Comparative efficacy assessment of pentamidine isethionate and diminazene aceturate in the chemotherapy of Trypanosoma brucei brucei infection in dogs

Veterinary Parasitology

Volumn 151, Issue 2-4, 2008, Pages 139-149

  Akpa, P O ^a   Ezeokonkwo, R C ^a   Eze, C A ^a   Anene, B M ^a  

^a UNIVERSITY OF NIGERIA   (Nigeria)

Author keywords

Comparative efficacy; Diminazene aceturate; Dogs; Pentamidine isethionate; Trypanosoma brucei

Indexed keywords

DIMINAZENE ACETURATE; PENTAMIDINE ISETHIONATE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BODY WEIGHT; CONTROLLED STUDY; DRUG EFFICACY; DRUG SAFETY; ERYTHROCYTE COUNT; HEMATOCRIT; HEMOGLOBIN BLOOD LEVEL; NONHUMAN; PARASITEMIA; RECTUM TEMPERATURE; RELAPSE; TREATMENT OUTCOME; TRYPANOSOMA BRUCEI;

ANIMALS; BLOOD CELL COUNT; BODY TEMPERATURE; DIMINAZENE; DOG DISEASES; DOGS; ENZYMES; FEMALE; HEMOGLOBINS; MALE; PENTAMIDINE; TIME FACTORS; TRYPANOCIDAL AGENTS; TRYPANOSOMA BRUCEI BRUCEI; TRYPANOSOMIASIS;

CANIS FAMILIARIS; TRYPANOSOMA BRUCEI; TRYPANOSOMA BRUCEI BRUCEI;

EID: 38049009436     PISSN: 03044017     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vetpar.2007.10.024     Document Type: Article

References (59)

1. Andrianarivo A.G., Muiya P., Opollo M., and Logan-Henry L.L. Trypanosoma congolense: comparative effects of a primary infection on bone marrow progenitor cells from N'dama and Boran cattle. Exp. Parasitol. 80 (1995) 407-418
2. Anene B.M., and Omamegbe J.O. Common diseases of dogs in Nigeria. Zariya Vet. 4 (1987) 11-18
3. Anene B.M., Chukwu C.C., and Anika S.M. Immunosupression and humoral immune response in canine trypanosomiasis. Microbes Lett. 40 (1989) 37-46
4. Anene B.M., and Ezekwe A.G. Trypanosomiasis in intensively reared muturu calves in Nigeria. Trop. Anim. Hlth. Prod. 27 (1995) 229-230
5. Anene B.M., Anika S.M., and Chukwu C.C. Effects of difluoromethylornithine after intravenous administration and its combination with diminazene aceturate against Trypanosoma brucei experimentally infected dogs in Nigeria. Revue d'elevage et de Medicine Veterinaire des pays tropicaux 50 (1997) 221-225
6. Anene B.M., Ogbuanya C.E., Mbah E.S., and Ezeokonkwo R.C. Preliminary efficacy trial of Cymelersan in dogs and mice artificially infected with Trypanosoma brucei isolated from dogs in Nigeria. Revue d'elevage et de Medicine Veterinaire des pays tropicaux 52 (1999) 123-128
7. Anene B.M., Onah D.N., and Nawa Y. Drug resistance in pathogenic African trypanosomes, what hopes for the future?. Vet. Parasitol. 96 (2001) 83-100
8. Anene B.M., Ezeokonkwo R.C., Mmesirionye T.I., Tettey J.N.A., Brock J.M., Barrett M.P., and De Koning H.P. A diminazene resisitant strain of Trypanosoma brucei brucei isolated from a dog is cross-resistant to Pentamidine in experimentally infected albino rats. Parasitology 132 (2006) 127-133
9. Anika S.M., Shetty S.N., Asuzu I.U., and Chimae A.B. Effects of some trypanocides and anti-inflammatory agents in experimental Trypanosoma brucei infection in mice. Zariya Vet. 2 (1987) 9-15
10. Anosa V.O., Logan-Henfrey L.L., and Wells C.W. The haematology of Trypanosoma congolense infection in cattle. I. Sequential cytomorphological changes in the blood and bone marrow of Boran cattle. Comp. Haematol. Int. 7 (1997) 14-22
11. Asuamah K.Y. Normadism and cattle production in Nigeria. In: Akerejola O.O., and Aliu Y.O. (Eds). Proceedings of First Continuous Education Course for Veterinarians. Zaria, Nigeria (1977) 275-283
12. Authie E., and Pobel T. Serum haemolytic complement activity and C3 levels in bovine trypanosomiases under natural conditions of challenge-early indications of susceptibility to disease. Vet. Parasitol. 35 (1990) 43-59
13. Bacchi C.J. Resistance to clinical drugs in African Trypanosomes. Parasitol. Today 9 (1993) 190-193
14. Barrett M.P. A possible veterinary link to drug resistance in human African trypanosomiasis. Lancet 358 (2001) 603-604
15. Barret M.P., Burchmore R.J.S., Stitch A., Lassan J.O., Frasch A.C., Cazzulo J., and Krishna S. The trypanosomiases. Lancet 362 9394 (2003) 1469-1480 (Seminar Report)
16. Blood D.C., Radostits O.M., and Gay C.C. Veterinary Medicine. A Textbook of Diseases of Cattle, Sheep, Pigs, Goats, and Horses. eight ed. (1994), Bailliere Tindall, London pp. 1212-1218
17. Boreham P.F.L. Autocoids: their release and possible role in the pathogenesis of African trypanosomosis. In: Tizard I. (Ed). Immunology and Pathogenesis of Trypanosomiasis (1985), CRC Press, Boca Raton, FL 45-66
18. Bray P.G., Barrett M.P., Ward S.A., and De Koning H.P. Pentamidine uptake and resistance in pathogenic protozoa: past, present and future. Trends Parasitol. 19 5 (2003) 232-239
19. Brown C.G.D., Hunter A.G., and Luckins A.G. In: Sewell M.M.H., and Brocklesby D.W. (Eds). Disease Caused by Protozoa in Hand book of Animal Diseases in the Tropics. fourth ed. (1990), Bailliere Tindall, London
20. Chukwu C.C., Anene B.M., Onuekwusi K.O., and Anika S.M. Relapse infection after chemotherapy in dogs experimentally infected with Trypanosoma brucei. J. Small Anim. Pract. 31 (1990) 41-44
21. Coles E.H. Veterinary Clinical Pathology. third ed. (1986), W.B. Saunders Company, Philadelphia pp. 145-151
22. Duncan O.D. Path analysis: sociological examples. Am. J. Sociol. 72 (1966) 1-16
23. Eze C.A., Ezeokonkwo R.C., Egbuji J.O., and Anene B.M. Effects of castration on the establishment and treatment of trypanosomosis with diminazene aceturate in albino rats. Nig. J. Exp. Appl. Biol. 7 1 (2006) 17-21
24. Ezeokonkwo R.C., Anene B.M., Nwafor C.E., Tettey J.N.A., Barrett M.P., and De Koning H.P. The comparative efficacy of pentamidine isethionate and isometamidium chloride in the treatment of relapsed cases of Trypanosoma brucei brucei in experimentally infected albino rats. Proceedings of the 29th Conference of the Nigerian Society for Animal Production (NSAP), vol. 29. Usman Dan Fodyo University, Sokoto, 21st-25th March, 2004 (2004) 78-82
25. FAO. Trypanotolerant cattle and livestock development in West African Farmers and buyers? Evidence from West Africa. Ecol. Econ. 45 3 (1987) 461-472
26. Fairlamb A.H., Carter N., Cunningham S.M., and Smith K. Characterization of Melarsen-resistant Trypanosoma brucei brucei with respect to cross resistance to other drugs and trypanothione metabolism. Mol. Biomech. Parasitol. 53 (1992) 213-222
27. Gall Y., Woitag T., Baver B., Sidibe I., McDermott J., Mehlitz D., and Clausen P.H. Trypanocidal failure suggested by PCR results in cattle field samples. Acta Trop. 92 1 (2004) 7-16
28. Geerts S., Holmes P.H., Diall O., and Eisler M.C. African Bovine trypanosomiasis. The problem of drug resistance. Trends Parasitol. 17 (2001) 25-28
29. Herbert W.J., and Lumsden W.H.R. Trypanosoma brucei: a rapid matching method for estimating the host's parasitaemia. Exp. Parasitol. 40 (1976) 427-428
30. Ikede B.O., and Losos G.J. Spontaneous canine Trypanosomiasis caused by Trypanosoma brucei meningoencephalitis with extravascular localization of trypanosomes in the brain. Bull. Epizootiol. Dis. Afr. 20 3 (1972) 221-228
31. Ilemobade A.A. Proceeding of the first National Conference on ILRAD Report. Nairobi Kenya (1981)
32. ILRAD Reports, 1994. Trypanosomiasis. The International Laboratory for Research on Animal trypanosomiasis, Nairobi, Kenya.
33. Jenings F.W., Whitelaw D.D., and Urquhart G.M. The relationship between duration of infection with T. brucei in mice and the efficacy of chemotherapy. Parasitology 75 (1977) 145-153
34. Jennings F.W., Urquhart G.M., Murray P.K., and Miller B.M. Berenil and Nitroimidazole combinations in the treatment of Trypanosoma brucei infections with Central Nervous System involvement. Int. J. Parasitol. 10 (1980) 27-33
35. Kaggwa E., Munya W.K., and Mugera G.M. Pathogenecity of Trypanosoma brucei brucei in dogs. Bull. Anim. Hlth. Prod. Afr. 32 (1984) 360-368
36. Kaggwa E., Munya W.K., and Mugera G.M. Relapses in dogs experimentally infected with Trypanosoma brucei and treated with Diminazene aceturate and Isometamidium chloride. Vet. Parasitol. 27 (1988) 199-208
37. Kalu A.U. Studies on the chemotherapeutic control of animal trypanosomiasis in Nigeria. Studies Res. Vet. Med. 3 (1995) 82-92
38. Katunguka-Rwakishaya E., Murray M., and Holmes P.H. The pathophysiology of ovine trypanosomiasis: haematological and blood biochemical changes. Vet. Parasitol. 45 (1992) 17-32
39. Kobayashi A., Tizard I.R., and Woo P.T.K. Studies on the anaemia in experimental African Trypanosomiasis. II. The pathogenesis of the anaemia in calves infected with Trypanosoma congolense. Am. J. Trop. Med. Hyg. 25 (1976) 401-406
40. Losos G.J., and Crocket E. Toxicity of berenil in dogs. Vet. Rec. 81 (1969) 196
41. Mulligan H.W., and Potts W.H. The African Trypanosomiases (1970), George Allen and Unwin Ltd., London
42. Murray M., Murray P.K., and McIntre W.I.M. An improved parasitological technique for diagnosis of African trypanosomiasis. Trans. R. Soc. Trop. Med. Hyg. 71 4 (1977) 325-326
43. Murray M., and Dexter T.M. Anaemia in bovine African trypanosomiasis. Acta Trop. 45 (1988) 389-432
44. Obidike I.R., Aka L., Momah C.V., and Ezeokonkwo R.C. Effects of Trypanosoma brucei infections and diminazene aceturate treatment on serum activities of certain enzymes. Sahel. J. Vet. Sci. 4 1 (2005) 17-23
45. Omeke B.C.O., and Ugwu D.O. Pig trypanosomiasis: comparative anaemia and histopathology of lymphoid organs. Revue d'Elevage et de Medicine Veterinaire des Pays Tropicaux 44 (1991) 267-272
46. Onyeyili P.A., and Anika S.M. Chemotherapy of Trypanosoma brucei brucei infections: use of DFMO, Diminazene aceturate alone and in combination. J. Small Anim. Pract. 30 (1989) 505-510
47. Onyeyili P.A., and Anika S.M. Effects of the combination of DL-difluoromethyl Ornithine and Diminazene aceturate in Trypanosoma congolense infection in dogs. Vet. Parasitol. 37 (1990) 9-19
48. Onyeyili P.A., and Anika S.M. Diminazene aceturate residues in the tissues of healthy Trypanosoma congolense and Trypanosoma brucei brucei infected dogs. Br. Vet. J. 147 (1991) 155-161
49. Pentreath V.W. Cytokines and blood-brain barrier in human experimental African trypanosomiasis. In: Dumas M., Bouteille B., and Buguet A. (Eds). Progress in Human African Trypanosomiasis, Sleeping Sickness (1999), Springer-Verlag, Paris 105-117
50. Pentreath V.W., and Kennedy P.G.E. Pathogenesis of human African Trypanosomiasis. In: Maudlin I., Homes P.H., and Miles M.A. (Eds). The Trypanosomiases (2004), CAB International, UK 283-301
51. Pepin J., and Milord F. The treatment of human African trypanosomiasis. Adv. Parasitol. 333 (1994) 1246-1250
52. Reitman S., and Frankel S. A colorimetric method for the determination of serum glutamic oxaloacetic and glutamic pyruvate transaminases. Am. J. Clin. Pathol. 28 (1957) 56-63
53. Sayer, D.D., Morison, W.I., Preston, J.M., Hird, S.F., Price, J.E., Murray, M., 1979. African Trypanosomiasis in the dog. In: 15th Meeting of the International Scientific Council for Trypanosomiasis Research and Control, Gambia, OAU/STRC Publication No 10, pp. 488-496.
54. Seed J.R., and Hall J.E. The possible role of trypanosome metabolite indole-3-ethanol in the neuropathology of trypanosomiasis. Abstracts of 5th International Congress of Protozoology, June 26-July 2, 1977. The Print-shop, New York (1977) Abstract 115
55. Seifert H.S.H. Tropical Animal Health. second ed. (1996), Kluwer Academic Publishers, Dordrecht, the Netherlands pp. 161-162
56. Sewell M.M.H., and Brocklesby D.W. Handbook of Animal Diseases in the Tropics. fourth ed. (1990), Bailliere Tindall, London pp. 205-217
57. Soulsby E.J.L. Helminths, Arthropods, and Protozoa of Domesticated Animals. seventh ed. (1982), Bailliere Tindall, London pp. 531-565
58. Stephen L.E. Trypanosomiasis. A Veterinary Perspective (1986), Pergamon Press, Oxford, UK pp. 225-268
59. Taylor K., and Authie E.M.L. Pathogenesis of African Trypanosomiasis. In: Maudlin I., Homes P.H., and Miles M.A. (Eds). The Trypanosomiases (2004), CAB International, UK 331-353