Activated hepatic stellate cells are dependent on self-collagen, cleaved by membrane type 1 matrix metalloproteinase for their growth

Journal of Biological Chemistry

Volumn 289, Issue 29, 2014, Pages 20209-20221

  Birukawa, Naoko Kubo ^a   Murase, Kazuyuki ^a   Sato, Yasushi ^a   Kosaka, Akemi ^a   Yoneda, Akihiro ^a   Nishita, Hiroki ^a   Fujita, Ryosuke ^a   Nishimura, Miyuki ^a   Ninomiya, Takafumi ^a   Kajiwara, Keiko ^a,b   Miyazaki, Miyono ^a,b   Nakashima, Yusuke ^a   Ota, Sigenori ^a   Murakami, Yuya ^a   Tanaka, Yasunobu ^a,b   Minomi, Kenjiro ^a,b   Tamura, Yasuaki ^c   Niitsu, Yoshiro ^a  

^a SAPPORO MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b NITTO DENKO CORPORATION   (Japan)

^c HOKKAIDO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CELL DEATH; SIGNAL TRANSDUCTION;

COLLAGEN SECRETION; DIPLOID CELLS; GRGDS PEPTIDES; HEPATIC STELLATE CELLS; MEMBRANE TYPE-1 MATRIX METALLOPROTEINASE; METALLOPROTEINASES; STELLATE CELLS; TISSUE INHIBITOR;

COLLAGEN;

ALPHA5 INTEGRIN; CASPASE 3; COLLAGEN; ECHISTATIN; GLYCOPROTEIN; GLYCOPROTEIN 46; I KAPPA B KINASE; INTERSTITIAL COLLAGENASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SMALL INTERFERING RNA; TISSUE INHIBITOR OF METALLOPROTEINASE 2; UNCLASSIFIED DRUG; VERY LATE ACTIVATION ANTIGEN 5;

AMINO ACID SEQUENCE; ANIMAL CELL; APOPTOSIS; ARTICLE; AUTOCRINE EFFECT; AUTOPHAGY; CELL COUNT; CELL GROWTH; CELL SURVIVAL; COLLAGEN SYNTHESIS; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTEIN SECRETION; QUANTITATIVE ANALYSIS; RAT; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STELLATE CELL; WESTERN BLOTTING;

APOPTOSIS; EXTRACELLULAR MATRIX; FIBROSIS; HEAT SHOCK PROTEIN (HSP); INTEGRIN;

ANIMALS; APOPTOSIS; CELL PROLIFERATION; CELL SURVIVAL; COLLAGEN; HEPATIC STELLATE CELLS; HSP47 HEAT-SHOCK PROTEINS; HUMANS; I-KAPPA B PROTEINS; INTEGRINS; LIVER CIRRHOSIS; MATRIX METALLOPROTEINASE 14; MATRIX METALLOPROTEINASE INHIBITORS; MICE; OLIGOPEPTIDES; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TISSUE INHIBITOR OF METALLOPROTEINASE-1;

EID: 84904497997     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.544494     Document Type: Article

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