Laboratory aid to the diagnosis and therapy of infection in the neonate

Pediatric Reports

Volumn 3, Issue 1, 2011, Pages

  Chirico, Gaetano ^a   Loda, Cristina ^a  

^a SPEDALI CIVILI   (Italy)

Author keywords

IgG antibodies; Neonatal sepsis

Indexed keywords

ANTIBIOTIC AGENT; BIOLOGICAL MARKER; C REACTIVE PROTEIN; CD64 ANTIGEN; INTERLEUKIN 6; PROCALCITONIN;

ARTICLE; BACTERIUM DETECTION; CEREBROSPINAL FLUID CULTURE; CLINICAL EFFECTIVENESS; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; EARLY CHILDHOOD INTERVENTION; EARLY DIAGNOSIS; ERYTHROCYTE SEDIMENTATION RATE; FUNCTIONAL GENOMICS; FUNCTIONAL PROTEOMICS; GENETIC VARIABILITY; HUMAN; LABORATORY DIAGNOSIS; LEUKOCYTE COUNT; NEWBORN; NEWBORN CARE; NEWBORN INFECTION; NEWBORN SCREENING; NEWBORN SEPSIS; NONHUMAN; PREDICTIVE VALUE; PROTEIN FUNCTION; SENSITIVITY AND SPECIFICITY; SINGLE NUCLEOTIDE POLYMORPHISM; URINE CULTURE;

EID: 83655196959     PISSN: None     EISSN: 20367503     Source Type: Journal    
DOI: 10.4081/pr.2011.e1     Document Type: Article

References (52)

1. Chirico G, Cortinovis S, Fonte C, Giudici G. Bacterial sepsis. J Chemother 2007;19:28-30.
2. Chirico G. Development of the Immune System in Neonates. J Arab Neonatal Forum 2005; 2:5-11.
3. Lewis DB, Tu W. The physiologic immunodeficiency of immaturity. In Immunologic disorders in infants and children. fifth Edition. Edited by Stiehm ER, Ochs HD, Winkelstein JA. Philadelphia, Elsevier Saunders Company, 2004.
4. Chirico G, Marzollo R, Cortinovis S, et al. Antiinfective properties of human milk. J Nutr 2008;138:1801S-1806S.
5. Russell JA. Management of Sepsis. N Engl J Med 2006;355:1699-713.
6. Stoll BJ, Hansen NI, Adams-Chapman I, et al. Neurodevelopmental and Growth Impairment Among Extremely Low-Birth-Weight Infants With Neonatal Infection. JAMA 2004;292:2357-2365.
7. Hermansen MC, Hermansen MG. Perinatal Infections and Cerebral Palsy. Clin Perinatol 2006; 33:315-33.
8. Dammann O, Leviton A. Inflammation, brain damage and visual dysfunction in preterm infants. Semin Fetal Neonatal Med 2006;11:363-8.
9. La Pine TR and Hill HR. Host defense mechanisms against bacteria. In: Polin RA, Fox WW, Abman SH, editors. Fetal and Neonatal Physiology, 3th ed. Philadelphia, Saunders 2004, p. 1475-1486.
10. Schelonka RL, Chai MK, Yoder BA, et al. Volume of blood required to detect common neonatal pathogens. J Pediatr 1996;129: 275-8.
11. Mishra UK, Jacobs SE, Doyle LW, Garland SM. Newer approaches to the diagnosis of early onset neonatal sepsis Arch Dis Child Fetal Neonatal Ed 2006;91:208-212.
12. Weinberg GA, D'Angio CT. Laboratory Aids for Diagnosis of Neonatal Sepsis. In Remington JS, Klein JO eds. Infectious Diseases of the Fetus and Newborn Infant, Sixth ed. Philadelphia, W.B. Saunders Company 2006, p. 1207-1222.
13. Deeks JJ. Systematic reviews in health care: Systematic reviews of evaluations of diag-nostic and screening tests. BMJ 2001;323:157-62.
14. Benitz WE. Adjunct laboratory tests in the diagnosis of early-onset neonatal sepsis. Clin Perinatol 2010;37:421-38.
15. Da Silva O, Ohlsson A, Kenyon C. Accuracy of leukocyte indices and C-reactive protein for diagnosis of neonatal sepsis: a critical review. Pediatr Infect Dis J 1995;14:362-6.
16. Hatherill M, Tibby SM, Sykes K, et al. Diagnostic markers of infection: comparison of procalcitonin with C reactive protein and leucocyte count. Arch Dis Child 1999; 81:417-21
17. Chirico G, Gasparoni A, Ciardelli L, et al. Leukocyte counts in relation to the method of delivery during the first five days of life. Biol Neonate 1999;75:294-9.
18. Mussap M, Degrandi R, Cataldi L, et al. Biochemical markers for the early assessment of neonatal sepsis: the role of procalcitonin. J Chemother 2007;19:35-8.
19. Assumma M, Signore F, Pacifico L, et al. Serum procalcitonin concentrations in term delivering mothers and their healthy offspring: a longitudinal study. Clin Chem 2000;46:1583-7.
20. Chiesa C, Signore F, Assumma M, et al. Serial measurements of C-reactive protein and interleukin-6 in the immediate postnatal period: reference intervals and analysis of maternal and perinatal confounders. Clin Chem 2001;47:1016-22.
21. Lapillonne A, Basson E, Monneret G, et al. Lack of specificity of procalcitonin for sepsis diagnosis in premature infants. Lancet 1998;351:1211-2.
22. Yu Z, Liu J, Sun Q, et al. The accuracy of the procalcitonin test for the diagnosis of neonatal sepsis: a meta-analysis. Scand J Infect Dis 2010;42:723-33.
23. Chirico G, Motta M, Villani P, et al. Late-onset neutropenia in very low birthweight infants. Acta Paediatr Suppl 2002;91:104-8.
24. Fowlie PW, Schmidt B. Diagnostic tests for bacterial infection from birth to 90 days a systematic review. Arch Dis Child 1998;78:F92-F98.
25. Berner R, Niemeyer CM, Leititis JU, Funke A, Schwab C, Rau U, Richter K, Tawfeek MS, Clad A, Brandis M: Plasma levels and gene expression of granulocyte colony-stimulating factor, tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6, IL-8, and soluble intercellular adhesion molecule-1 in neonatal early onset sepsis. Pediatr Res 1998; 44:469-77.
26. Buscher U, Chen FC, Pitzen A, Menon R, Vogel M, Obladen M, Dudenhausen JW. Il-1 beta, Il-6, Il-8 and G-CSF in the diagnosis of early-onset neonatal infections. J Perinat Med 2000;28:383-8.
27. Ng PC, Lam HS. Biomarkers for late-onset neonatal sepsis: cytokines and beyond. Clin Perinatol 2010;37:599-610.
28. Kantar M, Kultursay N, Kutukculer N, Akisu M, Cetingul N, Caglayan S. Plasma concentrations of granulocyte-macrophage colonystimulating factor and interleukin-6 in septic and healthy preterms. Eur J Pediatr 2000;159:156-7.
29. Chirico G, Ciardelli L, Cecchi P, De Amici M, Gasparoni A, Rondini G. Serum concentration of granulocyte colony stimulating factor in term and preterm infants. Eur J Pediatr 1997;156:269-71.
30. Krueger M, Nauck MS, Sang S, Hentschel R, Wieland H, Berner R. Cord blood levels of interleukin-6 and interleukin-8 for the immediate diagnosis of early-onset infection in premature infants. Biol Neonate 2001;80:118-23.
31. Romagnoli C, Frezza S, Cingolani A, De Luca A, Puopolo M, De Carolis MP, Vento G, Antinori A, Tortorolo G. Plasma levels of interleukin-6 and interleukin-10 in preterm neonates evaluated for sepsis. Eur J Pediatr 2001;160:345-50.
32. Bhandari V, Wang C, Rinder C, Rinder H. Hematologic profile of sepsis in neonates: neutrophil CD64 as a diagnostic marker. Pediatrics 2008;121:129-34.
33. Küster H, Weiss M, Willeitner AE, Detlefsen S, Jeremias I, Zbojan J, Geiger R, Lipowsky G, Simbruner G: Interleukin-1 receptor antagonist and interleukin-6 for early diagnosis of neonatal sepsis 2 days before clinical manifestation. Lancet 1998; 352: 1271-7.
34. Buhimschi IA, Buhimschi CS. The role of proteomics in the diagnosis of chorioamnionitis and early-onset neonatal sepsis. Clin Perinatol 2010;37:355-74.
35. Jordan JA, Durso MB, Butchko AR, Jones JG, Brozanski BS. Evaluating the near-term infant for early onset sepsis: progress and challenges to consider with 16S rDNA polymerase chain reaction testing. J Mol Diagn 2006;8:357-63.
36. Reier-Nilsen T, Farstad T, Nakstad B, Lauvrak V, Steinbakk M. Comparison of broad range 16S rDNA PCR and conventional blood culture for diagnosis of sepsis in the newborn: a case control study. BMC Pediatr 2009;9:5.
37. Makhoul IR, Yacoub A, Smolkin T, Sujov P, Kassis I, Sprecher H. Values of C-reactive protein, procalcitonin, and Staphylo coccusspecific PCR in neonatal late-onset sepsis. Acta Paediatr 2006;95:1218-23.
38. Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases. Prevention of Perinatal Group B Streptococcal Disease - Revised Guidelines from CDC, 2010. MMWR Recomm Rep 2010;59(RR-10):1-36.
39. Atkins KL, Atkinson RM, Shanks A, et al. Evaluation of polymerase chain reaction for group B streptococcus detection using a improved culture method. Obstet Gynecol 2006;108:488-91.
40. Kwiatkowski D. Science, medicine, and the future: susceptibility to infection. BMJ 2000;321:1061-5.
41. Schroder J, Kahlke V, Book M, Stuber F. Gender differences in sepsis: genetically determined? Shock 2000; 14:307-10.
42. Fleer A, Krediet TG. Innate immunity: tolllike receptors and some more. A brief history, basic organization and relevance for the human newborn. Neonatology 2007;92:145-57.
43. Misch EA, Hawn TR. Toll-like receptor polymorphisms and susceptibility to human disease. Clin Sci (Lond). 2008;114:347-60.
44. Del Vecchio A, Ladisa G, Laforgia N, De Felice C, Presta G, Latini G. Genetic polymorphisms in neonatal sepsis. Haematologica Reports 2006; 2:31-37 (available at http://www.pagepress.org/journals/index.php/hmr/article/viewFile/449/464)
45. Schueller AC, Heep A, Kattner E, Kroll M, Wisbauer M, Sander J, Bartmann P, Stuber F. Prevalence of Two Tumor Necrosis Factor Gene Polymorphisms in Premature Infants with Early Onset Sepsis. Biol Neonate 2006;90:229-32
46. Levy O. Genetic screening for susceptibility to infection in the NICU setting. Pediatr Res 2004;55:546-8.
47. Michalek J, Svetlikova P, Fedora M, Klimovic M, Klapacova L, Bartosova D, Hrstkova H, Hubacek JA. Interleukin-6 gene variants and the risk of sepsis development in children. Hum Immunol 2007;68:756-60
48. Chauhan M, McGuire W. Interleukin-6 (-174C) polymorphism and the risk of sepsis in very low birth weight infants: meta-analysis. Arch Dis Child Fetal Neonatal Ed. 2008;93:F427-9.
49. Henderson G, Craig S, Baier RJ, Helps N, Brocklehurst P, McGuire W. Cytokine gene polymorphisms in preterm infants with necrotising enterocolitis: genetic association study. Arch Dis Child Fetal Neonatal Ed. 2009;94:F124-8.
50. Del Vecchio A, Laforgia N, Capasso M, Iolascon A, Latini G. The role of molecular genetics in the pathogenesis and diagnosis of neonatal sepsis Clin Perinatol 2004;31: 53-67.
51. Abdel-Hady H, El-Naggar M, El-Nady G, Badr R,El-Daker M. Genetic Polymorphisms of IL-6-174 and IL-10-1082 in Neonatal Blood Stream Infections. JPID 2009; 4:357-65.
52. Chirico G, Chiappa S. Genetic polymorphisms and susceptibility to infection in neonates. JPID 2009; 4:317-20. Article Non-commercial use only