Effect of low doses of progesterone in the expression of the GABA(A) receptor α4 subunit and procaspase-3 in the hypothalamus of female rats

Endocrine

Volumn 46, Issue 3, 2014, Pages 561-567

  Arbo, Bruno D ^a   Andrade, Susie ^a   Osterkamp, Gabriela ^a   Gomez, Rosane ^a   Ribeiro, Maria Flávia M ^a  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

Depression; Neuroprotection; Neurosteroids; Serotonin

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR ALPHA4; CASPASE 3; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; MITOGEN ACTIVATED PROTEIN KINASE; PROCASPASE 3; PROGESTERONE; PROTEIN KINASE B; SEROTONIN; SEROTONIN TRANSPORTER; 4 AMINOBUTYRIC ACID A RECEPTOR; GABRA4 PROTEIN, RAT; PROTEIN SUBUNIT; RNA BINDING PROTEIN; SERT PROTEIN, RAT;

ANTIDEPRESSANT ACTIVITY; ARTICLE; CELL DEATH; CHRONIC DRUG ADMINISTRATION; CONTROLLED STUDY; DEPRESSION; DIESTRUS; ESTRUS CYCLE; FEMALE; FORCED SWIM TEST; HYPOTHALAMUS; NERVE DEGENERATION; NEUROPROTECTION; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; RAT; WESTERN BLOTTING; ANIMAL; DRUG EFFECTS; METABOLISM; PROTEIN SUBUNIT; WISTAR RAT;

ANIMALS; CASPASE 3; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; HYPOTHALAMUS; PROGESTERONE; PROTEIN SUBUNITS; RATS; RATS, WISTAR; RECEPTORS, GABA-A; RNA-BINDING PROTEINS;

EID: 84904552868     PISSN: 1355008X     EISSN: 15590100     Source Type: Journal    
DOI: 10.1007/s12020-013-0126-5     Document Type: Article

References (47)

1. B. Dubrovsky, Neurosteroids, neuroactive steroids, and symptoms of affective disorders. Pharmacol. Biochem. Behav. 84, 644-655 (2006)
2. Z. Amin, G.F. Mason, I. Cavus, J.H. Krystal, D.L. Rothman, C.N. Epperson, The interaction of neuroactive steroids and GABA in the development of neuropsychiatric disorders in women. Pharmacol. Biochem. Behav. 84, 635-643 (2006)
3. A.L. Morrow, Recent developments in the significance and therapeutic relevance of neuroactive steroids - introduction to the special issue. Pharmacol. Ther. 116, 1-6 (2007)
4. S. Andrade, B.D. Arbo, B.A. Batista, A.M. Neves, G. Branchini, I.S. Brum, H.M. Barros, R. Gomez, M.F. Ribeiro, Effect of progesterone on the expression of GABA(A) receptor subunits in the prefrontal cortex of rats: implications of sex differences and brain hemisphere. Cell Biochem. Funct. 30, 696-700 (2012)
5. S. Andrade, S.L. Silveira, B.D. Arbo, B.A. Batista, R. Gomez, H.M. Barros, M.F. Ribeiro, Sex-dependent antidepressant effects of lower doses of progesterone in rats. Physiol. Behav. 99, 687-690 (2010)
6. R. Cossart, C. Bernard, Y. Ben-Ari, Multiple facets of GABAergic neurons and synapses: multiple fates of GABA signalling in epilepsies. Trends Neurosci. 28, 108-115 (2005)
7. D. Chandra, F. Jia, J. Liang, Z. Peng, A. Suryanarayanan, D.F. Werner, I. Spigelman, C.R. Houser, R.W. Olsen, N.L. Harrison, G.E. Homanics, GABAA receptor alpha 4 subunits mediate extrasynaptic inhibition in thalamus and dentate gyrus and the action of gaboxadol. Proc. Natl. Acad. Sci. USA 103, 15230-15235 (2006)
8. J. Liang, N. Zhang, E. Cagetti, C.R. Houser, R.W. Olsen, I. Spigelman, Chronic intermittent ethanol-induced switch of ethanol actions from extrasynaptic to synaptic hippocampal GABAA receptors. J. Neurosci. 26, 1749-1758 (2006)
9. S.S. Smith, H. Shen, Q.H. Gong, X. Zhou, Neurosteroid regulation of GABA(A) receptors: focus on the alpha4 and delta sub-units. Pharmacol. Ther. 116, 58-76 (2007)
10. M. Gulinello, Q.H. Gong, X. Li, S.S. Smith, Short-term exposure to a neuroactive steroid increases alpha4 GABA(A) receptor subunit levels in association with increased anxiety in the female rat. Brain Res. 910, 55-66 (2001)
11. H. Shen, Q.H. Gong, M. Yuan, S.S. Smith, Short-term steroid treatment increases delta GABAA receptor subunit expression in rat CA1 hippocampus: pharmacological and behavioral effects. Neuropharmacology 49, 573-586 (2005)
12. A. Cipriani, T.A. Furukawa, J.R. Geddes, L. Malvini, A. Signoretti, H. McGuire, R. Churchill, A. Nakagawa, C. Barbui, MANGA Study Group: does randomized evidence support sertraline as first-line antidepressant for adults with acute major depression? A systematic review and meta-analysis. J. Clin. Psychiatry 69, 1732-1742 (2008)
13. G. Attali, A. Weizman, I. Gil-Ad, M. Rehavi, Opposite modulatory effects of ovarian hormones on rat brain dopamine and serotonin transporters. Brain Res. 756, 153-159 (1997)
14. S. Benmansour, R.S. Weaver, A.K. Barton, O.S. Adeniji, A. Frazer, Comparison of the effects of estradiol and progesterone on serotonergic function. Biol. Psychiatry 71, 633-641 (2012)
15. S. Campbell, G. Macqueen, An update on regional brain volume differences associated with mood disorders. Curr Opin Psychiatry 19, 25-33 (2006)
16. K.F. Manaye, D.L. Lei, Y. Tizabi, M.I. Dávila-García, P.R. Mouton, P.H. Kelly, Selective neuron loss in the paraventricular nucleus of hypothalamus in patients suffering from major depression and bipolar disorder. J. Neuropathol. Exp. Neurol. 64, 224-229 (2005)
17. A.M. Bao, G. Meynen, D.F. Swaab, The stress system in depression and neurodegeneration: focus on the human hypothalamus. Brain Res. Rev. 57, 531-553 (2008)
18. D.N. Bryant, L.C. Sheldahl, L.K. Marriott, R.A. Shapiro, D.M. Dorsa, Multiple pathways transmit neuroprotective effects of gonadal steroids. Endocrine 29, 199-207 (2006)
19. G.E. Hoffman, I. Merchenthaler, S.L. Zup, Neuroprotection by ovarian hormones in animal models of neurological disease. Endocrine 29, 217-231 (2006)
20. Y. Tokuyama, A.P. Reddy, C.L. Bethea, Neuroprotective actions of ovarian hormones without insult in the raphe region of rhesus macaques. Neuroscience 154, 720-731 (2008)
21. Y. Fan, H. Chen, B. Qiao, L. Luo, H. Ma, H. Li, J. Jiang, D. Niu, Z. Yin, Opposing effects of ERK and p38 MAP kinases on HeLa cell apoptosis induced by dipyrithione. Mol. Cells 23, 30-38 (2007)
22. R.D. Porsolt, G. Anton, N. Blavet, M. Jalfre, Behavioural despair in rats: a new model sensitive to antidepressant treatments. Eur. J. Pharmacol. 47, 379-391 (1978)
23. R.D. Porsolt, Behavioral despair, in Antidepressants: neurochemical, behavioral, and clinical perspectives, ed. by S.J. Enna (Raven Press, New York, 1981), pp. 121-139
24. D. da R. Janner, M.H. Jacob, M.P. Jahn, L.C. Kucharski, M.F. Ribeiro, Dehydroepiandrosterone effects on Akt signaling modulation in central nervous system of young and aged healthy rats. J. Steroid Biochem. Mol. Biol. 122, 142-148 (2010)
25. M.M. Bradford, A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248-254 (1976)
26. R.W. Olsen, H.J. Hanchar, P. Meera, M. Wallner, GABAA receptor subtypes: the "one glass of wine" receptors. Alcohol 41, 201-209 (2007)
27. P. Follesa, F. Biggio, G. Talani, L. Murru, M. Serra, E. Sanna, G. Biggio, Neurosteroids, GABAA receptors, and ethanol dependence. Psychopharmacology 186, 267-280 (2006)
28. J.L. Griffiths, T.A. Lovick, GABAergic neurones in the rat periaqueductal grey matter express alpha4, beta1 and delta GABAA receptor subunits: plasticity of expression during the estrous cycle. Neuroscience 136, 457-466 (2005)
29. F.C. Hsu, R. Waldeck, D.S. Faber, S.S. Smith, Neurosteroid effects on GABAergic synaptic plasticity in hippocampus. J. Neurophysiol. 89, 1929-1940 (2003)
30. M.S. Nin, F.B. Salles, L.A. Azeredo, A.P. Frazon, R. Gomez, H.M. Barros, Antidepressant effect and changes of GABAA receptor gamma2 subunit mRNA after hippocampal administration of allopregnanolone in rats. J. Psychopharmacol. 22, 477-485 (2008)
31. S.S. Smith, Q.H. Gong, F.C. Hsu, R.S. Markowitz, J.M. ffrench-Mullen, X. Li, GABA(A) receptor alpha4 subunit suppression prevents withdrawal properties of an endogenous steroid. Nature 392, 926-930 (1998)
32. R.C. Pierson, A.M. Lyons, L.J. Greenfield Jr., Gonadal steroids regulate GABAA receptor subunit mRNA expression in NT2-N neurons. Brain Res. Mol. Brain Res. 138, 105-115 (2005)
33. A. Kuver, H. Shen, S.S. Smith, Regulation of the surface expression of α4β2δ GABAA receptors by high efficacy states. Brain Res. 1463, 1-20 (2012)
34. N. Sabaliauskas, H. Shen, G.E. Homanics, S.S. Smith, C. Aoki, Knockout of the γ-aminobutyric acid receptor subunit α4 reduces functional δ-containing extrasynaptic receptors in hippocampal pyramidal cells at the onset of puberty. Brain Res. 1450, 11-23 (2012)
35. J. Sarkar, S. Wakefield, G. MacKenzie, S.J. Moss, J. Maguire, Neurosteroidogenesis is required for the physiological response to stress: role of neurosteroid-sensitive GABAA receptors. J. Neurosci. 31, 18198-18210 (2011)
36. E.R. de Kloet, M. Joëls, F. Holsboer, Stress and the brain: from adaptation to disease. Nat. Rev. Neurosci. 6, 463-475 (2005)
37. V. Uzunova, Y. Sheline, J.M. Davis, A. Rasmusson, D.P. Uzunov, E. Costa, A. Guidotti, Increase in the cerebrospinal fluid content of neurosteroids in patients with unipolar major depression who are receiving fluoxetine or fluvoxamine. Proc. Natl. Acad. Sci. USA 95, 3239-3244 (1998)
38. M.S. Nin, L.A. Martinez, F. Pibiri, M. Nelson, G. Pinna, Neurosteroids reduce social isolation-induced behavioral deficits: a proposed link with neurosteroid-mediated upregulation of BDNF expression. Front. Endocrinol. (Lausanne) 2, 73 (2011)
39. N.Z. Lu, A.J. Eshleman, A. Janowsky, C.L. Bethea, Ovarian steroid regulation of serotonin reuptake transporter (SERT) binding, distribution, and function in female macaques. Mol. Psychiatry 8, 353-360 (2003)
40. C.L. Bethea, A.P. Reddy, Y. Tokuyama, J.A. Henderson, F.B. Lima, Protective actions of ovarian hormones in the serotonin system of macaques. Front. Neuroendocrinol. 30, 212-238 (2009)
41. M. Maes, R. Yirmyia, J. Noraberg, S. Brene, J. Hibbeln, G. Perini, M. Kubera, P. Bob, B. Lerer, M. Maj, The inflammatory & neurodegenerative (I&ND) hypothesis of depression: leads for future research and new drug developments in depression. Metab. Brain Dis. 24, 27-53 (2009)
42. C. Guerra-Araiza, M.A. Amorim, R. Pinto-Almazán, A. González-Arenas, M.G. Campos, L.M. Garcia-Segura, Regulation of the phosphoinositide-3 kinase and mitogen-activated protein kinase signaling pathways by progesterone and its reduced metabolites in the rat brain. J. Neurosci. Res. 87, 470-481 (2009)
43. X. Wang, The expanding role of mitochondria in apoptosis. Genes Dev. 15, 2922-2933 (2001)
44. M. Kubera, E. Obuchowicz, L. Goehler, J. Brzeszcz, M. Maes, In animal models, psychosocial stress-induced (neuro)inflammation, apoptosis and reduced neurogenesis are associated to the onset of depression. Prog. Neuropsychopharmacol. Biol. Psychiatry 35, 744-759 (2011)
45. V.D. Nair, C.W. Olanow, Differential modulation of Akt/glycogen synthase kinase-3beta pathway regulates apoptotic and cytoprotective signaling responses. J. Biol. Chem. 283, 15469-15478 (2008)
46. C. Tang, Y.H. Lu, J.H. Xie, F. Wang, J.N. Zou, J.S. Yang, Y.Y. Xing, T. Xi, Downregulation of survivin and activation of caspase-3 through the PI3 K/Akt pathway in ursolic acid-induced HepG2 cell apoptosis. Anticancer Drugs 20, 249-258 (2009)
47. W. Hu, T. Shen, M.H. Wang, Cell cycle arrest and apoptosis induced by methyl 3,5-dicaffeoyl quinate in human colon cancer cells: involvement of the PI3 K/Akt and MAP kinase pathways. Chem. Biol. Interact. 194, 48-57 (2011)