Diagnostic utility of neutrophil CD64 as a marker for early-onset sepsis in preterm neonates

PLoS ONE

Volumn 9, Issue 7, 2014, Pages

  Du, Jikun ^a   Li, Li ^b   Dou, Yuhong ^a   Li, Peipei ^a   Chen, Rui ^c   Liu, Helu ^a  

^a GUANGZHOU MEDICAL UNIVERSITY   (China)

^b GUANGDONG MEDICAL UNIVERSITY   (China)

^c Birth Defects Prevention Research and Transformation Team   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; CD11B ANTIGEN; CD64 ANTIGEN; PHYCOERYTHRIN; BIOLOGICAL MARKER; C REACTIVE PROTEIN; FC RECEPTOR; ITGAM PROTEIN, HUMAN;

ANTIGEN EXPRESSION; ARTICLE; BLOOD CULTURE; CONTROLLED STUDY; DIAGNOSTIC VALUE; DISEASE ASSOCIATION; DISEASE MARKER; EARLY DIAGNOSIS; FEMALE; GESTATIONAL AGE; HUMAN; LEUKOCYTE COUNT; LOW BIRTH WEIGHT; MAJOR CLINICAL STUDY; MALE; MOLECULAR DYNAMICS; NEWBORN; NEWBORN SEPSIS; OUTCOME ASSESSMENT; PREDICTIVE VALUE; PREMATURITY; PROSPECTIVE STUDY; SENSITIVITY ANALYSIS; BLOOD; ERYTHROCYTE COUNT; IMMUNOLOGY; INFANT, NEWBORN, DISEASES; MICROBIOLOGY; NEUTROPHIL; NEWBORN INTENSIVE CARE; RECEIVER OPERATING CHARACTERISTIC; SEPSIS;

ANTIGENS, CD11B; BIOMARKERS; C-REACTIVE PROTEIN; ERYTHROCYTE COUNT; FEMALE; GESTATIONAL AGE; HUMANS; INFANT, NEWBORN; INFANT, NEWBORN, DISEASES; INFANT, PREMATURE; INTENSIVE CARE UNITS, NEONATAL; LEUKOCYTE COUNT; MALE; NEUTROPHILS; PROSPECTIVE STUDIES; RECEPTORS, IGG; ROC CURVE; SEPSIS;

EID: 84904498006     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0102647     Document Type: Article

References (39)

1. Bizzarro MJ, Raskind C, Baltimore RS, Gallagher PG (2005) Seventy-five years of neonatal sepsis at Yale: 1928-2003. Pediatrics 116: 595-602. (Pubitemid 44336674)
2. Stoll BJ, Hansen NI, Sánchez PJ, Faix RG, Poindexter BB, et al. (2011) Early onset neonatal sepsis: the burden of group B Streptococcal and E. coli disease continues. Pediatrics 127: 817-826.
3. Ng PC (2004) Diagnostic markers of infection in neonates. Arch Dis Child Fetal Neonatal Ed 89: F229-F235.
4. Gerdes JS (1991) Clinicopathologic approach to the diagnosis of neonatal sepsis. Clin Perinatol 18: 361-381.
5. Gonzalez BE, Mercado CK, Johnson L, Brodsky NL, Bhandari V (2003) Early markers of late-onset sepsis in premature neonates: clinical, hematological and cytokine profile. J Perinat Med 31: 60-68. (Pubitemid 36286027)
6. Streimish I, Bizzarro M, Northrup V, Wang C, Renna S, et al. (2012) Neutrophil CD64 as a diagnostic marker in neonatal sepsis. Pediatr Infect Dis J 31: 777-781.
7. Clark RH, Bloom BT, Spitzer AR, Gerstmann DR (2006) Reported medication use in the neonatal intensive care unit: data from a large national data set. Pediatrics 117: 1979-1987. (Pubitemid 46071242)
8. Bhandari V, Wang C, Rinder C, Rinder H (2008) Hematologic profile of sepsis in neonates: neutrophil CD64 as a diagnostic marker. Pediatrics 121: 129-134.
9. Bhandari V (2000) Cytokines in neonatal sepsis: diagnostic and therapeutic considerations. In: Singhi S, ed. Current Concepts in Pediatric Intensive Care. Chandigarh, India: Relume Printec 2000: 92-107.
10. Chirico G, Loda C (2011) Laboratory aid to the diagnosis and therapy of infection in the neonate. Pediatr Rep 3: e1.
11. Umlauf VN, Dreschers S, Orlikowsky TW (2013) Flow cytometry in the detection of neonatal sepsis. Int J Pediatr 2013: 763191.
12. Tang BM, Eslick GD, Craig JC, McLean AS (2007) Accuracy of procalcitonin for sepsis diagnosis in critically ill patients: systematic review and meta-analysis. Lancet Infect Dis 2007, 7: 210-217. (Pubitemid 46274517)
13. Ng PC, Lam HS (2006) Diagnostic markers for neonatal sepsis. Curr Opin Pediatr 18: 125-131.
14. Fjaertoft G, Håkansson L, Ewald U, Foucard T, Venge P (1999) Neutrophils from term and preterm newborn infants express the high affinity Fcgamma-receptor I (CD64) during bacterial infections. Pediatr Res 45: 871-876. (Pubitemid 29250098)
15. van der Meer W, Pickkers P, Scott CS, van der Hoeven JG, Gunnewiek JK (2007) Hematological indices, inflammatory markers and neutrophil CD64 expression: comparative trends during experimental human endotoxemia. J Endotoxin Res 13: 94-100. (Pubitemid 47471325)
16. Nuutila J, Hohenthal U, Laitinen I, Kotilainen P, Rajamäki A, et al. (2007) Simultaneous quantitative analysis of Fcgamma RI (CD64) expression on neutrophils and monocytes: a new, improved way to detect infections. J Immunol Methods 328: 189-200. (Pubitemid 350007630)
17. Pencina MJ, D'Agostino RB, D'Agostino RB, Vasan RS (2008) Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond. Stat Med 27: 157-172. (Pubitemid 351193639)
18. Ganatra HA, Stoll BJ, Zaidi AK (2010) International perspective on early-onset neonatal sepsis. Clin Perinatol 37: 501-523.
19. Kayange N, Kamugisha E, Mwizamholya DL, Jeremiah S, Mshana SE (2010) Predictors of positive blood culture and deaths among neonates with suspected neonatal sepsis in a tertiary hospital, Mwanza-Tanzania. BMC Pediatr 4; 10: 39.
20. Soni S, Wadhwa N, Kumar R, Faridi MM, Sharma S, et al. (2013) Evaluation of CD64 expression on neutrophils as an early indicator of neonatal sepsis. Pediatr Infect Dis J 32: e33-37.
21. Messaritakis J, Anagnostakis D, Laskari H, Katerelos C (1990) Rectal-skin temperature difference in septicaemic newborn infants. Arch Dis Child 65: 380-382. (Pubitemid 20147183)
22. Rodwell RL, Leslie AL, Tudehope DI (1988) Early diagnosis of neonatal sepsis using a hematologic scoring system. J Pediatr 112: 761-767.
23. Buhimschi CS, Buhimschi IA, Abdel-Razeq S, Rosenberg VA, Thung SF, et al. (2007) Proteomic biomarkers of intra-amniotic inflammation: relationship with funisitis and early-onset sepsis in the premature neonate. Pediatr Res 61: 318-324.
24. Da Silva O, Ohlsson A, Kenyon C (1995) Accuracy of leukocyte indices and C-reactive protein for diagnosis of neonatal sepsis: a critical review. Pediatr Infect Dis J 14: 362-366.
25. Ozdemir A, Oygür N, Gültekin M, Coşkun M, Yeǧin O (1994) Neonatal tumor necrosis factor, interleukin-1 alpha, interleukin-1 beta, and interleukin-6 response to infection. Am J Perinatol 11: 282-285. (Pubitemid 24251940)
26. Onal EE, Kitapçi F, Dilmen U, Adam B (1999) Interleukin-6 concentrations in neonatal sepsis. Lancet 353: 239-240.
27. Romagnoli C, Frezza S, Cingolani A, De Luca A, Puopolo M, et al. (2001) Plasma levels of interleukin-6 and interleukin-10 in preterm neonates evaluated for sepsis. Eur J Pediatr 160: 345-350. (Pubitemid 32449145)
28. Levy MM, Fink MP, Marshall JC, Abraham E, Angus D, et al. (2003) SCCM/ESICM/ACCP/ATS/SIS.2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit Care Med 31: 1250-1256. (Pubitemid 36444440)
29. Fjaertoft G, Håkansson L, Foucard T, Ewald U, Venge P (2005) CD64 (Fc gamma receptor I) cell surface expression on maturing neutrophils from preterm and term newborn infants. Acta Paediatr 94: 295-302.
30. Ng PC, Li G, Chui KM, Chu WC, Li K, et al. (2004) Neutrophil CD64 is a sensitive diagnostic marker for early-onset neonatal infection. Pediatr Res 56: 796-803. (Pubitemid 39403408)
31. Ng PC, Li K, Wong RP, Chui KM, Wong E, et al. (2002) Neutrophil CD64 expression: a sensitive diagnostic marker for late-onset nosocomial infection in very low birth weight infants. Pediatr Res 51: 296-303. (Pubitemid 34174964)
32. Weirich E, Rabin RL, Maldonado Y, Benitz W, Modler S, et al. (1998) Neutrophil CD11b expression as a diagnostic marker for early-onset neonatal infection. J Pediatr 132: 445-451. (Pubitemid 28180248)
33. Weinschenk NP, Farina A, Bianchi DW (2000) Premature infants respond to early-onset and late-onset sepsis with leukocyte activation. J Pediatr 137: 345-350.
34. Streimish I, Bizzarro M, Northrup V, Wang C, Renna S, et al. (2014) Neutrophil CD64 with Hematologic Criteria for Diagnosis of Neonatal Sepsis. Am J Perinatol 31: 21-30.
35. Layseca-Espinosa E, Pérez-González LF, Torres-Montes A, Baranda L, de la Fuente H, et al. (2002) Expression of CD64 as a potential marker of neonatal sepsis. Pediatr Allergy Immunol 13: 319-327. (Pubitemid 35407856)
36. Zeitoun AA, Gad SS, Attia FM, Abu Maziad AS, Bell EF (2010) Evaluation of neutrophilic CD64, interleukin 10 and procalcitonin as diagnostic markers of early- and late-onset neonatal sepsis. Scand J Infect Dis 42: 299-305.
37. Gros A, Roussel M, Sauvadet E, Gacouin A, Marqué S, et al. (2012) The sensitivity of neutrophil CD64 expression as a biomarker of bacterial infection is low in critically ill patients. Intensive Care Med 38: 445-452.
38. Roussel M, Gros A, Sauvadet E, Gacouin A, Marqué S, et al. (2012) CD64, a reliable biomarker of bacterial infection in intensive care units? Am J Respir Crit Care Med 186: 1058.
39. Icardi M, Erickson Y, Kilborn S, Stewart B, Grief B, et al. (2009) CD64 index provides simple and predictive testing for detection and monitoring of sepsis and bacterial infection in hospital patients. J Clin Microbiol 47: 3914-3919.