Directed differentiation of patient-specific induced pluripotent stem cells identifies the transcriptional repression and epigenetic modification of NKX2-5, HAND1, and NOTCH1 in hypoplastic left heart syndrome

PLoS ONE

Volumn 9, Issue 7, 2014, Pages

  Kobayashi, Junko ^a   Yoshida, Masashi ^a   Tarui, Suguru ^a   Hirata, Masataka ^a   Nagai, Yusuke ^a   Kasahara, Shingo ^a   Naruse, Keiji ^a   Ito, Hiroshi ^a   Sano, Shunji ^a   Oh, Hidemasa ^b  

^a OKAYAMA UNIVERSITY   (Japan)

^b OKAYAMA UNIVERSITY HOSPITAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE H3; NOTCH1 RECEPTOR; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR NKX2.5; TRANSCRIPTION FACTOR TBX2; UNCLASSIFIED DRUG; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; HELIX-LOOP-HELIX PROTEIN, EHAND; HISTONE; HOMEODOMAIN PROTEIN; NKX2-5 PROTEIN, HUMAN; NOTCH1 PROTEIN, HUMAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DIFFERENTIATION; CELL ISOLATION; CONTROLLED STUDY; EPIGENETICS; GENE; GENE EXPRESSION; GENE IDENTIFICATION; GENETIC ASSOCIATION; HAND1 GENE; HISTONE ACETYLATION; HISTONE METHYLATION; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOPLASTIC LEFT HEART SYNDROME; MALE; MOLECULAR PATHOLOGY; MOUSE; NONHUMAN; NOTCH1 GENE; PLURIPOTENT STEM CELL; PROMOTER REGION; QUANTITATIVE ANALYSIS; SERUM RESPONSIVE ELEMENT; SIGNAL TRANSDUCTION; TNNT2 GENE; TRANSCRIPTION FACTOR NKX2.5 GENE; TRANSCRIPTION REGULATION; ANIMAL; CARDIAC MUSCLE CELL; CELL CULTURE; GENETIC EPIGENESIS; GENETIC TRANSCRIPTION; GENETICS; INDUCED PLURIPOTENT STEM CELL; METABOLISM; NONOBESE DIABETIC MOUSE; PATHOLOGY; PHYSIOLOGY; PROTEIN PROCESSING; SCID MOUSE;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL DIFFERENTIATION; CELLS, CULTURED; EPIGENESIS, GENETIC; HISTONES; HOMEODOMAIN PROTEINS; HUMANS; HYPOPLASTIC LEFT HEART SYNDROME; INDUCED PLURIPOTENT STEM CELLS; MICE, INBRED NOD; MICE, SCID; MYOCYTES, CARDIAC; PROMOTER REGIONS, GENETIC; PROTEIN PROCESSING, POST-TRANSLATIONAL; RECEPTOR, NOTCH1; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 84904608539     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0102796     Document Type: Article

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