Enantioselective HPLC determination and pharmacokinetic study of secnidazole enantiomers in rats

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 965, Issue , 2014, Pages 224-230

  Du, Jiangbo ^a   Zhang, Yifan ^a   Chen, Yao ^a   Liu, Dongqin ^a   Chen, Xiaoyan ^a   Zhong, Dafang ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Enantiomers; Enantioselective high performance liquid chromatography; Pharmacokinetics; Secnidazole

Indexed keywords

BODY FLUIDS; CHROMATOGRAPHY; DICHLOROMETHANE; ENANTIOSELECTIVITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PHARMACOKINETICS; RATS;

CONCENTRATION RANGES; ENANTIOSELECTIVE HPLC; LOWER LIMIT OF QUANTIFICATIONS; PHARMACOKINETIC PROPERTIES; PHARMACOKINETIC STUDIES; RELATIVE STANDARD DEVIATIONS; SECNIDAZOLE; ULTRA VIOLET DETECTION;

ENANTIOMERS;

AMMONIUM ACETATE; DICHLOROMETHANE; ETHER; METHANOL; ORNIDAZOLE; SECNIDAZOLE; METRONIDAZOLE;

ANALYTICAL ERROR; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG HALF LIFE; ENANTIOMER; ENANTIOSELECTIVITY; FLOW RATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIMIT OF QUANTITATION; MALE; MAXIMUM PLASMA CONCENTRATION; MEAN RESIDENCE TIME; NONHUMAN; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL; RAT; TIME TO MAXIMUM PLASMA CONCENTRATION; VALIDATION STUDY; ANALOGS AND DERIVATIVES; ANIMAL; BLOOD; CHEMISTRY; DRUG STABILITY; LIMIT OF DETECTION; PROCEDURES; REPRODUCIBILITY; SPRAGUE DAWLEY RAT; STATISTICAL MODEL; STEREOISOMERISM;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG STABILITY; LIMIT OF DETECTION; LINEAR MODELS; MALE; METRONIDAZOLE; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; STEREOISOMERISM;

EID: 84904582765     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2014.06.036     Document Type: Article

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