Effect of diminazene aceturate, levamisole and vitamin C combination therapy in rats experimentally infected with Trypanosoma brucei brucei

Asian Pacific Journal of Tropical Medicine

Volumn 7, Issue 6, 2014, Pages 438-445

  Chekwube, Adieme Ijeoma ^a   Onyema, Ezeh Ikenna ^a   Ikenna, Ugochukwu Emmanuel ^a   Ezeokonkwo, Romanus Chukwuduruo ^a  

^a UNIVERSITY OF NIGERIA   (Nigeria)

Author keywords

Diminazene aceturate; Levamisole; Rats; Therapy; Trypanosoma brucei brucei; Vitamin C

Indexed keywords

ASCORBIC ACID; DIMINAZENE ACETURATE; HEMOGLOBIN; LEVAMISOLE; TRYPAZEN; UNCLASSIFIED DRUG; ANTITRYPANOSOMAL AGENT; DIMINAZENE;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DRUG EFFICACY; HEMATOCRIT; LEUKOCYTE COUNT; LYMPHOCYTE COUNT; MALE; MONOTHERAPY; NAGANA; NEUTROPHIL COUNT; NONHUMAN; PARASITE CLEARANCE; PARASITEMIA; PRIORITY JOURNAL; RAT; RECTUM TEMPERATURE; SURVIVAL RATE; WEIGHT CHANGE; ANALOGS AND DERIVATIVES; ANIMAL; BODY TEMPERATURE; BODY WEIGHT; DRUG COMBINATION; DRUG EFFECTS; PARASITE LOAD; TRYPANOSOMA BRUCEI BRUCEI; TRYPANOSOMIASIS, AFRICAN; VETERINARY;

ANIMALS; ASCORBIC ACID; BODY TEMPERATURE; BODY WEIGHT; DIMINAZENE; DRUG THERAPY, COMBINATION; HEMOGLOBINS; LEUKOCYTE COUNT; LEVAMISOLE; MALE; PARASITE LOAD; RATS; TRYPANOCIDAL AGENTS; TRYPANOSOMA BRUCEI BRUCEI; TRYPANOSOMIASIS, AFRICAN;

EID: 84904670753     PISSN: 19957645     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1995-7645(14)60071-7     Document Type: Article

References (45)

1. Tabel H, Wei G, Shi M T cells and immunopathogenesis of experimental African trypanosomiasis. Immunol Rev 2008, 225:128-139.
2. Omotainse SO, Edeghere H, Omoogun GA, Elhassan EO, Thompson G, Igwe CA, et al. The prevalence of animal trypanosomosis in Konshisha local government area of Benue State, Nigeria. Is J Vet Med 2000, 55(4):142-144.
3. Mhalanga JD Sleeping sickness: Perspectives in African trypanosomosis. Sci Prog 1996, 79(3):83-214.
4. Askoy S, Maudlin I, Dale C, Robinson AS, O'Neill SL Prospects for the control of African ttrypanosomosis by tsetse vector manipulation. Trends Parasitol 2001, 17(1):29-35.
5. Uilenberg G A field guide for the diagnosis, treatment and prevention of African animal trypanosomosis 1998, Food and Agriculture Organisation of the United Nations, Rome.
6. Anene BM, Onah DN, Nawa Y Drug resistance in pathogenic African Trypanosomes: What hopes for the future?. Vet Parasitol 2001, 96:83-100.
7. Ezeokonkwo RC, Kpogban EA, Ogbodo OM, Iheagwam CN, Ezeh IO Efficacy of Samorecide-plus in the treatment of experimental Trypanosoma brucei brucei infection of albino rats. Nig J Exp Appl Biol 2010, 10(2):157-163.
8. Ezeokonkwo RC, Okoro FC, Ezeh IO The efficacy of increasing doses of Samorenil in the treatment of Trypanosoma brucei infected albino rats. Nig Vet J 2007, 28(2):24-32.
9. Chitanga S, Marcotty T, Namangala B, Van den Bossche P, Van den Abeeche J, Delespaux V High prevalence of drug resistance in animal trypanosomes without a history of drug exposure. PLoS Negl Trop Dis 2011, 5(12):e1454.
10. Jennings FW, Atouguia JM, Murray M Topical chemotherapy for experimental murine African CNS-trypanosomiasis: the successful use of the arsenical, melasorprol, combined with the 5-nitroimidazoles, fexinidazole or MK-436. Trop Med Int Health 1996, 1(5):590-598.
11. Anene BM, Anika SM, Chukwu CC Effect of DFMO after intravenous administration and its combination with Diminazene aceturate against Trypanosoma brucei experimentally infected Dog in Nigeria. Rev Elev Med Vet pays Trop 1997, 50:221-225.
12. Brown CGD, Hunter AG, Luckin AG Disease caused by protozoa. Handbook of animal disease in the tropics 1990, 161-226. Bailliere Tindall, London. 4th ed. M.M.H. Sewell, D.W. Brocklesby (Eds.).
13. Greets S, Holmes PH, Diall O, Eisler MC African Bovine trypanosomosis. The problem of drug resistance. Trends Parasitol 2001, 17:25-28.
14. Logan LL, Goodwin JT, Tembely S, Craig TM Maintaining Zebu maure cattle in a tsetse infested area of Mali. Trop Anim Health Prod 1984, 16(1):1-12.
15. Apted FIC Treatment of human trypanosomiasis. The African Trypanosomiasis 1970, 684-710. George Allen and Unwin, London. H.W. Mulligan, W.H. Potts (Eds.).
16. Wilkes JM, Peregrine AS, Zilbestein D The accumulation and compartmentalisation of isometamidium chloride in Trypanosoma congolense monitored by its intrinsic fluorescence. Biochem J 1995, 312:319-329.
17. Soulsby EJL Helminths, arthropods and protozoa of domesticated animals 1982, Bailliere Tindall, London. 7th ed.
18. Rickman LR, Robson J The blood incubation infectivity test: a simple test which may distinguish Trypanosma brucei from T. rhodesiense. Bull Wld Hlth Org 1970, 42:650-651.
19. Coles EH Veterinary clinical pathology 1986, 45-151. W.B. Saunders, Philadelphia. 3rd ed.
20. Schalm OW, Jain NC, Carol EJ Veterinary haematology 1975, Hea and Febiger, Philadelphia. 3rd Edition.
21. Duncan OD Path analysis: sociological examples. Am J Sociol 1966, 72:1-16.
22. Taylor K, Authie EM Pathogenesis of animal trypanosomosis. The Trypanosomiasis 2004, 331-353. CAB International, United Kingdon. I. Maudlin, P.H. Holmes, M.A. Miles (Eds.).
23. Sewell MMH, Brocklesby DW Handbook of animal diseases in the tropics 1990, Bailliere Tindall, London. 4th Ed.
24. Anene BM, Ezeokonkwo RC, Mmesirionye TI, Tettey JNA, Brock JM, Barret MP, et al. A diminazene-Resistant strain of Trypanosoma brucei isolated from a dog in cross resistant to Pentamidium in experimentally infected albino rats. Parasitol 2006, 132:127-133.
25. Ezeokonkwo RC, Agu WE Experimental infection of domestic rabbits (Oryctologus cuniculus) with Trypanosoma brucei and Trypanosoma congolense: A comparative study. Nig J Anim Prod 2004, 31(1):100-111.
26. Seifert HSH Tropical animal health 1996, Kluwer Academic Publishers, Netherlands. 2nd Ed.
27. Anene BM, Ogbuanya CE, Mbah ES, Ezeokonkwo RC Preliminary efficacy trial of cymelarsen in dogs and mice artificially infected with Trypanosoma brucei isolated from dogs in Nigeria. Rev Elev Med Vet Pays Trop 1999, 52(2):123-128.
28. Rani NL, Suresh K Canine trypanosomiasis. Ind Vet J 2007, 84:186-187.
29. Akpa PO, Ezeokonkwo RC, Eze CA, Anene BM Comparative efficacy assessment of pentamidine isethionate and diminazene aceturate in the chemotherapy of Trypanosoma brucei infection in dogs. Vet Parasitol 2008, 151(2-4):139-149.
30. Abenga JN, Ezebuiro CO, David K, Fajinmi AO, Samdi S Studies on anaemia in Nigerian local puppies infected with Trypanosoma congolense. Vet Arhiv 2005, 75(2):165-174.
31. Mbaya AW, Aliyu MM, Gamba B The effects of single and combined chemotherapy of DL-a-difluoromethylornithine and diminazene aceturate in experimental Trypanosoma brucei gambiense infection in mice. Nig Vet J 2008, 29(1):49-56.
32. Biryomumaisho S, Katunguka-Rwakishya Eli, Rubaire-Akiiki CM Serum biochemical changes in experimental T. congolense and T. brucei infection in small East African goats. Vet Arhiv 2003, 73(3):167-180.
33. Obidike IR, Aka L, Momah CV, Ezeokonkwo RC Effect of Trypanosoma brucei infections and diminazene aceturate treatment on serum activities of certain enzymes. Sahel J Vet Sc 2005, 4(1):17-23.
34. Eze CA, Ezeokonkwo RC, Egbuji JO, Anene BM Effect of castration on the establishment and treatment of trypanosomosis with diminazene aceturate in albino rats. Nig J Exp Appl Biol 2006, 7(1):17-21.
35. Stephen LE Trypanosomosis: A veterinary perspective 1986, Pergamon Press, United Kingdom.
36. Ezeh IO, Agbo LI, Emehelu CO, Nweze EN, Ezeokonkwo RC, Onah DN Berenil-resistant Trypanosoma brucei brucei infection in a dog in Nsukka area of Enugu State, Nigeria. Nig Vet J 2009, 29(4):34-42.
37. Dinarello CA Infection, fever, and exogenous and endogenous pyrogen: some concepts have changed. J Endotox Res 2004, 10(4):201-222.
38. Holmes PH, Katunguka-Rwakishaya E, Bennison JJ, Wassink GJ, Parkins JJ Impact of nutrition on the pathophysiology of bovine trypanosomiasis. Parasitol 2000, 120:373-385.
39. Anosa VO, Logan-Henfreg LL, Wells CW The haematology of Trypanosoma congolense infection in cattle. 1. Sequential cytomorphological changes in the blood and bone marrow of Boran cattle. Comp Haematol Int 1997, 7:14-22.
40. Kagira JM, Thuita JK, Ngotho M, Mdachi R, Mwangangi DM, Ndung'u JM Haematology of experimental Trypanosoma brucei rhodesiense infection in Vervet monkeys. Afr J Health Sci 2006, 13:59-65.
41. Murray M, Dexter TM Anaemia in bovine African trypanosomosis. Acta Trop 1998, 45:389-432.
42. Mbaya AW, Aliyu MM, Nwosu CO, Egbe-Nwinyi T The relationship between parasitaemia and anaemia in concurrent Trypanosoma brucei and Haemonchus contortus infection in red fronted gazelles (Gazella rufifrons). Vet Arhiv 2009, 79(5):451-460.
43. Kumar S, Dewey CE, Friendship RM, Bowland SL, Shewen PE Improved weight gain in pigs using levamisole as an immunomodulator. Swine Health Prod 1999, 7(3):103-107.
44. Singla LD, Juyal PD Blood cellular responses in Trypanosoma evansi infected and Levamisol treated bovine calves. J Vet Parasitol 2000, 14(2):137-139.
45. Abenga JN, David KM, Ezebuiro CO, Samdi S, Fajinmi AO Leucocyte and thrombocyte changes in young dogs infected with Trypanosoma congolense. J Protozool Res 2004, 14(1-2):8-15.