Up-regulation of eEF1A2 promotes proliferation and inhibits apoptosis in prostate cancer

Biochemical and Biophysical Research Communications

Volumn 450, Issue 1, 2014, Pages 1-6

  Sun, Yue ^a   Du, Chengli ^a   Wang, Bo ^a   Zhang, Yanling ^a   Liu, Xiaoyan ^a   Ren, Guoping ^a  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Apoptosis; Caspase3; eEF1A2; Proliferation; Prostate cancer (PCa)

Indexed keywords

CASPASE 3; ELONGATION FACTOR 1; ELONGATION FACTOR 1A2; PROTEIN BAD; PROTEIN BAX; PUMA PROTEIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ADULT; AGED; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CANCER TISSUE; CARCINOGENESIS; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; FLOW CYTOMETRY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; PRIORITY JOURNAL; PROSTATE CANCER; PROSTATE CANCER CELL LINE; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; WESTERN BLOTTING;

APOPTOSIS; CASPASE3; EEF1A2; PROLIFERATION; PROSTATE CANCER (PCA);

AGED; AGED, 80 AND OVER; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CELL PROLIFERATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; MIDDLE AGED; PEPTIDE ELONGATION FACTOR 1; PROSTATIC NEOPLASMS; TUMOR CELLS, CULTURED; UP-REGULATION;

EID: 84904689591     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2014.05.045     Document Type: Article

References (27)

1. R. Siegel, D. Naishadham, and A. Jemal Cancer statistics, 2012 CA Cancer J. Clin. 62 2012 10 29
2. M. Gleave, H. Miyake, and K. Chi Beyond simple castration: targeting the molecular basis of treatment resistance in advanced prostate cancer Cancer Chemother. Pharmacol. 56 Suppl. 1 2005 47 57
3. H. Miyake, C. Nelson, and P.S. Rennie et al. Overexpression of insulin-like growth factor binding protein-5 helps accelerate progression to androgen-independence in the human prostate LNCaP tumor model through activation of phosphatidylinositol 3′-kinase pathway Endocrinology 141 2000 2257 2265
4. P. Rocchi, A. So, and S. Kojima et al. Heat shock protein 27 increases after androgen ablation and plays a cytoprotective role in hormone-refractory prostate cancer Cancer Res. 64 2004 6595 6602
5. G.J. Browne, and C.G. Proud Regulation of peptide-chain elongation in mammalian cells Eur. J. Biochem. 269 2002 5360 5368
6. S. Ejiri Moonlighting functions of polypeptide elongation factor 1: from actin bundling to zinc finger protein R1-associated nuclear localization Biosci. Biotechnol. Biochem. 66 2002 1 21
7. S.M. Knudsen, J. Frydenberg, and B.F. Clark et al. Tissue-dependent variation in the expression of elongation factor-1 alpha isoforms: isolation and characterisation of a cDNA encoding a novel variant of human elongation-factor 1 alpha Eur. J. Biochem. 215 1993 549 554
8. S. Lee, A.M. Francoeur, and S. Liu et al. Tissue-specific expression in mammalian brain, heart, and muscle of S1, a member of the elongation factor-1 alpha gene family J. Biol. Chem. 267 1992 24064 24068
9. A. Khalyfa, D. Bourbeau, and E. Chen et al. Characterization of elongation factor-1A (eEF1A-1) and eEF1A-2/S1 protein expression in normal and wasted mice J. Biol. Chem. 276 2001 22915 22922
10. N. Anand, S. Murthy, and G. Amann et al. Protein elongation factor EEF1A2 is a putative oncogene in ovarian cancer Nat. Genet. 31 2002 301 305
11. S. Sharma, J. Tammela, and X. Wang et al. Characterization of a putative ovarian oncogene, elongation factor 1alpha, isolated by panning a synthetic phage display single-chain variable fragment library with cultured human ovarian cancer cells Clin. Cancer Res. 13 2007 5889 5896
12. A. Amiri, F. Noei, and S. Jeganathan et al. eEF1A2 activates Akt and stimulates Akt-dependent actin remodeling, invasion and migration Oncogene 26 2007 3027 3040
13. H. Cao, Q. Zhu, and J. Huang et al. Regulation and functional role of eEF1A2 in pancreatic carcinoma Biochem. Biophys. Res. Commun. 380 2009 11 16
14. H. Duanmin, X. Chao, and Z. Qi eEF1A2 protein expression correlates with lymph node metastasis and decreased survival in pancreatic ductal adenocarcinoma Hepatogastroenterology 60 2013 870 875
15. Z. Li, C.F. Qi, and D.M. Shin et al. Eef1a2 promotes cell growth, inhibits apoptosis and activates JAK/STAT and AKT signaling in mouse plasmacytomas PLoS One 5 2010 e10755
16. R. Chang, and E. Wang Mouse translation elongation factor eEF1A-2 interacts with Prdx-I to protect cells against apoptotic death induced by oxidative stress J. Cell. Biochem. 100 2007 267 278
17. C. Xu, D.M. Hu, and Q. Zhu eEF1A2 promotes cell migration, invasion and metastasis in pancreatic cancer by upregulating MMP-9 expression through Akt activation Clin. Exp. Metastasis 30 2013 933 944
18. R. Pellegrino, D.F. Calvisi, and O. Neumann et al. EEF1A2 inactivates p53 via PI3K/AKT/mTOR-dependent stabilization of MDM4 in hepatocellular carcinoma Hepatology 2013
19. B. Scaggiante, B. Dapas, and S. Bonin et al. Dissecting the expression of EEF1A1/2 genes in human prostate cancer cells: the potential of EEF1A2 as a hallmark for prostate transformation and progression Br. J. Cancer 106 2012 166 173
20. J. Cheng, H.Y. Xie, and X. Xu et al. NDRG1 as a biomarker for metastasis, recurrence and of poor prognosis in hepatocellular carcinoma Cancer Lett. 310 2011 35 45
21. D. Hanahan, and R.A. Weinberg Hallmarks of cancer: the next generation Cell 144 2011 646 674
22. T. Eisenberg, S. Buttner, and G. Kroemer et al. The mitochondrial pathway in yeast apoptosis Apoptosis 12 2007 1011 1023
23. J. Kale, Q. Liu, and B. Leber et al. Shedding light on apoptosis at subcellular membranes Cell 151 2012 1179 1184
24. I.M. Ghobrial, T.E. Witzig, and A.A. Adjei Targeting apoptosis pathways in cancer therapy CA Cancer J. Clin. 55 2005 178 194
25. C.D. Buckley, D. Pilling, and N.V. Henriquez et al. RGD peptides induce apoptosis by direct caspase-3 activation Nature 397 1999 534 539
26. S. Gaumer, I. Guenal, and S. Brun et al. Bcl-2 and Bax mammalian regulators of apoptosis are functional in Drosophila Cell Death Differ. 7 2000 804 814
27. R.N. Winter, A. Kramer, and A. Borkowski et al. Loss of caspase-1 and caspase-3 protein expression in human prostate cancer Cancer Res. 61 2001 1227 1232