메뉴 건너뛰기




Volumn 29, Issue 5, 2009, Pages 511-525

Ceftobiprole: First cephalosporin with activity against methicillin-resistant Staphylococcus aureus

Author keywords

BAL9141; Ceftobiprole; Complicated skin and skin structure infections; CSSSI; Methicillin resistant Staphylococcus aureus; MRSA

Indexed keywords

AMIKACIN; AMOXICILLIN PLUS CLAVULANIC ACID; AMPICILLIN; BETA LACTAMASE; CEFEPIME; CEFOXITIN; CEFTAZIDIME; CEFTOBIPROLE; CEFTOBIPROLE MEDOCARIL; CEFTRIAXONE; CIPROFLOXACIN; IMIPENEM; LEVOFLOXACIN; LINEZOLID; MEROPENEM; OXACILLIN; PENICILLIN BINDING PROTEIN 2A; PENICILLIN BINDING PROTEIN 2X; PENICILLIN G; PIPERACILLIN PLUS TAZOBACTAM; PLACEBO; TOBRAMYCIN; VANCOMYCIN;

EID: 66249125680     PISSN: 02770008     EISSN: None     Source Type: Journal    
DOI: 10.1592/phco.29.5.511     Document Type: Review
Times cited : (22)

References (76)
  • 1
    • 44149113314 scopus 로고    scopus 로고
    • Epidemiology of methicillin-resistant Staphylococcus aureus
    • Boucher HW, Corey GR. Epidemiology of methicillin-resistant Staphylococcus aureus. Clin Infect Dis 2008;46(suppl 5): S344-9.
    • (2008) Clin Infect Dis , vol.46 , Issue.SUPPL. 5
    • Boucher, H.W.1    Corey, G.R.2
  • 2
    • 31044456290 scopus 로고    scopus 로고
    • Klevens RM, Edwards JR, Tenover FC, McDonald LC, Horan T, Gaynes R. Changes in the epidemiology of methicillinresistant Staphylococcus aureus in intensive care units in U.S. hospitals, 1992-2003. Clin Infect Dis 2006;42:389-91.
    • Klevens RM, Edwards JR, Tenover FC, McDonald LC, Horan T, Gaynes R. Changes in the epidemiology of methicillinresistant Staphylococcus aureus in intensive care units in U.S. hospitals, 1992-2003. Clin Infect Dis 2006;42:389-91.
  • 3
    • 42149136323 scopus 로고    scopus 로고
    • Incidence, antibiotic resistance and clonal relations of MRSA strains isolated from a Romanian university hospital
    • Szekely E, Lorinczi L, Bilca D, Fodor E, Soki J, Sabau M. Incidence, antibiotic resistance and clonal relations of MRSA strains isolated from a Romanian university hospital. Acta Microbiol Immunol Hung 2008;55:1-13.
    • (2008) Acta Microbiol Immunol Hung , vol.55 , pp. 1-13
    • Szekely, E.1    Lorinczi, L.2    Bilca, D.3    Fodor, E.4    Soki, J.5    Sabau, M.6
  • 5
    • 0036359208 scopus 로고    scopus 로고
    • Methicillin resistance in Staphylococcus aureus: Mechanisms and modulation
    • Stapleton PD, Taylor PW. Methicillin resistance in Staphylococcus aureus: mechanisms and modulation. Sci Prog 2002;85:57-72.
    • (2002) Sci Prog , vol.85 , pp. 57-72
    • Stapleton, P.D.1    Taylor, P.W.2
  • 6
    • 44149101032 scopus 로고    scopus 로고
    • Increasing antibiotic resistance among methicillin-resistant Staphylococcus aureus strains
    • Sakoulas G, Moellering RC Jr. Increasing antibiotic resistance among methicillin-resistant Staphylococcus aureus strains. Clin Infect Dis 2008;46(suppl 5):S360-7.
    • (2008) Clin Infect Dis , vol.46 , Issue.SUPPL. 5
    • Sakoulas, G.1    Moellering Jr., R.C.2
  • 7
    • 0035115180 scopus 로고    scopus 로고
    • In vitro and in vivo properties of Ro 63-9141, a novel broad-spectrum cephalosporin with activity against methicillinresistant staphylococci
    • Hebeisen P, Heinze-Krauss I, Angehrn P, Hohl P, Page MG, Then RL. In vitro and in vivo properties of Ro 63-9141, a novel broad-spectrum cephalosporin with activity against methicillinresistant staphylococci. Antimicrob Agents Chemother 2001;45:825-36.
    • (2001) Antimicrob Agents Chemother , vol.45 , pp. 825-836
    • Hebeisen, P.1    Heinze-Krauss, I.2    Angehrn, P.3    Hohl, P.4    Page, M.G.5    Then, R.L.6
  • 8
    • 3042621802 scopus 로고    scopus 로고
    • Single-dose pharmacokinetics and safety of a novel broad-spectrum cephalosporin (BAL5788) in healthy volunteers
    • Schmitt-Hoffmann A, Roos B, Schleimer M, et al. Single-dose pharmacokinetics and safety of a novel broad-spectrum cephalosporin (BAL5788) in healthy volunteers. Antimicrob Agents Chemother 2004;48:2570-5.
    • (2004) Antimicrob Agents Chemother , vol.48 , pp. 2570-2575
    • Schmitt-Hoffmann, A.1    Roos, B.2    Schleimer, M.3
  • 11
    • 34147160821 scopus 로고    scopus 로고
    • Anti-MRSA β-lactams in development, with a focus on ceftobiprole: The first anti-MRSA β-lactam to demonstrate clinical efficacy
    • Bush K, Heep M, Macielag MJ, Noel GJ. Anti-MRSA β-lactams in development, with a focus on ceftobiprole: the first anti-MRSA β-lactam to demonstrate clinical efficacy. Expert Opin Investig Drugs 2007;16:419-29.
    • (2007) Expert Opin Investig Drugs , vol.16 , pp. 419-429
    • Bush, K.1    Heep, M.2    Macielag, M.J.3    Noel, G.J.4
  • 12
    • 34548118782 scopus 로고    scopus 로고
    • Evaluation of ceftobiprole medocaril against Enterococcus faecalis in a mouse peritonitis model
    • Arias CA, Singh KV, Panesso D, Murray BE. Evaluation of ceftobiprole medocaril against Enterococcus faecalis in a mouse peritonitis model. J Antimicrob Chemother 2007;60:594-8.
    • (2007) J Antimicrob Chemother , vol.60 , pp. 594-598
    • Arias, C.A.1    Singh, K.V.2    Panesso, D.3    Murray, B.E.4
  • 13
    • 20944431809 scopus 로고    scopus 로고
    • Antipneumococcal activity of ceftobiprole, a novel broad-spectrum cephalosporin
    • Kosowska K, Hoellman DB, Lin G, et al. Antipneumococcal activity of ceftobiprole, a novel broad-spectrum cephalosporin. Antimicrob Agents Chemother 2005;49:1932-42.
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 1932-1942
    • Kosowska, K.1    Hoellman, D.B.2    Lin, G.3
  • 14
    • 34447254695 scopus 로고    scopus 로고
    • Binding of ceftobiprole and comparators to the penicillinbinding proteins of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae
    • Davies TA, Page MG, Shang W, Andrew T, Kania M, Bush K. Binding of ceftobiprole and comparators to the penicillinbinding proteins of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae. Antimicrob Agents Chemother 2007;51:2621-4.
    • (2007) Antimicrob Agents Chemother , vol.51 , pp. 2621-2624
    • Davies, T.A.1    Page, M.G.2    Shang, W.3    Andrew, T.4    Kania, M.5    Bush, K.6
  • 15
    • 40049097830 scopus 로고    scopus 로고
    • In vitro activity profile of ceftobiprole, an anti-MRSA cephalosporin, against recent gram-positive and gram-negative isolates of European origin
    • Pillar CM, Aranza MK, Shah D, Sahm DF. In vitro activity profile of ceftobiprole, an anti-MRSA cephalosporin, against recent gram-positive and gram-negative isolates of European origin. J Antimicrob Chemother 2008;61:595-602.
    • (2008) J Antimicrob Chemother , vol.61 , pp. 595-602
    • Pillar, C.M.1    Aranza, M.K.2    Shah, D.3    Sahm, D.F.4
  • 16
    • 66249092898 scopus 로고    scopus 로고
    • Janssen-Ortho, Inc. Zeftera (ceftobiprole medocaril) package insert. Toronto, Ontario, Canada; 2008
    • Janssen-Ortho, Inc. Zeftera (ceftobiprole medocaril) package insert. Toronto, Ontario, Canada; 2008.
  • 17
    • 50949091699 scopus 로고    scopus 로고
    • In vitro activity of ceftobiprole against pathogens from two phase 3 complicated skin and skin structure infection clinical trials
    • Amsler KM, Davies TA, Shang W, Jacobs MR, Bush K. In vitro activity of ceftobiprole against pathogens from two phase 3 complicated skin and skin structure infection clinical trials. Antimicrob Agents Chemother 2008;52:3418-23.
    • (2008) Antimicrob Agents Chemother , vol.52 , pp. 3418-3423
    • Amsler, K.M.1    Davies, T.A.2    Shang, W.3    Jacobs, M.R.4    Bush, K.5
  • 18
    • 41949113200 scopus 로고    scopus 로고
    • Antimicrobial activity of ceftobiprole, a novel anti-methicillin-resistant Staphylococcus aureus cephalosporin, tested against contemporary pathogens: Results from the SENTRY antimicrobial surveillance program (2005-2006)
    • Fritsche TR, Sader HS, Jones RN. Antimicrobial activity of ceftobiprole, a novel anti-methicillin-resistant Staphylococcus aureus cephalosporin, tested against contemporary pathogens: results from the SENTRY antimicrobial surveillance program (2005-2006). Diagn Microbiol Infect Dis 2008;61:86-95.
    • (2008) Diagn Microbiol Infect Dis , vol.61 , pp. 86-95
    • Fritsche, T.R.1    Sader, H.S.2    Jones, R.N.3
  • 19
    • 0036924109 scopus 로고    scopus 로고
    • In vitro evaluation of BAL9141, a novel parenteral cephalosporin active against oxacillin-resistant staphylococci
    • Jones RN, Deshpande LM, Mutnick AH, Biedenbach DJ. In vitro evaluation of BAL9141, a novel parenteral cephalosporin active against oxacillin-resistant staphylococci. J Antimicrob Chemother 2002;50:915-32.
    • (2002) J Antimicrob Chemother , vol.50 , pp. 915-932
    • Jones, R.N.1    Deshpande, L.M.2    Mutnick, A.H.3    Biedenbach, D.J.4
  • 21
    • 0036171859 scopus 로고    scopus 로고
    • In vitro activities of BAL9141, a novel broad-spectrum pyrrolidinone cephalosporin, against gram-negative nonfermenters
    • Zbinden R, Punter V, von Graevenitz A. In vitro activities of BAL9141, a novel broad-spectrum pyrrolidinone cephalosporin, against gram-negative nonfermenters. Antimicrob Agents Chemother 2002;46:871-4.
    • (2002) Antimicrob Agents Chemother , vol.46 , pp. 871-874
    • Zbinden, R.1    Punter, V.2    von Graevenitz, A.3
  • 22
    • 34247863918 scopus 로고    scopus 로고
    • Antianaerobe activity of ceftobiprole, a new broad-spectrum cephalosporin
    • Ednie L, Shapiro S, Appelbaum PC. Antianaerobe activity of ceftobiprole, a new broad-spectrum cephalosporin. Diagn Microbiol Infect Dis 2007;58:133-6.
    • (2007) Diagn Microbiol Infect Dis , vol.58 , pp. 133-136
    • Ednie, L.1    Shapiro, S.2    Appelbaum, P.C.3
  • 23
    • 0036118954 scopus 로고    scopus 로고
    • BAL9141, a new broad-spectrum pyrrolidinone cephalosporin: Activity against clinically significant anaerobes in comparison with 10 other antimicrobials
    • Wootton M, Bowker KE, Holt HA, MacGowan AP. BAL9141, a new broad-spectrum pyrrolidinone cephalosporin: activity against clinically significant anaerobes in comparison with 10 other antimicrobials. J Antimicrob Chemother 2002;49:535-9.
    • (2002) J Antimicrob Chemother , vol.49 , pp. 535-539
    • Wootton, M.1    Bowker, K.E.2    Holt, H.A.3    MacGowan, A.P.4
  • 25
    • 38149045013 scopus 로고    scopus 로고
    • Activity of ceftobiprole compared with those of other agents against Staphylococcus aureus strains with different resistotypes by time-kill analysis
    • Lin G, Appelbaum PC. Activity of ceftobiprole compared with those of other agents against Staphylococcus aureus strains with different resistotypes by time-kill analysis. Diagn Microbiol Infect Dis 2008;60:233-5.
    • (2008) Diagn Microbiol Infect Dis , vol.60 , pp. 233-235
    • Lin, G.1    Appelbaum, P.C.2
  • 27
    • 33746871153 scopus 로고    scopus 로고
    • In vitro activities of ceftobiprole, tigecycline, daptomycin, and 19 other antimicrobials against methicillin-resistant Staphylococcus aureus strains from a national survey of Belgian hospitals
    • Denis O, Deplano A, Nonhoff C, et al. In vitro activities of ceftobiprole, tigecycline, daptomycin, and 19 other antimicrobials against methicillin-resistant Staphylococcus aureus strains from a national survey of Belgian hospitals. Antimicrob Agents Chemother 2006;50:2680-5.
    • (2006) Antimicrob Agents Chemother , vol.50 , pp. 2680-2685
    • Denis, O.1    Deplano, A.2    Nonhoff, C.3
  • 28
    • 34347339330 scopus 로고    scopus 로고
    • In vitro activity of ceftobiprole, daptomycin, linezolid, and vancomycin against methicillin-resistant staphylococci associated with endocarditis and bone and joint infection
    • Rouse MS, Steckelberg JM, Patel R. In vitro activity of ceftobiprole, daptomycin, linezolid, and vancomycin against methicillin-resistant staphylococci associated with endocarditis and bone and joint infection. Diagn Microbiol Infect Dis 2007;58:363-5.
    • (2007) Diagn Microbiol Infect Dis , vol.58 , pp. 363-365
    • Rouse, M.S.1    Steckelberg, J.M.2    Patel, R.3
  • 29
    • 5444249695 scopus 로고    scopus 로고
    • Bactericidal activity of BAL9141, a novel parenteral cephalosporin against contemporary gram-positive and gram-negative isolates
    • Deshpande L, Rhomberg PR, Fritsche TR, et al. Bactericidal activity of BAL9141, a novel parenteral cephalosporin against contemporary gram-positive and gram-negative isolates. Diagn Microbiol Infect Dis 2004;50:73-5.
    • (2004) Diagn Microbiol Infect Dis , vol.50 , pp. 73-75
    • Deshpande, L.1    Rhomberg, P.R.2    Fritsche, T.R.3
  • 30
    • 25844481076 scopus 로고    scopus 로고
    • Comparative in vitro activity of ceftobiprole against staphylococci displaying normal and small-colony variant phenotypes
    • von Eiff C, Friedrich AW, Becker K, Peters G. Comparative in vitro activity of ceftobiprole against staphylococci displaying normal and small-colony variant phenotypes. Antimicrob Agents Chemother 2005;49:4372-4.
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 4372-4374
    • von Eiff, C.1    Friedrich, A.W.2    Becker, K.3    Peters, G.4
  • 31
    • 0030053627 scopus 로고    scopus 로고
    • Modification of penicillinbinding protein 5 associated with high-level ampicillin resistance in Enterococcus faecium
    • Ligozzi M, Pittaluga F, Fontana R. Modification of penicillinbinding protein 5 associated with high-level ampicillin resistance in Enterococcus faecium. Antimicrob Agents Chemother 1996;40:354-7.
    • (1996) Antimicrob Agents Chemother , vol.40 , pp. 354-357
    • Ligozzi, M.1    Pittaluga, F.2    Fontana, R.3
  • 33
    • 45749156804 scopus 로고    scopus 로고
    • In vitro activity of ceftobiprole against clinical isolates of Pseudomonas aeruginosa obtained from Canadian intensive care unit (ICU) patients as part of the CAN-ICU study
    • Walkty A, Decorby M, Nichol K, Karlowsky JA, Hoban DJ, Zhanel GG. In vitro activity of ceftobiprole against clinical isolates of Pseudomonas aeruginosa obtained from Canadian intensive care unit (ICU) patients as part of the CAN-ICU study. J Antimicrob Chemother 2008;62:206-8.
    • (2008) J Antimicrob Chemother , vol.62 , pp. 206-208
    • Walkty, A.1    Decorby, M.2    Nichol, K.3    Karlowsky, J.A.4    Hoban, D.J.5    Zhanel, G.G.6
  • 35
  • 36
    • 24144435354 scopus 로고    scopus 로고
    • Intensive therapy with ceftobiprole medocaril of experimental foreign-body infection by methicillin-resistant Staphylococcus aureus
    • Vaudaux P, Gjinovci A, Bento M, Li D, Schrenzel J, Lew DP. Intensive therapy with ceftobiprole medocaril of experimental foreign-body infection by methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother 2005;49:3789-93.
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 3789-3793
    • Vaudaux, P.1    Gjinovci, A.2    Bento, M.3    Li, D.4    Schrenzel, J.5    Lew, D.P.6
  • 37
    • 14744278669 scopus 로고    scopus 로고
    • Evaluation of ceftobiprole in a rabbit model of aortic valve endocarditis due to methicillin-resistant and vancomycin-intermediate Staphylococcus aureus
    • Chambers HF. Evaluation of ceftobiprole in a rabbit model of aortic valve endocarditis due to methicillin-resistant and vancomycin-intermediate Staphylococcus aureus. Antimicrob Agents Chemother 2005;49:884-8.
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 884-888
    • Chambers, H.F.1
  • 41
    • 44449086040 scopus 로고    scopus 로고
    • Antibiotic resistance mechanisms in bacteria: Biochemical and genetic aspects
    • Dzidic S, Suskovic J, Kos B. Antibiotic resistance mechanisms in bacteria: biochemical and genetic aspects. Food Technol Biotechnol 2008;46:11-21.
    • (2008) Food Technol Biotechnol , vol.46 , pp. 11-21
    • Dzidic, S.1    Suskovic, J.2    Kos, B.3
  • 42
    • 34248191869 scopus 로고    scopus 로고
    • In vitro profile of a new β-lactam, ceftobiprole, with activity against methicillin-resistant Staphylococcus aureus
    • Jones ME. In vitro profile of a new β-lactam, ceftobiprole, with activity against methicillin-resistant Staphylococcus aureus. Clin Microbiol Infect 2007;13(suppl 2):17-24.
    • (2007) Clin Microbiol Infect , vol.13 , Issue.SUPPL. 2 , pp. 17-24
    • Jones, M.E.1
  • 43
    • 33745599645 scopus 로고    scopus 로고
    • Activities of ceftobiprole and other β-lactams against Streptococcus pneumoniae clinical isolates from the United States with defined substitutions in penicillin-binding proteins PBP1a, PBP2b, and PBP2x
    • Davies TA, Shang W, Bush K. Activities of ceftobiprole and other β-lactams against Streptococcus pneumoniae clinical isolates from the United States with defined substitutions in penicillin-binding proteins PBP1a, PBP2b, and PBP2x. Antimicrob Agents Chemother 2006;50:2530-2.
    • (2006) Antimicrob Agents Chemother , vol.50 , pp. 2530-2532
    • Davies, T.A.1    Shang, W.2    Bush, K.3
  • 44
    • 44449108557 scopus 로고    scopus 로고
    • In vitro selection and characterization of ceftobiprole-resistant methicillin-resistant Staphylococcus aureus
    • Banerjee R, Gretes M, Basuino L, Strynadka N, Chambers HF. In vitro selection and characterization of ceftobiprole-resistant methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother 2008;52:2089-96.
    • (2008) Antimicrob Agents Chemother , vol.52 , pp. 2089-2096
    • Banerjee, R.1    Gretes, M.2    Basuino, L.3    Strynadka, N.4    Chambers, H.F.5
  • 47
    • 0012902831 scopus 로고
    • A Paradoxical zone phenomenon in the bactericidal action of penicillin in vitro.Science
    • Eagle H. A Paradoxical zone phenomenon in the bactericidal action of penicillin in vitro.Science 1948;107:44-5.
    • (1948) , vol.107 , pp. 44-45
    • Eagle, H.1
  • 48
    • 0242456130 scopus 로고    scopus 로고
    • Bactericidal activity and synergy studies of BAL9141, a novel pyrrolidinone-3-ylidenemethyl cephem, tested against streptococci, enterococci and methicillin-resistant staphylococci
    • Deshpande LM, Jones RN. Bactericidal activity and synergy studies of BAL9141, a novel pyrrolidinone-3-ylidenemethyl cephem, tested against streptococci, enterococci and methicillin-resistant staphylococci. Clin Microbiol Infect 2003;9:1120-4.
    • (2003) Clin Microbiol Infect , vol.9 , pp. 1120-1124
    • Deshpande, L.M.1    Jones, R.N.2
  • 49
    • 3042531426 scopus 로고    scopus 로고
    • Multiple-dose pharmacokinetics and safety of a novel broad-spectrum cephalosporin (BAL5788) in healthy volunteers
    • Schmitt-Hoffmann A, Nyman L, Roos B, et al. Multiple-dose pharmacokinetics and safety of a novel broad-spectrum cephalosporin (BAL5788) in healthy volunteers. Antimicrob Agents Chemother 2004;48:2576-80.
    • (2004) Antimicrob Agents Chemother , vol.48 , pp. 2576-2580
    • Schmitt-Hoffmann, A.1    Nyman, L.2    Roos, B.3
  • 50
    • 37149012591 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of ceftobiprole, an anti-MRSA cephalosporin with broad-spectrum activity
    • Murthy B, Schmitt-Hoffmann A. Pharmacokinetics and pharmacodynamics of ceftobiprole, an anti-MRSA cephalosporin with broad-spectrum activity. Clin Pharmacokinet 2008;47:21-33.
    • (2008) Clin Pharmacokinet , vol.47 , pp. 21-33
    • Murthy, B.1    Schmitt-Hoffmann, A.2
  • 51
    • 33644821638 scopus 로고    scopus 로고
    • Ceftobiprole: In vivo profile of a bactericidal cephalosporin
    • Chambers HF. Ceftobiprole: in vivo profile of a bactericidal cephalosporin. Clin Microbiol Infect 2006;12(suppl 2):17-22.
    • (2006) Clin Microbiol Infect , vol.12 , Issue.SUPPL. 2 , pp. 17-22
    • Chambers, H.F.1
  • 56
    • 34248192771 scopus 로고    scopus 로고
    • Probability of target attainment for ceftobiprole as derived from a population pharmacokinetic analysis of 150 subjects
    • Lodise TP Jr, Pypstra R, Kahn JB, et al. Probability of target attainment for ceftobiprole as derived from a population pharmacokinetic analysis of 150 subjects. Antimicrob Agents Chemother 2007;51:2378-87.
    • (2007) Antimicrob Agents Chemother , vol.51 , pp. 2378-2387
    • Lodise Jr, T.P.1    Pypstra, R.2    Kahn, J.B.3
  • 57
    • 33750603827 scopus 로고    scopus 로고
    • Postantibiotic effect of ceftobiprole against 12 gram-positive organisms
    • Pankuch GA, Appelbaum PC. Postantibiotic effect of ceftobiprole against 12 gram-positive organisms. Antimicrob Agents Chemother 2006;50:3956-8.
    • (2006) Antimicrob Agents Chemother , vol.50 , pp. 3956-3958
    • Pankuch, G.A.1    Appelbaum, P.C.2
  • 58
    • 54049138039 scopus 로고    scopus 로고
    • In vivo pharmacodynamics of ceftobiprole against multiple bacterial pathogens in murine thigh and lung infection models
    • Craig WA, Andes DR. In vivo pharmacodynamics of ceftobiprole against multiple bacterial pathogens in murine thigh and lung infection models. Antimicrob Agents Chemother 2008;52:3492-6.
    • (2008) Antimicrob Agents Chemother , vol.52 , pp. 3492-3496
    • Craig, W.A.1    Andes, D.R.2
  • 59
    • 48749116554 scopus 로고    scopus 로고
    • Evaluation of the activity of ceftobiprole, linezolid, vancomycin, and daptomycin against community-associated (CA-MRSA) and hospital-associated (HA-MRSA) methicillin-resistant Staphylococcus aureus
    • Leonard SN, Cheung CM, Rybak MJ. Evaluation of the activity of ceftobiprole, linezolid, vancomycin, and daptomycin against community-associated (CA-MRSA) and hospital-associated (HA-MRSA) methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother 2008;52:2974-6.
    • (2008) Antimicrob Agents Chemother , vol.52 , pp. 2974-2976
    • Leonard, S.N.1    Cheung, C.M.2    Rybak, M.J.3
  • 61
    • 34250172067 scopus 로고    scopus 로고
    • Time-kill and synergism studies of ceftobiprole against Enterococcus faecalis, including β-lactamase-producing and vancomycin-resistant isolates
    • Arias CA, Singh KV, Panesso D, Murray BE. Time-kill and synergism studies of ceftobiprole against Enterococcus faecalis, including β-lactamase-producing and vancomycin-resistant isolates. Antimicrob Agents Chemother 2007;51:2043-7.
    • (2007) Antimicrob Agents Chemother , vol.51 , pp. 2043-2047
    • Arias, C.A.1    Singh, K.V.2    Panesso, D.3    Murray, B.E.4
  • 62
    • 66249146998 scopus 로고    scopus 로고
    • Ceftobiprole and levofloxacin are synergistic against an isolate of Pseudomonas aeruginosa as evaluated in a neutropenic mouse thigh infection model
    • Presented at the, Barcelona, Spain, April 19-22
    • Louie A, Fregeau C, Liu W, Bush K, Noel G, Drusano GL. Ceftobiprole and levofloxacin are synergistic against an isolate of Pseudomonas aeruginosa as evaluated in a neutropenic mouse thigh infection model. Presented at the 18th European congress of clinical microbiology and infectious diseases, Barcelona, Spain, April 19-22, 2008.
    • (2008) 18th European congress of clinical microbiology and infectious diseases
    • Louie, A.1    Fregeau, C.2    Liu, W.3    Bush, K.4    Noel, G.5    Drusano, G.L.6
  • 63
    • 66249126954 scopus 로고    scopus 로고
    • Kresken M, Heep M. In vitro activity of ceftobiprole in combination with ciprofloxacin, levofloxacin, amikacin, and tobramycin against clinical isolates of Pseudomonas aeruginosa. Presented as a poster at the 45th interscience conference on antimicrobial agents and chemotherapy, Washington, DC, December 16-19, 2005.
    • Kresken M, Heep M. In vitro activity of ceftobiprole in combination with ciprofloxacin, levofloxacin, amikacin, and tobramycin against clinical isolates of Pseudomonas aeruginosa. Presented as a poster at the 45th interscience conference on antimicrobial agents and chemotherapy, Washington, DC, December 16-19, 2005.
  • 64
    • 0036136841 scopus 로고    scopus 로고
    • BAL9141, a novel extended-spectrum cephalosporin active against methicillin-resistant Staphylococcus aureus in treatment of experimental endocarditis
    • Entenza JM, Hohl P, Heinze-Krauss I, Glauser MP, Moreillon P. BAL9141, a novel extended-spectrum cephalosporin active against methicillin-resistant Staphylococcus aureus in treatment of experimental endocarditis. Antimicrob Agents Chemother 2002;46:171-7.
    • (2002) Antimicrob Agents Chemother , vol.46 , pp. 171-177
    • Entenza, J.M.1    Hohl, P.2    Heinze-Krauss, I.3    Glauser, M.P.4    Moreillon, P.5
  • 65
    • 42949105446 scopus 로고    scopus 로고
    • Efficacies of ceftobiprole medocaril and comparators in a rabbit model of osteomyelitis due to methicillin-resistant Staphylococcus aureus
    • Yin LY, Calhoun JH, Thomas JK, Shapiro S, Schmitt-Hoffmann A. Efficacies of ceftobiprole medocaril and comparators in a rabbit model of osteomyelitis due to methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother 2008;52:1618-22.
    • (2008) Antimicrob Agents Chemother , vol.52 , pp. 1618-1622
    • Yin, L.Y.1    Calhoun, J.H.2    Thomas, J.K.3    Shapiro, S.4    Schmitt-Hoffmann, A.5
  • 66
    • 33746440232 scopus 로고    scopus 로고
    • Ceftobiprole medocaril (BAL5788) treatment of experimental Haemophilus influenzae , Enterobacter cloacae, and Klebsiella pneumoniae murine pneumonia
    • Rouse MS, Hein MM, Anguita-Alonso P, Steckelberg JM, Patel R. Ceftobiprole medocaril (BAL5788) treatment of experimental Haemophilus influenzae , Enterobacter cloacae, and Klebsiella pneumoniae murine pneumonia. Diagn Microbiol Infect Dis 2006;55:333-6.
    • (2006) Diagn Microbiol Infect Dis , vol.55 , pp. 333-336
    • Rouse, M.S.1    Hein, M.M.2    Anguita-Alonso, P.3    Steckelberg, J.M.4    Patel, R.5
  • 67
    • 46249085997 scopus 로고    scopus 로고
    • Pharmacodynamic characterization of ceftobiprole in experimental pneumonia caused by phenotypically diverse Staphylococcus aureus strains
    • Laohavaleeson S, Tessier PR, Nicolau DP. Pharmacodynamic characterization of ceftobiprole in experimental pneumonia caused by phenotypically diverse Staphylococcus aureus strains. Antimicrob Agents Chemother 2008;52:2389-94.
    • (2008) Antimicrob Agents Chemother , vol.52 , pp. 2389-2394
    • Laohavaleeson, S.1    Tessier, P.R.2    Nicolau, D.P.3
  • 69
    • 37849009009 scopus 로고    scopus 로고
    • Results of a double-blind, randomized trial of ceftobiprole treatment of complicated skin and skin structure infections caused by gram-positive bacteria
    • Noel GJ, Strauss RS, Amsler K, Heep M, Pypstra R, Solomkin JS. Results of a double-blind, randomized trial of ceftobiprole treatment of complicated skin and skin structure infections caused by gram-positive bacteria. Antimicrob Agents Chemother 2008;52:37-44.
    • (2008) Antimicrob Agents Chemother , vol.52 , pp. 37-44
    • Noel, G.J.1    Strauss, R.S.2    Amsler, K.3    Heep, M.4    Pypstra, R.5    Solomkin, J.S.6
  • 70
    • 39749117473 scopus 로고    scopus 로고
    • A randomized, double-blind trial comparing ceftobiprole medocaril with vancomycin plus ceftazidime for the treatment of patients with complicated skin and skin-structure infections
    • Noel GJ, Bush K, Bagchi P, Ianus J, Strauss RS. A randomized, double-blind trial comparing ceftobiprole medocaril with vancomycin plus ceftazidime for the treatment of patients with complicated skin and skin-structure infections. Clin Infect Dis 2008;46:647-55.
    • (2008) Clin Infect Dis , vol.46 , pp. 647-655
    • Noel, G.J.1    Bush, K.2    Bagchi, P.3    Ianus, J.4    Strauss, R.S.5
  • 71
    • 84898696950 scopus 로고    scopus 로고
    • Efficacy of ceftobiprole compared to ceftriaxone ± linezolid for the treatment of subjects hospitalized with community-acquired pneumoniae
    • Presented at the, Toronto, Ontario, Canada, May 16-21
    • Nicholson SC, Strauss RS, Michiels B, Noel GJ. Efficacy of ceftobiprole compared to ceftriaxone ± linezolid for the treatment of subjects hospitalized with community-acquired pneumoniae. Presented at the international conference of the American Thoracic Society, Toronto, Ontario, Canada, May 16-21, 2008.
    • (2008) international conference of the American Thoracic Society
    • Nicholson, S.C.1    Strauss, R.S.2    Michiels, B.3    Noel, G.J.4
  • 73
    • 84868952233 scopus 로고    scopus 로고
    • Available from, Accessed July 9, 2008
    • National Institutes of Health. Clinical trials for ceftobiprole. Available from http://clinicaltrials.gov/ct2/results?term=ceftobiprole. Accessed July 9, 2008.
    • Clinical trials for ceftobiprole
  • 74
    • 41949123083 scopus 로고    scopus 로고
    • The efficacy and safety of ceftobiprole in the treatment of complicated skin and skin structure infections: Evidence from 2 clinical trials
    • Deresinski SC. The efficacy and safety of ceftobiprole in the treatment of complicated skin and skin structure infections: evidence from 2 clinical trials. Diagn Microbiol Infect Dis 2008;61:103-9.
    • (2008) Diagn Microbiol Infect Dis , vol.61 , pp. 103-109
    • Deresinski, S.C.1
  • 75
    • 66249097868 scopus 로고    scopus 로고
    • Balis D, Strauss R, Murthy B, Tiian H, Noel GJ. QT/QTc assessment of ceftobiprole in a single-dose study. Presented as a poster at the 17th European congress of clinical microbiology and infectious diseases, Munich, Germany, March 31-April 2, 2007.
    • Balis D, Strauss R, Murthy B, Tiian H, Noel GJ. QT/QTc assessment of ceftobiprole in a single-dose study. Presented as a poster at the 17th European congress of clinical microbiology and infectious diseases, Munich, Germany, March 31-April 2, 2007.
  • 76
    • 50249187001 scopus 로고    scopus 로고
    • Compatibility of ceftobiprole medocaril with selected drugs during simulated Ysite administration
    • Chan P, Bishop A, Kupiec TC, et al. Compatibility of ceftobiprole medocaril with selected drugs during simulated Ysite administration. Am J Health Syst Pharm 2008;65:1545-51.
    • (2008) Am J Health Syst Pharm , vol.65 , pp. 1545-1551
    • Chan, P.1    Bishop, A.2    Kupiec, T.C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.