Structure and specificity of an antibody targeting a proteolytically cleaved IgG hinge

Proteins: Structure, Function and Bioinformatics

Volumn 82, Issue 8, 2014, Pages 1656-1667

  Malia, Thomas J ^a   Teplyakov, Alexey ^a   Brezski, Randall J ^a   Luo, Jinquan ^a   Kinder, Michelle ^a   Sweet, Raymond W ^a   Almagro, Juan C ^a,b   Jordan, Robert E ^a   Gilliland, Gary L ^a  

^a JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

^b PFIZER INC   (United States)

Author keywords

Antibody engineering; Crystal structure; Disulfide; Hinge; IdeS; Proteolysis

Indexed keywords

AUTOANTIBODY; DISULFIDE; IMMUNOGLOBULIN F(AB) FRAGMENT; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G1; MONOCLONAL ANTIBODY; PEPTIDE;

ANTIBODY ENGINEERING; ANTIBODY SPECIFICITY; ANTIBODY STRUCTURE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CRYSTAL STRUCTURE; IMMUNE RESPONSE; PRIORITY JOURNAL; PROTEIN DEGRADATION; RABBIT; AMINO ACID SEQUENCE; ANIMAL; CHEMISTRY; HEK293 CELL LINE; HUMAN; IMMUNOLOGY; METABOLISM; MOLECULAR DOCKING; MOLECULAR GENETICS; PROTEIN CONFORMATION; X RAY CRYSTALLOGRAPHY;

ORYCTOLAGUS CUNICULUS;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; CRYSTALLOGRAPHY, X-RAY; HEK293 CELLS; HUMANS; IMMUNOGLOBULIN FAB FRAGMENTS; IMMUNOGLOBULIN G; MOLECULAR DOCKING SIMULATION; MOLECULAR SEQUENCE DATA; PEPTIDES; PROTEIN CONFORMATION; PROTEOLYSIS; RABBITS;

EID: 84904507035     PISSN: 08873585     EISSN: 10970134     Source Type: Journal    
DOI: 10.1002/prot.24545     Document Type: Article

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