Novel pyrrole-containing progesterone receptor modulators

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 9, 2004, Pages 2185-2189

  Collins, Mark A ^a   Hudak, Valerie ^a   Bender, Reinhold ^a   Fensome, Andrew ^a   Zhang, Puwen ^a   Miller, Lori ^a   Winneker, Richard C ^a   Zhang, Zhiming ^a   Zhu, Yuan ^a   Cohen, Jeffrey ^a   Unwalla, Rayomond J ^a   Wrobel, Jay ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGESTAGEN; PROGESTERONE RECEPTOR; PROGESTERONE RECEPTOR AGONIST; PROGESTERONE RECEPTOR MODULATOR; PYRROLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; PREDICTION; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; SUBSTITUTION REACTION;

BENZOXAZINES; INDOLES; PYRROLES; RECEPTORS, PROGESTERONE;

EID: 11144354665     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.02.054     Document Type: Article

References (13)

1. Mangelsdorf D.J., Thummel C., Beato M., Herrlich P., Schütz G., Umesono K., Blumberg B., Kastner P., Mark M., Chambon P., Evans R.M. Cell. 83:1995;835.
2. Jeppsson S. Acta Obstet. Gynecol. Scand. Suppl. 101:1981;7.
3. O'Connell B.J. Curr. Opin. Pediatr. 7:1995;371.
4. Ulmann A., Peyron R., Silvestre L. Ann. N.Y. Acad. Sci. 761:1995;248.
5. Kekkonen R., Lahteenmaki P., Luukkainen T., Tuominen J. Fertil. Steril. 60:1993;610.
6. (c) Chwalisz, K; Stockemann, K. World patent application WO 96/19997, 1996
7. Lázár G., Lázár G. Jr., Husztik E., Duda E., Agarwal K.K. Ann. N.Y. Acad. Sci. 277:1995;248.
8. Zhang P., Terefenko E.A., Fensome A., Wrobel J., Winneker R., Lundeen S., Marschke K.B., Zhang Z. J. Med. Chem. 45:2002;4379.
9. Fensome A., Bender R., Cohen J., Collins M.A., Mackner V.A., Miller L.L., Ullrich J.W., Winneker R., Wrobel J., Zhang P., Zhang Z., Zhu Y. Bioorg. Med. Chem. Lett. 12:2002;3487.
10. Alvarez A., Guzman A., Ruiz A., Velarde E., Muchowski J.M. J. Org. Chem. 57:1992;1653.
11. Zhang Z., Lundeen S.G., Zhu Y., Caver J.M., Winneker R.C. Steroids. 65:2000;637.
12. Zhang Z., Funk C., Glasser S.R., Mulholland J. Endocrinology. 135:1994;1256.
13. 2, C, 68.31; H, 5.37; N, 14.94. Found, C, 68.41; H, 5.51; N, 14.56.