A diminazene-resistant strain of Trypanosoma brucei brucei isolated from a dog is cross-resistant to pentamidine in experimentally infected albino rats

Parasitology

Volumn 132, Issue 1, 2006, Pages 127-133

  Anene, B M ^a   Ezeokonkwo, R C ^a   Mmesirionye, T I ^a   Tettey, J N A ^b   Brock, J M ^c   Barrett, M P ^c   De Koning, H P ^c  

^a UNIVERSITY OF NIGERIA   (Nigeria)

^b UNIVERSITY OF STRATHCLYDE   (United Kingdom)

^c UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

Canine trypanosomosis; Cross resistance; Diminazene aceturate; Drug resistance; Pentamidine isethionate; Trypanosoma brucei brucei

Indexed keywords

DIMINAZENE; DIMINAZENE ACETURATE; PENTAMIDINE ISETHIONATE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CROSS RESISTANCE; DOG; DRUG QUALITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NIGERIA; NONHUMAN; PARASITE ISOLATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTOZOAL INFECTION; RAT; RELAPSE; TRYPANOSOMA BRUCEI;

ANIMALS; DIMINAZENE; DISEASE MODELS, ANIMAL; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE; FEMALE; PARASITIC SENSITIVITY TESTS; PENTAMIDINE; RANDOM ALLOCATION; RATS; RECURRENCE; TIME FACTORS; TREATMENT OUTCOME; TRYPANOCIDAL AGENTS; TRYPANOSOMA BRUCEI BRUCEI; TRYPANOSOMIASIS, AFRICAN;

ANIMALIA; CANIS FAMILIARIS; TRYPANOSOMA BRUCEI; TRYPANOSOMA BRUCEI BRUCEI;

EID: 30144440601     PISSN: 00311820     EISSN: 14698161     Source Type: Journal    
DOI: 10.1017/S0031182005008760     Document Type: Article

References (36)

1. Anene, B. M. and Omamegbe, J. O. (1987). Common diseases of dogs in Nigeria. Zariya Veterinarian 2, 46-55.
2. Anene, B. M., Chukwu, C. C., Chime, A. B. and Anika, S. M. (1989). Comparative clinical and haematological observations in dogs infected with Trypanosoma brucei brucei and Trypanosoma congolense treated with diminazene aceturate. Zariya Veterinarian 4, 11-18.
3. Anene, B. M., Chukwu, C. C. and Anika, S. M. (1999). Sensitivity to diminazene aceturate and isometamidium chloride of trypanosomes isolated from dogs in Nsukka area, Nigeria. Revue d'Elevage et de Medecine Veterinaire des Pays Tropicaux 52, 129-131.
4. Anene, B. M., Onah, D. N. and Nawa, Y. (2001). Drug resistance in pathogenic African trypanosomes: what hopes for the future? Veterinary Parasitology 96, 83-100.
5. Anika, S. M., Shetty, S. N., Asuzu, I. U. and Chime, A. B. (1987). Effects of some trypanocides and anti-inflammatory agents in experimental Trypanosoma brucei infection in mice. Zariya Veterinarian 2, 9-15.
6. Atsriku, C., Watson, D. G., Tettey, J. N. A., Grant, M. H. and Skellern, G. G. (2002). Determination of diminazene aceturate in pharmaceutical formulations by HPLC and identification of related substances by LC/MS. Journal of Pharmaceutical and Biomedical Analysis 30, 979-986.
7. Bacchi, C. J. (1993). Resistance to clinical drugs in African trypanosomes. Parasitology Today 9, 190-193.
8. Barrett, M. P. and Fairlamb, A. H. (1999). The biochemical basis for arsenical-diamidine cross-resistance in African trypanosomes. Parasitology Today 15, 136-140.
9. Berger, B. J., Carter, N. S. and Fairlamb, A. H. (1995). Characterisation of pentamidine-resistant Trypanosoma brucei brucei. Molecular and Biochemical Parasitology 69, 289-298.
10. Bray, P. G., Barrett, M. P., Ward, S. A. and De Koning, H. P. (2003). Pentamidine uptake and resistance in pathogenic protozoa. Trends in Parasitology 19, 232-239.
11. Chukwu, C. C., Anene, B. M. and Anika, S. M. (1990). Relapse infection after chemotherapy in dogs experimentally infected with Trypanosoma brucei brucei. Journal of Small Animal Practice 31, 141-144.
12. De Koning, H. P. (2001a). Uptake of Pentamidine in Trypanosoma brucei brucei is mediated by three distinct transporters: Implications for cross-resistance with arsenicals. Molecular Pharmacology 59, 586-592.
13. De Koning, H. P. (2001b). Transporters in African trypanosomes: role in drug action and resistance. International Journal for Parasitology 31, 512-522.
14. De Koning, H. P., Anderson, L. F., Stewart, M., Burchmore, R. J. S., Wallace, L. J. M. and Barrett, M. P. (2004). The trypanocide diminazene aceturate is accumulated predominantly through the TbAT1 purine transporter: Additional insights on diamidine resistance in African trypanosomes. Antimicrobial Agents and Chemotherapy 48, 1515-1519.
15. De Koning, H. P., MacLeod, A., Barrett, M. P., Cover, B. and Jarvis, S. M. (2000). Further evidence for a link between melarsoprol resistance and P2 transporter function in African trypanosomes. Molecular and Biochemical Parasitology 106, 181-185.
16. Fairlamb, A. H., Carter, N. S., Cuningham, M. and Smith, K. (1992). Characterisation of Melarsen-resistant Trypanosoma brucei brucei with respect to other drugs and trypanothione metabolism. Molecular and Biochemical Parasitology 53, 213-222.
17. Geerts, S., Holmes, P. H., Diall, O. and Eisler, M. C. (2001). African bovine trypanosomiasis: the problem of drug resistance. Trends in Parasitology 17, 25-29.
18. Herbert, W. J. and Lumsden, W. H. R. (1976). Trypanosoma brucei: a rapid "matching" method for estimating the host's parasitaemia. Experimental Parasitology 40, 427-431.
19. Jennings, F. W., Whitelaw, D. D. and Urquhart, G. M. (1977). The relationship between duration of infection with Trypanosoma brucei in mice and the efficacy of chemotherapy. Parasitology 75, 143-153.
20. Jennings, F. W., Whitelaw, D. D., Holmes, P. H., Chizyuka, H. G. B. and Urquhart, G. M. (1979). The brain as a source of relapsing T. brucei infection in mice after chemotherapy. International Journal for Parasitology 9, 381-384.
21. Kaggwa, E., Munyua, W. K. and Mugera, G. M. (1984). The pathogenicity of Trypanosoma brucei brucei in dogs. Bulletin of Animal Health and Production in Africa 82, 360-368.
22. Kaggwa, E., Munyua, W. K. and Mugera, G. M. (1988). Relapses in dogs experimentally infected with Trypanosoma brucei and treated with diminazene aceturate or isometamidium chloride. Veterinary Parasitology 27, 199-208.
23. Kalu, A. U. (1995a). Studies on the chemotherapeutic control of animal trypanosomiasis in Nigeria. Studies and Researches in Veterinary Medicine 3, 82-89.
24. Kalu, A. U. (1995b). Sensitivity of animal-derived Trypanozoon stocks from sleeping sickness endemic foci of Nigeria to trypanocides and human plasma. Revue d'Elevage et de Medecine Veterinaire des Pays Tropicaux 48, 139-144.
25. Kaminsky, R. and Mäser, P. (2000). Drug resistance in African trypanosomes. Current Opinion in Anti-infective Investigational Drugs 2, 76-82.
26. Masiga, D. K., Smyth, A. J., Hayes, P., Bromridge, T. J. and Gibson, W. C. (1992). Sensitive detection of trypanosomes in tsetse flies by DNA amplification. International Journal for Parasitology 22, 909-918.
27. Matovu, E., Seebeck, T., Enyaru, J. C. K. and Kaminsky, R. (2001). Drug resistance in Trypanosoma brucei spp., the causative agents of sleeping sickness in man and nagana in cattle. Microbes and Infection 3, 763-770.
28. Matovu, E., Stewart, M., Geiser, F., Brun, R., Mäser, P., Wallace, L. J. M., Burchmore, R. J. S., Enyaru, J. C. K., Barrett, M. P., Kaminsky, R., Seebeck, T. and De Koning, H. P. (2003). Mechanisms of arsenical and diamidine uptake and resistance in Trypanosoma brucei. Eukaryotic Cell 2, 1003-1008.
29. Mbwanbo, H. A., Mella, P. N. P. and Lekaki, K. A. (1988). Berenil (diminazene aceturate) resistant Trypanosoma congolense in cattle under natural tse tse challenge at Kilaha Tanzania. Acta Tropica 45, 239-244.
30. Omamegbe, J. O., Orajaka, L. J. E. and Emehelu, C. O. (1984). The incidence and clinical forms of naturally occurring canine trypanosomiasis in two Veterinary clinics in Anambra State of Nigeria. Bulletin of Animal Health and Production in Africa 32, 23-29.
31. Pepin, T. and Milord, F. (1994). The treatment of human African trypanosomiasis. Advances in Parasitology 33, 1-47.
32. Peregrine, A. S. (1991). Chemotherapy and delivery systems ; haemoparasites. Veterinary Parasitology 54, 223-248.
33. Radwanska, M., Claws, F., Magez, S., Magnus, E., Perez-Morga, D., Pays, E. and Büscher, P. (2002). Novel primer sequences for polymerase chain reaction-based detection of Trypanosoma brucei gambiense. American Journal of Tropical Medicine and Hygiene 67, 289-295.
34. Sayer, P. G., Morrison, W. I., Preston, T. M., Hird, S. F., Price, J. E. and Murray, M. (1979). African trypanosomiasis in the dog. In 15th International Scientific Council for Trypanosomiasis Research and Control (OAU/STRC), Banjul, The Gambia. pp. 489-496.
35. Soulsby, E. J. L. (1982). Helminths, Arthropods and Protozoa of Domesticated Animals, 7th Edn. Bailliere Tindall, London, UK.
36. Tait, A., Babiker, E. A. and Le Ray, D. (1984). Enzyme variation in Trypanosoma brucei spp. I Evidence for the sub-speciation of Trypanosoma brucei gambiense. Parasitology 89, 311-326.