Substance P and norepinephrine modulate murine chondrocyte proliferation and apoptosis

Arthritis and Rheumatism

Volumn 64, Issue 3, 2012, Pages 729-739

  Opolka, Alfred ^a,b   Straub, Rainer H ^b   Pasoldt, Anja ^a   Grifka, Joachim ^a   Grässel, Susanne ^a  

^a UNIVERSITY HOSPITAL REGENSBURG   (Germany)

^b UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

3 [3,5 BIS(TRIFLUOROMETHYL)BENZYLOXY] 2 PHENYLPIPERIDINE; ALPHA ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR; BROXURIDINE; COLLAGEN TYPE 1; COLLAGEN TYPE 2; COLLAGEN TYPE 9; L 733560; NEUROKININ 1 RECEPTOR; NORADRENALIN; SUBSTANCE P;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CARTILAGE CELL; CELL ADHESION; CELL CULTURE; CELL ISOLATION; CELL METABOLISM; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; EXTRACELLULAR MATRIX; IMMUNOHISTOCHEMISTRY; MORPHOMETRICS; MOUSE; NEWBORN; NICK END LABELING; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS;

ANIMALS; ANIMALS, NEWBORN; APOPTOSIS; CELL PROLIFERATION; CELLS, CULTURED; CHONDROCYTES; EXTRACELLULAR MATRIX; GENE EXPRESSION; MICE; MICE, INBRED C57BL; NOREPINEPHRINE; RECEPTORS, ADRENERGIC, ALPHA; RECEPTORS, ADRENERGIC, BETA; RECEPTORS, NEUROKININ-1; SUBSTANCE P; TYROSINE 3-MONOOXYGENASE;

EID: 84857749960     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.33449     Document Type: Article

References (44)

1. Besedovsky HO, del Rey A,. Immune-neuro-endocrine interactions: facts and hypotheses. Endocr Rev 1996; 17: 64-102.
2. Jones KB, Mollano AV, Morcuende JA, Cooper RR, Saltzman CL,. Bone and brain: a review of neural, hormonal, and musculoskeletal connections. Iowa Orthop J 2004; 24: 123-32.
3. Garcia-Castellano JM, Diaz-Herrera P, Morcuende JA,. Is bone a target-tissue for the nervous system? New advances on the understanding of their interactions. Iowa Orthop J 2000; 20: 49-58.
4. Haberland M, Schilling AF, Rueger JM, Amling M,. Brain and bone: central regulation of bone mass. A new paradigm in skeletal biology. J Bone Joint Surg Am 2001; 83-A: 1871-6.
5. Hukkanen M, Konttinen YT, Santavirta S, Paavolainen P, Gu XH, Terenghi G, et al. Rapid proliferation of calcitonin gene-related peptide-immunoreactive nerves during healing of rat tibial fracture suggests neural involvement in bone growth and remodelling. Neuroscience 1993; 54: 969-79.
6. Madsen JE, Hukkanen M, Aune AK, Basran I, Moller JF, Polak JM, et al. Fracture healing and callus innervation after peripheral nerve resection in rats. Clin Orthop Relat Res 1998; 351: 230-40.
7. Jones KB, Ferguson PC, Deheshi B, Riad S, Griffin A, Bell RS, et al. Complete femoral nerve resection with soft tissue sarcoma: functional outcomes. Ann Surg Oncol 2010; 17: 401-6.
8. Gajda M, Adriaensen D, Cichocki T,. Development of the innervation of long bones: expression of the growth-associated protein 43. Folia Histochem Cytobiol 2000; 38: 103-10.
9. Mackie EJ, Ahmed YA, Tatarczuch L, Chen KS, Mirams M,. Endochondral ossification: how cartilage is converted into bone in the developing skeleton. Int J Biochem Cell Biol 2008; 40: 46-62.
10. Von Euler US, Gaddum JH,. An unidentified depressor substance in certain tissue extracts. J Physiol 1931; 72: 74-87.
11. Takeda Y, Chou KB, Takeda J, Sachais BS, Krause JE,. Molecular cloning, structural characterization and functional expression of the human substance P receptor. Biochem Biophys Res Commun 1991; 179: 1232-40.
12. Shih C, Bernard GW,. Neurogenic substance P stimulates osteogenesis in vitro. Peptides 1997; 18: 323-6.
13. Goto T, Nakao K, Gunjigake KK, Kido MA, Kobayashi S, Tanaka T,. Substance P stimulates late-stage rat osteoblastic bone formation through neurokinin-1 receptors. Neuropeptides 2007; 41: 25-31.
14. Nilsson J, von Euler AM, Dalsgaard CJ,. Stimulation of connective tissue cell growth by substance P and substance K. Nature 1985; 315: 61-3.
15. Wang L, Zhao R, Shi X, Wei T, Halloran BP, Clark DJ, et al. Substance P stimulates bone marrow stromal cell osteogenic activity, osteoclast differentiation, and resorption activity in vitro. Bone 2009; 45: 309-20.
16. Imai S, Matsusue Y,. Neuronal regulation of bone metabolism and anabolism: calcitonin gene-related peptide-, substance P-, and tyrosine hydroxylase-containing nerves and the bone. Microsc Res Tech 2002; 58: 61-9.
17. Bjurholm A, Kreicbergs A, Terenius L, Goldstein M, Schultzberg M,. Neuropeptide Y-, tyrosine hydroxylase- and vasoactive intestinal polypeptide-immunoreactive nerves in bone and surrounding tissues. J Auton Nerv Syst 1988; 25: 119-25.
18. 2-adrenoreceptor ligands regulate osteoclast differentiation in vitro by direct and indirect mechanisms. Arch Biochem Biophys 2009; 482: 96-103.
19. 2-adrenergic receptors in human osteoblasts. J Cell Physiol 2009; 220: 267-75.
20. Lai KB, Sanderson JE, Yu CM,. High dose norepinephrine-induced apoptosis in cultured rat cardiac fibroblast. Int J Cardiol 2009; 136: 33-9.
21. Communal C, Singh K, Pimentel DR, Colucci WS,. Norepinephrine stimulates apoptosis in adult rat ventricular myocytes by activation of the β-adrenergic pathway. Circulation 1998; 98: 1329-34.
22. Elefteriou F, Ahn JD, Takeda S, Starbuck M, Yang X, Liu X, et al. Leptin regulation of bone resorption by the sympathetic nervous system and CART. Nature 2005; 434: 514-20.
23. Suzuki A, Palmer G, Bonjour JP, Caverzasio J,. Catecholamines stimulate the proliferation and alkaline phosphatase activity of MC3T3-E1 osteoblast-like cells. Bone 1998; 23: 197-203.
24. 2 adrenergic receptors responsible for protection against oxidative stress through promotion of glutathione synthesis after Nrf2 upregulation in undifferentiated mesenchymal C3H10T1/2 stem cells. J Cell Physiol 2009; 218: 268-75.
25. Millward-Sadler SJ, Mackenzie A, Wright MO, Lee HS, Elliot K, Gerrard L, et al. Tachykinin expression in cartilage and function in human articular chondrocyte mechanotransduction. Arthritis Rheum 2003; 48: 146-56.
26. Oliva F, Tarantino U, Maffulli N,. Immunohistochemical localization of calcitonin gene-related peptide and substance P in the rat knee cartilage at birth. Physiol Res 2005; 54: 549-56.
27. 2-adrenergic receptors expressed on murine chondrocytes stimulate cellular growth and inhibit the expression of Indian hedgehog and collagen type X. J Cell Biochem 2008; 104: 545-53.
28. Belluoccio D, Etich J, Rosenbaum S, Frie C, Grskovic I, Stermann J, et al. Sorting of growth plate chondrocytes allows the isolation and characterization of cells of a defined differentiation status. J Bone Miner Res 2010; 25: 1267-81.
29. Rickert M, Dreier R, Radons J, Opolka A, Grifka J, Anders S, et al. Interaction of periosteal explants with articular chondrocytes alters expression profile of matrix metalloproteinases. J Orthop Res 2010; 28: 1576-85.
30. Budde B, Blumbach K, Ylostalo J, Zaucke F, Ehlen HW, Wagener R, et al. Altered integration of matrilin-3 into cartilage extracellular matrix in the absence of collagen IX. Mol Cell Biol 2005; 25: 10465-78.
31. Opolka A, Ratzinger S, Schubert T, Spiegel HU, Grifka J, Bruckner P, et al. Collagen IX is indispensable for timely maturation of cartilage during fracture repair in mice. Matrix Biol 2007; 26: 85-95.
32. Lerner UH, Persson E,. Osteotropic effects by the neuropeptides calcitonin gene-related peptide, substance P and vasoactive intestinal peptide. J Musculoskelet Neuronal Interact 2008; 8: 154-65.
33. Cherruau M, Facchinetti P, Baroukh B, Saffar JL,. Chemical sympathectomy impairs bone resorption in rats: a role for the sympathetic system on bone metabolism. Bone 1999; 25: 545-51.
34. Steyaert A, Burssens P, Forsyth R, Vanderstraeten G,. Qualitative analysis of substance P, NK1-receptor and nerve ingrowth in substance P-treated ruptured rat Achilles tendon. Acta Orthop Belg 2010; 76: 387-95.
35. Burssens P, Steyaert A, Forsyth R, van Ovost EJ, Depaepe Y, Verdonk R,. Exogenously administered substance P and neutral endopeptidase inhibitors stimulate fibroblast proliferation, angiogenesis and collagen organization during Achilles tendon healing. Foot Ankle Int 2005; 26: 832-9.
36. Koon HW, Zhao D, Na X, Moyer MP, Pothoulakis C,. Metalloproteinases and transforming growth factor-α mediate substance P-induced mitogen-activated protein kinase activation and proliferation in human colonocytes. J Biol Chem 2004; 279: 45519-27.
37. Park SW, Yan YP, Satriotomo I, Vemuganti R, Dempsey RJ,. Substance P is a promoter of adult neural progenitor cell proliferation under normal and ischemic conditions. J Neurosurg 2007; 107: 593-9.
38. Im HJ, Li X, Muddasani P, Kim GH, Davis F, Rangan J, et al. Basic fibroblast growth factor accelerates matrix degradation via a neuro-endocrine pathway in human adult articular chondrocytes. J Cell Physiol 2008; 215: 452-63.
39. Ashton IK, Eisenstein SM,. The effect of substance P on proliferation and proteoglycan deposition of cells derived from rabbit intervertebral disc. Spine 1996; 21: 421-6.
40. Halliday DA, McNeil JD, Scicchitano R,. Failure of tachykinins including substance P and its fragments to influence proteoglycan and protein synthesis in bovine chondrocytes in vitro. Biochim Biophys Acta 1992; 1137: 29-33.
41. Mauro LJ, Wenzel SJ, Sindberg GM,. Regulation of chick bone growth by leptin and catecholamines. Poult Sci 2010; 89: 697-708.
42. Communal C, Colucci WS,. The control of cardiomyocyte apoptosis via the β-adrenergic signaling pathways. Arch Mal Coeur Vaiss 2005; 98: 236-41.
43. Wu C, Dedhar S,. Integrin-linked kinase (ILK) and its interactors: a new paradigm for the coupling of extracellular matrix to actin cytoskeleton and signaling complexes. J Cell Biol 2001; 155: 505-10.
44. Sood AK, Armaiz-Pena GN, Halder J, Nick AM, Stone RL, Hu W, et al. Adrenergic modulation of focal adhesion kinase protects human ovarian cancer cells from anoikis. J Clin Invest 2010; 120: 1515-23.