A chiral high-performance liquid chromatography-tandem mass spectrometry method for the stereospecific determination of morinidazole in human plasma

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 961, Issue , 2014, Pages 49-55

  Zhong, Kan ^a   Gao, Zhiwei ^a   Li, Qin ^b   Zhong, Dafang ^a   Chen, Xiaoyan ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b Jiangsu Hansoh Pharmaceutical Co Ltd   (China)

Author keywords

5 Nitroimidazole antimicrobial drug; Liquid chromatography tandem mass spectrometry; Morinidazole enantiomer; Stereoselective pharmacokinetics

Indexed keywords

CHIRALITY; CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PHARMACOKINETICS; PLASMA (HUMAN); STEREOSELECTIVITY;

ANTIMICROBIAL DRUG; HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; LOWER LIMIT OF QUANTIFICATIONS; MORINIDAZOLE; MULTIPLE-REACTION MONITORING MODES; SENSITIVE LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; STEREOSELECTIVE PHARMACOKINETICS;

ENANTIOMERS;

5 NITROIMIDAZOLE DERIVATIVE; CELLULOSE; GLUCURONIDE; METHANOL; MORINIDAZOLE; SULFATE; TERT BUTYL METHYL ETHER; UNCLASSIFIED DRUG; WATER; ETHER DERIVATIVE; NITROIMIDAZOLE DERIVATIVE;

ACCURACY; AREA UNDER THE CURVE; ARTICLE; CALIBRATION; CHIRAL CHROMATOGRAPHY; CONTINUOUS INFUSION; CORRELATION COEFFICIENT; DIPOLE; DRUG BLOOD LEVEL; DRUG STABILITY; ENANTIOMER; ENANTIOSELECTIVITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; HYDROGEN BOND; LIMIT OF QUANTITATION; LIQUID LIQUID EXTRACTION; PLASMA CLEARANCE; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL; SEVERE RENAL IMPAIRMENT; SIGNAL NOISE RATIO; STEREOCHEMISTRY; STEREOSPECIFICITY; TANDEM MASS SPECTROMETRY; BLOOD; PROCEDURES; REPRODUCIBILITY; STEREOISOMERISM; VALIDATION STUDY;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; LIQUID-LIQUID EXTRACTION; METHYL ETHERS; NITROIMIDAZOLES; REPRODUCIBILITY OF RESULTS; STEREOISOMERISM; TANDEM MASS SPECTROMETRY;

EID: 84901237642     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2014.04.049     Document Type: Article

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