Design and synthesis of nonsteroidal progesterone receptor antagonists based on C,C′-diphenylcarborane scaffold as a hydrophobic pharmacophore

European Journal of Medicinal Chemistry

Volumn 84, Issue , 2014, Pages 264-277

  Fujii, Shinya ^a,b   Yamada, Ayumi ^a   Nakano, Eiichi ^a   Takeuchi, Yuki ^a   Mori, Shuichi ^a   Masuno, Hiroyuki ^a   Kagechika, Hiroyuki ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

Carborane; Hydrophobic pharmacophore; Progesterone receptor (PR); Scaffold

Indexed keywords

1 (3 ACETAMIDOPHENYL) 7 (4 CYANOPHENYL) 1,7 DICARBA CLOSO DODECABORANE; 1 (3 AMINOPHENYL) 7 (4 CYANOPHENYL) 1,7 DICARBA CLOSO DODECABORANE; 1 (3 N METHYLACETAMIDOPHENYL) 7 (4 CYANOPHENYL) 1,7 DICARBA CLOSO DODECABORANE; 1 (3 N METHYLMETHYLSULFONAMIDOPHENYL) 7 (4 CYANOPHENYL) 1,7 DICARBA CLOSO DODECABORANE; 1 (4 ACETAMIDOPHENYL) 2 (4 CYANOPHENYL) 1,2 DICARBA CLOSO DODECABORANE; 1 (4 ACETAMIDOPHENYL) 7 (4 CYANOPHENYL) 1,7 DICARBA CLOSO DODECABORANE; 1 (4 AMINOPHENYL) 2 (4 CYANOPHENYL) 1,2 DICARBA CLOSO DODECABORANE; 1 (4 AMINOPHENYL) 7 (4 CYANOPHENYL) 1,7 DICARBA CLOSO DODECABORANE; 1 (4 BENZENESULFONAMIDOPHENYL) 7 (4 CYANOPHENYL) 1,7 DICARBA CLOSO DODECABORANE; 1 (4 BENZOYLAMINOPHENYL ) 27 (4 CYANOPHENYL) 1,7 DICARBA CLOSO DODECABORANE; 1 (4 BENZOYLAMINOPHENYL) 2 (4 CYANOPHENYL) 1,2 DICARBA CLOSO DODECABORANE; 1 (4 BENZYLOXYCARBONYLAMINOPHENYL) 2 (4 CYANOPHENYL) 1,2 DICARBA CLOSO DODECABORANE; 1 (4 CYANOPHENYL) 1,2 DICARBA CLOSO DODECABORANE; 1 (4 CYANOPHENYL) 2 (4 METHANESULFONYLAMINOPHENYL) 1,2 DICARBA CLOSO DODECABORANE; 1 (4 CYANOPHENYL) 2 (4 METHYLAMINOPHENYL) 1,2 DICARBA CLOSO DODECABORANE; 1 (4 CYANOPHENYL) 2 (4 NITROPHENYL) 1,2 DICARBA CLOSO DODECABORANE; 1 (4 CYANOPHENYL) 7 (3 METHYLSULFONAMIDOPHENYL) 1,7 DICARBA CLOSO DODECABORANE; 1 (4 CYANOPHENYL) 7 (3 NITROPHENYL) 1,7 DICARBA CLOSO DODECABORANE; 1 (4 CYANOPHENYL) 7 (4 METHANESULFONYLAMINOPHENYL) 1,7 DICARBA CLOSO DODECABORANE; 1 (4 CYANOPHENYL) 7 (4 METHYLAMINOPHENYL) 1,7 DICARBA CLOSO DODECABORANE; 1 (4 CYANOPHENYL) 7 (4 N METHYLBENZENESULFONAMIDOPHENYL) 1,7 DICARBA CLOSO DODECABORANE; 1 (4 CYANOPHENYL) 7 (4 N METHYLMETHYLSULFONAMIDOPHENYL) 1,7 DICARBA CLOSO DODECABORANE; 1 (4 CYANOPHENYL) 7 (4 NITROPHENYL) 1,7 DICARBA CLOSO DODECABORANE; 1 (4 CYANOPHENYL) 7 PHENYL 1,7 DICARBA CLOSO DODECABORANE; 1 PHENYL 1,7 DICARBA CLOSO DODECABORANE; 1 {4 (BENZYLOXYCARBONYL)(METHYL)AMINOPHENYL} 2 (4 CYANOPHENYL) 1,2 DICARBA CLOSO DODECARBORANE; ANTIGESTAGEN; CARBORANE DERIVATIVE; MOLECULAR SCAFFOLD; UNCLASSIFIED DRUG; UNINDEXED DRUG; 1-(4-CYANOPHENYL)-7-(4-(N-METHYLACETAMIDO)PHENYL))-1,7-DICARBA-CLOSO-DODECABORANE; ACETANILIDE DERIVATIVE; BORON DERIVATIVE; PROGESTERONE RECEPTOR;

ARTICLE; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HYDROPHOBICITY; IC 50; LIGAND BINDING; PHARMACOPHORE; PHYSIOLOGICAL PROCESS; ANTAGONISTS AND INHIBITORS; CHEMICAL PHENOMENA; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ACETANILIDES; BORON COMPOUNDS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; RECEPTORS, PROGESTERONE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84904535513     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.07.034     Document Type: Article

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