Garcinol, an acetyltransferase inhibitor, suppresses proliferation of breast cancer cell line MCF-7 promoted by 17β-estradiol

Asian Pacific Journal of Cancer Prevention

Volumn 15, Issue 12, 2014, Pages 5001-5007

  Ye, Xia ^a   Yuan, Lei ^a   Zhang, Li ^a   Zhao, Jing ^a   Zhang, Chun Mei ^a   Deng, Hua Yu ^a  

^a CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

Acetylation; Breast cancer; Garcinol; Histone; NF B ac P65

Indexed keywords

ACYLTRANSFERASE; CYCLIN D1; ESTRADIOL; ESTROGEN; GARCINOL; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; PROTEIN BCL 2; TERPENE; TUMOR MARKER;

ANTAGONISTS AND INHIBITORS; APOPTOSIS; BREAST NEOPLASMS; CELL CYCLE; CELL PROLIFERATION; CHEMICALLY INDUCED; DRUG EFFECTS; ENZYME IMMUNOASSAY; FEMALE; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; PATHOLOGY; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR CELL CULTURE; WESTERN BLOTTING;

ACETYLTRANSFERASES; APOPTOSIS; BLOTTING, WESTERN; BREAST NEOPLASMS; CELL CYCLE; CELL PROLIFERATION; CYCLIN D1; ESTRADIOL; ESTROGENS; FEMALE; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOENZYME TECHNIQUES; NF-KAPPA B; PROTO-ONCOGENE PROTEINS C-BCL-2; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TERPENES; TUMOR CELLS, CULTURED; TUMOR MARKERS, BIOLOGICAL;

EID: 84904597934     PISSN: 15137368     EISSN: 2476762X     Source Type: Journal    
DOI: 10.7314/APJCP.2014.15.12.5001     Document Type: Article

References (30)

1. Arif M, Pradhan SK, Thanuja GR, et al (2009). Mechanism of p300 specific histone acetyltransferase inhibition by small molecules. J Med Chem, 52, 267-77.
2. Balasubramanyam K, Altaf M, Varier RA, et al (2004). Polyisoprenylated benzophenone, garcinol, a natural histone acetyltransferase inhibitor, represses chromatin transcription and alters global gene expression. J Biol Chem, 279, 33716-26.
3. Baumgarten SC, Frasor J (2012). Minireview: Inflammation: an instigator of more aggressive estrogen receptor (ER) positive breast cancers. Mol Endocrinol, 26, 360-71.
4. Chen LF, Mu Y, Greene WC (2002). Acetylation of RelA at discrete sites regulates distinct nuclear functions of NFkappaB. EMBO J, 21, 6539-48.
5. Chen H, Ln RJ, Xie W, et al (1999). Regulation of hormoneinduced histone hyperacetylation and gene activation via acetylation of an acetylase. Cell, 98, 675-86.
6. Dhalluin C, Carlson JE, Zeng L, et al (1999). Structure and ligand of a histone acetyltransferase bromodomain. Nature, 399, 491-6.
7. Dicerbo V, Schneider R (2013). Cancers with wrong HATs: the impact of acetylation. Brief Funct Genomics, 12, 231-43.
8. Han D, Denison MS, Tachibana H, et al (2002). Effects of estrogenic compounds on immunoglobulin production by mouse splenocytes. Biol Pharm Bull, 25, 1263-7.
9. Iiuzka M, Takahashi Y, Mizzen CA, et al (2009). Histone acetyltransferase Hbo1: catalytic activity, cellular abundance, and links to primary cancers. Gene, 436, 108-14.
10. Jin W, Chen L, ChenY, et al (2010). UHRF1 is associated with epigenetic silencing of BRCA1 in sporadic breast cancer. Breast Cancer Res Treat, 123, 359-73.
11. Jin W, Liu Y, Chen L, et al (2011). Involvement of MyoD and c-myb in regulation of basal and estrogen-induced transcription activity of the BRCA1 gene. Breast Cancer Res Treat, 125, 699-713.
12. Jana D, Das S, Sarkar DK, et al (2012). Role of nuclear factor-κB in female breast cancer: a study in Indian patients. Asian Pac J Cancer Prev, 13, 5511-5.
13. Jemal A, Siegel R, Ward E, et al (2009). Cancer statistics, 2009. CA Cancer J Clin, 59, 225-49.
14. Kininis M, Chen BS, Diehl AG, et al (2007). Genomic analyses of transcription factor binding, histone acetylation, and gene expression reveal mechanistically distinct classes of estrogen-regulated promoters. Mol Cell Biol, 27, 5090-104.
15. Kutanzi KR, Koturbash I, Kovalchuk O (2010). Reversibility of pre-malignant estrogen-induced epigenetic changes. Cell Cycle, 9, 3078-84.
16. Kim JW, Jang SM, Kim CH, et al (2012). New molecular bridge between RelA/p65 and NF-kappaB target genes via histone acetyltransferase TIP60 cofactor. J Biol Chem, 287, 7780-91.
17. Khan ZN, Sabir M, Kayani MA, et al (2013). Acetylation of retinoblastoma like protein2 (Rb2/p130) in tumor tissues. Asian Pac J Cancer Prev, 14, 2255-8.
18. Lee DY, Hayes JJ, Pruss D, et al (1993). A positive role for histone acetylation in transcription factor access to nucleosomal DNA. Cell, 72, 73-84.
19. Minatoya M, Kutomi G, Asakura S, et al (2013). Equol, adiponectin, insulin levels and risk of breast cancer. Asian Pac J Cancer Prev, 14, 2191-9.
20. Mooney SM, Goel A, D'assoro AB, et al (2010). Pleiotropic effects of p300-mediated acetylation on p68 and p72 RNA helicase. J Biol Chem, 285, 30443-52.
21. Marmorstein R, Trievel RC (2009). Histone modifying enzymes: structures, mechanisms, and specificities. Biochim Biophys Acta, 1789, 58-68.
22. Pradhan M, Baumgarten SC, Bembinster LA, et al (2012). CBP mediates NF-kappaB-dependent histone acetylation and estrogen receptor recruitment to an estrogen response element in the BIRC3 promoter. Mol Cell Biol, 32, 569-75.
23. Quivy V, Van Lint C (2004). Regulation at multiple levels of NF-kappaB-mediated transactivation by protein acetylation. Biochem Pharmacol, 68, 1221-9.
24. Rubio MF, Werbajh S, Cafferatae G, et al (2006). TNF-alpha enhances estrogen-induced cell proliferation of estrogendependent breast tumor cells through a complex containing nuclear factor-kappa B. Oncogene, 25, 1367-77.
25. Singh BN, Zhang G, Hwa YL, et al (2010). Nonhistone protein acetylation as cancer therapy targets. Expert Rev Anticancer Ther, 10, 935-54.
26. Sung B, Pandey MK, Ahn KS, et al (2008). Anacardic acid (6-nonadecyl salicylic acid), an inhibitor of histone acetyltransferase, suppresses expression of nuclear factorkappaB-regulated gene products involved in cell survival, proliferation, invasion, and inflammation through inhibition of the inhibitory subunit of nuclear factor-kappaBalpha kinase, leading to potentiation of apoptosis. Blood, 111, 4880-91.
27. Saadat N, Gupta SV (2012). Potential role of garcinol as an anticancer agent. J Oncol, 2012, 647206.
28. Wang GG, Allis CD, Chi P (2007). Chromatin remodeling and cancer, Part I: Covalent histone modifications. Trends Mol Med, 13, 363-72.
29. Zhang CM, Zhao J, Deng HY (2013). 17beta-estradiol upregulates miR-155 expression and reduces TP53INP1 expression in MCF-7 breast cancer cells. Mol Cell Biochem, 379, 201-11.
30. Zubair A, Frieri M (2013). Role of nuclear factor-kB in breast and colorectal cancer. Curr Allergy Asthma Rep, 13, 44-9.