Adiponectin and markers of metabolic syndrome in obese children and adolescents: Impact of 8-mo regular physical exercise program

Pediatric Research

Volumn 76, Issue 2, 2014, Pages 159-165

  Nascimento, Henrique ^a,b   Costa, Elísio ^a,b   Rocha, Susana ^a,b   Lucena, Clarice ^a,c   Rocha Pereira, Petronila ^d   Rêgo, Carla ^a   Mansilha, Helena Ferreira ^e   Quintanilha, Alexandre ^a,b   Aires, Luísa ^a,c   Mota, Jorge ^a   Santos Silva, Alice ^a,b   Belo, Luís ^a,b  

^a UNIVERSITY OF PORTO   (Portugal)

^b UNIVERSITY OF PORTO   (Portugal)

^c UNIVERSITY INSTITUTE OF MAIA   (Portugal)

^d UNIVERSITY OF BEIRA INTERIOR   (Portugal)

^e Centro Hospitalar Universitario do Porto   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN; C REACTIVE PROTEIN; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LIPID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL; BIOLOGICAL MARKER; GLUCOSE BLOOD LEVEL;

ADULT; ARTICLE; CHILD; CHILDHOOD OBESITY; DISEASE MARKER; DYSLIPIDEMIA; EXERCISE; HEALTH PROGRAM; HUMAN; INFLAMMATION; MAJOR CLINICAL STUDY; METABOLIC SYNDROME X; MOLECULAR WEIGHT; PRIORITY JOURNAL; ADOLESCENT; BLOOD; CROSS-SECTIONAL STUDY; GLUCOSE BLOOD LEVEL; KINESIOTHERAPY; LONGITUDINAL STUDY; METABOLISM; OBESITY; PROCEDURES;

ADIPONECTIN; ADOLESCENT; BIOLOGICAL MARKERS; BLOOD GLUCOSE; C-REACTIVE PROTEIN; CHILD; CROSS-SECTIONAL STUDIES; EXERCISE THERAPY; HUMANS; INSULIN; LIPIDS; LONGITUDINAL STUDIES; METABOLIC SYNDROME X; OBESITY;

EID: 84904691963     PISSN: 00313998     EISSN: 15300447     Source Type: Journal    
DOI: 10.1038/pr.2014.73     Document Type: Article

References (30)

1. Maeda K, Okubo K, Shimomura I, Funahashi T, Matsuzawa Y, Matsubara K. cDNA cloning and expression of a novel adipose specific collagenlike factor, apM1 (AdiPose Most abundant Gene transcript 1). Biochem Biophys Res Commun 1996;221:286-9
2. Saito K, Tobe T, Minoshima S, et al. Organization of the gene for gelatinbinding protein (GBP28). Gene 1999;229:67-73
3. Calcaterra V, De Amici M, Klersy C, et al. Adiponectin, IL-10 and metabolic syndrome in obese children and adolescents. Acta Biomed 2009;80:117-23
4. Yoshinaga M, Takahashi H, Shinomiya M, Miyazaki A, Kuribayashi N, Ichida F. Impact of having one cardiovascular risk factor on other cardiovascular risk factor levels in adolescents. J Atheroscler Thromb 2010;17:1167-75
5. Xu A, Wang Y, Keshaw H, Xu LY, Lam KS, Cooper GJ. The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice. J Clin Invest 2003;112:91-100
6. Nascimento H, Silva L, Lourenco P, et al. Lipid profile in Portuguese obese children and adolescents: Interaction of apolipoprotein E polymorphism with adiponectin levels. Arch Pediatr Adolesc Med 2009;163:1030-6
7. Maeda N, Takahashi M, Funahashi T, et al. PPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein. Diabetes 2001;50:2094-9
8. Bruun JM, Lihn AS, Verdich C, et al. Regulation of adiponectin by adipose tissue-derived cytokines: In vivo and in vitro investigations in humans. Am J Physiol Endocrinol Metab 2003;285:E527-33
9. Nadeau KJ, Zeitler PS, Bauer TA, et al. Insulin resistance in adolescents with type 2 diabetes is associated with impaired exercise capacity. J Clin Endocrinol Metab 2009;94:3687-95
10. Urbina EM, Khoury P, Martin LJ, D'Alessio D, Dolan LM. Gender differences in the relationships among obesity, adiponectin and brachial artery distensibility in adolescents and young adults. Int J Obes (Lond) 2009;33:1118-25
11. Reinehr T, Roth C, Menke T, Andler W. Adiponectin before and after weight loss in obese children. J Clin Endocrinol Metab 2004;89: 3790-4
12. Cnop M, Havel PJ, Utzschneider KM, et al. Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: Evidence for independent roles of age and sex. Diabetologia 2003;46:459-69
13. Ogawa Y, Kikuchi T, Nagasaki K, Hiura M, Tanaka Y, Uchiyama M. Usefulness of serum adiponectin level as a diagnostic marker of metabolic syndrome in obese Japanese children. Hypertens Res 2005;28:51-7
14. Kwon K, Jung SH, Choi C, Park SH. Reciprocal association between visceral obesity and adiponectin: In healthy premenopausal women. Int J Cardiol 2005;101:385-90
15. Schober F, Neumeier M, Weigert J, et al. Low molecular weight adiponectin negatively correlates with the waist circumference and monocytic IL-6 release. Biochem Biophys Res Commun 2007;361:968-73
16. Araki S, Dobashi K, Kubo K, Asayama K, Shirahata A. High molecular weight, rather than total, adiponectin levels better reflect metabolic abnormalities associated with childhood obesity. J Clin Endocrinol Metab 2006;91:5113-6
17. Liu Y, Retnakaran R, Hanley A, Tungtrongchitr R, Shaw C, Sweeney G. Total and high molecular weight but not trimeric or hexameric forms of adiponectin correlate with markers of the metabolic syndrome and liver injury in Thai subjects. J Clin Endocrinol Metab 2007;92:4313-8
18. Neumeier M, Sigruener A, Eggenhofer E, et al. High molecular weight adiponectin reduces apolipoprotein B and E release in human hepatocytes. Biochem Biophys Res Commun 2007;352:543-8
19. Murdolo G, Nowotny B, Celi F, et al. Inflammatory adipokines, high molecular weight adiponectin, and insulin resistance: A population-based survey in prepubertal schoolchildren. PLoS One 2011;6:e17264
20. Christiansen T, Paulsen SK, Bruun JM, Pedersen SB, Richelsen B. Exercise training versus diet-induced weight-loss on metabolic risk factors and inflammatory markers in obese subjects: A 12-week randomized intervention study. Am J Physiol Endocrinol Metab 2010;298:E824-31
21. Pedrosa C, Oliveira BM, Albuquerque I, Simoes-Pereira C, Vaz-de- Almeida MD, Correia F. Metabolic syndrome, adipokines and ghrelin in overweight and obese schoolchildren: Results of a 1-year lifestyle intervention programme. Eur J Pediatr 2011;170:483-92
22. Elloumi M, Ben Ounis O, Makni E, Van Praagh E, Tabka Z, Lac G. Effect of individualized weight-loss programmes on adiponectin, leptin and resistin levels in obese adolescent boys. Acta Paediatr 2009;98:1487-93
23. Eckel RH, Alberti KG, Grundy SM, Zimmet PZ. The metabolic syndrome. Lancet 2010;375:181-3
24. Araki S, Dobashi K, Yamamoto Y, Asayama K, Kusuhara K. Increased plasma isoprostane is associated with visceral fat, high molecular weight adiponectin, and metabolic complications in obese children. Eur J Pediatr 2010;169:965-70
25. Nascimento H, Costa E, Rocha-Pereira P, et al. Cardiovascular risk factors in portuguese obese children and adolescents: Impact of small reductions in body mass index imposed by lifestyle modifications. Open Biochem J 2012;6:43-50
26. Ibanez L, Lopez-Bermejo A, Diaz M, Angulo M, Sebastiani G, De Zegher F. High-molecular-weight adiponectin in children born small- or appropriate- for-gestational-Age. J Pediatr 2009;155:740-2
27. Center for Disease Control and Prevention. National Health and Nutrition Examination Survey (NHANES) - Anthropometry Procedures Manual, 2009. http://www.cdc.gov/nchs/data/nhanes/nhanes-09-10/BodyMeasures-09.pdf
28. Cole TJ, Bellizzi MC, Flegal KM, Dietz WH. Establishing a standard definition for child overweight and obesity worldwide: International survey. BMJ 2000;320:1240-3
29. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972;18:499-502
30. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: Insulin resistance and betacell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985;28:412-9.