. Goldberg, T.E., Egan, M.F., Gscheidle, T., Coppola, R., Weickert, T., Kolachana, B.S., Goldman, D. & Weinberger, D.R. (2003) Executive subprocesses in working memory: relationship to Catechol-O-methyltransferase Val158Met genotype and schizophrenia. Arch Gen Psychiatry 60, 889-896.
36. Gotlib, I.H. & Joormann, J. (2010) Cognition and depression: current status and future directions. Annu Rev Clin Psychol 6, 285-312.
37. Gottesman, I.I. & Gould, T.D. (2003) The endophenotype concept in psychiatry: etymology and strategic intentions. Am J Psychiatry 160, 636-645.
38. Gupta, R. & Kar, B.R. (2012) Attention and memory biases as stable abnormalities among currently depressed and currently remitted individuals with unipolar depression. Front Psychiatry 3, 99.
39. Hallion, L.S. & Ruscio, A.M. (2011) A meta-analysis of the effect of cognitive bias modification on anxiety and depression. Psychol Bull 137, 940-958.
40. Harkness, K.L. & Monroe, S.M. (2006) Severe melancholic depression is more vulnerable than non-melancholic depression to minor precipitating life events. J Affect Disord 91, 257-263.
41. Harmer, C.J., Bhagwagar, Z., Perrett, D.I., Völlm, B.A., Cowen, P.J. & Goodwin, G.M. (2003) Acute SSRI administration affects the processing of social cues in healthy volunteers. Neuropsychopharmacology 28, 148-152.
42. Hasler, G., Drevets, W.C., Manji, H.K. & Charney, D.S. (2004) Discovering endophenotypes for major depression. Neuropsychopharmacology 29, 1765-1781.
43. Hertel, P.T. & Mathews, A. (2011) Cognitive bias modification: past perspectives, current findings, and future applications. Perspect Psychol Sci 6, 521-536.
44. Hovens, J.G., Wiersma, J.E., Giltay, E.J., van Oppen, P., Spinhoven, P., Penninx, B.W. & Zitman, F.G. (2010) Childhood life events and childhood trauma in adult patients with depressive, anxiety and comorbid disorders vs. controls. Acta Psychiatr Scand 122, 66-74.
45. Joormann, J. & Gotlib, I.H. (2007) Selective attention to emotional faces following recovery from depression. J Abnorm Psychol 116, 80-85.
46. Joormann, J., Yoon, K.L. & Zetsche, U. (2007) Cognitive inhibition in depression. Appl Prev Psychol 12, 128-139.
47. Kempton, M.J., Salvador, Z., Munafò, M.R., Geddes, J.R., Simmons, A., Frangou, S. & Williams, S.C.R. (2011) Structural neuroimaging studies in major depressive disorder: meta-analysis and comparison with bipolar disorder. Arch Gen Psychiatry 68, 675-690.
48. Kendler, K.S. & Neale, M.C. (2010) Endophenotype: a conceptual analysis. Mol Psychiatry 15, 789-797.
49. Kendler, K.S., Karkowski, L.M. & Prescott, C.A. (1999) Causal relationship between stressful life events and the onset of major depression. Am J Psychiatry 156, 837-841.
50. Lachman, H.M., Papolos, D.F., Saito, T., Yu, Y.M., Szumlanski, C.L. & Weinshilboum, R.M. (1996) Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders. Pharmacogenetics 6, 243-250.
51. Langner, O., Dotsch, R., Bijlstra, G., Wigboldus, D.H.J., Hawk, S.T. & van Knippenberg, A. (2010) Presentation and validation of the Radboud Faces Database. Cogn Emot 24, 1377-1388.
52. Lau, J.Y., Goldman, D., Buzas, B., Hodgkinson, C., Leibenluft, E., Nelson, E., Sankin, L., Pine, D.S. & Ernst, M. (2010) BDNF gene polymorphism (Val66Met) predicts amygdala and anterior hippocampus responses to emotional faces in anxious and depressed adolescents. Neuroimage 53, 952-961.
53. Leppanen, J.M. (2006) Emotional information processing in mood disorders: a review of behavioral and neuroimaging findings. Curr Opin Psychiatry 19, 34-39.
54. Levine, A.J., Sinsheimer, J.S., Bilder, R., Shapshak, P. & Singer, E.J. (2012) Functional polymorphisms in dopamine-related genes: effect on neurocognitive functioning in HIV+ adults. J Clin Exp Neuropsychol 34, 78-91.
55. Lo, B.C.Y. & Allen, N.B. (2011) Affective bias in internal attention shifting among depressed youth. Psychiatry Res 187, 125-129.
56. Massat, I., Souery, D., Del-Favero, J., Nothen, M., Blackwood, D., Muir, W., Kaneva, R., Serretti, A., Lorenzi, C., Rietschel, M., Milanova, V., Papadimitriou, G.N., Dikeos, D., Van Broekhoven, C. & Mendlewicz, J. (2005) Association between COMT (Val158Met) functional polymorphism and early onset in patients with major depressive disorder in a European multicenter genetic association study. Mol Psychiatry 10, 598-605.
57. Mathews, A. & MacLeod, C. (2005) Cognitive vulnerability to emotional disorders. Annu Rev Clin Psychol 1, 167-195.
58. McCabe, S.B., Gotlib, I.H. & Martin, R.A. (2000) Cognitive vulnerability for depression: deployment of attention as a function of history of depression and current mood state. Cogn Ther Res 24, 427-444.
59. Moffitt, T.E., Caspi, A. & Rutter, M. (2006) Measured geneenvironment interactions in psychopathology. Perspect Psychol Sci 1, 5-27.
60. Monk, C., McClure, E.B., Nelson, E.B., Zarahn, E., Bilder, R.M., Leibenluft, E., Charney, D.S., Ernst, M. & Pine, D.S. (2003) Adolescent immaturity in attention-related brain engagement to emotional facial expressions. Neuroimage 20, 420-428.
61. Montag, C., Reuter, M., Newport, B., Elger, C. & Weber, B. (2008) The BDNF Val66Met polymorphism affects amygdala activity in response to emotional stimuli: evidence from a genetic imaging study. Neuroimage 42, 1554-1559.
62. Murgatroyd, C., Patchev, A.V., Wu, Y., Micale, V., Bockmuhl, Y., Fischer, D., Holsboer, F., Wotjak, C.T., Almeida, O.F.X. & Spengler, D. (2009) Dynamic DNA methylation programs persistent adverse effects of early-life stress. Nat Neurosci 12, 1559-1566.
63. Murgatroyd, C., Wu, Y., Bockmuhl, Y. & Spengler, D. (2010) Genes learn from stress: howinfantile trauma programs us for depression. Epigenetics 5, 194-199.
64. Orozco, S. & Ehlers, C.L. (1998) Gender differences in electrophysiological responses to facial stimuli. Biol Psychiatry 44, 281-289.
65. Ravindran, A.V., Matheson, K., Griffiths, J., Merali, Z. & Anisman, H. (2002) Stress, coping, uplifts, and quality of life in subtypes of depression: a conceptual frame and emerging data. J Affect Disord 71, 121-130.
66. Savitz, J., Solms, M. & Ramesar, R. (2006) The molecular genetics of cognition: dopamine, COMT and BDNF. Genes Brain Behav 5, 311-328.
67. Scharinger, C., Rabl, U., Sitte, H.H. & Pezawas, L. (2010) Imaging genetics of mood disorders. Neuroimage 53, 810-821.
68. Schellekens, A.F., Franke, B., Ellenbroek, B., Cools, A., de Jong, C.A., Buitelaar, J.K. & Verkes, R.-J. (2012) COMT Val158Met modulates the effect of childhood adverse experiences on the risk of alcohol dependence. Addict Biol 18, 344-356.
69. Scher, C.D., Ingram, R.E. & Segal, Z.V. (2005) Cognitive reactivity and vulnerability: empirical evaluation of construct activation and cognitive diathesis in unipolar depression. Clin Psychol Rev 25, 487-510.
70. Schofield, P.R., Williams, L.M., Paul, R.H., Gatt, J.M., Brown, K., Luty, A., Cooper, N., Grieve, S., Dobson-Stone, C., Morris, C., Kuan, S.A. & Gordon, E. (2009) Disturbances in selective information processing associated with the BDNF Val66Met polymorphism: evidence from cognition, the P300 and frontohippocampal systems. Biol Psychol 80, 176-188.
71. Shirayama, Y., Chen, A.C., Nakagawa, S., Russell, D.S. & Duman, R.S. (2002) Brain derived neurotrophic factor produces antidepressant effects in behavioral models of depression. J Neurosci 22, 3251-3261.
72. Skre, I., Onstad, S., Torgersen, S. & Kringlen, E. (1991) High interrater reliability for the Structured Clinical Interview for DSM-III-R Axis I (SCID-I). Acta Psychiatr Scand 84, 167-173.
73. Smolka, M.N., Schumann, G., Wrase, J., Grusser, S.M., Flor, H. & Mann, K. (2005) Catechol-O-methyltransferase val158-met genotype affects processing of emotional stimuli in the amygdala and prefrontal cortex. J Neurosci 25, 836-842.
74. Sullivan, P.F., Neale, M.C. & Kendler, K.S. (2000) Genetic epidemiology of major depression: review and metaanalysis. Am J Psychiatry 157, 1552-1562.
75. Swanson, B. & Mallinckrodt, B. (2001) Family environment, love withdrawal, childhood sexual abuse, and patterns of adult attachment. Psychother Res 11, 455-472.
76. Urani, A., Chourbaji, S. & Gass, P. (2005) Mutant mouse models of depression: candidate genes and current mouse lines. Neurosci Biobehav Rev 29, 805-828.
77. Van Oostrom, I., Franke, B., Rijpkema, M., Gerritsen, L., Arias-Vasquez, A., Fernández, G. & Tendolkar, I. (2012) Interaction between BDNF Val66Met and childhood stressful life events is associated to affective memory bias in men but not women. Biol Psychol 89, 214-219.
78. Van Wingen, G., Rijpkema, M., Franke, B., Van Eijndhoven, P., Tendolkar, I., Verkes, R.J., Buitelaar, J. & Fernández, G. (2011) The brain-derived neurotrophic factor Val66Met polymorphism affects memory formation and retrieval of biologically salient stimuli. Neuroimage 50, 1212-1218.
79. Watson, D.E. & Li, B. (2005) TaqMan applications in genetic and molecular toxicology. Int J Toxicol 24, 139-145.
80. Williams, J.B., Gibbon, M., First, M.B., Spitzer, R.L., Davis, M., Borus, J., Howes, M.J., Kane, J., Pope, H.G., Rounsaville, B. & Wittchen, H.-U. (1992) The Structured Clinical Interview for DSM-III-R (SCID): multisite test-retest reliability. Arch Gen Psychiatry 49, 630-636.
81. Williams, L.M., Gatt, J.M., Grieve, S.M., Dobson-Stone, C., Paul, R.H., Gordon, E. & Schofield, P.R. (2010) COMT Val(108/158)Met polymorphism effects on emotional brain function and negativity bias. Neuroimage 53, 918-925.
82. Yamada, K. & Nabeshima, T. (2003) Brain-derived neurotrophic Factor/TrkB signaling in memory processes. J Pharmacol Sci 91, 267-270.