Discovery of small-molecule glucokinase regulatory protein modulators that restore glucokinase activity

Journal of Biomolecular Screening

Volumn 19, Issue 7, 2014, Pages 1014-1023

  Chen, Kui ^a   Michelsen, Klaus ^a   Kurzeja, Robert J M ^a   Han, Joon ^a   Vazir, Mukta ^a   St Jean, David J ^a   Hale, Clarence ^a   Wahl, Robert C ^a  

^a AMGEN INC   (United States)

Author keywords

differential scanning fluorimetry (DSF); glucokinase (GK); glucokinase regulatory protein (GKRP); isothermal titration calorimetry (ITC); luminescence assay; NADPH coupled fluorescence assay; surface plasmon resonance (SPR)

Indexed keywords

AMG 6861; ENZYME ACTIVATOR; FRUCTOSE 1 PHOSPHATE; GLUCOKINASE; GLUCOKINASE REGULATORY PROTEIN; GLUCOKINASE REGULATORY PROTEIN MODULATOR; HEXOSE PHOSPHATE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; REGULATOR PROTEIN; RO 28 1675; SORBITOL 6 PHOSPHATE; UNCLASSIFIED DRUG; ADENOSINE TRIPHOSPHATE; FRUCTOSE PHOSPHATE; FRUCTOSE-1-PHOSPHATE; FRUCTOSE-6-PHOSPHATE; GCKR PROTEIN, HUMAN; GLUCOSE BLOOD LEVEL; PROTEIN BINDING; SIGNAL TRANSDUCING ADAPTOR PROTEIN; SORBITOL 6-PHOSPHATE;

CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; ENZYME ACTIVATION; ENZYME ACTIVITY; FLUORESCENCE ANALYSIS; HIGH THROUGHPUT SCREENING; IMAGE SUBTRACTION; ISOTHERMAL TITRATION CALORIMETRY; LUMINESCENCE; MOLECULAR LIBRARY; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; REVIEW; SURFACE PLASMON RESONANCE; ALLOSTERISM; ANALYSIS; ANIMAL; CALORIMETRY; CHEMISTRY; DIABETES MELLITUS, TYPE 2; DRUG DEVELOPMENT; FLUORESCENCE; FLUOROMETRY; GLUCOSE BLOOD LEVEL; HOMEOSTASIS; HUMAN; HYPOGLYCEMIA; IC50; LIVER CELL; METABOLISM; PROCEDURES; PROTEIN ANALYSIS; PROTEIN CONFORMATION; RAT;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADENOSINE TRIPHOSPHATE; ALLOSTERIC REGULATION; ANIMALS; BLOOD GLUCOSE; CALORIMETRY; DIABETES MELLITUS, TYPE 2; DRUG DISCOVERY; FLUORESCENCE; FLUOROMETRY; FRUCTOSEPHOSPHATES; GLUCOKINASE; HEPATOCYTES; HEXOSEPHOSPHATES; HOMEOSTASIS; HUMANS; HYPOGLYCEMIA; INHIBITORY CONCENTRATION 50; LUMINESCENCE; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN INTERACTION MAPPING; RATS; SURFACE PLASMON RESONANCE;

EID: 84904615428     PISSN: 10870571     EISSN: 1552454X     Source Type: Journal    
DOI: 10.1177/1087057114530468     Document Type: Review

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