Anti-inflammatory potential of alpha-linolenic acid mediated through selective COX inhibition: Computational and experimental data

Inflammation

Volumn 37, Issue 4, 2014, Pages 1297-1306

  Anand, Richa ^a   Kaithwas, Gaurav ^b  

^a INDIAN INSTITUTE OF INFORMATION TECHNOLOGY   (India)

^b BABASAHEB BHIMRAO AMBEDKAR UNIVERSITY   (India)

Author keywords

alpha linolenic acid; computational docking; cyclooxygenase; inflammation; linoleic acid; lipoxygenase; structure based docking

Indexed keywords

ANTIINFLAMMATORY AGENT; ARACHIDONATE 5 LIPOXYGENASE; ARACHIDONIC ACID; CARRAGEENAN; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; INTERLEUKIN 1BETA; INTERLEUKIN 2; LEUKOTRIENE; LINOLEIC ACID; LINOLENIC ACID; LIPOXYGENASE; PROSTAGLANDIN; PROSTAGLANDIN SYNTHASE INHIBITOR; TUMOR NECROSIS FACTOR ALPHA; LIPOXYGENASE INHIBITOR;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME INHIBITION; IN VITRO STUDY; MEDIATOR RELEASE; MOLECULAR DOCKING; NONHUMAN; PAW EDEMA; PROTEIN STRUCTURE; RAT; ANIMAL; ARTHRITIS; CHEMISTRY; EDEMA; METABOLISM; MOLECULAR GENETICS; PATHOPHYSIOLOGY; PROTEIN CONFORMATION; WISTAR RAT;

RATTUS;

ALPHA-LINOLENIC ACID; AMINO ACID SEQUENCE; ANIMALS; ANTI-INFLAMMATORY AGENTS; ARACHIDONATE 5-LIPOXYGENASE; ARACHIDONIC ACID; ARTHRITIS; CARRAGEENAN; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE INHIBITORS; EDEMA; LEUKOTRIENES; LIPOXYGENASE INHIBITORS; MOLECULAR DOCKING SIMULATION; MOLECULAR SEQUENCE DATA; PROSTAGLANDINS; PROTEIN CONFORMATION; RATS; RATS, WISTAR;

EID: 84904737191     PISSN: 03603997     EISSN: 15732576     Source Type: Journal    
DOI: 10.1007/s10753-014-9857-6     Document Type: Article

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