EGFR gene copy number assessment from areas with highest EGFR expression predicts response to anti-EGFR therapy in colorectal cancer

British Journal of Cancer

Volumn 105, Issue 2, 2011, Pages 255-262

  Algars A ^a,b   Lintunen, M ^a,c   Carpen O ^a,c   Ristamaki R ^a   Sundstrom J ^a,c  

^a TURKU UNIVERSITY HOSPITAL   (Finland)

^b UNIVERSITY OF TURKU   (Finland)

^c UNIVERSITY OF TURKU   (Finland)

Author keywords

anti EGFR therapy; colorectal cancer; immunohistochemistry; predictive marker; silver in situ hybridisation

Indexed keywords

CAPECITABINE; CETUXIMAB; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR ANTIBODY; IRINOTECAN; K RAS PROTEIN; OXALIPLATIN; PANITUMUMAB;

ACCURACY; ADULT; AGED; ARTICLE; AUTOMATION; CANCER GRADING; CANCER SURVIVAL; CHROMOSOME 7; CLINICAL ASSESSMENT; COLORECTAL CANCER; CONTROLLED STUDY; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE DOSAGE; GENE EXPRESSION; GENE MUTATION; GENETIC ANALYSIS; GENETIC ASSOCIATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MAJOR CLINICAL STUDY; MALE; METASTASIS; OVERALL SURVIVAL; PRIORITY JOURNAL; PROGRESSION FREE SURVIVAL; PROTEIN ANALYSIS; SILVER IN SITU HYBRIDIZATION; TREATMENT RESPONSE;

ADULT; AGED; ANTIBODIES, MONOCLONAL; ANTINEOPLASTIC AGENTS; BIOMARKERS, PHARMACOLOGICAL; CARCINOMA; COLORECTAL NEOPLASMS; DNA MUTATIONAL ANALYSIS; FEMALE; GENE DOSAGE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, ERBB-1; GENES, RAS; HUMANS; IMMUNOTHERAPY; IN SITU HYBRIDIZATION; MALE; MIDDLE AGED; PROGNOSIS; RECEPTOR, EPIDERMAL GROWTH FACTOR; RETROSPECTIVE STUDIES; TREATMENT OUTCOME;

EID: 79960202409     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/bjc.2011.223     Document Type: Article

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