Metabolism and pharmacokinetics of morinidazole in humans: Identification of diastereoisomeric morpholine N +-glucuronides catalyzed by UDP glucuronosyltransferase 1A9

Drug Metabolism and Disposition

Volumn 40, Issue 3, 2012, Pages 556-567

  Gao, Ruina ^a   Li, Liang ^a   Xie, Cen ^a   Diao, Xingxing ^a   Zhong, Dafang ^a   Chen, Xiaoyan ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG METABOLITE; GLUCURONOSYLTRANSFERASE 1A9; HYDROXYL GROUP; MORINIDAZOLE; MORINIDAZOLE GLUCURONIDE; NITROGEN; NITROIMIDAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ADULT; AREA UNDER THE CURVE; ARTICLE; CLINICAL TRIAL; CONTINUOUS INFUSION; CONTROLLED STUDY; DRUG CLEARANCE; DRUG ELIMINATION; DRUG GLUCURONIDATION; DRUG METABOLISM; DRUG STRUCTURE; FEMALE; HUMAN; HUMAN EXPERIMENT; IN VITRO STUDY; LIVER MICROSOME; MALE; MAXIMUM PLASMA CONCENTRATION; MICHAELIS MENTEN KINETICS; NORMAL HUMAN; OPEN STUDY; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL; STEREOCHEMISTRY; TIME OF FLIGHT MASS SPECTROMETRY; TIME TO MAXIMUM PLASMA CONCENTRATION; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; URINARY EXCRETION;

ADULT; BIOTRANSFORMATION; CATALYSIS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FEMALE; GLUCURONIDES; GLUCURONOSYLTRANSFERASE; HUMANS; KINETICS; MALE; MASS SPECTROMETRY; MICROSOMES, LIVER; MORPHOLINES; NITROIMIDAZOLES; STEREOISOMERISM; YOUNG ADULT;

EID: 84863148950     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.111.042689     Document Type: Article

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