-
1
-
-
3242720345
-
Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer
-
Cunningham D., Humblet Y., Siena S., et al. Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. N Engl J Med 2004, 351:337-345.
-
(2004)
N Engl J Med
, vol.351
, pp. 337-345
-
-
Cunningham, D.1
Humblet, Y.2
Siena, S.3
-
2
-
-
34147103678
-
Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer
-
Van Cutsem E., Peeters M., Siena S., et al. Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer. J Clin Oncol 2007, 25:1658-1664.
-
(2007)
J Clin Oncol
, vol.25
, pp. 1658-1664
-
-
Van Cutsem, E.1
Peeters, M.2
Siena, S.3
-
4
-
-
44249111440
-
EPIC: Phase III trial of cetuximab plus irinotecan after fluoropyrimidine and oxaliplatin failure in patients with metastatic colorectal cancer
-
Sobrero A.F., Maurel J., Fehrenbacher L., et al. EPIC: Phase III trial of cetuximab plus irinotecan after fluoropyrimidine and oxaliplatin failure in patients with metastatic colorectal cancer. J Clin Oncol 2008, 26:2311-2319.
-
(2008)
J Clin Oncol
, vol.26
, pp. 2311-2319
-
-
Sobrero, A.F.1
Maurel, J.2
Fehrenbacher, L.3
-
5
-
-
78149250536
-
Randomized, phase III trial of panitumumab with infusional fluorouracil, leucovorin, and oxaliplatin (FOLFOX4) versus FOLFOX4 alone as first-line treatment in patients with previously untreated metastatic colorectal cancer: the PRIME study
-
Douillard J.Y., Siena S., Cassidy J., et al. Randomized, phase III trial of panitumumab with infusional fluorouracil, leucovorin, and oxaliplatin (FOLFOX4) versus FOLFOX4 alone as first-line treatment in patients with previously untreated metastatic colorectal cancer: the PRIME study. J Clin Oncol 2010, 28:4697-4705.
-
(2010)
J Clin Oncol
, vol.28
, pp. 4697-4705
-
-
Douillard, J.Y.1
Siena, S.2
Cassidy, J.3
-
6
-
-
40149088765
-
KRAS wild-type state predicts survival and is associated to early radiological response in metastatic colorectal cancer treated with cetuximab
-
De Roock W., Piessevaux H., De Schutter J., et al. KRAS wild-type state predicts survival and is associated to early radiological response in metastatic colorectal cancer treated with cetuximab. Ann Oncol 2008, 19:508-515.
-
(2008)
Ann Oncol
, vol.19
, pp. 508-515
-
-
De Roock, W.1
Piessevaux, H.2
De Schutter, J.3
-
7
-
-
38649099966
-
KRAS mutations as an independent prognostic factor in patients with advanced colorectal cancer treated with cetuximab
-
Lièvre A., Bachet J.B., Boige V., et al. KRAS mutations as an independent prognostic factor in patients with advanced colorectal cancer treated with cetuximab. J Clin Oncol 2008, 26:374-379.
-
(2008)
J Clin Oncol
, vol.26
, pp. 374-379
-
-
Lièvre, A.1
Bachet, J.B.2
Boige, V.3
-
8
-
-
54949085398
-
K-ras mutations and benefit from cetuximab in advanced colorectal cancer
-
Karapetis C.S., Khambata-Ford S., Jonker D.J., et al. K-ras mutations and benefit from cetuximab in advanced colorectal cancer. N Engl J Med 2008, 359:1757-1765.
-
(2008)
N Engl J Med
, vol.359
, pp. 1757-1765
-
-
Karapetis, C.S.1
Khambata-Ford, S.2
Jonker, D.J.3
-
9
-
-
33646585797
-
Prognostic significance of epidermal growth factor receptor expression in colon cancer patients undergoing curative surgery
-
Galizia G., Lieto E., Ferraraccio F., et al. Prognostic significance of epidermal growth factor receptor expression in colon cancer patients undergoing curative surgery. Ann Surg Oncol 2006, 13:823-835.
-
(2006)
Ann Surg Oncol
, vol.13
, pp. 823-835
-
-
Galizia, G.1
Lieto, E.2
Ferraraccio, F.3
-
10
-
-
74249092482
-
Prognostic effect of activated EGFR expression in human colon carcinomas: comparison with EGFR status
-
Rego R.L., Foster N.R., Smyrk T.C., et al. Prognostic effect of activated EGFR expression in human colon carcinomas: comparison with EGFR status. Br J Cancer 2010, 102:165-172.
-
(2010)
Br J Cancer
, vol.102
, pp. 165-172
-
-
Rego, R.L.1
Foster, N.R.2
Smyrk, T.C.3
-
11
-
-
2142641698
-
Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor
-
Saltz L.B., Meropol N.J., Loehrer P.J., et al. Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor. J Clin Oncol 2004, 22:1201-1208.
-
(2004)
J Clin Oncol
, vol.22
, pp. 1201-1208
-
-
Saltz, L.B.1
Meropol, N.J.2
Loehrer, P.J.3
-
12
-
-
33748146468
-
Lack of usefulness of epidermal growth factor receptor expression determination for cetuximab therapy in patients with colorectal cancer
-
Hebbar M., Wacrenier A., Desauw C., et al. Lack of usefulness of epidermal growth factor receptor expression determination for cetuximab therapy in patients with colorectal cancer. Anticancer Drugs 2006, 17:855-857.
-
(2006)
Anticancer Drugs
, vol.17
, pp. 855-857
-
-
Hebbar, M.1
Wacrenier, A.2
Desauw, C.3
-
13
-
-
20144381957
-
Cetuximab shows activity in colorectal cancer patients with tumors that do not express the epidermal growth factor receptor by immunohistochemistry
-
Chung K.Y., Shia J., Kemeny N.E., et al. Cetuximab shows activity in colorectal cancer patients with tumors that do not express the epidermal growth factor receptor by immunohistochemistry. J Clin Oncol 2005, 23:1803-1810.
-
(2005)
J Clin Oncol
, vol.23
, pp. 1803-1810
-
-
Chung, K.Y.1
Shia, J.2
Kemeny, N.E.3
-
14
-
-
17844362179
-
Gene copy number for epidermal growth factor receptor EGFR and clinical response to antiEGFR treatment in colorectal cancer: a cohort study
-
Moroni M., Veronese S., Benvenuti S., et al. Gene copy number for epidermal growth factor receptor EGFR and clinical response to antiEGFR treatment in colorectal cancer: a cohort study. Lancet Oncol 2005, 6:279-286.
-
(2005)
Lancet Oncol
, vol.6
, pp. 279-286
-
-
Moroni, M.1
Veronese, S.2
Benvenuti, S.3
-
15
-
-
34548258303
-
Epidermal growth factor receptor gene copy number and clinical outcome of metastatic colorectal cancer treated with panitumumab
-
Sartore-Bianchi A., Moroni M., Veronese S., et al. Epidermal growth factor receptor gene copy number and clinical outcome of metastatic colorectal cancer treated with panitumumab. J Clin Oncol 2007, 25:3238-3245.
-
(2007)
J Clin Oncol
, vol.25
, pp. 3238-3245
-
-
Sartore-Bianchi, A.1
Moroni, M.2
Veronese, S.3
-
16
-
-
41549097718
-
EGFR FISH assay predicts for response to cetuximab in chemotherapy refractory colorectal cancer patients
-
Cappuzzo F., Finocchiaro G., Rossi E., et al. EGFR FISH assay predicts for response to cetuximab in chemotherapy refractory colorectal cancer patients. Ann Oncol 2007, 194:717-723.
-
(2007)
Ann Oncol
, vol.194
, pp. 717-723
-
-
Cappuzzo, F.1
Finocchiaro, G.2
Rossi, E.3
-
17
-
-
53249123419
-
Cinical usefulness of EGFR gene copy number as a predictive marker in colorectal cancer patients treated with cetuximab: a fluorescent in situ hybridization study
-
Personeni N., Fieuws S., Piessevaux H., et al. Cinical usefulness of EGFR gene copy number as a predictive marker in colorectal cancer patients treated with cetuximab: a fluorescent in situ hybridization study. Clin Cancer Res 2008, 14:5869-5876.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 5869-5876
-
-
Personeni, N.1
Fieuws, S.2
Piessevaux, H.3
-
18
-
-
77449117770
-
Visualization of FISH probes by dual-color chromogenic in situ hybridization
-
Hoff K., Jørgensen J.T., Müller S., et al. Visualization of FISH probes by dual-color chromogenic in situ hybridization. Am J Clin Pathol 2010, 133:205-211.
-
(2010)
Am J Clin Pathol
, vol.133
, pp. 205-211
-
-
Hoff, K.1
Jørgensen, J.T.2
Müller, S.3
-
19
-
-
77955277111
-
Effects of KRAS, BRAF, NRAS and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis
-
De Roock W., Claes B., Bernasconi D., et al. Effects of KRAS, BRAF, NRAS and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis. Lancet Oncol 2010, 11:753-762.
-
(2010)
Lancet Oncol
, vol.11
, pp. 753-762
-
-
De Roock, W.1
Claes, B.2
Bernasconi, D.3
-
20
-
-
57449095367
-
Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer
-
Di Nicolantonio F., Martini M., Molinari F., et al. Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer. J Clin Oncol 2008, 26:5705-5712.
-
(2008)
J Clin Oncol
, vol.26
, pp. 5705-5712
-
-
Di Nicolantonio, F.1
Martini, M.2
Molinari, F.3
-
21
-
-
68749119351
-
KRAS codon 61, 146 and BRAF mutations predict resistance to cetuximab plus irinotecan in KRAS codon 12 and 13 wild-type metastatic colorectal cancer
-
Loupakis F., Ruzzo A., Cremolini C., et al. KRAS codon 61, 146 and BRAF mutations predict resistance to cetuximab plus irinotecan in KRAS codon 12 and 13 wild-type metastatic colorectal cancer. Br J Cancer 2009, 101:715-721.
-
(2009)
Br J Cancer
, vol.101
, pp. 715-721
-
-
Loupakis, F.1
Ruzzo, A.2
Cremolini, C.3
-
22
-
-
84860634396
-
PIK3CA exon 20 mutations as a potential biomarker for resistance to anti-EGFR monoclonal antibodies in KRAS wild-type metastatic colorectal cancer: a systematic review and meta-analysis
-
Mao C., Yang Z.Y., Hu X.F., et al. PIK3CA exon 20 mutations as a potential biomarker for resistance to anti-EGFR monoclonal antibodies in KRAS wild-type metastatic colorectal cancer: a systematic review and meta-analysis. Ann Oncol 2012, 23:1518-1525.
-
(2012)
Ann Oncol
, vol.23
, pp. 1518-1525
-
-
Mao, C.1
Yang, Z.Y.2
Hu, X.F.3
-
23
-
-
73349094741
-
Analysis of PTEN, BRAF, and EGFR status in determining benefit from cetuximab therapy in wild-type KRAS metastatic colon cancer
-
Laurent-Puig P., Cayre A., Manceau G., et al. Analysis of PTEN, BRAF, and EGFR status in determining benefit from cetuximab therapy in wild-type KRAS metastatic colon cancer. J Clin Oncol 2009, 27:5924-5930.
-
(2009)
J Clin Oncol
, vol.27
, pp. 5924-5930
-
-
Laurent-Puig, P.1
Cayre, A.2
Manceau, G.3
-
24
-
-
73349140213
-
EGFR fluorescence in situ hybridisation assay: guidelines for application to non-small-cell lung cancer
-
Varella-Garcia M., Diebold J., Eberhard D.A., et al. EGFR fluorescence in situ hybridisation assay: guidelines for application to non-small-cell lung cancer. J Clin Pathol 2009, 62:970-977.
-
(2009)
J Clin Pathol
, vol.62
, pp. 970-977
-
-
Varella-Garcia, M.1
Diebold, J.2
Eberhard, D.A.3
-
25
-
-
84875734469
-
Predictive value of epidermal growth factor receptor expression for first-line chemotherapy plus cetuximab in patients with head and neck and colorectal cancer: analysis of data from the EXTREME and CRYSTAL studies
-
Licitra L., Störkel S., Kerr K.M., et al. Predictive value of epidermal growth factor receptor expression for first-line chemotherapy plus cetuximab in patients with head and neck and colorectal cancer: analysis of data from the EXTREME and CRYSTAL studies. Eur J cancer 2013, 49:1161-1168.
-
(2013)
Eur J cancer
, vol.49
, pp. 1161-1168
-
-
Licitra, L.1
Störkel, S.2
Kerr, K.M.3
-
26
-
-
79960202409
-
EGFR gene copy number assessment from areas with highest EGFR expression predicts response to anti-EGFR therapy in colorectal cancer
-
Ålgars A., Lintunen M., Carpén O., et al. EGFR gene copy number assessment from areas with highest EGFR expression predicts response to anti-EGFR therapy in colorectal cancer. Br J Cancer 2011, 105:255-262.
-
(2011)
Br J Cancer
, vol.105
, pp. 255-262
-
-
Ålgars, A.1
Lintunen, M.2
Carpén, O.3
-
28
-
-
34247278727
-
Clinical relevance of KRAS mutation detection in metastatic colorectal cancer treated by cetuximab plus chemotherapy
-
Di Fiore F., Blanchard F., Charbonnier F., et al. Clinical relevance of KRAS mutation detection in metastatic colorectal cancer treated by cetuximab plus chemotherapy. Br J Cancer 2007, 96:1166-1169.
-
(2007)
Br J Cancer
, vol.96
, pp. 1166-1169
-
-
Di Fiore, F.1
Blanchard, F.2
Charbonnier, F.3
-
29
-
-
84857051602
-
Mucinous adenocarcinomas: poor prognosis in metastatic colorectal cancer
-
Mekenkamp L.J., Heesterbeek K.J., Koopman M., et al. Mucinous adenocarcinomas: poor prognosis in metastatic colorectal cancer. Eur J Cancer 2012, 484:501-509.
-
(2012)
Eur J Cancer
, vol.484
, pp. 501-509
-
-
Mekenkamp, L.J.1
Heesterbeek, K.J.2
Koopman, M.3
-
30
-
-
84859865072
-
Prognostic role of PIK3CA mutation in colorectal cancer: cohort study and literature review
-
Liao X., Morikawa T., Lochhead P., et al. Prognostic role of PIK3CA mutation in colorectal cancer: cohort study and literature review. Clin Cancer Res 2012, 188:2257-2268.
-
(2012)
Clin Cancer Res
, vol.188
, pp. 2257-2268
-
-
Liao, X.1
Morikawa, T.2
Lochhead, P.3
|