Proteomic biomarkers of intra-amniotic inflammation: Relationship with funisitis and early-onset sepsis in the premature neonate

Pediatric Research

Volumn 61, Issue 3, 2007, Pages 318-324

  Buhimschi, Catalin S ^a   Buhimschi, Irina A ^a   Abdel Razeq, Sonya ^a   Rosenberg, Victor A ^a   Thung, Stephen F ^a   Zhao, Guomao ^a   Wang, Erica ^a   Bhandari, Vineet ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; CALGRANULIN; CALGRANULIN C; DEFENSIN 1; DEFENSIN 2; PROTEIN; UNCLASSIFIED DRUG;

ADULT; AMNIOCENTESIS; AMNION FLUID; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DELIVERY; DISEASE SEVERITY; FEMALE; FUNISITIS; GESTATIONAL AGE; HISTOLOGY; HUMAN; INFLAMMATION; MAJOR CLINICAL STUDY; NEUTROPHIL; NEWBORN SEPSIS; PREMATURE LABOR; PREMATURITY; PRIORITY JOURNAL; PROTEOMICS; SCORING SYSTEM;

ADULT; AMNIOTIC FLUID; BIOLOGICAL MARKERS; CALGRANULIN A; CHORIOAMNIONITIS; DEFENSINS; FEMALE; HUMANS; INFANT, NEWBORN; INFANT, PREMATURE; MALE; PREGNANCY; PROSPECTIVE STUDIES; PROTEOMICS; S100 PROTEINS; SEPSIS;

EID: 33847226584     PISSN: 00313998     EISSN: None     Source Type: Journal    
DOI: 10.1203/01.pdr.0000252439.48564.37     Document Type: Article

References (35)

1. Hoyert DL, Mathews TJ, Menacker F, Strobino DM, Guyer B 2006 Annual summary of vital statistics: 2004. Pediatrics 117:168-183
2. Green NS, Damus K, Simpson JL, Iams J, Reece EA, Hobel CJ, Merkatz IR, Greene MF, Schwarz RH March Of Dimes Scientific Advisory Committee On Prematurity. 2005 Research agenda for preterm birth: recommendations from the March of Dimes. Am J Obstet Gynecol 193:626-635.
3. Lau J, Magee F, Qiu Z, Hoube J, Von Dadelszen P, Lee SK 2005 Chorioamnionitis with a fetal inflammatory response is associated with higher neonatal mortality, morbidity, and resource use than chorioamnionitis displaying a maternal inflammatory response only. Am J Obstet Gynecol 193:708-713
4. Buhimschi IA, Buhimschi CS, Weiner CP 2003 Protective effect of N-acetylcysteine against fetal death and preterm labor induced by maternal inflammation. Am J Obstet Gynecol 188:203-208
5. Eschenbach DA 1997 Amniotic fluid infection and cerebral palsy. Focus on the fetus. JAMA 278:247-248
6. Yoon BH, Park CW, Chaiworapongsa T 2003 Intrauterine infection and the development of cerebral palsy. BJOG 110:124-127
7. Salafia CM, Sherer DM, Spong CY, Lencki S, Eglinton GS, Parkash V, Marley E, Lage JM 1997 Fetal but not maternal serum cytokine levels correlate with histologic acute placental inflammation. Am J Perinatol 14:419-422
8. Rogers BB, Alexander JM, Head J, McIntire D, Leveno KJ 2002 Umbilical vein interleukin-6 levels correlate with the severity of placental inflammation and gestational age. Hum Pathol 33:335-340
9. Yoon BH, Romero R, Park JS, Kim M, Oh SY, Kim CJ, Jun JK 2000 The relationship among inflammatory lesions of the umbilical cord (funisitis), umbilical cord plasma interleukin 6 concentration, amniotic fluid infection, and neonatal sepsis. Am J Obstet Gynecol 183:1124-1129
10. Lee SD, Kim MR, Hwang PG, Shim SS, Yoon BH, Kim CJ 2004 Chorionic plate vessels as an origin of amniotic fluid neutrophils. Pathol Int 54:516-522
11. Kim CJ, Yoon BH, Kim M, Park JO, Cho SY, Chi JG 2001 Histo-topographic distribution of acute inflammation of the human umbilical cord. Pathol Int 51:861-865
12. Ng PC, Lam HS 2006 Diagnostic markers for neonatal sepsis. Curr Opin Pediatr 18:125-131
13. Martius JA, Roos T, Gora B, Oehler MK, Schrod L, Papadopoulos T, Gross U 1999 Risk factors associated with early-onset sepsis in premature infants. Eur J Obstet Gynecol Reprod Biol 85:151-158
14. Buhimschi IA, Christner R, Buhimschi CS 2005 Proteomic biomarker analysis of amniotic fluid for identification of intra-amniotic inflammation. BJOG 112:173-181
15. Weiner CP, Lee KY, Buhimschi CS, Christner R, Buhimschi IA 2005 Proteomic biomarkers that predict the clinical success of rescue cerclage. Am J Obstet Gynecol 192:710-718
16. Lewis DF, Bergstedt S, Edwards MS, Burlison S, Gallaspy JW, Brooks GG, Adair CD 1997 Successful magnesium sulfate tocolysis: is "weaning" the drug necessary? Am J Obstet Gynecol 177:742-745
17. Romero R, Yoon BH, Mazor M, Gomez R, Gonzalez R, Diamond MP, Baumann P, Araneda H, Kenney JS, Cotton DB, Sehgal P 1993 A comparative study of the diagnosis performance of amniotic fluid performance of amniotic fluid glucose, white blood cell count, interleukin-6, and Gram stain in the detection of microbial invasion in patients with preterm premature rupture of the membranes. Am J Obstet Gynecol 169:839-851
18. Naef RW Allbert JR, Ross EL, Weber BM, Martin RW, Morrison JC 1998 Premature rupture of membranes at 34 to 37 weeks' gestation: aggressive versus conservative management. Am J Obstet Gynecol 178:126-130
19. Edwards RK, Clark P, Locksmith Gregory J, Duff P 2001 Performance characteristics of putative tests for subclinical chorioamnionitis. Infect Dis Obstet Gynecol 9:209-214
20. Garry D, Figueroa R, Aguero-Rosenfeld M, Martinez E, Visintainer P, Tejani N 1996 A comparison of rapid amniotic fluid markers in the prediction of microbial invasion of the uterine cavity and preterm delivery. Am J Obstet Gynecol 175:1336-1341
21. Buhimschi IA, Buhimschi CS, Christner R, Weiner CP 2005 Proteomics technology for the accurate diagnosis of inflammation in twin pregnancies. BJOG 112:250-255
22. Salafia CM, Weigl C, Silberman L 1989 The prevalence and distribution of acute placental inflammation in uncomplicated term pregnancies. Obstet Gynecol 73:383-389
23. Smulian JC, Bhandari V, Campbell WA, Rodis JF, Vintzileos AM 1997 Value of umbilical artery and vein levels of interleukin-6 and soluble intracellular adhesion molecule-1 as predictors of neonatal hematologic indices and suspected early sepsis. J Matern Fetal Med 6:254-259
24. Rodwell RL, Leslie AL, Tudehope DI 1988 Early diagnosis of neonatal sepsis using a hematologic scoring system. J Pediatr 112:761-767
25. Rodwell RL, Taylor KM, Tudehope DI, Gray PH 1993 Hematologic scoring system in early diagnosis of sepsis in neutropenic newborns. Pediatr Infect Dis J 12:372-376
26. Park JS, Romero R, Yoon BH, Moon JB, Oh SY, Han SY, Ko EM 2001 The relationship between amniotic fluid matrix metalloproteinase-8 and funisitis. Am J Obstet Gynecol 185:1156-1161
27. Wu YW, Colford JM 2000 Chorioamnionitis as a risk factor for cerebral palsy: A meta-analysis. JAMA 284:1417-1424.
28. Leviton A, Paneth N, Reuss ML, Susser M, Allred EN, Dammann O, Kuban K, Van Marter LJ, Pagano M, Hegyi T, Hiatt M, Sanocka U, Shahrivar F, Abiri M, Disalvo D, Doubilet P, Kairam R, Kazam E, Kirpekar M, Rosenfeld D, Schonfeld S, Share J, Collins M, Genest D, Shen-Schwarz S 1999 Maternal infection, fetal inflammatory response, and brain damage in very low birth weight infants. Developmental Epidemiology Network Investigators. Pediatr Res 46:566-575
29. Stoll BJ, Hansen NI, Adams-Chapman I, Fanaroff AA, Hintz SR, Vohr B, Higgins RD National Institute of Child Health and Human Development Neonatal Research Network 2004 Neurodevelopment and growth impairment among extremely low birth weight infants is associated with poor neonatal infection. JAMA 292:2357-2365.
30. Gonzalez BE, Mercado CK, Johnson L, Brodsky NL, Bhandari V 2003 Early markers of late-onset sepsis in premature neonates: clinical, hematological and cytokine profile. J Perinat Med 31:60-68
31. Buhimschi CS, Weiner CP, Buhimschi IA 2006 Clinical proteomics: A novel diagnostic tool for the new biology of Preterm Labor, Part I: Proteomics tool. Obstet Gynecol Surv 61:481-486
32. Salafia CM, Ghidini A, Sherer DM, Pezzullo JC 1998 Abnormalities of the fetal heart rate in preterm deliveries are associated with acute intra-amniotic infection. J Soc Gynecol Investig 5:188-191
33. Watterberg K 2006 Anti-inflammatory therapy in the neonatal intensive care unit: present and future. Semin Fetal Neonatal Med 11:378-384
34. Kim CJ, Yoon BH, Romero R, Moon JB, Kim M, Park SS, Chi JG 2001 Umbilical arteritis and phlebitis mark different stages of the fetal inflammatory response. Am J Obstet Gynecol 185:496-500
35. Buhimschi IA, Buhimschi CS, Weiner CP, Kimura T, Hamar BD, Sfakianaki AK, Norwitz ER, Funai EF, Ratner E 2005 Proteomic but not enzyme-linked immunosorbent assay technology detects amniotic fluid monomeric calgranulins from their complexed calprotectin form. Clin Diagn Lab Immunol 12:837-844