Stereoselective pharmacokinetics of ornidazole after intravenous administration of individual enantiomers and the racemate

Chirality

Volumn 18, Issue 10, 2006, Pages 799-802

  Chen, Yan ^a   Liu, Xiao Quan ^a   Zhong, Jiao ^a   Zhao, Xiaoping ^a   Wang, Yongsheng ^a   Wang, Guangji ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

(+) ONZ; ( ) ONZ; Chiral high performance liquid chromatography analysis; rac ONZ; Stereoselective pharmacokinetics

Indexed keywords

ORNIDAZOLE;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CHIRAL CHROMATOGRAPHY; CHIRAL HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; CHIRALITY; DOG; DRUG BLOOD LEVEL; DRUG ELIMINATION; DRUG HALF LIFE; ENANTIOMER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NONHUMAN; PRIORITY JOURNAL; RACEMIC MIXTURE; SPECTRUM; STEREOCHEMISTRY; ULTRAVIOLET SPECTROSCOPY;

ANIMALS; DOGS; INJECTIONS, INTRAVENOUS; MOLECULAR STRUCTURE; ORNIDAZOLE; STEREOISOMERISM;

EID: 33750352885     PISSN: 08990042     EISSN: 1520636X     Source Type: Journal    
DOI: 10.1002/chir.20322     Document Type: Article

References (11)

1. López Nigro MM, Palermo AM, Mudry MD, Carballo MA. Cytogenetic evaluation of two nitroimidazole derivatives. Toxicol in Vitro 2003;17:35-40.
2. Özkan SA, Senturk Z, Biryol I. Determination of ornidazole in pharmaceutical dosage forms based on reduction at an activated glassy carbon electrode. Int J Pharm 1997;157:137-144.
3. McClain RM, Downing JC. Reproduction studies in rats treated with ornidazole. Toxicol Appl Pharmacol 1988;92:480-487.
4. Linder RE, Strader LF, Slott VL, Suarez JD. Endpoints of spermatoxicity in the rat after short duration exposures to fourteen reproductive toxins. Reprod Toxicol 1992;6:491-505.
5. Bone W, Yeung CH, Skupin R, Haufe G, Cooper TG. Toxicity of ornidazole and its analogues to rat spermatozoa as reflected in motility parameters. Int J Androl 1997;20:347-355.
6. Cooper TG, Yeung CH, Skupin R, Haufe G. Antifertiliy potential of ornidazole analogues in rats. J Androl 1997;18:431-438.
7. Ariens EJ. Nonchiral, homochiral and composite chiral drugs. Trends Pharmacol Sci 1993;14:68-75.
8. Brocks DR, Jamali F. Stereochemical aspects of pharmacotheraphy. Pharmacotherapy 1995;15:551-564.
9. Mehvar A. Input rate-dependent stereoselective pharmacokinetics enantiomeric: Oral bioavailability and blood concentration ratios after constant oral input. Biopharm Drug Dispos 1992;13:597-615.
10. Longstreth JA. A chrial challenge to the pharmacokinetic and pharmacodynamic assessment of bioavailability and bioequivalence. In: Wainer WI, editor. Drug stereochemistry: Analytical methods and pharmacology. New York: Marcel Dekker; 1993. pp 315,316.
11. Heizmann P, Geschke R, Zinapold K. Determination of ornidazole and its main metabolites in biological fluid. Chromatography 1990;534:233-240.