Mass-spectrometry-directed analysis and purification of pyrrolizidine alkaloid cis/trans isomers in Gynura japonica

Journal of Separation Science

Volumn 37, Issue 15, 2014, Pages 2032-2038

  Fang, Lianxiang ^a   Xiong, Aizhen ^a,b   Yang, Xiao ^a   Cheng, Wenzhi ^a   Yang, Li ^a,b   Wang, Zhengtao ^a,b  

^a SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^b Shanghai R and D Centre for Standardization of Chinese Medicines   (China)

Author keywords

Auto purification systems; Gynura japonica; Isomers; mass spectrometry; Pyrrolizidine alkaloids

Indexed keywords

CHROMATOGRAPHY; HIGH PRESSURE LIQUID CHROMATOGRAPHY; ISOMERS; MASS SPECTROMETRY; METABOLITES; NITROGEN COMPOUNDS; PURIFICATION; TOXICITY;

GYNURA JAPONICA; HEPATOTOXIC EFFECTS; LIQUID CHROMATOGRAPHY WITH TANDEM MASS SPECTROMETRIES; PREPARATIVE LIQUID CHROMATOGRAPHY; PURIFICATION SYSTEMS; PYRROLIZIDINE ALKALOID; REFERENCE COMPOUNDS; REFERENCE SUBSTANCE;

ALKALOIDS;

GYNURA JAPONICA EXTRACT; HERBACEOUS AGENT; INTEGERRIMINE; PYRROLIZIDINE ALKALOID; SENECIONINE; SENECIONINE N OXIDE; SENECIPHYLLINE; SENECIPHYLLINE N OXIDE; UNCLASSIFIED DRUG; PLANT EXTRACT;

ARTICLE; CHINA; CHINESE MEDICINE; CHROMATOGRAPHY; DRUG ISOLATION; EXTRACTION; GYNURA JAPONICA; HERBAL MEDICINE; ISOMER; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MEDICINAL PLANT; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PAIN; PLANT ROOT; PRIORITY JOURNAL; ULTRAVIOLET SPECTROPHOTOMETRY; ASTERACEAE; CHEMISTRY; EVALUATION STUDY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOLATION AND PURIFICATION; ISOMERISM; PROCEDURES;

ASTERACEAE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ISOMERISM; MASS SPECTROMETRY; PLANT EXTRACTS; PYRROLIZIDINE ALKALOIDS;

EID: 84904676651     PISSN: 16159306     EISSN: 16159314     Source Type: Journal    
DOI: 10.1002/jssc.201400314     Document Type: Article

References (35)

1. Wiedenfeld, H., Food Addit. Contam. Part A 2011, 28, 282-292.
2. Lin, G., Wang, J. Y., Li, N., Li, M., Gao, H., Ji, Y., Zhang, F., Wang, H., Zhou, Y., Ye, Y., Xu, H. X., Zheng, J., J. Hepatol. 2011, 54, 666-673.
3. Fu, P. P., Xia, Q., Lin, G., Chou, M. W., Drug Metab. Rev. 2004, 36, 1-55.
4. Zhou, J., Ouedraogo, M., Qu, F., Duez, P., Phytother. Res. 2013.
5. Chen, T., Mei, N., Fu, P. P., J. Appl. Toxicol. 2010, 30, 183-196.
6. Li, N., Xia, Q., Ruan, J., P Fu, P., Lin, G., Curr. Drug Metab. 2011, 12, 823-834.
7. Ji, L., Chen, Y., Liu, T., Wang, Z., Toxicol. Appl. Pharmacol. 2008, 231, 393-400.
8. Ji, L.-L., Zhang, M., Sheng, Y.-C., Wang, Z.-T., Toxicol. In Vitro 2005, 19, 41-46.
9. Liu, T.-Y., Chen, Y., Wang, Z.-Y., Ji, L.-L., Wang, Z.-T., Exp. Toxicol. Pathol. 2010, 62, 251-257.
10. Niessen, W., Lin, J., Bondoux, G. C., J. Chromatogr. A 2002, 970, 131-140.
11. Zhou, Y., Li, N., Choi, F. F. K., Qiao, C. F., Song, J. Z., Li, S. L., Liu, X., Cai, Z. W., Fu, P. P., Lin, G., Anal. Chim. Acta 2010, 681, 33-40.
12. Verdoorn, G. H., van Wyk, B. E., Phytochemistry 1992, 31, 369-371.
13. Cooper, R. A., Bowers, R. J., Beckham, C. J., Huxtable, R. J., J. Chromatogr. A 1996, 732, 43-50.
14. Alali, F. Q., Tahboub, Y. R., Ibrahim, E. S., Qandil, A. M., Tawaha, K., Burgess, J. P., Sy, A., Nakanishi, Y., Kroll, D. J., Oberlies, N. H., Phytochemistry 2008, 69, 2341-2346.
15. Pawar, R. S., Grundel, E., Mazzola, E., White, K. D., Krynitsky, A. J., Rader, J. I., J. Sep. Sci. 2010, 33, 200-205.
16. Crews, C., Berthiller, F., Krska, R., Anal. Bioanal. Chem. 2010, 396, 327-338.
17. Blunt, J. W., Calder, V. L., Fenwick, G. D., Lake, R. J., McCombs, J. D., Munro, M. H., Perry, N. B., J. Nat. Prod. 1987, 50, 290-292.
18. Chen, W., Yang, M., Yu, Z., Li, Y., Chin. J. Hepatol. 2005, 5, 394-395.
19. Li, Y., Du, N., Wang, F., Lv, X., Chin. J. Clin. Hepatol. 2006, 4, 319-320.
20. Yan, H., Bai, L., Peng, M., Mod. Digestion Interv. 2006, 4, 258.
21. Chen, M. Y., Cai, J. T., Du, Q., Eur. J. Intern. Med. 2007, 18, 609-609.
22. Dai, N., Yu, Y. C., Ren, T. H., Wu, J. G., Jiang, Y., Shen, L. G., Zhang, L., World J. Gastroenterol. 2007, 13, 1628-1631.
23. Wu, X. J., Zhang, K., Yu, M. Y., Lv, H. P., Zhang, G. D., Chin. J. Clin. Hepatol. 2007, 15, 151-153.
24. Li, C., Liang, X. S., Li, C. Z., Clin. Toxicol. 2010, 48, 962-964.
25. Qi, X. Y., Wang, S. F., Wu, B., Qu, H. B., Chromatographia 2009, 70, 281-285.
26. Yang, M., Li, J. Y., Li, X. Y., Cong, L. B., Zhu, J., Xie, H., Yuan, H. L., Xiao, X. H., Anal. Lett. 2009, 42, 1820-1830.
27. Chen, Z., Huo, J.-R., Neth. J. Med. 2010, 68, 252-260.
28. Yuan, S. Q., Gu, G. M., Wei, T. T., Acta Pharm. Sin. 1990, 25, 191-197.
29. Qi, X. Y., Wu, B., Cheng, Y. Y., Qu, H. B., Rapid Commun. Mass Spectrom. 2009, 23, 291-302.
30. Noorwala, M., Mohammad, F., Ahmad, V., Sener, B., Ergun, F., Deliorman, D., Fitoterapia 2000, 71, 618-620.
31. Mori, H., Sugie, S., Yoshimi, N., Asada, Y., Furuya, T., Williams, G. M., Cancer Res. 1985, 45, 3125.
32. Huxtable, R. J., Hepatology 1989, 9, 510-511.
33. Mattocks, A., Chemistry and Toxicology of Pyrrolizidine Alkaloids, Academic Press, London 1986.
34. Chou, M. W., Wang, Y. P., Yan, J., Yang, Y. C., Beger, R. D., Williams, L. D., Doerge, D. R., Fu, P. P., Toxicol. Lett. 2003, 145, 239-247.
35. Jiang, J., Xu, D., Pu, S., Pharm. Clin. Res. 2008, 16, 178-180.