Design, synthesis and biological evaluation of mitochondria targeting theranostic agents

Chemical Communications

Volumn 50, Issue 64, 2014, Pages 8919-8922

  Wu, Song ^a,b   Cao, Qizhen ^a   Wang, Xiaolin ^a,c   Cheng, Kai ^a   Cheng, Zhen ^a  

^a STANFORD UNIVERSITY   (United States)

^b WUHAN UNIVERSITY   (China)

^c SUN YAT SEN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; MITOCHONDRIA TARGETING THERANOSTIC AGENT; UNCLASSIFIED DRUG; 4-(2-(INDOL-3-YL)VINYL)-1-METHYLPYRIDINIUM; CATION; INDOLE DERIVATIVE; ORGANOPHOSPHORUS COMPOUND; PYRIDINIUM DERIVATIVE; TETRAPHENYLPHOSPHONIUM;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER CELL LINE; CELL PROLIFERATION; CONJUGATE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; DRUG UPTAKE; HUMAN; HUMAN CELL; IC 50; DIAGNOSTIC USE; DRUG EFFECTS; FLUORESCENCE IMAGING; METABOLISM; MITOCHONDRION; SYNTHESIS; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG DESIGN; HUMANS; INDOLES; MITOCHONDRIA; ONIUM COMPOUNDS; OPTICAL IMAGING; ORGANOPHOSPHORUS COMPOUNDS; PYRIDINIUM COMPOUNDS;

EID: 84904430423     PISSN: 13597345     EISSN: 1364548X     Source Type: Journal    
DOI: 10.1039/c4cc03296a     Document Type: Article

References (19)

1. N. Apostolova, A. Blas-Garcia, J. V. Esplgues, Curr. Pharm. Des., 2011, 17:4047
2. S. J. Tabrizi, J. Workman, P. E. Hart, L. Mangiarini, A. Mahal, G. Bates, J. M. Cooper, A. H. Schapira, Ann. Neurol., 2000, 47:80
3. V. Gogvadze, Curr. Pharm. Des., 2011, 17:4034
4. R. Rotem, A. Heyfets, O. Fingrut, D. Blickstein, M. Shaklai, E. Flescher, Cancer Res., 2005, 65:1984
5. L. B. Chen, Annu. Rev. Cell Biol., 1988, 4:155
6. T. A. Prime, F. H. Blaikie, C. Evans, S. M. Nadtochiy, A. M. James, C. C. Dahm, D. A. Vitturi, R. P. Patel, C. R. Hiley, I. Abakumova, R. Requejo, E. T. Chouchani, T. R. Hurd, J. F. Garvey, C. T. Taylor, P. S. Brookes, R. A. Smith, M. P. Murphy, Proc. Natl. Acad. Sci. U. S. A., 2009, 106:10764
7. J.-J. Min, S. Biswal, C. Deroose, S. S. Gambhir, J. Nucl. Med., 2004, 45:636
8. Z. Cheng, R. C. Winant, S. S. Gambhir, J. Nucl. Med., 2005, 46:878
9. G. S. Gurm, S. B. Danik, T. M. Shoup, S. Weise, K. Tarahashi, S. Laferrier, D. R. Elmaleh, H. Gewirtz, J. Am. Coll. Cardiol., 2012, 5:285
10. D. Y. Kim, H. J. Kim, K. H. Yu, J. J. Min, Bioconjugate Chem., 2012, 23:431
11. I. Madar, H. Ravert, B. Nelkin, M. Abro, M. Pomper, R. Dannals, J. J. Frost, Eur. J. Nucl. Med. Mol. Imaging, 2007, 34:2057
12. J. Wang, C. T. Yang, Y. S. Kim, S. G. Sreerama, Q. Cao, Z. B. Li, Z. He, X. Chen, S. Liu, J. Med. Chem., 2007, 50:5057
13. Y. S. Kim, C. T. Yang, J. Wang, L. Wang, Z. B. Li, X. Chen, S. Liu, J. Med. Chem., 2008, 51:2971
14. S. Chalmers, S. T. Caldwell, C. Quin, T. A. Prime, A. M James, A. Cairns, M. P. Murphy, J. G. MacCarron, R. C. Hartley, J. Am. Chem. Soc., 2012, 134:758
15. H. M. Cocheme, A. Logan, T. A. Prime, I. Abakumova, C. Quin, S. J. McQuaker, J. V. Patel, I. M. Fearnley, A. M. James, C. M. Porteous, R. A. Smith, R. C. Hartley, L. Partridge, M. P. Murphy, Nat. Protocols, 2012, 7:946
16. V. R. Fantin, M. J. Berardi, L. Scorrano, S. J. Korsmeyer, P. Leader, Cancer Cell, 2002, 2:29
17. R. Fantin, P. Leader, Cancer Res., 2004, 64:329
18. S. Keereweer, J. F. Kerrebijin, P. A. van Driel, B. Xie, E. Kaijzek, T. A. Snoeks, I. Que, M. Hutteman, J. van der Vorst, J. S. Mieog, A. Vahrmeijer, C. H. van de Velde, R. Baatenburg de Jong, C. G. Lowiks, Mol. Imaging Biol., 2011, 13:199
19. M. Millard, D. Pathania, Y. Shabaik, L. Taheri, J. Deng, N. Neamati, PLoS One, 2010, 5:e13131