메뉴 건너뛰기




Volumn 16, Issue 9, 2014, Pages

Current status of molecular biomarkers in endometrial cancer

Author keywords

Biomarker validation; Clinical utility; Endometrial cancer; Gynaecologic cancer; Molecular biomarkers; Predictive biomarkers; Prognostic biomarkers

Indexed keywords

BIOLOGICAL MARKER; CELL ADHESION MOLECULE; EPIDERMAL GROWTH FACTOR RECEPTOR 2; HORMONE RECEPTOR; MOLECULAR MARKER; PROTEIN P53; STATHMIN; TUMOR MARKER; DNA;

EID: 84904516125     PISSN: 15233790     EISSN: 15346269     Source Type: Journal    
DOI: 10.1007/s11912-014-0403-3     Document Type: Review
Times cited : (54)

References (109)
  • 1
    • 84859421288 scopus 로고    scopus 로고
    • Contemporary management of endometrial cancer
    • doi:10.1016/S0140-6736(12)60442-5
    • Wright JD, Barrena Medel NI, Sehouli J, Fujiwara K, Herzog TJ. Contemporary management of endometrial cancer. Lancet. 2012;379(9823):1352-60. doi:10.1016/S0140-6736(12)60442-5.
    • (2012) Lancet , vol.379 , Issue.9823 , pp. 1352-1360
    • Wright, J.D.1    Barrena Medel, N.I.2    Sehouli, J.3    Fujiwara, K.4    Herzog, T.J.5
  • 2
    • 38949108241 scopus 로고    scopus 로고
    • Body-mass index and incidence of cancer: A systematic review and meta-analysis of prospective observational studies
    • DOI 10.1016/S0140-6736(08)60269-X, PII S014067360860269X
    • Renehan AG, Tyson M, Egger M, Heller RF, Zwahlen M. Bodymass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies. Lancet. 2008;371(9612):569-78. doi:10.1016/S0140-6736(08) 60269-X. (Pubitemid 351232031)
    • (2008) The Lancet , vol.371 , Issue.9612 , pp. 569-578
    • Renehan, A.G.1    Tyson, M.2    Egger, M.3    Heller, R.F.4    Zwahlen, M.5
  • 3
    • 84946222849 scopus 로고    scopus 로고
    • Obesity and gynecologic cancer etiology and survival
    • Alexandria: American Society of Clinical Oncology; doi:10.1200/EdBook-AM. 2013.33.e222
    • Webb PM. Obesity and gynecologic cancer etiology and survival. In: 2013 educational book. Alexandria: American Society of Clinical Oncology; 2013. doi:10.1200/EdBook-AM.2013.33.e222.
    • (2013) 2013 Educational Book
    • Webb, P.M.1
  • 4
    • 80051715595 scopus 로고    scopus 로고
    • Trends in endometrial cancer incidence rates in the United States, 1999-2006
    • doi:10.1089/jwh.2010.2529
    • Duong LM, Wilson RJ, Ajani UA, Singh SD, Eheman CR. Trends in endometrial cancer incidence rates in the United States, 1999-2006. J Womens Health. 2011;20(8):1157-63. doi:10.1089/jwh.2010.2529.
    • (2011) J Womens Health , vol.20 , Issue.8 , pp. 1157-1163
    • Duong, L.M.1    Wilson, R.J.2    Ajani, U.A.3    Singh, S.D.4    Eheman, C.R.5
  • 5
    • 80052010923 scopus 로고    scopus 로고
    • Phase II study of temsirolimus in women with recurrent or metastatic endometrial cancer: A trial of the NCIC Clinical Trials Group
    • doi:10.1200/JCO.2010.34.1578
    • Oza AM, Elit L, Tsao MS, Kamel-Reid S, Biagi J, Provencher DM, et al. Phase II study of temsirolimus in women with recurrent or metastatic endometrial cancer: a trial of the NCIC Clinical Trials Group. J Clin Oncol. 2011;29(24):3278-85. doi:10.1200/JCO.2010.34.1578.
    • (2011) J Clin Oncol , vol.29 , Issue.24 , pp. 3278-3285
    • Oza, A.M.1    Elit, L.2    Tsao, M.S.3    Kamel-Reid, S.4    Biagi, J.5    Provencher, D.M.6
  • 6
    • 84864330983 scopus 로고    scopus 로고
    • Markers for individualised therapy in endometrial carcinoma
    • doi:10.1016/S1470-2045(12)70213-9
    • Salvesen HB, Haldorsen IS, Trovik J. Markers for individualised therapy in endometrial carcinoma. Lancet Oncol. 2012;13(8):e353-61. doi:10.1016/S1470- 2045(12)70213-9.
    • (2012) Lancet Oncol , vol.13 , Issue.8
    • Salvesen, H.B.1    Haldorsen, I.S.2    Trovik, J.3
  • 7
    • 0020660717 scopus 로고
    • Two pathogenetic types of endometrial carcinoma
    • DOI 10.1016/0090-8258(83)90111-7
    • Bokhman JV. Two pathogenetic types of endometrial carcinoma. Gynecol Oncol. 1983;15(1):10-7. (Pubitemid 13194678)
    • (1983) Gynecologic Oncology , vol.15 , Issue.1 , pp. 10-17
    • Bokhman, J.V.1
  • 9
    • 0035100888 scopus 로고    scopus 로고
    • Biomarkers and surrogate endpoints: Preferred definitions and conceptual framework
    • Biomarkers Definitions Working G doi:10.1067/mcp.2001.113989
    • Biomarkers Definitions Working G. Biomarkers and surrogate endpoints: preferred definitions and conceptual framework. Clin Pharmacol Ther. 2001;69(3):89-95. doi:10.1067/mcp.2001.113989.
    • (2001) Clin Pharmacol Ther , vol.69 , Issue.3 , pp. 89-95
  • 10
    • 84859607775 scopus 로고    scopus 로고
    • Improved survival related to changes in endometrial cancer treatment, A 30-year population based perspective
    • doi:10.1016/j.ygyno.2012.01.050
    • Trovik J, Mauland KK, Werner HM, Wik E, Helland H, Salvesen HB. Improved survival related to changes in endometrial cancer treatment, a 30-year population based perspective. Gynecol Oncol. 2012;125(2):381-7. doi:10.1016/j.ygyno.2012.01.050.
    • (2012) Gynecol Oncol , vol.125 , Issue.2 , pp. 381-387
    • Trovik, J.1    Mauland, K.K.2    Werner, H.M.3    Wik, E.4    Helland, H.5    Salvesen, H.B.6
  • 11
    • 84883063002 scopus 로고    scopus 로고
    • Diagnostic accuracy of preoperative tests for lymph node status in endometrial cancer: A systematic review
    • doi:10.1102/1470-7330.2013.0032
    • Pelikan HM, Trum JW, Bakers FC, Beets-Tan RG, Smits LJ, Kruitwagen RF. Diagnostic accuracy of preoperative tests for lymph node status in endometrial cancer: a systematic review. Cancer Imaging. 2013;13(3):314-22. doi:10.1102/1470-7330.2013.0032.
    • (2013) Cancer Imaging , vol.13 , Issue.3 , pp. 314-322
    • Pelikan, H.M.1    Trum, J.W.2    Bakers, F.C.3    Beets-Tan, R.G.4    Smits, L.J.5    Kruitwagen, R.F.6
  • 12
    • 78650997227 scopus 로고    scopus 로고
    • Paraaortic lymphadenectomy in themanagement of preoperative grade 1 endometrial cancer confined to the uterine corpus
    • doi:10.1245/s10434-010-1199-5
    • Yoon JH, Yoo SC, Kim WY, Chang SJ, Chang KH, Ryu HS. Paraaortic lymphadenectomy in themanagement of preoperative grade 1 endometrial cancer confined to the uterine corpus. Ann Surg Oncol. 2010;17(12):3234-40. doi:10.1245/s10434-010-1199-5.
    • (2010) Ann Surg Oncol , vol.17 , Issue.12 , pp. 3234-3240
    • Yoon, J.H.1    Yoo, S.C.2    Kim, W.Y.3    Chang, S.J.4    Chang, K.H.5    Ryu, H.S.6
  • 13
    • 57349198710 scopus 로고    scopus 로고
    • Systematic pelvic lymphadenectomy vs. no lymphadenectomy in early-stage endometrial carcinoma: Randomized clinical trial
    • doi:10.1093/jnci/djn397
    • Benedetti Panici P, Basile S, Maneschi F, Alberto Lissoni A, Signorelli M, Scambia G, et al. Systematic pelvic lymphadenectomy vs. no lymphadenectomy in early-stage endometrial carcinoma: randomized clinical trial. J Natl Cancer Inst. 2008;100(23):1707-16. doi:10.1093/jnci/djn397.
    • (2008) J Natl Cancer Inst , vol.100 , Issue.23 , pp. 1707-1716
    • Benedetti Panici, P.1    Basile, S.2    Maneschi, F.3    Alberto Lissoni, A.4    Signorelli, M.5    Scambia, G.6
  • 14
    • 58149191223 scopus 로고    scopus 로고
    • Efficacy of systematic pelvic lymphadenectomy in endometrial cancer (MRC ASTEC trial): A randomised study
    • group As, doi:10.1016/S0140-6736(08)61766-3
    • group As, Kitchener H, Swart AM, Qian Q, Amos C, Parmar MK. Efficacy of systematic pelvic lymphadenectomy in endometrial cancer (MRC ASTEC trial): a randomised study. Lancet. 2009;373(9658):125-36. doi:10.1016/S0140-6736(08) 61766-3.
    • (2009) Lancet , vol.373 , Issue.9658 , pp. 125-136
    • Kitchener, H.1    Swart, A.M.2    Qian, Q.3    Amos, C.4    Parmar, M.K.5
  • 15
  • 16
    • 33750183757 scopus 로고    scopus 로고
    • The incidence of symptomatic lower-extremity lymphedema following treatment of uterine corpus malignancies: A 12-year experience at Memorial Sloan-Kettering Cancer Center
    • DOI 10.1016/j.ygyno.2006.03.055, PII S0090825806003106
    • Abu-Rustum NR, Alektiar K, Iasonos A, Lev G, Sonoda Y, Aghajanian C, et al. The incidence of symptomatic lower-extremity lymphedema following treatment of uterine corpus malignancies: a 12-year experience at Memorial Sloan-Kettering Cancer Center. Gynecol Oncol. 2006;103(2):714-8. doi:10.1016/j.ygyno.2006.03. 055. (Pubitemid 44602163)
    • (2006) Gynecologic Oncology , vol.103 , Issue.2 , pp. 714-718
    • Abu-Rustum, N.R.1    Alektiar, K.2    Iasonos, A.3    Lev, G.4    Sonoda, Y.5    Aghajanian, C.6    Chi, D.S.7    Barakat, R.R.8
  • 17
    • 64049094855 scopus 로고    scopus 로고
    • Revised FIGO staging for carcinoma of the vulva, cervix, and endometrium
    • Pecorelli S.Revised FIGO staging for carcinoma of the vulva, cervix, and endometrium. Int J Gynaecol Obstet. 2009;105(2):103-4.
    • (2009) Int J Gynaecol Obstet , vol.105 , Issue.2 , pp. 103-104
    • Pecorelli, S.1
  • 18
    • 63749130362 scopus 로고    scopus 로고
    • Sentinel lymph node mapping for grade 1 endometrial cancer: Is it the answer to the surgical staging dilemma?
    • doi:10.1016/j.ygyno.2009.01.003
    • Abu-Rustum NR, Khoury-Collado F, Pandit-Taskar N, Soslow RA, Dao F, Sonoda Y, et al. Sentinel lymph node mapping for grade 1 endometrial cancer: is it the answer to the surgical staging dilemma? Gynecol Oncol. 2009;113(2):163-9. doi:10.1016/j.ygyno.2009.01.003.
    • (2009) Gynecol Oncol , vol.113 , Issue.2 , pp. 163-169
    • Abu-Rustum, N.R.1    Khoury-Collado, F.2    Pandit-Taskar, N.3    Soslow, R.A.4    Dao, F.5    Sonoda, Y.6
  • 19
    • 84888287800 scopus 로고    scopus 로고
    • Sentinel lymph nodemapping with pathologic ultrastaging: A valuable tool for assessing nodal metastasis in low-grade endometrial cancer with superficial myoinvasion
    • doi:10.1016/j.ygyno.2013.09.027
    • Kim CH, Khoury-Collado F, Barber EL, Soslow RA, Makker V, Leitao Jr MM, et al. Sentinel lymph nodemapping with pathologic ultrastaging: a valuable tool for assessing nodal metastasis in low-grade endometrial cancer with superficial myoinvasion. Gynecol Oncol. 2013;131(3):714-9. doi:10.1016/j.ygyno.2013.09.027.
    • (2013) Gynecol Oncol , vol.131 , Issue.3 , pp. 714-719
    • Kim, C.H.1    Khoury-Collado, F.2    Barber, E.L.3    Soslow, R.A.4    Makker, V.5    Leitao Jr., M.M.6
  • 20
    • 77956481221 scopus 로고    scopus 로고
    • Does the use of the 2009 FIGO classification of endometrial cancer impact on indications of the sentinel node biopsy?
    • doi:10.1186/1471-2407-10-465
    • Ballester M, Koskas M, Coutant C, Chereau E, Seror J, Rouzier R, et al. Does the use of the 2009 FIGO classification of endometrial cancer impact on indications of the sentinel node biopsy? BMC Cancer. 2010;10:465. doi:10.1186/1471-2407-10-465.
    • (2010) BMC Cancer , vol.10 , pp. 465
    • Ballester, M.1    Koskas, M.2    Coutant, C.3    Chereau, E.4    Seror, J.5    Rouzier, R.6
  • 22
    • 80052411397 scopus 로고    scopus 로고
    • Biomarkers and microsatellite instability analysis of curettings can predict the behavior of FIGO stage I endometrial endometrioid adenocarcinoma
    • doi:10.1038/modpathol.2011.75
    • Steinbakk A, Malpica A, Slewa A, Skaland I, Gudlaugsson E, Janssen EA, et al. Biomarkers and microsatellite instability analysis of curettings can predict the behavior of FIGO stage I endometrial endometrioid adenocarcinoma. Mod Pathol. 2011;24(9):1262-71. doi:10.1038/modpathol.2011.75.
    • (2011) Mod Pathol , vol.24 , Issue.9 , pp. 1262-1271
    • Steinbakk, A.1    Malpica, A.2    Slewa, A.3    Skaland, I.4    Gudlaugsson, E.5    Janssen, E.A.6
  • 23
    • 78650460392 scopus 로고    scopus 로고
    • Stathmin is superior to AKT and phospho-AKT staining for the detection of phosphoinositide 3-kinase activation and aggressive endometrial cancer
    • doi:10.1111/j.1365-2559.2010.03661.x
    • Trovik J, Wik E, Stefansson I, Carter SL, Beroukhim R, Oyan AM, et al. Stathmin is superior to AKT and phospho-AKT staining for the detection of phosphoinositide 3-kinase activation and aggressive endometrial cancer. Histopathology. 2010;57(4):641-6. doi:10.1111/j.1365-2559.2010.03661.x.
    • (2010) Histopathology , vol.57 , Issue.4 , pp. 641-646
    • Trovik, J.1    Wik, E.2    Stefansson, I.3    Carter, S.L.4    Beroukhim, R.5    Oyan, A.M.6
  • 24
    • 84885183578 scopus 로고    scopus 로고
    • Hormone receptor loss in endometrial carcinoma curettage predicts lymph node metastasis and poor outcome in prospective multicentre trial
    • doi:10.1016/j.ejca.2013.06.016
    • Trovik J,Wik E, Werner HM, Krakstad C, Helland H, Vandenput I, et al. Hormone receptor loss in endometrial carcinoma curettage predicts lymph node metastasis and poor outcome in prospective multicentre trial. Eur J Cancer. 2013;49(16):3431-41. doi:10.1016/j.ejca.2013.06.016.
    • (2013) Eur J Cancer , vol.49 , Issue.16 , pp. 3431-3441
    • Trovik, J.1    Wik, E.2    Werner, H.M.3    Krakstad, C.4    Helland, H.5    Vandenput, I.6
  • 25
    • 0030847190 scopus 로고    scopus 로고
    • Value of preoperative CA 125 level in the management of uterine cancer and prediction of clinical outcome
    • DOI 10.1016/S0029-7844(97)00286-X, PII S002978449700286X
    • Sood AK, Buller RE, Burger RA, Dawson JD, Sorosky JI, Berman M. Value of preoperative CA 125 level in the management of uterine cancer and prediction of clinical outcome. Obstet Gynecol. 1997;90(3):441-7. (Pubitemid 27357939)
    • (1997) Obstetrics and Gynecology , vol.90 , Issue.3 , pp. 441-447
    • Sood, A.K.1    Buller, R.E.2    Burger, R.A.3    Dawson, J.D.4    Sorosky, J.I.5    Berman, M.6
  • 26
    • 82455208819 scopus 로고    scopus 로고
    • Advancements in the use of blood tests for cancer screening in women at high risk for endometrial and breast cancer
    • doi:10.2217/fon.11.127
    • Ambeba E, Linkov F. Advancements in the use of blood tests for cancer screening in women at high risk for endometrial and breast cancer. Future Oncol. 2011;7(12):1399-414. doi:10.2217/fon.11.127.
    • (2011) Future Oncol , vol.7 , Issue.12 , pp. 1399-1414
    • Ambeba, E.1    Linkov, F.2
  • 27
    • 84886892919 scopus 로고    scopus 로고
    • HE4 and CA125 levels in the preoperative assessment of endometrial cancer patients: A prospective multicenter study (ENDOMET)
    • doi:10.1111/aogs.12235
    • Antonsen SL, Hogdall E, Christensen IJ, Lydolph M, Tabor A, Loft Jakobsen A, et al. HE4 and CA125 levels in the preoperative assessment of endometrial cancer patients: a prospective multicenter study (ENDOMET). Acta Obstet Gynecol Scand. 2013;92(11):1313-22. doi:10.1111/aogs.12235.
    • (2013) Acta Obstet Gynecol Scand , vol.92 , Issue.11 , pp. 1313-1322
    • Antonsen, S.L.1    Hogdall, E.2    Christensen, I.J.3    Lydolph, M.4    Tabor, A.5    Loft Jakobsen, A.6
  • 28
    • 79960390271 scopus 로고    scopus 로고
    • Elevated plasma growth differentiation factor-15 correlates with lymph node metastases and poor survival in endometrial cancer
    • doi:10.1158/1078-0432.CCR-11-0715
    • Staff AC, Trovik J, Eriksson AG, Wik E, Wollert KC, Kempf T, et al. Elevated plasma growth differentiation factor-15 correlates with lymph node metastases and poor survival in endometrial cancer. Clin Cancer Res. 2011;17(14):4825-33. doi:10.1158/1078-0432.CCR-11-0715.
    • (2011) Clin Cancer Res , vol.17 , Issue.14 , pp. 4825-4833
    • Staff, A.C.1    Trovik, J.2    Eriksson, A.G.3    Wik, E.4    Wollert, K.C.5    Kempf, T.6
  • 29
    • 79951578968 scopus 로고    scopus 로고
    • Three-dimensional ultrasound for assessing women with gynecological cancer: A systematic review
    • doi:10.1016/j.ygyno.2010.10.023
    • Alcazar JL, Jurado M. Three-dimensional ultrasound for assessing women with gynecological cancer: a systematic review. Gynecol Oncol. 2011;120(3):340-6. doi:10.1016/j.ygyno.2010.10.023.
    • (2011) Gynecol Oncol , vol.120 , Issue.3 , pp. 340-346
    • Alcazar, J.L.1    Jurado, M.2
  • 30
    • 84864413436 scopus 로고    scopus 로고
    • Magnetic resonance imaging performs better than endocervical curettage for preoperative prediction of cervical stromal invasion in endometrial carcinomas
    • doi:10.1016/j.ygyno.2012.05.009
    • Haldorsen IS, Berg A, Werner HM, Magnussen IJ, Helland H, Salvesen OO, et al. Magnetic resonance imaging performs better than endocervical curettage for preoperative prediction of cervical stromal invasion in endometrial carcinomas. Gynecol Oncol. 2012;126(3):413-8. doi:10.1016/j.ygyno.2012.05.009.
    • (2012) Gynecol Oncol , vol.126 , Issue.3 , pp. 413-418
    • Haldorsen, I.S.1    Berg, A.2    Werner, H.M.3    Magnussen, I.J.4    Helland, H.5    Salvesen, O.O.6
  • 31
    • 84655161371 scopus 로고    scopus 로고
    • Staging of endometrial carcinomas with MRI using traditional and novel MRI techniques
    • doi:10.1016/j.crad.2011.02.018
    • Haldorsen IS, Salvesen HB. Staging of endometrial carcinomas with MRI using traditional and novel MRI techniques. Clin Radiol. 2012;67(1):2-12. doi:10.1016/j.crad.2011.02.018.
    • (2012) Clin Radiol , vol.67 , Issue.1 , pp. 2-12
    • Haldorsen, I.S.1    Salvesen, H.B.2
  • 32
    • 84872864383 scopus 로고    scopus 로고
    • MRI, PET/CT and ultrasound in the preoperative staging of endometrial cancer - A multicenter prospective comparative study
    • doi:10.1016/j.ygyno.2012.11.025
    • Antonsen SL, Jensen LN, Loft A, Berthelsen AK, Costa J, Tabor A, et al. MRI, PET/CT and ultrasound in the preoperative staging of endometrial cancer - a multicenter prospective comparative study. Gynecol Oncol. 2013;128(2):300-8. doi:10.1016/j.ygyno.2012.11.025.
    • (2013) Gynecol Oncol , vol.128 , Issue.2 , pp. 300-308
    • Antonsen, S.L.1    Jensen, L.N.2    Loft, A.3    Berthelsen, A.K.4    Costa, J.5    Tabor, A.6
  • 33
    • 54849432745 scopus 로고    scopus 로고
    • GATA3 expression in estrogen receptor alpha-negative endometrial carcinomas identifies aggressive tumors with high proliferation and poor patient survival
    • doi:10.1016/j.ajog.2008.04.043
    • Engelsen IB, Stefansson IM, Akslen LA, Salvesen HB. GATA3 expression in estrogen receptor alpha-negative endometrial carcinomas identifies aggressive tumors with high proliferation and poor patient survival. Am J Obstet Gynecol. 2008;199(5):543.e1-7. doi:10.1016/j.ajog.2008.04.043.
    • (2008) Am J Obstet Gynecol , vol.199 , Issue.5
    • Engelsen, I.B.1    Stefansson, I.M.2    Akslen, L.A.3    Salvesen, H.B.4
  • 34
    • 60449115147 scopus 로고    scopus 로고
    • Expression of estrogen receptor-alpha and -beta and progesterone receptor-A and -B in a large cohort of patients with endometrioid endometrial cancer
    • doi:10.1016/j.ygyno.2008.10.032
    • Jongen V, Briet J, de Jong R, ten Hoor K, Boezen M, van der Zee A, et al. Expression of estrogen receptor-alpha and -beta and progesterone receptor-A and -B in a large cohort of patients with endometrioid endometrial cancer. Gynecol Oncol. 2009;112(3):537-42. doi:10.1016/j.ygyno.2008.10.032.
    • (2009) Gynecol Oncol , vol.112 , Issue.3 , pp. 537-542
    • Jongen, V.1    Briet, J.2    De Jong, R.3    Ten Hoor, K.4    Boezen, M.5    Van Der Zee, A.6
  • 35
    • 33748805531 scopus 로고    scopus 로고
    • Pathologic expression of p53 or p16 in preoperative curettage specimens identifies high-risk endometrial carcinomas
    • DOI 10.1016/j.ajog.2006.02.045, PII S0002937806002894
    • Engelsen IB, Stefansson I, Akslen LA, Salvesen HB. Pathologic expression of p53 or p16 in preoperative curettage specimens identifies high-risk endometrial carcinomas. Am J Obstet Gynecol. 2006;195(4):979-86. doi:10.1016/j.ajog.2006.02.045. (Pubitemid 44415644)
    • (2006) American Journal of Obstetrics and Gynecology , vol.195 , Issue.4 , pp. 979-986
    • Engelsen, I.B.1    Stefansson, I.2    Akslen, L.A.3    Salvesen, H.B.4
  • 36
    • 84871121234 scopus 로고    scopus 로고
    • Molecular pathology of endometrial carcinoma
    • doi:10.1111/his.12053
    • Matias-Guiu X, Prat J. Molecular pathology of endometrial carcinoma. Histopathology. 2013;62(1):111-23. doi:10.1111/his.12053.
    • (2013) Histopathology , vol.62 , Issue.1 , pp. 111-123
    • Matias-Guiu, X.1    Prat, J.2
  • 37
    • 73949154691 scopus 로고    scopus 로고
    • p53 overexpression in morphologically ambiguous endometrial carcinomas correlates with adverse clinical outcomes
    • doi:10.1038/modpathol.2009.153
    • Garg K, Leitao Jr MM, Wynveen CA, Sica GL, Shia J, Shi W, et al. p53 overexpression in morphologically ambiguous endometrial carcinomas correlates with adverse clinical outcomes. Mod Pathol. 2010;23(1):80-92. doi:10.1038/modpathol.2009.153.
    • (2010) Mod Pathol , vol.23 , Issue.1 , pp. 80-92
    • Garg, K.1    Leitao Jr., M.M.2    Wynveen, C.A.3    Sica, G.L.4    Shia, J.5    Shi, W.6
  • 38
    • 84867400480 scopus 로고    scopus 로고
    • DNA ploidy may be a prognostic marker in stage I and II serous adenocarcinoma of the endometrium
    • doi:10.1007/s00428-012-1275-2
    • Pradhan M, Davidson B, Abeler VM, Danielsen HE, Trope CG, Kristensen GB, et al. DNA ploidy may be a prognostic marker in stage I and II serous adenocarcinoma of the endometrium. Virchows Arch. 2012;461(3):291-8. doi:10.1007/s00428-012-1275-2.
    • (2012) Virchows Arch , vol.461 , Issue.3 , pp. 291-298
    • Pradhan, M.1    Davidson, B.2    Abeler, V.M.3    Danielsen, H.E.4    Trope, C.G.5    Kristensen, G.B.6
  • 39
    • 50349102805 scopus 로고    scopus 로고
    • Aneuploidy predicts outcome in patients with endometrial carcinoma and is related to lack of CDH13 hypermethylation
    • doi:10.1158/1078-0432.CCR-07-4609
    • Suehiro Y, Okada T,Okada T, Anno K, Okayama N, Ueno K, et al. Aneuploidy predicts outcome in patients with endometrial carcinoma and is related to lack of CDH13 hypermethylation. Clin Cancer Res. 2008;14(11):3354-61. doi:10.1158/1078-0432.CCR-07-4609.
    • (2008) Clin Cancer Res , vol.14 , Issue.11 , pp. 3354-3361
    • Suehiro, Y.1    Okada, T.2    Okada, T.3    Anno, K.4    Okayama, N.5    Ueno, K.6
  • 40
    • 33847385938 scopus 로고    scopus 로고
    • Ten-year results of a prospective study on the prognostic role of ploidy in endometrial carcinoma: DNA aneuploidy identifies high-risk cases among the so-called 'low-risk' patients with well and moderately differentiated tumors
    • DOI 10.1002/cncr.22465
    • Susini T, Amunni G, Molino C, Carriero C, Rapi S, Branconi F, et al. Ten-year results of a prospective study on the prognostic role of ploidy in endometrial carcinoma: dNA aneuploidy identifies high-risk cases among the so-called 'low-risk' patients with well and moderately differentiated tumors. Cancer. 2007;109(5):882-90. doi:10.1002/cncr.22465. (Pubitemid 46333530)
    • (2007) Cancer , vol.109 , Issue.5 , pp. 882-890
    • Susini, T.1    Amunni, G.2    Molino, C.3    Carriero, C.4    Rapi, S.5    Branconi, F.6    Marchionni, M.7    Taddei, G.8    Scarselli, G.9
  • 41
    • 70749115766 scopus 로고    scopus 로고
    • Deoxyribonucleic acid ploidy in endometrial carcinoma: A reproducible and valid prognosticmarker in a routine diagnostic setting
    • doi:10.1016/j.ajog.2009.07.029
    • Wik E, Trovik J, Iversen OE, Engelsen IB, Stefansson IM, Vestrheim LC, et al. Deoxyribonucleic acid ploidy in endometrial carcinoma: a reproducible and valid prognosticmarker in a routine diagnostic setting. Am J Obstet Gynecol. 2009;201(6):603.e1-7. doi:10.1016/j.ajog.2009.07.029.
    • (2009) Am J Obstet Gynecol , vol.201 , Issue.6
    • Wik, E.1    Trovik, J.2    Iversen, O.E.3    Engelsen, I.B.4    Stefansson, I.M.5    Vestrheim, L.C.6
  • 42
    • 84874852214 scopus 로고    scopus 로고
    • Lack of estrogen receptor-alpha is associated with epithelial-mesenchymal transition and PI3K alterations in endometrial carcinoma
    • doi:10.1158/1078-0432.CCR-12-3039
    • Wik E, Raeder MB, Krakstad C, Trovik J, Birkeland E, Hoivik EA, et al. Lack of estrogen receptor-alpha is associated with epithelial-mesenchymal transition and PI3K alterations in endometrial carcinoma. Clin Cancer Res. 2013;19(5):1094-105. doi:10.1158/1078-0432.CCR-12-3039.
    • (2013) Clin Cancer Res , vol.19 , Issue.5 , pp. 1094-1105
    • Wik, E.1    Raeder, M.B.2    Krakstad, C.3    Trovik, J.4    Birkeland, E.5    Hoivik, E.A.6
  • 43
    • 84898436511 scopus 로고    scopus 로고
    • Clinical value of DNA content assessment in endometrial cancer
    • doi:10.1002/cyto.b.21164
    • Mauland KK, Wik E, Salvesen HB. Clinical value of DNA content assessment in endometrial cancer. Cytom Part B. 2014;86(3):154-63. doi:10.1002/cyto.b. 21164.
    • (2014) Cytom Part B , vol.86 , Issue.3 , pp. 154-163
    • Mauland, K.K.1    Wik, E.2    Salvesen, H.B.3
  • 45
    • 84860771546 scopus 로고    scopus 로고
    • Loss of GPER identifies new targets for therapy among a subgroup of ERalpha-positive endometrial cancer patients with poor outcome
    • doi:10.1038/bjc.2012.91. Evaluation of hormone receptor status can potentially improve patient selection for endocrine treatment in endometrial cancer. This study shows that G-protein-coupled OR, an alternative OR, predicts poor survival in an OR-positive subgroup. The significant increase in biomarker loss from primary to metastatic disease may be important
    • .• Krakstad C, Trovik J, Wik E, Engelsen IB, Werner HM, Birkeland E, et al. Loss of GPER identifies new targets for therapy among a subgroup of ERalpha-positive endometrial cancer patients with poor outcome. Br J Cancer. 2012;106(10):1682-8. doi:10.1038/bjc.2012.91. Evaluation of hormone receptor status can potentially improve patient selection for endocrine treatment in endometrial cancer. This study shows that G-protein-coupled OR, an alternative OR, predicts poor survival in an OR-positive subgroup. The significant increase in biomarker loss from primary to metastatic disease may be important.
    • (2012) Br J Cancer , vol.106 , Issue.10 , pp. 1682-1688
    • Krakstad, C.1    Trovik, J.2    Wik, E.3    Engelsen, I.B.4    Werner, H.M.5    Birkeland, E.6
  • 46
    • 63849308483 scopus 로고    scopus 로고
    • Integrated genomic profiling of endometrial carcinoma associates aggressive tumors with indicators of PI3 kinase activation
    • doi:10.1073/pnas.0806514106
    • Salvesen HB, Carter SL, Mannelqvist M, Dutt A, Getz G, Stefansson IM, et al. Integrated genomic profiling of endometrial carcinoma associates aggressive tumors with indicators of PI3 kinase activation. Proc Natl Acad Sci U S A. 2009;106(12):4834-9. doi:10.1073/pnas.0806514106.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , Issue.12 , pp. 4834-4839
    • Salvesen, H.B.1    Carter, S.L.2    Mannelqvist, M.3    Dutt, A.4    Getz, G.5    Stefansson, I.M.6
  • 47
    • 79958820962 scopus 로고    scopus 로고
    • PIK3R1 (p85alpha) is somatically mutated at high frequency in primary endometrial cancer
    • doi:10.1158/0008-5472.CAN-11-0549
    • Urick ME, Rudd ML, Godwin AK, Sgroi D, Merino M, Bell DW. PIK3R1 (p85alpha) is somatically mutated at high frequency in primary endometrial cancer. Cancer Res. 2011;71(12):4061-7. doi:10.1158/0008-5472.CAN-11-0549.
    • (2011) Cancer Res , vol.71 , Issue.12 , pp. 4061-4067
    • Urick, M.E.1    Rudd, M.L.2    Godwin, A.K.3    Sgroi, D.4    Merino, M.5    Bell, D.W.6
  • 48
    • 80054778946 scopus 로고    scopus 로고
    • High frequency of PIK3R1 and PIK3R2 mutations in endometrial cancer elucidates a novel mechanism for regulation of PTEN protein stability
    • doi:10.1158/2159-8290.CD-11-0039
    • Cheung LW, Hennessy BT, Li J, Yu S, Myers AP, Djordjevic B, et al. High frequency of PIK3R1 and PIK3R2 mutations in endometrial cancer elucidates a novel mechanism for regulation of PTEN protein stability. Cancer Discov. 2011;1(2):170-85. doi:10.1158/2159-8290.CD-11-0039.
    • (2011) Cancer Discov , vol.1 , Issue.2 , pp. 170-185
    • Cheung, L.W.1    Hennessy, B.T.2    Li, J.3    Yu, S.4    Myers, A.P.5    Djordjevic, B.6
  • 49
    • 84877254190 scopus 로고    scopus 로고
    • Integrated genomic characterization of endometrial carcinoma
    • Cancer Genome Atlas Research Network doi:10.1038/nature12113
    • Cancer Genome Atlas Research Network. Integrated genomic characterization of endometrial carcinoma. Nature. 2013;497(7447):67-73. doi:10.1038/ nature12113.
    • (2013) Nature , vol.497 , Issue.7447 , pp. 67-73
  • 50
    • 0034651530 scopus 로고    scopus 로고
    • The frequency of p53, K-ras mutations, and microsatellite instability differs in uterine endometrioid and serous carcinoma: Evidence of distinct molecular genetic pathways
    • DOI 10.1002/(SICI)1097-0142(20000215)88:4<814::AID
    • Lax SF, Kendall B, Tashiro H, Slebos RJ, Hedrick L. The frequency of p53, K-ras mutations, and microsatellite instability differs in uterine endometrioid and serous carcinoma: evidence of distinct molecular genetic pathways. Cancer. 2000;88(4):814-24. (Pubitemid 30091101)
    • (2000) Cancer , vol.88 , Issue.4 , pp. 814-824
    • Lax, S.F.1    Kendall, B.2    Tashiro, H.3    Slebos, R.J.C.4    Ellenson, L.H.5
  • 51
    • 0034667718 scopus 로고    scopus 로고
    • Clinical significance of microsatellite instability in endometrial carcinoma
    • Basil JB, Goodfellow PJ, Rader JS, Mutch DG, Herzog TJ. Clinical significance of microsatellite instability in endometrial carcinoma. Cancer. 2000;89(8):1758-64.
    • (2000) Cancer , vol.89 , Issue.8 , pp. 1758-1764
    • Basil, J.B.1    Goodfellow, P.J.2    Rader, J.S.3    Mutch, D.G.4    Herzog, T.J.5
  • 52
    • 63949083916 scopus 로고    scopus 로고
    • Concomitant PI3KAKT and p53 alterations in endometrial carcinomas are associated with poor prognosis
    • doi:10.1038/modpathol.2009.5
    • Catasus L, Gallardo A, Cuatrecasas M, Prat J. Concomitant PI3KAKT and p53 alterations in endometrial carcinomas are associated with poor prognosis. Mod Pathol. 2009;22(4):522-9. doi:10.1038/modpathol.2009.5.
    • (2009) Mod Pathol , vol.22 , Issue.4 , pp. 522-529
    • Catasus, L.1    Gallardo, A.2    Cuatrecasas, M.3    Prat, J.4
  • 53
    • 33744828734 scopus 로고    scopus 로고
    • HER-2 is an independent prognostic factor in endometrial cancer: Association with outcome in a large cohort of surgically staged patients
    • DOI 10.1200/JCO.2005.03.4827
    • Morrison C, Zanagnolo V, Ramirez N, Cohn DE, Kelbick N, Copeland L, et al. HER-2 is an independent prognostic factor in endometrial cancer: association with outcome in a large cohort of surgically staged patients. J Clin Oncol. 2006;24(15):2376-85. doi:10.1200/JCO.2005.03.4827. (Pubitemid 46630670)
    • (2006) Journal of Clinical Oncology , vol.24 , Issue.15 , pp. 2376-2385
    • Morrison, C.1    Zanagnolo, V.2    Ramirez, N.3    Cohn, D.E.4    Kelbick, N.5    Copeland, L.6    Maxwell, L.G.7    Fowler, J.M.8
  • 54
    • 84872164766 scopus 로고    scopus 로고
    • Prognostic impact of EMT (epithelial-mesenchymal-transition)-related protein expression in endometrial cancer
    • doi:10.4161/cbt.22625
    • Tanaka Y, Terai Y, Kawaguchi H, Fujiwara S, Yoo S, Tsunetoh S, et al. Prognostic impact of EMT (epithelial-mesenchymal-transition)-related protein expression in endometrial cancer. Cancer Biol Ther. 2013;14(1):13-9. doi:10.4161/cbt.22625.
    • (2013) Cancer Biol Ther , vol.14 , Issue.1 , pp. 13-19
    • Tanaka, Y.1    Terai, Y.2    Kawaguchi, H.3    Fujiwara, S.4    Yoo, S.5    Tsunetoh, S.6
  • 55
    • 78650451402 scopus 로고    scopus 로고
    • Prognostic value of E-cadherin expression and CDH1 promoter methylation in patients with endometrial carcinoma
    • doi:10.3109/07357907.2010.512603
    • Yi TZ, Guo J, Zhou L, Chen X, Mi RR, Qu QX, et al. Prognostic value of E-cadherin expression and CDH1 promoter methylation in patients with endometrial carcinoma. Cancer Investig. 2011;29(1):86-92. doi:10.3109/07357907.2010.512603.
    • (2011) Cancer Investig , vol.29 , Issue.1 , pp. 86-92
    • Yi, T.Z.1    Guo, J.2    Zhou, L.3    Chen, X.4    Mi, R.R.5    Qu, Q.X.6
  • 57
    • 84857549430 scopus 로고    scopus 로고
    • FGFR2 point mutations in 466 endometrioid endometrial tumors: Relationship with MSI, KRAS, PIK3CA, CTNNB1 mutations and clinicopathological features
    • doi:10.1371/journal.pone.0030801
    • Byron SA, Gartside M, Powell MA, Wellens CL, Gao F, Mutch DG, et al. FGFR2 point mutations in 466 endometrioid endometrial tumors: relationship with MSI, KRAS, PIK3CA, CTNNB1 mutations and clinicopathological features. PLoS One. 2012;7(2):e30801. doi:10.1371/journal.pone.0030801.
    • (2012) PLoS One , vol.7 , Issue.2
    • Byron, S.A.1    Gartside, M.2    Powell, M.A.3    Wellens, C.L.4    Gao, F.5    Mutch, D.G.6
  • 58
    • 84870777479 scopus 로고    scopus 로고
    • KRAS gene amplification and overexpression but not mutation associates with aggressive and metastatic endometrial cancer
    • doi:10.1038/bjc.2012.477
    • Birkeland E, Wik E, Mjos S, Hoivik EA, Trovik J, Werner HM, et al. KRAS gene amplification and overexpression but not mutation associates with aggressive and metastatic endometrial cancer. Br J Cancer. 2012;107(12):1997- 2004. doi:10.1038/bjc.2012.477.
    • (2012) Br J Cancer , vol.107 , Issue.12 , pp. 1997-2004
    • Birkeland, E.1    Wik, E.2    Mjos, S.3    Hoivik, E.A.4    Trovik, J.5    Werner, H.M.6
  • 59
    • 2142760943 scopus 로고    scopus 로고
    • Prognostic impact of alterations in P-cadherin expression and related cell adhesion markers in endometrial cancer
    • DOI 10.1200/JCO.2004.09.034
    • Stefansson IM, Salvesen HB, Akslen LA. Prognostic impact of alterations in P-cadherin expression and related cell adhesion markers in endometrial cancer. J Clin Oncol. 2004;22(7):1242-52. doi:10.1200/JCO.2004.09.034. (Pubitemid 41079838)
    • (2004) Journal of Clinical Oncology , vol.22 , Issue.7 , pp. 1242-1252
    • Stefansson, I.M.1    Salvesen, H.B.2    Akslen, L.A.3
  • 60
    • 84865486066 scopus 로고    scopus 로고
    • Does the loss of ARID1A (BAF-250a) expression in endometrial clear cell carcinomas have any clinicopathologic significance? A pilot assessment
    • doi:10.7150/jca.4140
    • Fadare O, Renshaw IL, Liang SX. Does the loss of ARID1A (BAF-250a) expression in endometrial clear cell carcinomas have any clinicopathologic significance? A pilot assessment. J Cancer. 2012;3:129-36. doi:10.7150/jca.4140.
    • (2012) J Cancer , vol.3 , pp. 129-136
    • Fadare, O.1    Renshaw, I.L.2    Liang, S.X.3
  • 61
    • 79958238185 scopus 로고    scopus 로고
    • Loss of BAF250a (ARID1A) is frequent in high-grade endometrial carcinomas
    • doi:10.1002/path.2911
    • Wiegand KC, Lee AF, Al-Agha OM, Chow C, Kalloger SE, Scott DW, et al. Loss of BAF250a (ARID1A) is frequent in high-grade endometrial carcinomas. J Pathol. 2011;224(3):328-33. doi:10.1002/path.2911.
    • (2011) J Pathol , vol.224 , Issue.3 , pp. 328-333
    • Wiegand, K.C.1    Lee, A.F.2    Al-Agha, O.M.3    Chow, C.4    Kalloger, S.E.5    Scott, D.W.6
  • 62
    • 84875218081 scopus 로고    scopus 로고
    • ARID1A loss is prevalent in endometrial hyperplasia with atypia and low-grade endometrioid carcinomas
    • doi:10.1038/modpathol.2012.174
    • Werner HM, Berg A, Wik E, Birkeland E, Krakstad C, Kusonmano K, et al. ARID1A loss is prevalent in endometrial hyperplasia with atypia and low-grade endometrioid carcinomas. Mod Pathol. 2013;26(3):428-34. doi:10.1038/modpathol. 2012.174.
    • (2013) Mod Pathol , vol.26 , Issue.3 , pp. 428-434
    • Werner, H.M.1    Berg, A.2    Wik, E.3    Birkeland, E.4    Krakstad, C.5    Kusonmano, K.6
  • 63
    • 79956000555 scopus 로고    scopus 로고
    • Stathmin overexpression identifies high-risk patients and lymph node metastasis in endometrial cancer
    • doi:10.1158/1078-0432.CCR-10-2412
    • Trovik J, Wik E, Stefansson IM, Marcickiewicz J, Tingulstad S, Staff AC, et al. Stathmin overexpression identifies high-risk patients and lymph node metastasis in endometrial cancer. Clin Cancer Res. 2011;17(10):3368-77. doi:10.1158/1078-0432.CCR-10-2412.
    • (2011) Clin Cancer Res , vol.17 , Issue.10 , pp. 3368-3377
    • Trovik, J.1    Wik, E.2    Stefansson, I.M.3    Marcickiewicz, J.4    Tingulstad, S.5    Staff, A.C.6
  • 64
    • 84881657484 scopus 로고    scopus 로고
    • L1CAMin early-stage type I endometrial cancer: Results of a large multicenter evaluation
    • doi:10.1093/jnci/djt144. Although only published recently and so far in only one study, L1 cell adhesion molecule seems a very promising prognostic biomarker that may help to select those type 1 stage 1 endometrial cancer patients who need adjuvant treatment. Validation studies, also focused on the biological rationale, are needed
    • .• Zeimet AG, Reimer D, Huszar M, Winterhoff B, Puistola U, Azim SA, et al. L1CAMin early-stage type I endometrial cancer: results of a large multicenter evaluation. J Natl Cancer Inst. 2013;105(15):1142-50. doi:10.1093/jnci/djt144. Although only published recently and so far in only one study, L1 cell adhesion molecule seems a very promising prognostic biomarker that may help to select those type 1 stage 1 endometrial cancer patients who need adjuvant treatment. Validation studies, also focused on the biological rationale, are needed.
    • (2013) J Natl Cancer Inst , vol.105 , Issue.15 , pp. 1142-1150
    • Zeimet, A.G.1    Reimer, D.2    Huszar, M.3    Winterhoff, B.4    Puistola, U.5    Azim, S.A.6
  • 65
    • 84892817677 scopus 로고    scopus 로고
    • Serum HE4 as a prognostic marker in endometrial cancer - A population based study
    • doi:10.1016/j.ygyno.2013.10.036
    • Brennan DJ, Hackethal A, Metcalf AM, Coward J, Ferguson K, Oehler MK, et al. Serum HE4 as a prognostic marker in endometrial cancer - a population based study. Gynecol Oncol. 2014;132(1):159-65. doi:10.1016/j.ygyno.2013.10.036.
    • (2014) Gynecol Oncol , vol.132 , Issue.1 , pp. 159-165
    • Brennan, D.J.1    Hackethal, A.2    Metcalf, A.M.3    Coward, J.4    Ferguson, K.5    Oehler, M.K.6
  • 66
    • 84862544682 scopus 로고    scopus 로고
    • The utility of serum CA-125 in predicting extra-uterine disease in apparent early-stage endometrial cancer
    • doi:10.1002/ijc.26433
    • Nicklin J, Janda M, Gebski V, Jobling T, Land R, Manolitsas T, et al. The utility of serum CA-125 in predicting extra-uterine disease in apparent early-stage endometrial cancer. Int J Cancer. 2012;131(4):885-90. doi:10.1002/ijc.26433.
    • (2012) Int J Cancer , vol.131 , Issue.4 , pp. 885-890
    • Nicklin, J.1    Janda, M.2    Gebski, V.3    Jobling, T.4    Land, R.5    Manolitsas, T.6
  • 67
    • 84862886235 scopus 로고    scopus 로고
    • HE4 is an independent prognostic marker in endometrial cancer patients
    • doi:10.1016/j.ygyno.2012.04.022
    • Mutz-Dehbalaie I, Egle D, Fessler S, Hubalek M, Fiegl H, Marth C, et al. HE4 is an independent prognostic marker in endometrial cancer patients. Gynecol Oncol. 2012;126(2):186-91. doi:10.1016/j.ygyno.2012.04.022.
    • (2012) Gynecol Oncol , vol.126 , Issue.2 , pp. 186-191
    • Mutz-Dehbalaie, I.1    Egle, D.2    Fessler, S.3    Hubalek, M.4    Fiegl, H.5    Marth, C.6
  • 68
    • 84872867358 scopus 로고    scopus 로고
    • Human epididymis protein 4 as a serum marker for diagnosis of endometrial carcinoma and prediction of clinical outcome
    • doi:10.1515/cclm-2011-0757
    • Zanotti L, Bignotti E, Calza S, Bandiera E, Ruggeri G, Galli C, et al. Human epididymis protein 4 as a serum marker for diagnosis of endometrial carcinoma and prediction of clinical outcome. Clin Chem Lab Med. 2012;50(12):2189-98. doi:10.1515/cclm-2011-0757.
    • (2012) Clin Chem Lab Med , vol.50 , Issue.12 , pp. 2189-2198
    • Zanotti, L.1    Bignotti, E.2    Calza, S.3    Bandiera, E.4    Ruggeri, G.5    Galli, C.6
  • 69
    • 0021688634 scopus 로고
    • The neu oncogene: An erb-B-related gene encoding a 185,000-M(r) tumour antigen
    • DOI 10.1038/312513a0
    • Schechter AL, Stern DF, Vaidyanathan L, Decker SJ, Drebin JA, Greene MI, et al. The neu oncogene: an erb-B-related gene encoding a 185,000-Mr tumour antigen. Nature. 1984;312(5994):513-6. (Pubitemid 15182278)
    • (1984) Nature , vol.312 , Issue.5994 , pp. 513-516
    • Schechter, A.L.1    Stern, D.F.2    Vaidyanathan, L.3
  • 70
    • 84905716593 scopus 로고    scopus 로고
    • Food and Drug Administration. Drugs. http://www.fda.gov/Drugs (2014).
    • (2014) Drugs
  • 71
    • 33846995628 scopus 로고    scopus 로고
    • Economics of new oncology drug development
    • DOI 10.1200/JCO.2006.09.0803
    • DiMasi JA, Grabowski HG. Economics of new oncology drug development. J Clin Oncol. 2007;25(2):209-16. doi:10.1200/JCO.2006.09.0803. (Pubitemid 350003036)
    • (2007) Journal of Clinical Oncology , vol.25 , Issue.2 , pp. 209-216
    • DiMasi, J.A.1    Grabowski, H.G.2
  • 72
    • 69249162912 scopus 로고    scopus 로고
    • Systemic therapy for recurrent endometrial cancer: A review of North American trials
    • doi:10.1586/era.09.54
    • Dellinger TH, Monk BJ. Systemic therapy for recurrent endometrial cancer: a review of North American trials. Expert Rev Anticancer Ther. 2009;9(7):905-16. doi:10.1586/era.09.54.
    • (2009) Expert Rev Anticancer Ther , vol.9 , Issue.7 , pp. 905-916
    • Dellinger, T.H.1    Monk, B.J.2
  • 73
    • 34347395733 scopus 로고    scopus 로고
    • Trastuzumab - Mechanism of action and use in clinical practice
    • DOI 10.1056/NEJMra043186
    • Hudis CA. Trastuzumab-mechanism of action and use in clinical practice. N Engl J Med. 2007;357(1):39-51. doi:10.1056/NEJMra043186. (Pubitemid 47026733)
    • (2007) New England Journal of Medicine , vol.357 , Issue.1 , pp. 39-51
    • Hudis, C.A.1
  • 75
    • 70449711127 scopus 로고    scopus 로고
    • Improved early event-free survival with imatinib in Philadelphia chromosome-positive acute lymphoblastic leukemia: A children's oncology group study
    • doi:10.1200/JCO.2008.21.2514
    • Schultz KR, Bowman WP, Aledo A, Slayton WB, Sather H, Devidas M, et al. Improved early event-free survival with imatinib in Philadelphia chromosome-positive acute lymphoblastic leukemia: a children's oncology group study. J Clin Oncol. 2009;27(31):5175-81. doi:10.1200/JCO.2008.21.2514.
    • (2009) J Clin Oncol , vol.27 , Issue.31 , pp. 5175-5181
    • Schultz, K.R.1    Bowman, W.P.2    Aledo, A.3    Slayton, W.B.4    Sather, H.5    Devidas, M.6
  • 76
    • 84863275566 scopus 로고    scopus 로고
    • High EGFR gene copy number and skin rash as predictive markers for EGFR tyrosine kinase inhibitors in patients with advanced squamous cell lung carcinoma
    • doi:10.1158/1078-0432.CCR-11-2582
    • Lee Y, Shim HS, Park MS, Kim JH, Ha SJ, Kim SH, et al. High EGFR gene copy number and skin rash as predictive markers for EGFR tyrosine kinase inhibitors in patients with advanced squamous cell lung carcinoma. Clin Cancer Res. 2012;18(6):1760- 8. doi:10.1158/1078-0432.CCR-11-2582.
    • (2012) Clin Cancer Res , vol.18 , Issue.6 , pp. 1760-1768
    • Lee, Y.1    Shim, H.S.2    Park, M.S.3    Kim, J.H.4    Ha, S.J.5    Kim, S.H.6
  • 77
    • 79956158534 scopus 로고    scopus 로고
    • Evolution in endometrial cancer: Evidence from an immunohistochemical study
    • doi:10.1097/IGC.0b013e31820575f5
    • Vandenput I, Trovik J, Leunen K, Wik E, Stefansson I, Akslen L, et al. Evolution in endometrial cancer: evidence from an immunohistochemical study. Int J Gynecol Cancer. 2011;21(2):316-22. doi:10.1097/IGC.0b013e31820575f5.
    • (2011) Int J Gynecol Cancer , vol.21 , Issue.2 , pp. 316-322
    • Vandenput, I.1    Trovik, J.2    Leunen, K.3    Wik, E.4    Stefansson, I.5    Akslen, L.6
  • 78
    • 34548700355 scopus 로고    scopus 로고
    • Hormone therapy in advanced and recurrent endometrial cancer: A systematic review
    • DOI 10.1111/j.1525-1438.2007.00897.x
    • Decruze SB, Green JA. Hormone therapy in advanced and recurrent endometrial cancer: a systematic review. Int J Gynecol Cancer. 2007;17(5):964-78. doi:10.1111/j.1525-1438.2007.00897.x. (Pubitemid 47414814)
    • (2007) International Journal of Gynecological Cancer , vol.17 , Issue.5 , pp. 964-978
    • Decruze, S.B.1    Green, J.A.2
  • 79
    • 84893764401 scopus 로고    scopus 로고
    • Molecular determinants of outcome with mammalian target of rapamycin inhibition in endometrial cancer
    • doi:10.1002/cncr.28414. No combination of biomarkers was found to be predictive of mammalian target of rapamycin inhibitor activity in this study using archival tissue from nearly 100 women with recurrent endometrial cancer. The authors call for caution in enriching trials for patients with certain biomarker characteristics
    • .• Mackay HJ, Eisenhauer EA, Kamel-Reid S, Tsao M, Clarke B, Karakasis K, et al. Molecular determinants of outcome with mammalian target of rapamycin inhibition in endometrial cancer. Cancer. 2013. doi:10.1002/cncr. 28414. No combination of biomarkers was found to be predictive of mammalian target of rapamycin inhibitor activity in this study using archival tissue from nearly 100 women with recurrent endometrial cancer. The authors call for caution in enriching trials for patients with certain biomarker characteristics.
    • (2013) Cancer
    • Mackay, H.J.1    Eisenhauer, E.A.2    Kamel-Reid, S.3    Tsao, M.4    Clarke, B.5    Karakasis, K.6
  • 80
    • 84863338519 scopus 로고    scopus 로고
    • PI3K/AKT/mTOR inhibitors in patients with breast and gynecologic malignancies harboring PIK3CA mutations
    • doi:10.1200/JCO.2011.36.1196
    • Janku F, Wheler JJ, Westin SN, Moulder SL, Naing A, Tsimberidou AM, et al. PI3K/AKT/mTOR inhibitors in patients with breast and gynecologic malignancies harboring PIK3CA mutations. J Clin Oncol. 2012;30(8):777-82. doi:10.1200/JCO.2011.36.1196.
    • (2012) J Clin Oncol , vol.30 , Issue.8 , pp. 777-782
    • Janku, F.1    Wheler, J.J.2    Westin, S.N.3    Moulder, S.L.4    Naing, A.5    Tsimberidou, A.M.6
  • 81
    • 84897866380 scopus 로고    scopus 로고
    • Stathmin protein level, A potential predictive marker for taxane treatment response in endometrial cancer
    • doi:10.1371/journal.pone.0090141
    • Werner HM, Trovik J, Halle MK, Wik E, Akslen LA, Birkeland E, et al. Stathmin protein level, a potential predictive marker for taxane treatment response in endometrial cancer. PLoS One. 2014;9(2):e90141. doi:10.1371/journal. pone.0090141.
    • (2014) PLoS One , vol.9 , Issue.2
    • Werner, H.M.1    Trovik, J.2    Halle, M.K.3    Wik, E.4    Akslen, L.A.5    Birkeland, E.6
  • 82
    • 84900435582 scopus 로고    scopus 로고
    • The search continues: Looking for predictive biomarkers for response to Mammalian target of rapamycin inhibition in endometrial cancer
    • doi:10.1097/IGC.0000000000000118
    • Meyer LA, Slomovitz BM, Djordjevic B, Westin SN, Iglesias DA, Munsell MF, et al. The search continues: looking for predictive biomarkers for response to Mammalian target of rapamycin inhibition in endometrial cancer. Int Gynecol Cancer. 2014;24(4):713-7. doi:10.1097/IGC.0000000000000118.
    • (2014) Int Gynecol Cancer , vol.24 , Issue.4 , pp. 713-717
    • Meyer, L.A.1    Slomovitz, B.M.2    Djordjevic, B.3    Westin, S.N.4    Iglesias, D.A.5    Munsell, M.F.6
  • 83
    • 70749097152 scopus 로고    scopus 로고
    • Phase II trial of trastuzumab in women with advanced or recurrent, HER2-positive endometrial carcinoma: A Gynecologic Oncology Group study
    • doi:10.1016/j.ygyno.2009.09.025
    • Fleming GF, Sill MW, Darcy KM, McMeekin DS, Thigpen JT, Adler LM, et al. Phase II trial of trastuzumab in women with advanced or recurrent, HER2-positive endometrial carcinoma: a Gynecologic Oncology Group study. Gynecol Oncol. 2010;116(1):15-20. doi:10.1016/j.ygyno.2009.09.025.
    • (2010) Gynecol Oncol , vol.116 , Issue.1 , pp. 15-20
    • Fleming, G.F.1    Sill, M.W.2    Darcy, K.M.3    McMeekin, D.S.4    Thigpen, J.T.5    Adler, L.M.6
  • 84
    • 84905704872 scopus 로고    scopus 로고
    • NCT01237067 Accessed Apr 2014
    • National Institutes of Health. NCT01237067. 2014. http://clinicaltrials. gov/show/NCT01237067. Accessed Apr 2014.
    • (2014)
  • 85
    • 84864413479 scopus 로고    scopus 로고
    • Improved risk assessment of endometrial cancer by combined analysis of MSI, PI3KAKT, Wnt/β-catenin and P53 pathway activation
    • doi:10.1016/j.ygyno.2012.05.012
    • Nout RA, Bosse T, Creutzberg CL, Jurgenliemk-Schulz IM, Jobsen JJ, Lutgens LC, et al. Improved risk assessment of endometrial cancer by combined analysis of MSI, PI3KAKT, Wnt/β-catenin and P53 pathway activation. Gynecol Oncol. 2012;126(3):466-73. doi:10.1016/j.ygyno.2012.05.012.
    • (2012) Gynecol Oncol , vol.126 , Issue.3 , pp. 466-473
    • Nout, R.A.1    Bosse, T.2    Creutzberg, C.L.3    Jurgenliemk-Schulz, I.M.4    Jobsen, J.J.5    Lutgens, L.C.6
  • 87
    • 84863393080 scopus 로고    scopus 로고
    • Intratumor heterogeneity and branched evolution revealed by multiregion sequencing
    • doi:10.1056/NEJMoa1113205
    • Gerlinger M, Rowan AJ, Horswell S, Larkin J, Endesfelder D, Gronroos E, et al. Intratumor heterogeneity and branched evolution revealed by multiregion sequencing. N Engl J Med. 2012;366(10):883-92. doi:10.1056/NEJMoa1113205.
    • (2012) N Engl J Med , vol.366 , Issue.10 , pp. 883-892
    • Gerlinger, M.1    Rowan, A.J.2    Horswell, S.3    Larkin, J.4    Endesfelder, D.5    Gronroos, E.6
  • 88
    • 84867121875 scopus 로고    scopus 로고
    • Intratumor heterogeneity: Evolution through space and time
    • doi:10.1158/0008-5472.CAN-12-2217
    • Swanton C. Intratumor heterogeneity: evolution through space and time. Cancer Res. 2012;72(19):4875-82. doi:10.1158/0008-5472.CAN-12-2217.
    • (2012) Cancer Res , vol.72 , Issue.19 , pp. 4875-4882
    • Swanton, C.1
  • 89
    • 84886280120 scopus 로고    scopus 로고
    • Marked heterogeneity of HER2/NEU gene amplification in endometrial serous carcinoma
    • doi:10.1002/gcc.22113
    • Buza N, Hui P. Marked heterogeneity of HER2/NEU gene amplification in endometrial serous carcinoma. Genes Chromosomes Cancer. 2013. doi:10.1002/gcc.22113.
    • (2013) Genes Chromosomes Cancer
    • Buza, N.1    Hui, P.2
  • 90
    • 84870002199 scopus 로고    scopus 로고
    • Clinicopathologic analysis of matched primary and recurrent endometrial carcinoma
    • doi:10.1097/PAS.0b013e318273591a
    • Soslow RA, Wethington SL, Cesari M, Chiappetta D, Olvera N, Shia J, et al. Clinicopathologic analysis of matched primary and recurrent endometrial carcinoma. Am J Surg Pathol. 2012;36(12):1771-81. doi:10.1097/PAS. 0b013e318273591a.
    • (2012) Am J Surg Pathol , vol.36 , Issue.12 , pp. 1771-1781
    • Soslow, R.A.1    Wethington, S.L.2    Cesari, M.3    Chiappetta, D.4    Olvera, N.5    Shia, J.6
  • 91
    • 78049459908 scopus 로고    scopus 로고
    • Prospective comparison of switches in biomarker status between primary and recurrent breast cancer: The Breast Recurrence In Tissues Study (BRITS)
    • doi:10.1186/bcr2771
    • Thompson AM, Jordan LB, Quinlan P, Anderson E, Skene A, Dewar JA, et al. Prospective comparison of switches in biomarker status between primary and recurrent breast cancer: the Breast Recurrence In Tissues Study (BRITS). Breast Cancer Res. 2010;12(6):R92. doi:10.1186/bcr2771.
    • (2010) Breast Cancer Res , vol.12 , Issue.6
    • Thompson, A.M.1    Jordan, L.B.2    Quinlan, P.3    Anderson, E.4    Skene, A.5    Dewar, J.A.6
  • 92
    • 78650219264 scopus 로고    scopus 로고
    • Variation in hormone receptor and HER-2 status between primary and metastatic breast cancer: Review of the literature
    • doi:10.1517/14656566.2011.537260
    • Arslan C, Sari E, Aksoy S, Altundag K. Variation in hormone receptor and HER-2 status between primary and metastatic breast cancer: review of the literature. Expert Opin Ther Targets. 2011;15(1):21-30. doi:10.1517/14656566. 2011.537260.
    • (2011) Expert Opin Ther Targets , vol.15 , Issue.1 , pp. 21-30
    • Arslan, C.1    Sari, E.2    Aksoy, S.3    Altundag, K.4
  • 93
    • 79551510050 scopus 로고    scopus 로고
    • The need to examine metastatic tissue at the time of progression of breast cancer: Is re-biopsy a necessity or a luxury?
    • doi:10.1007/s11912-010-0137-9
    • Khasraw M, Brogi E, Seidman AD. The need to examine metastatic tissue at the time of progression of breast cancer: is re-biopsy a necessity or a luxury? Curr Oncol Rep. 2011;13(1):17-25. doi:10.1007/s11912-010-0137-9.
    • (2011) Curr Oncol Rep , vol.13 , Issue.1 , pp. 17-25
    • Khasraw, M.1    Brogi, E.2    Seidman, A.D.3
  • 94
    • 69849090104 scopus 로고    scopus 로고
    • Does confirmatory tumor biopsy alter the management of breast cancer patients with distant metastases?
    • doi:10.1093/annonc/mdp028
    • Simmons C, Miller N, Geddie W, Gianfelice D, Oldfield M, Dranitsaris G, et al. Does confirmatory tumor biopsy alter the management of breast cancer patients with distant metastases? Ann Oncol. 2009;20(9):1499-504. doi:10.1093/annonc/mdp028.
    • (2009) Ann Oncol , vol.20 , Issue.9 , pp. 1499-1504
    • Simmons, C.1    Miller, N.2    Geddie, W.3    Gianfelice, D.4    Oldfield, M.5    Dranitsaris, G.6
  • 96
    • 84864085607 scopus 로고    scopus 로고
    • Clinically used breast cancer markers such as estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 are unstable throughout tumor progression
    • doi:10.1200/JCO.2011.37.2482
    • Lindstrom LS, Karlsson E, Wilking UM, Johansson U, Hartman J, Lidbrink EK, et al. Clinically used breast cancer markers such as estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 are unstable throughout tumor progression. J Clin Oncol. 2012;30(21):2601-8. doi:10.1200/JCO.2011.37.2482.
    • (2012) J Clin Oncol , vol.30 , Issue.21 , pp. 2601-2608
    • Lindstrom, L.S.1    Karlsson, E.2    Wilking, U.M.3    Johansson, U.4    Hartman, J.5    Lidbrink, E.K.6
  • 97
    • 84861699124 scopus 로고    scopus 로고
    • Tissue confirmation of disease recurrence in breast cancer patients: Pooled analysis of multi-centre, multi-disciplinary prospective studies
    • doi:10.1016/j.ctrv.2011.11.006
    • Amir E, Clemons M, Purdie CA, Miller N, Quinlan P, Geddie W, et al. Tissue confirmation of disease recurrence in breast cancer patients: pooled analysis of multi-centre, multi-disciplinary prospective studies. Cancer Treat Rev. 2012;38(6):708-14. doi:10.1016/j.ctrv.2011.11.006.
    • (2012) Cancer Treat Rev , vol.38 , Issue.6 , pp. 708-714
    • Amir, E.1    Clemons, M.2    Purdie, C.A.3    Miller, N.4    Quinlan, P.5    Geddie, W.6
  • 98
    • 84857568955 scopus 로고    scopus 로고
    • Prospective study evaluating the impact of tissue confirmation of metastatic disease in patients with breast cancer
    • doi:10.1200/JCO.2010.33.5232
    • Amir E, Miller N, Geddie W, Freedman O, Kassam F, Simmons C, et al. Prospective study evaluating the impact of tissue confirmation of metastatic disease in patients with breast cancer. J Clin Oncol. 2012;30(6):587-92. doi:10.1200/JCO.2010.33.5232.
    • (2012) J Clin Oncol , vol.30 , Issue.6 , pp. 587-592
    • Amir, E.1    Miller, N.2    Geddie, W.3    Freedman, O.4    Kassam, F.5    Simmons, C.6
  • 99
    • 84896540649 scopus 로고    scopus 로고
    • Evidence of clinical utility: An unmet need in molecular diagnostics for patients with cancer
    • doi:10.1158/1078-0432.CCR-13-2961
    • Parkinson DR, McCormack RT, Keating SM, Gutman SI, Hamilton SR, Mansfield EA, et al. Evidence of clinical utility: an unmet need in molecular diagnostics for patients with cancer. Clin Cancer Res. 2014;20(6):1428-44. doi:10.1158/1078-0432.CCR-13-2961.
    • (2014) Clin Cancer Res , vol.20 , Issue.6 , pp. 1428-1444
    • Parkinson, D.R.1    McCormack, R.T.2    Keating, S.M.3    Gutman, S.I.4    Hamilton, S.R.5    Mansfield, E.A.6
  • 100
    • 84877278637 scopus 로고    scopus 로고
    • Implementing personalized cancer genomics in clinical trials
    • doi:10.1038/nrd3979
    • Simon R, Roychowdhury S. Implementing personalized cancer genomics in clinical trials. Nat Rev Drug Discov. 2013;12(5):358-69. doi:10.1038/nrd3979.
    • (2013) Nat Rev Drug Discov , vol.12 , Issue.5 , pp. 358-369
    • Simon, R.1    Roychowdhury, S.2
  • 101
    • 77949667760 scopus 로고    scopus 로고
    • Guidelines for the development and incorporation of biomarker studies in early clinical trials of novel agents
    • doi:10.1158/1078-0432.CCR-09-2167
    • Dancey JE, Dobbin KK, Groshen S, Jessup JM, Hruszkewycz AH, Koehler M, et al. Guidelines for the development and incorporation of biomarker studies in early clinical trials of novel agents. Clin Cancer Res. 2010;16(6):1745 -55. doi:10.1158/1078-0432.CCR-09-2167.
    • (2010) Clin Cancer Res , vol.16 , Issue.6 , pp. 1745-1755
    • Dancey, J.E.1    Dobbin, K.K.2    Groshen, S.3    Jessup, J.M.4    Hruszkewycz, A.H.5    Koehler, M.6
  • 102
    • 84890281763 scopus 로고    scopus 로고
    • Companion biomarkers: Paving the pathway to personalized treatment for cancer
    • doi:10.1373/clinchem.2012.200477
    • Duffy MJ, Crown J. Companion biomarkers: paving the pathway to personalized treatment for cancer. Clin Chem. 2013;59(10):1447-56. doi:10.1373/clinchem.2012.200477.
    • (2013) Clin Chem , vol.59 , Issue.10 , pp. 1447-1456
    • Duffy, M.J.1    Crown, J.2
  • 103
    • 79957789708 scopus 로고    scopus 로고
    • Comparison of effect sizes associated with biomarkers reported in highly cited individual articles and in subsequent meta-analyses
    • doi:10.1001/jama.2011.713
    • Ioannidis JP, Panagiotou OA. Comparison of effect sizes associated with biomarkers reported in highly cited individual articles and in subsequent meta-analyses. JAMA. 2011;305(21):2200-10. doi:10.1001/jama.2011.713.
    • (2011) JAMA , vol.305 , Issue.21 , pp. 2200-2210
    • Ioannidis, J.P.1    Panagiotou, O.A.2
  • 105
    • 84896705997 scopus 로고    scopus 로고
    • Cancer systems biology: A peek into the future of patient care?
    • doi:10.1038/nrclinonc.2014.6
    • Werner HM, Mills GB, Ram PT. Cancer systems biology: a peek into the future of patient care? Nat Rev Clin Oncol. 2014;11(3):167-76. doi:10.1038/nrclinonc.2014.6.
    • (2014) Nat Rev Clin Oncol , vol.11 , Issue.3 , pp. 167-176
    • Werner, H.M.1    Mills, G.B.2    Ram, P.T.3
  • 106
    • 84891857197 scopus 로고    scopus 로고
    • Increased microvascular proliferation is negatively correlated to tumour blood flow and is associated with unfavourable outcome in endometrial carcinomas
    • doi:10.1038/bjc.2013.694. Functional imaging results exemplify the potential of advanced imaging to non-invasively and preoperatively identify a patient group with aggressive disease and poor survival. The results are well correlated with known immunohistochemistry parameters reflecting microvascular proliferation
    • .• Haldorsen IS, Stefansson I, Gruner R, Husby JA, Magnussen IJ, Werner HM, et al. Increased microvascular proliferation is negatively correlated to tumour blood flow and is associated with unfavourable outcome in endometrial carcinomas. Br J Cancer. 2014;110(1):107-14. doi:10.1038/bjc.2013.694. Functional imaging results exemplify the potential of advanced imaging to non-invasively and preoperatively identify a patient group with aggressive disease and poor survival. The results are well correlated with known immunohistochemistry parameters reflecting microvascular proliferation.
    • (2014) Br J Cancer , vol.110 , Issue.1 , pp. 107-114
    • Haldorsen, I.S.1    Stefansson, I.2    Gruner, R.3    Husby, J.A.4    Magnussen, I.J.5    Werner, H.M.6
  • 107
    • 84880502601 scopus 로고    scopus 로고
    • Designing transformative clinical trials in the cancer genome era
    • doi:10.1200/JCO.2012.45.3639
    • Sleijfer S, Bogaerts J, Siu LL. Designing transformative clinical trials in the cancer genome era. J Clin Oncol. 2013;31(15):1834-41. doi:10.1200/JCO.2012.45.3639.
    • (2013) J Clin Oncol , vol.31 , Issue.15 , pp. 1834-1841
    • Sleijfer, S.1    Bogaerts, J.2    Siu, L.L.3
  • 108
    • 77957364747 scopus 로고    scopus 로고
    • Translating cancer research into targeted therapeutics
    • doi:10.1038/nature09339
    • de Bono JS, Ashworth A. Translating cancer research into targeted therapeutics. Nature. 2010;467(7315):543-9. doi:10.1038/nature09339.
    • (2010) Nature , vol.467 , Issue.7315 , pp. 543-549
    • De Bono, J.S.1    Ashworth, A.2
  • 109
    • 84858258851 scopus 로고    scopus 로고
    • Development and use of integral assays in clinical trials
    • doi:10.1158/1078-0432.CCR-11-2202
    • Schilsky RL, Doroshow JH, Leblanc M, Conley BA. Development and use of integral assays in clinical trials. Clin Cancer Res. 2012;18(6):1540-6. doi:10.1158/1078-0432.CCR-11-2202.
    • (2012) Clin Cancer Res , vol.18 , Issue.6 , pp. 1540-1546
    • Schilsky, R.L.1    Doroshow, J.H.2    Leblanc, M.3    Conley, B.A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.